气候变化领域集成服务门户(CCPortal): Maintenance of neural stem cell positional identity by mixed-lineage leukemia 1

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DOI	10.1126/science.aba5960
	Maintenance of neural stem cell positional identity by mixed-lineage leukemia 1
	Delgado R.N.; Mansky B.; Ahanger S.H.; Lu C.; Andersen R.E.; Dou Y.; Alvarez-Buylla A.; Lim D.A.
发表日期	2020
ISSN	0036-8075
卷号	368 期号:6486
英文摘要	Neural stem cells (NSCs) in the developing and postnatal brain have distinct positional identities that dictate the types of neurons they generate. Although morphogens initially establish NSC positional identity in the neural tube, it is unclear how such regional differences are maintained as the forebrain grows much larger and more anatomically complex. We found that the maintenance of NSC positional identity in the murine brain requires a mixed-lineage leukemia 1 (Mll1)-dependent epigenetic memory system. After establishment by sonic hedgehog, ventral NSC identity became independent of this morphogen. Even transient MLL1 inhibition caused a durable loss of ventral identity, resulting in the generation of neurons with the characteristics of dorsal NSCs in vivo. Thus, spatial information provided by morphogens can be transitioned to epigenetic mechanisms that maintain regionally distinct developmental programs in the forebrain. © 2020 American Association for the Advancement of Science. All rights reserved.
关键词	mixed lineage leukemia 1 protein mixed lineage leukemia protein morphogen sonic hedgehog protein unclassified drug anatomy brain cell component developmental biology inhibition adult animal cell animal experiment animal tissue Article controlled study embryo epigenetics forebrain in vivo study memory Mll1 gene mouse nerve cell nerve cell differentiation neural stem cell nonhuman priority journal Erinaceidae Murinae
语种	英语
来源机构	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133587
推荐引用方式 GB/T 7714	Delgado R.N.,Mansky B.,Ahanger S.H.,et al. Maintenance of neural stem cell positional identity by mixed-lineage leukemia 1[J]. Science,2020,368(6486).
APA	Delgado R.N..,Mansky B..,Ahanger S.H..,Lu C..,Andersen R.E..,...&Lim D.A..(2020).Maintenance of neural stem cell positional identity by mixed-lineage leukemia 1.,368(6486).
MLA	Delgado R.N.,et al."Maintenance of neural stem cell positional identity by mixed-lineage leukemia 1".368.6486(2020).