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Elesclomol alleviates Menkes pathology and mortality by escorting Cu to cuproenzymes in mice 期刊论文
, 2020, 卷号: 368, 期号: 6491
作者:  Guthrie L.M.;  Soma S.;  Yuan S.;  Silva A.;  Zulkifli M.;  Snavely T.C.;  Greene H.F.;  Nunez E.;  Lynch B.;  de Ville C.;  Shanbhag V.;  Lopez F.R.;  Acharya A.;  Petris M.J.;  Kim B.-E.;  Gohil V.M.;  Sacchettini J.C.
收藏  |  浏览/下载：37/0  |  提交时间：2020/07/28
copper  copper zinc superoxide dismutase  cytochrome c oxidase  dopamine beta monooxygenase  elesclomol  monophenol monooxygenase  protein lysine 6 oxidase  copper  cytochrome c oxidase  elesclomol  hydrazine derivative  copper  cytochrome  enzyme  enzyme activity  mitochondrion  mortality  mutation  pathology  rodent  survival  animal cell  animal experiment  animal model  animal tissue  Article  cohort analysis  controlled study  disease severity  drug mechanism  Golgi complex  H9c2(2-1) cell line  in vivo study  male  Menkes syndrome  mitochondrial dynamics  mortality rate  mouse  nerve degeneration  nonhuman  priority journal  secretory pathway  survival rate  animal  brain  cell line  degenerative disease  disease model  drug effect  genetics  knockout mouse  Menkes syndrome  metabolism  mitochondrion  pathology  rat  transport at the cellular level  Murinae  Mus  Animals  Biological Transport  Brain  Cell Line  Copper  Copper Transporter 1  Disease Models, Animal  Electron Transport Complex IV  Hydrazines  Male  Menkes Kinky Hair Syndrome  Mice  Mice, Knockout  Mitochondria  Neurodegenerative Diseases  Rats  
Microglia monitor and protect neuronal function through specialized somatic purinergic junctions 期刊论文
, 2020, 卷号: 367, 期号: 6477
作者:  Cserép C.;  Pósfai B.;  Lénárt N.;  Fekete R.;  László Z.I.;  Lele Z.;  Orsolits B.;  Molnár G.;  Heindl S.;  Schwarcz A.D.;  Ujvári K.;  Környei Z.;  Tóth K.;  Szabadits E.;  Sperlágh B.;  Baranyi M.;  Csiba L.;  Hortobágyi T.;  Maglóczky Z.;  Martinecz B.;  Szabó G.;  Erdélyi F.;  Szipocs R.;  Tamkun M.M.;  Gesierich B.;  Duering M.;  Katona I.;  Liesz A.;  Tamás G.;  Dénes Á.
收藏  |  浏览/下载：42/0  |  提交时间：2020/07/28
calcium  purinergic P2Y12 receptor  brain  cell component  homeostasis  inhibition  protein  animal cell  Article  brain injury  controlled study  functional connectivity  human  human cell  microglia  mitochondrion  mouse  nerve cell  neuroprotection  nonhuman  perikaryon  priority journal  signal transduction  somatic microglia neuron junction  
Correlative three-dimensional super-resolution and block-face electron microscopy of whole vitreously frozen cells 期刊论文
, 2020, 卷号: 367, 期号: 6475
作者:  Hoffman D.P.;  Shtengel G.;  Xu C.S.;  Campbell K.R.;  Freeman M.;  Wang L.;  Milkie D.E.;  Pasolli H.A.;  Iyer N.;  Bogovic J.A.;  Stabley D.R.;  Shirinifard A.;  Pang S.;  Peale D.;  Schaefer K.;  Pomp W.;  Chang C.-L.;  Lippincott-Schwartz J.;  Kirchhausen T.;  Solecki D.J.;  Betzig E.;  Hess H.F.
收藏  |  浏览/下载：50/0  |  提交时间：2020/07/28
cell  compartmentalization  cryopreservation  electron microscopy  image resolution  protein  three-dimensional modeling  ultrastructure  article  chromatin  electron microscopy  endoplasmic reticulum  genetic transcription  human cell  mammal cell  nerve cell culture  protein domain  ultrastructure  whole cell  workflow  animal  cell adhesion  cells  Chlorocebus aethiops  cryoelectron microscopy  CV-1 cell line  fluorescence microscopy  freezing  HeLa cell line  human  mouse  procedures  three-dimensional imaging  tumor cell line  ultrastructure  Mammalia  Animals  Cell Adhesion  Cell Line, Tumor  Cells  Chlorocebus aethiops  COS Cells  Cryoelectron Microscopy  Freezing  HeLa Cells  Humans  Imaging, Three-Dimensional  Mice  Microscopy, Fluorescence  
Dopaminylation of histone H3 in ventral tegmental area regulates cocaine seeking 期刊论文
, 2020, 卷号: 368, 期号: 6487
作者:  Lepack A.E.;  Werner C.T.;  Stewart A.F.;  Fulton S.L.;  Zhong P.;  Farrelly L.A.;  Smith A.C.W.;  Ramakrishnan A.;  Lyu Y.;  Bastle R.M.;  Martin J.A.;  Mitra S.;  O'Connor R.M.;  Wang Z.-J.;  Molina H.;  Turecki G.;  Shen L.;  Yan Z.;  Calipari E.S.;  Dietz D.M.;  Kenny P.J.;  Maze I.
