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期刊论文 [11]
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2020 [11]
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英语 [11]
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Science [9]
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Human CNS barrier-forming organoids with cerebrospinal fluid production
期刊论文
, 2020, 卷号: 369, 期号: 6500
作者:
Pellegrini L.
;
Bonfio C.
;
Chadwick J.
;
Begum F.
;
Skehel M.
;
Lancaster M.A.
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2020/07/28
blood brain barrier
cell culture technique
cerebrospinal fluid
choroid plexus
gene expression profiling
human
metabolism
organoid
physiology
protein cerebrospinal fluid level
proteomics
single cell analysis
Blood-Brain Barrier
Cell Culture Techniques
Cerebrospinal Fluid
Cerebrospinal Fluid Proteins
Choroid Plexus
Gene Expression Profiling
Humans
Organoids
Proteomics
Single-Cell Analysis
Widespread receptor-driven modulation in peripheral olfactory coding
期刊论文
, 2020, 卷号: 368, 期号: 6487
作者:
Xu L.
;
Li W.
;
Voleti V.
;
Zou D.-J.
;
Hillman E.M.C.
;
Firestein S.
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2020/07/28
antagonism
cell component
detection method
odor
olfaction
protein
animal cell
animal experiment
article
excitation
high throughput analysis
male
microscopy
mouse
nonhuman
odor
olfactory epithelium
olfactory receptor neuron
animal
confocal microscopy
innervation
mutant mouse strain
olfactory mucosa
physiology
single cell analysis
acetophenone
acetophenone derivative
benzyl acetate
benzyl derivative
citral
fragrance
Acetophenones
Acyclic Monoterpenes
Animals
Benzyl Compounds
Mice
Mice, Mutant Strains
Microscopy, Confocal
Odorants
Olfactory Mucosa
Olfactory Receptor Neurons
Single-Cell Analysis
Smell
Metabolomics and mass spectrometry imaging reveal channeled de novo purine synthesis in cells
期刊论文
, 2020, 卷号: 368, 期号: 6488
作者:
Pareek V.
;
Tian H.
;
Winograd N.
;
Benkovic S.J.
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2020/07/28
adenosine phosphate
guanosine phosphate
multienzyme complex
nucleotide
purine
purine
purine derivative
cell
experimental study
imaging method
mass spectrometry
metabolism
protein
Article
biochemistry
enzyme assay
gas cluster ion beam secondary ion mass spectrometry
image analysis
mass spectrometry
metabolomics
mitochondrion
molecular imaging
molecular probe
priority journal
purine synthesis
reaction analysis
single cell analysis
biosynthesis
fluorescence imaging
HeLa cell line
human
metabolism
metabolomics
procedures
secondary ion mass spectrometry
HeLa Cells
Humans
Metabolomics
Mitochondria
Multienzyme Complexes
Optical Imaging
Purines
Single-Cell Analysis
Spectrometry, Mass, Secondary Ion
Single-cell transcriptional diversity is a hallmark of developmental potential
期刊论文
, 2020, 卷号: 367, 期号: 6476
作者:
Gulati G.S.
;
Sikandar S.S.
;
Wesche D.J.
;
Manjunath A.
;
Bharadwaj A.
;
Berger M.J.
;
Ilagan F.
;
Kuo A.H.
;
Hsieh R.W.
;
Cai S.
;
Zabala M.
;
Scheeren F.A.
;
Lobo N.A.
;
Qian D.
;
Yu F.B.
;
Dirbas F.M.
;
Clarke M.F.
;
Newman A.M.
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2020/07/28
cell
cell component
developmental biology
experimental study
genetic analysis
tumor
Article
breast cancer
breast carcinogenesis
carcinogenesis
cell differentiation
computer model
embryonic stem cell
gene expression
genetic code
genetic variability
human
in vivo study
nonhuman
phenotype
priority journal
scoring system
single cell RNA seq
upregulation
Very fast CRISPR on demand
期刊论文
, 2020, 卷号: 368, 期号: 6496
作者:
Liu Y.
;
Zou R.S.
;
He S.
;
Nihongaki Y.
;
Li X.
;
Razavi S.
;
Wu B.
;
Ha T.
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2020/07/28
Cas9 endonuclease Streptococcus pyogenes
double strand break repair protein MRE11
H2AX protein, human
histone
MRE11 protein, human
CRISPR Cas system
DNA cleavage
DNA repair
double stranded DNA break
fluorescence imaging
gene editing
genetics
HEK293 cell line
human
light
metabolism
phosphorylation
procedures
radiation response
single cell analysis
CRISPR-Associated Protein 9
CRISPR-Cas Systems
DNA Breaks, Double-Stranded
DNA Cleavage
DNA Repair
Gene Editing
HEK293 Cells
Histones
Humans
Light
MRE11 Homologue Protein
Optical Imaging
Phosphorylation
Single-Cell Analysis
The evolutionary dynamics and fitness landscape of clonal hematopoiesis
期刊论文
, 2020, 卷号: 367, 期号: 6485
作者:
Watson C.J.
;
Papula A.L.
;
Poon G.Y.P.
;
Wong W.H.
;
Young A.L.
;
Druley T.E.
;
Fisher D.S.
;
Blundell J.R.
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2020/07/28
DNA methyltransferase 3A
blood
cancer
evolutionary biology
fitness
gene expression
genetic drift
hematology
mutation
pathogenicity
acute myeloid leukemia
age distribution
allele
Article
cancer risk
cell expansion
cell population
clonal hematopoiesis
epigenetics
gene mutation
genetic variability
hematological parameters
hematopoiesis
hematopoietic stem cell
human
molecular evolution
mutational analysis
nonhuman
priority journal
single nucleotide polymorphism
somatic mutation
stem cell self-renewal
Massively multiplex chemical transcriptomics at single-cell resolution
期刊论文
, 2020, 卷号: 367, 期号: 6473
作者:
Srivatsan S.R.
