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| DOI | 10.1016/j.scib.2020.04.012 |
| Biomaterial scaffold-based local drug delivery systems for cancer immunotherapy | |
| Yang C.; Blum N.T.; Lin J.; Qu J.; Huang P. | |
| 发表日期 | 2020 |
| ISSN | 20959273 |
| 起始页码 | 1489 |
| 结束页码 | 1504 |
| 卷号 | 65期号:17 |
| 英文摘要 | Immunotherapy has attracted tremendous attention due to the remarkable clinical successes for treating a broad spectrum of tumors. One challenge for cancer immunotherapy is the inability to control localization and sustain concentrations of therapeutics at tumor sites. Local drug delivery systems (LDDSs) like the biomaterial scaffold-based drug delivery systems have emerged as a promising approach for delivering immunotherapeutic agents facilely and intensively in situ with reduced systemic toxicity. In this review, recent advances in biomaterial scaffold-based LDDSs for the administration of immunotherapeutic agents including vaccines, immunomodulators, and immune cells are summarized. Moreover, co-delivery systems are also evaluated for local immunotherapy-involving combination anti-tumor therapy, including chemotherapy-immunotherapy, photothermal-immunotherapy, and other combination therapies. Finally, the current challenges and future perspectives on the development of next-generation LDDSs for cancer immunotherapy are discussed. © 2020 Science China Press |
| 关键词 | Cancer immunotherapyCombination therapyControlled drug deliveryHydrogelLocal drug delivery systemScaffold |
| 英文关键词 | Chemotherapy; Diseases; Scaffolds (biology); Targeted drug delivery; Tumors; Biomaterial scaffolds; Cancer immunotherapy; Combination therapy; Drug delivery system; Future perspectives; Immunotherapeutic; Local drug delivery; Systemic toxicities; Controlled drug delivery |
| 语种 | 英语 |
| 来源期刊 | Science Bulletin
 |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/207254 |
| 作者单位 | Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Health Science Center, Shenzhen, 518060, China; Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen, 518060, China |
| 推荐引用方式 GB/T 7714 | Yang C.,Blum N.T.,Lin J.,et al. Biomaterial scaffold-based local drug delivery systems for cancer immunotherapy[J],2020,65(17). |
| APA | Yang C.,Blum N.T.,Lin J.,Qu J.,&Huang P..(2020).Biomaterial scaffold-based local drug delivery systems for cancer immunotherapy.Science Bulletin,65(17). |
| MLA | Yang C.,et al."Biomaterial scaffold-based local drug delivery systems for cancer immunotherapy".Science Bulletin 65.17(2020). |
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