气候变化领域集成服务门户(CCPortal): Janus γ-Fe2O3/SiO2-based nanotheranostics for dual-modal imaging and enhanced synergistic cancer starvation/chemodynamic therapy

CCPortal

DOI	10.1016/j.scib.2019.12.024
	Janus γ-Fe2O3/SiO2-based nanotheranostics for dual-modal imaging and enhanced synergistic cancer starvation/chemodynamic therapy
	Zhang Y.; Wan Y.; Liao Y.; Hu Y.; Jiang T.; He T.; Bi W.; Lin J.; Gong P.; Tang L.; Huang P.
发表日期	2020
ISSN	20959273
起始页码	564
结束页码	572
卷号	65 期号:7
英文摘要	Multimodal cancer synergistic therapy exhibited remarkable advantages over monotherapy in producing an improved therapeutic efficacy. In this work, Janus-type γ-Fe2O3/SiO2 nanoparticles (JFSNs) are conjugated with glucose oxidase (GOx) for synergistic cancer starvation/chemodynamic therapy. The γ-Fe2O3 hemisphere of JFSNs can perform photoacoustic/T2 magnetic resonance dual-modal imaging of tumors. GOx on the surface of JFSNs catalyzes the decomposition of glucose and produces H2O2 for cancer starvation therapy. Subsequently, the γ-Fe2O3 hemisphere catalyzes the disproportionation of H2O2 to generate highly reactive hydroxyl radicals in an acidic tumor microenvironment. The close distance between GOx and JFSNs ensures adequate contact between the γ-Fe2O3 hemisphere and its substrate H2O2, thus enhancing the catalytic efficiency. This synergy of glucose depletion, biotoxic H2O2 and hydroxyl radicals significantly suppresses 4T1 mammary tumor growth with minimal adverse effects. © 2020 Science China Press
关键词	Fenton-like reaction Glucose oxidase Janus nanoparticles Synergistic therapy Theranostics
英文关键词	Catalysis; Diseases; Glucose; Glucose oxidase; Glucose sensors; Magnetic resonance; Nanoparticles; Oxidation; Tumors; Catalytic efficiencies; Fenton-like reactions; Glucose oxidases (GOx); Janus nanoparticles; Synergistic therapy; Theranostics; Therapeutic efficacy; Tumor microenvironment; Hematite
语种	英语
来源期刊	Science Bulletin
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/207311
作者单位	Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Health Science Center, Shenzhen, 518060, China; State Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou, 310027, China; Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China; Department of General Surgery, Shenzhen University General Hospital, Shenzhen, 518055, China
推荐引用方式 GB/T 7714	Zhang Y.,Wan Y.,Liao Y.,et al. Janus γ-Fe2O3/SiO2-based nanotheranostics for dual-modal imaging and enhanced synergistic cancer starvation/chemodynamic therapy[J],2020,65(7).
APA	Zhang Y..,Wan Y..,Liao Y..,Hu Y..,Jiang T..,...&Huang P..(2020).Janus γ-Fe2O3/SiO2-based nanotheranostics for dual-modal imaging and enhanced synergistic cancer starvation/chemodynamic therapy.Science Bulletin,65(7).
MLA	Zhang Y.,et al."Janus γ-Fe2O3/SiO2-based nanotheranostics for dual-modal imaging and enhanced synergistic cancer starvation/chemodynamic therapy".Science Bulletin 65.7(2020).