Climate Change Data Portal
| DOI | 10.1126/science.aax6752 |
| Microglia monitor and protect neuronal function through specialized somatic purinergic junctions | |
| Cserép C.; Pósfai B.; Lénárt N.; Fekete R.; László Z.I.; Lele Z.; Orsolits B.; Molnár G.; Heindl S.; Schwarcz A.D.; Ujvári K.; Környei Z.; Tóth K.; Szabadits E.; Sperlágh B.; Baranyi M.; Csiba L.; Hortobágyi T.; Maglóczky Z.; Martinecz B.; Szabó G.; Erdélyi F.; Szipocs R.; Tamkun M.M.; Gesierich B.; Duering M.; Katona I.; Liesz A.; Tamás G.; Dénes Á. | |
| 发表日期 | 2020 |
| ISSN | 0036-8075 |
| 起始页码 | 528 |
| 结束页码 | 537 |
| 卷号 | 367期号:6477 |
| 英文摘要 | Microglia are the main immune cells in the brain and have roles in brain homeostasis and neurological diseases. Mechanisms underlying microglia-neuron communication remain elusive. Here, we identified an interaction site between neuronal cell bodies and microglial processes in mouse and human brain. Somatic microglia-neuron junctions have a specialized nanoarchitecture optimized for purinergic signaling. Activity of neuronal mitochondria was linked with microglial junction formation, which was induced rapidly in response to neuronal activation and blocked by inhibition of P2Y12 receptors. Brain injury-induced changes at somatic junctions triggered P2Y12 receptor-dependent microglial neuroprotection, regulating neuronal calcium load and functional connectivity. Thus, microglial processes at these junctions could potentially monitor and protect neuronal functions. © 2020 American Association for the Advancement of Science. All rights reserved. |
| 关键词 | calciumpurinergic P2Y12 receptorbraincell componenthomeostasisinhibitionproteinanimal cellArticlebrain injurycontrolled studyfunctional connectivityhumanhuman cellmicrogliamitochondrionmousenerve cellneuroprotectionnonhumanperikaryonpriority journalsignal transductionsomatic microglia neuron junction |
| 语种 | 英语 |
| 来源机构 | Science |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/133748 |
| 推荐引用方式 GB/T 7714 | Cserép C.,Pósfai B.,Lénárt N.,et al. Microglia monitor and protect neuronal function through specialized somatic purinergic junctions[J]. Science,2020,367(6477). |
| APA | Cserép C..,Pósfai B..,Lénárt N..,Fekete R..,László Z.I..,...&Dénes Á..(2020).Microglia monitor and protect neuronal function through specialized somatic purinergic junctions.,367(6477). |
| MLA | Cserép C.,et al."Microglia monitor and protect neuronal function through specialized somatic purinergic junctions".367.6477(2020). |
| 条目包含的文件 | 条目无相关文件。 | |||||
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