收藏  |  浏览/下载：51/0  |  提交时间：2020/07/28
amidase  dopamine  histone H3  histone transamidase  protein glutamine gamma glutamyltransferase 2  RNA  unclassified drug  brain  cell  chemical compound  chemical reaction  gene expression  genetic analysis  protein  action potential  amino acid substitution  amino terminal sequence  Article  cocaine dependence  controlled study  dopamine release  dopaminergic nerve cell  dopaminergic transmission  down regulation  drug seeking behavior  enzyme activity  gene expression  histone dopaminylation  histone modification  human  human tissue  hyperpolarization  in vitro study  motivation  nerve cell plasticity  nerve projection  neuropathology  nucleus accumbens  priority journal  protein expression  protein function  reward  RNA sequence  ventral tegmentum  Rattus  
A central master driver of psychosocial stress responses in the rat 期刊论文
, 2020, 卷号: 367, 期号: 6482
作者:  Kataoka N.;  Shima Y.;  Nakajima K.;  Nakamura K.
收藏  |  浏览/下载：50/0  |  提交时间：2020/07/28
vesicular glutamate transporter 1  glutamic acid  Slc17a7 protein, rat  vesicular glutamate transporter 1  brain  homeostasis  physiological response  psychology  rodent  Article  behavioral stress  brain region  emotion  forebrain  homeostasis  human  hypothalamus  in vivo study  innervation  mental stress  nerve cell  nerve tract  nonhuman  optogenetics  priority journal  social defeat  social stress  tenia tecta  thermogenesis  animal  dorsomedial hypothalamic nucleus  female  Long Evans cinnamon rat  male  mental stress  metabolism  physiology  prefrontal cortex  psychosomatic disorder  rat  signal transduction  social behavior  Wistar rat  Rattus  Animals  Dorsomedial Hypothalamic Nucleus  Emotions  Female  Glutamic Acid  Homeostasis  Male  Neurons  Prefrontal Cortex  Prosencephalon  Psychophysiologic Disorders  Rats  Rats, Inbred LEC  Rats, Wistar  Signal Transduction  Social Behavior  Stress, Psychological  Vesicular Glutamate Transport Protein 1  
Regenerative potential of prostate luminal cells revealed by single-cell analysis 期刊论文
, 2020, 卷号: 368, 期号: 6490
作者:  Karthaus W.R.;  Hofree M.;  Choi D.;  Linton E.L.;  Turkekul M.;  Bejnood A.;  Carver B.;  Gopalan A.;  Abida W.;  Laudone V.;  Biton M.;  Chaudhary O.;  Xu T.;  Masilionis I.;  Manova K.;  Mazutis L.;  Pe’er D.;  Regev A.;  Sawyers C.L.
