气候变化领域集成服务门户(CCPortal): Nanomedicine enables autophagy-enhanced cancer-cell ferroptosis

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DOI	10.1016/j.scib.2020.10.021
	Nanomedicine enables autophagy-enhanced cancer-cell ferroptosis
	Yang J.; Ding L.; Yu L.; Wang Y.; Ge M.; Jiang Q.; Chen Y.
发表日期	2021
ISSN	20959273
起始页码	464
结束页码	477
卷号	66 期号:5
英文摘要	Ferroptosis and autophagy, playing significant roles in tumor treatment, are two typical forms of the programmed cell death. However, the rational combination of ferroptosis and autophagy for synergistic tumor therapy is still highly challenging. Herein, we report on an intriguing nanomedicine strategy for achieving autophagy-enhanced ferroptosis on efficiently combating cancer, which was based on the construction of trehalose-loaded mSiO2@MnOx-mPEG (TreMMM) nanoparticles with satisfactory biocompatibility. The nanoparticles are endowed with high glutathione (GSH) consumption efficiency, thereby inducing cancer-cell ferroptosis via inactivating glutathione peroxidases 4 (GPX4). Subsequently, the TreMMM degradation due to the GSH depletion and pH sensitivity contributed to the trehalose release for inducing autophagy, promoting/enhancing ferroptosis by NCOA4-mediated degradation of ferritin. A substantial in vitro and in vivo antitumor effect was achieved by such an intriguing autophagy-enhanced ferroptosis. Therefore, the rational combination of GSH-consumption-induced ferroptosis and trehalose-induced autophagy by nanomedicine design provides an alternative but effective strategy for tumor treatment. © 2020 Science China Press
关键词	Autophagy Ferroptosis Manganese oxide Mesoporous silica Trehalose Tumor therapy
英文关键词	Biocompatibility; Diseases; Medical nanotechnology; Nanoparticles; Peptides; Tumors; Antitumor effect; Cancer cells; Glutathione peroxidase; Glutathiones; PH sensitivity; Programmed cell deaths; Tumor therapy; Tumor treatment; Cell death
语种	英语
来源期刊	Science Bulletin
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/207634
作者单位	State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China; Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing, 100049, China
推荐引用方式 GB/T 7714	Yang J.,Ding L.,Yu L.,et al. Nanomedicine enables autophagy-enhanced cancer-cell ferroptosis[J],2021,66(5).
APA	Yang J..,Ding L..,Yu L..,Wang Y..,Ge M..,...&Chen Y..(2021).Nanomedicine enables autophagy-enhanced cancer-cell ferroptosis.Science Bulletin,66(5).
MLA	Yang J.,et al."Nanomedicine enables autophagy-enhanced cancer-cell ferroptosis".Science Bulletin 66.5(2021).