;
McFaline-Figueroa J.L.
;
Ramani V.
;
Saunders L.
;
Cao J.
;
Packer J.
;
Pliner H.A.
;
Jackson D.L.
;
Daza R.M.
;
Christiansen L.
;
Zhang F.
;
Steemers F.
;
Shendure J.
;
Trapnell C.
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2020/07/28
4 (2 aminoethylamino) 1,8 dimethylimidazo[1,2 a]quinoxaline
abexinostat
acetic acid
belinostat
cudc 101
fimepinostat
givinostat
histone deacetylase inhibitor
m 344
n [2 [3 (1 piperazinylmethyl)imidazo[2,1 b]thiazol 6 yl]phenyl] 2 quinoxalinecarboxamide
panobinostat
pracinostat
rec 2282
trametinib
transcriptome
trichostatin A
unclassified drug
transcriptome
cancer
cell
chemical analysis
detection method
experimental study
genetic analysis
resolution
A-549 cell line
animal cell
animal experiment
Article
cell function
cell heterogeneity
cell labeling
cell proliferation
chromatin
controlled study
dose response
drug activity
experimentation
gene control
genetic transcription
human
human cell
K-562 cell line
MCF-7 cell line
mouse
nonhuman
pilot study
priority journal
proof of concept
RNA sequence
screening
single cell analysis
transcriptomics
cell nucleus
drug effect
genetics
genomics
high throughput screening
metabolism
neoplasm
procedures
single cell analysis
A549 Cells
Acetates
Cell Nucleus
Chromatin
Genomics
High-Throughput Screening Assays
Histone Deacetylase Inhibitors
Humans
K562 Cells
MCF-7 Cells
Neoplasms
RNA-Seq
Single-Cell Analysis
Transcriptome
Regenerative potential of prostate luminal cells revealed by single-cell analysis
期刊论文
, 2020, 卷号: 368, 期号: 6490
作者:
Karthaus W.R.
;
Hofree M.
;
Choi D.
;
Linton E.L.
;
Turkekul M.
;
Bejnood A.
;
Carver B.
;
Gopalan A.
;
Abida W.
;
Laudone V.
;
Biton M.
;
Chaudhary O.
;
Xu T.
;
Masilionis I.
;
Manova K.
;
Mazutis L.
;
Pe’er D.
;
Regev A.
;
Sawyers C.L.
收藏
  |  
浏览/下载:202/0
  |  
提交时间:2020/07/28
androgen
growth factor
Nrg2 growth factor
Rspo3 growth factor
unclassified drug
androgen binding protein
antiandrogen
ataxin 1
Atxn1 protein, mouse
glycosylphosphatidylinositol anchored protein
homeodomain protein
nerve growth factor
Nkx3-1 protein, mouse
Nrg2 protein, mouse
probasin
Psca protein, mouse
R-spondin3 protein, mouse
thrombospondin
transcription factor
tumor antigen
tumor protein
androgen
cancer
cell
gene expression
RNA
rodent
ablation therapy
animal cell
animal tissue
Article
cell differentiation
cell population
cell regeneration
cells by body anatomy
controlled study
gene
gene expression
human
luminal cell
male
mesenchyme cell
mouse
nonhuman
paracrine signaling
priority journal
prostate cell
prostate tissue
protein expression
Psca gene
RNA sequencing
Sca1 gene
single cell analysis
animal
genetics
mesenchymal stem cell
metabolism
organ size
organoid
physiology
prostate
prostate tumor
regeneration
sequence analysis
single cell analysis
Mus
Androgen Antagonists
Androgen-Binding Protein
Androgens
Animals
Antigens, Neoplasm
Ataxin-1
Cell Differentiation
Gene Expression
GPI-Linked Proteins
Homeodomain Proteins
Humans
Male
Mesenchymal Stem Cells
Mice
Neoplasm Proteins
Nerve Growth Factors
Organ Size
Organoids
Prostate
Prostatic Neoplasms
Regeneration
Sequence Analysis, RNA
Single-Cell Analysis
Thrombospondins
Transcription Factors
Cell position fates and collective fountain flow in bacterial biofilms revealed by light-sheet microscopy
期刊论文
, 2020, 卷号: 369, 期号: 6499
作者:
Qin B.
;
Fei C.
;
Bridges A.A.
;
Mashruwala A.A.
;
Stone H.A.
;
Wingreen N.S.
;
Bassler B.L.
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2020/07/28
bacterial protein
scleroprotein
biofilm
cytology
genetics
metabolism
microscopy
motion
mutation
physiology
procedures
single cell analysis
Vibrio cholerae
Bacterial Proteins
Biofilms
Extracellular Matrix Proteins
Microscopy
Motion
Mutation
Single-Cell Analysis
Vibrio cholerae
Lineage tracing on transcriptional landscapes links state to fate during differentiation
期刊论文
, 2020, 卷号: 367, 期号: 6479
作者:
Weinreb C.
;
Rodriguez-Fraticelli A.
;
Camargo F.D.
;
Klein A.M.
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2020/07/28
biology
cell component
differentiation
DNA
RNA
transcriptome
algorithm
animal
cell lineage
cytology
DNA barcoding
gene expression
genetics
hematopoiesis
monocyte
mouse
procedures
single cell analysis
Algorithms
Animals
Cell Lineage
DNA Barcoding, Taxonomic
Gene Expression
Hematopoiesis
Mice
Monocytes
RNA-Seq
Single-Cell Analysis
Transcriptome