收藏  |  浏览/下载：229/0  |  提交时间：2020/07/28
androgen  growth factor  Nrg2 growth factor  Rspo3 growth factor  unclassified drug  androgen binding protein  antiandrogen  ataxin 1  Atxn1 protein, mouse  glycosylphosphatidylinositol anchored protein  homeodomain protein  nerve growth factor  Nkx3-1 protein, mouse  Nrg2 protein, mouse  probasin  Psca protein, mouse  R-spondin3 protein, mouse  thrombospondin  transcription factor  tumor antigen  tumor protein  androgen  cancer  cell  gene expression  RNA  rodent  ablation therapy  animal cell  animal tissue  Article  cell differentiation  cell population  cell regeneration  cells by body anatomy  controlled study  gene  gene expression  human  luminal cell  male  mesenchyme cell  mouse  nonhuman  paracrine signaling  priority journal  prostate cell  prostate tissue  protein expression  Psca gene  RNA sequencing  Sca1 gene  single cell analysis  animal  genetics  mesenchymal stem cell  metabolism  organ size  organoid  physiology  prostate  prostate tumor  regeneration  sequence analysis  single cell analysis  Mus  Androgen Antagonists  Androgen-Binding Protein  Androgens  Animals  Antigens, Neoplasm  Ataxin-1  Cell Differentiation  Gene Expression  GPI-Linked Proteins  Homeodomain Proteins  Humans  Male  Mesenchymal Stem Cells  Mice  Neoplasm Proteins  Nerve Growth Factors  Organ Size  Organoids  Prostate  Prostatic Neoplasms  Regeneration  Sequence Analysis, RNA  Single-Cell Analysis  Thrombospondins  Transcription Factors  
The integrated stress response: From mechanism to disease 期刊论文
, 2020, 卷号: 368, 期号: 6489
作者:  [无可用作者姓名]
收藏  |  浏览/下载：30/0  |  提交时间：2020/07/28
initiation factor 2  cell component  cognition  disease  homeostasis  protein  quality control  5' untranslated region  adulthood  Article  cell reprogramming technique  cellular stress response  cognitive defect  diabetes mellitus  disease activity  eukaryotic cell  gene expression  human  long term memory  malignant neoplasm  metabolic disorder  nerve degeneration  nonhuman  oxidative stress  pathogenesis  phosphorylation  priority journal  protein defect  protein homeostasis  RNA translation  signal transduction  translation initiation  virus infection  
Maintenance of neural stem cell positional identity by mixed-lineage leukemia 1 期刊论文
, 2020, 卷号: 368, 期号: 6486
作者:  Delgado R.N.;  Mansky B.;  Ahanger S.H.;  Lu C.;  Andersen R.E.;  Dou Y.;  Alvarez-Buylla A.;  Lim D.A.
收藏  |  浏览/下载：30/0  |  提交时间：2020/07/28
mixed lineage leukemia 1 protein  mixed lineage leukemia protein  morphogen  sonic hedgehog protein  unclassified drug  anatomy  brain  cell component  developmental biology  inhibition  adult  animal cell  animal experiment  animal tissue  Article  controlled study  embryo  epigenetics  forebrain  in vivo study  memory  Mll1 gene  mouse  nerve cell  nerve cell differentiation  neural stem cell  nonhuman  priority journal  Erinaceidae  Murinae  
An atlas of the protein-coding genes in the human, pig, and mouse brain 期刊论文
, 2020, 卷号: 367, 期号: 6482
作者:  Sjöstedt E.;  Zhong W.;  Fagerberg L.;  Karlsson M.;  Mitsios N.;  Adori C.;  Oksvold P.;  Edfors F.;  Limiszewska A.;  Hikmet F.;  Huang J.;  Du Y.;  Lin L.;  Dong Z.;  Yang L.;  Liu X.;  Jiang H.;  Xu X.;  Wang J.;  Yang H.;  Bolund L.;  Mardinoglu A.;  Zhang C.;  von Feilitzen K.;  Lindskog C.;  Pontén F.;  Luo Y.;  Hökfelt T.;  Uhlén M.;  Mulder J.
收藏  |  浏览/下载：34/0  |  提交时间：2020/07/28
nerve protein  transcriptome  animal  antibody specificity  book  brain  C57BL mouse  comparative study  female  gene expression regulation  genetics  human  information processing  male  mouse  physiology  pig  species difference  Animals  Atlases as Topic  Brain  Datasets as Topic  Female  Gene Expression Regulation  Humans  Male  Mice  Mice, Inbred C57BL  Nerve Tissue Proteins  Organ Specificity  Species Specificity  Swine  Transcriptome  
An atlas of the protein-coding genes in the human, pig, and mouse brain 期刊论文
, 2020, 卷号: 367, 期号: 6482
作者:  Sjöstedt E.;  Zhong W.;  Fagerberg L.;  Karlsson M.;  Mitsios N.;  Adori C.;  Oksvold P.;  Edfors F.;  Limiszewska A.;  Hikmet F.;  Huang J.;  Du Y.;  Lin L.;  Dong Z.;  Yang L.;  Liu X.;  Jiang H.;  Xu X.;  Wang J.;  Yang H.;  Bolund L.;  Mardinoglu A.;  Zhang C.;  Von Feilitzen K.;  Lindskog C.;  Pontén F.;  Luo Y.;  Hökfelt T.;  Uhlén M.;  Mulder J.
收藏  |  浏览/下载：46/0  |  提交时间：2020/07/28
G protein coupled receptor  neurotransmitter  atlas  brain  gene  gene expression  pig  protein  Article  astrocyte  cerebellum  gene expression level  gene expression profiling  gene mapping  genetic code  genome-wide association study  genomics  human  hypothalamus  in situ hybridization  microglia  nerve cell  nonhuman  oligodendroglia  pig  priority journal  species comparison  tissue specificity  transcriptomics  Mammalia  Suidae