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| DOI | 10.1126/science.aay4106 |
| An atlas of the protein-coding genes in the human, pig, and mouse brain | |
| Sjöstedt E.; Zhong W.; Fagerberg L.; Karlsson M.; Mitsios N.; Adori C.; Oksvold P.; Edfors F.; Limiszewska A.; Hikmet F.; Huang J.; Du Y.; Lin L.; Dong Z.; Yang L.; Liu X.; Jiang H.; Xu X.; Wang J.; Yang H.; Bolund L.; Mardinoglu A.; Zhang C.; Von Feilitzen K.; Lindskog C.; Pontén F.; Luo Y.; Hökfelt T.; Uhlén M.; Mulder J. | |
| 发表日期 | 2020 |
| ISSN | 0036-8075 |
| 卷号 | 367期号:6482 |
| 英文摘要 | The brain, with its diverse physiology and intricate cellular organization, is the most complex organ of the mammalian body. To expand our basic understanding of the neurobiology of the brain and its diseases, we performed a comprehensive molecular dissection of 10 major brain regions and multiple subregions using a variety of transcriptomics methods and antibody-based mapping. This analysis was carried out in the human, pig, and mouse brain to allow the identification of regional expression profiles, as well as to study similarities and differences in expression levels between the three species. The resulting data have been made available in an open-access Brain Atlas resource, part of the Human Protein Atlas, to allow exploration and comparison of the expression of individual protein-coding genes in various parts of the mammalian brain. © 2020 American Association for the Advancement of Science. All rights reserved. |
| 关键词 | G protein coupled receptorneurotransmitteratlasbraingenegene expressionpigproteinArticleastrocytecerebellumgene expression levelgene expression profilinggene mappinggenetic codegenome-wide association studygenomicshumanhypothalamusin situ hybridizationmicroglianerve cellnonhumanoligodendrogliapigpriority journalspecies comparisontissue specificitytranscriptomicsMammaliaSuidae |
| 语种 | 英语 |
| 来源机构 | Science |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/133648 |
| 推荐引用方式 GB/T 7714 | Sjöstedt E.,Zhong W.,Fagerberg L.,et al. An atlas of the protein-coding genes in the human, pig, and mouse brain[J]. Science,2020,367(6482). |
| APA | Sjöstedt E..,Zhong W..,Fagerberg L..,Karlsson M..,Mitsios N..,...&Mulder J..(2020).An atlas of the protein-coding genes in the human, pig, and mouse brain.,367(6482). |
| MLA | Sjöstedt E.,et al."An atlas of the protein-coding genes in the human, pig, and mouse brain".367.6482(2020). |
| 条目包含的文件 | 条目无相关文件。 | |||||
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