中文版 | English

在结果中检索

CCPortal

浏览/检索结果: 共14条，第1-10条 帮助

已选(0)清除 条数/页：   排序方式：
Elesclomol alleviates Menkes pathology and mortality by escorting Cu to cuproenzymes in mice 期刊论文
, 2020, 卷号: 368, 期号: 6491
作者:  Guthrie L.M.;  Soma S.;  Yuan S.;  Silva A.;  Zulkifli M.;  Snavely T.C.;  Greene H.F.;  Nunez E.;  Lynch B.;  de Ville C.;  Shanbhag V.;  Lopez F.R.;  Acharya A.;  Petris M.J.;  Kim B.-E.;  Gohil V.M.;  Sacchettini J.C.
收藏  |  浏览/下载：41/0  |  提交时间：2020/07/28
copper  copper zinc superoxide dismutase  cytochrome c oxidase  dopamine beta monooxygenase  elesclomol  monophenol monooxygenase  protein lysine 6 oxidase  copper  cytochrome c oxidase  elesclomol  hydrazine derivative  copper  cytochrome  enzyme  enzyme activity  mitochondrion  mortality  mutation  pathology  rodent  survival  animal cell  animal experiment  animal model  animal tissue  Article  cohort analysis  controlled study  disease severity  drug mechanism  Golgi complex  H9c2(2-1) cell line  in vivo study  male  Menkes syndrome  mitochondrial dynamics  mortality rate  mouse  nerve degeneration  nonhuman  priority journal  secretory pathway  survival rate  animal  brain  cell line  degenerative disease  disease model  drug effect  genetics  knockout mouse  Menkes syndrome  metabolism  mitochondrion  pathology  rat  transport at the cellular level  Murinae  Mus  Animals  Biological Transport  Brain  Cell Line  Copper  Copper Transporter 1  Disease Models, Animal  Electron Transport Complex IV  Hydrazines  Male  Menkes Kinky Hair Syndrome  Mice  Mice, Knockout  Mitochondria  Neurodegenerative Diseases  Rats  
Single-cell transcriptional diversity is a hallmark of developmental potential 期刊论文
, 2020, 卷号: 367, 期号: 6476
作者:  Gulati G.S.;  Sikandar S.S.;  Wesche D.J.;  Manjunath A.;  Bharadwaj A.;  Berger M.J.;  Ilagan F.;  Kuo A.H.;  Hsieh R.W.;  Cai S.;  Zabala M.;  Scheeren F.A.;  Lobo N.A.;  Qian D.;  Yu F.B.;  Dirbas F.M.;  Clarke M.F.;  Newman A.M.
收藏  |  浏览/下载：48/0  |  提交时间：2020/07/28
cell  cell component  developmental biology  experimental study  genetic analysis  tumor  Article  breast cancer  breast carcinogenesis  carcinogenesis  cell differentiation  computer model  embryonic stem cell  gene expression  genetic code  genetic variability  human  in vivo study  nonhuman  phenotype  priority journal  scoring system  single cell RNA seq  upregulation  
A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV 期刊论文
, 2020, 卷号: 368, 期号: 6491
作者:  Yuan M.;  Wu N.C.;  Zhu X.;  Lee C.-C.D.;  So R.T.Y.;  Lv H.;  Mok C.K.P.;  Wilson I.A.
收藏  |  浏览/下载：31/0  |  提交时间：2020/07/28
angiotensin converting enzyme 2  epitope  neutralizing antibody  virus hemagglutinin  virus spike protein  angiotensin converting enzyme 2  coronavirus receptors  coronavirus spike glycoprotein  dipeptidyl carboxypeptidase  epitope  neutralizing antibody  spike glycoprotein, SARS-CoV  spike protein, SARS-CoV-2  virus antibody  virus antigen  virus receptor  antibody  antigen  chemical binding  crystal structure  protein  respiratory disease  viral disease  virus  amino terminal sequence  antibody isolation  antigen binding  antigenicity  Article  binding affinity  binding site  conservation biology  controlled study  coronavirus disease 2019  cross reaction  cryoelectron microscopy  crystal structure  enzyme linked immunosorbent assay  epidemic  glycosylation  human  hydrophobicity  immune response  in vitro study  in vivo study  light chain  nonhuman  priority journal  protein conformation  protein domain  protein interaction  protein localization  protein structure  protein targeting  receptor binding  SARS coronavirus  Severe acute respiratory syndrome coronavirus 2  amino acid sequence  antibody affinity  Betacoronavirus  binding site  chemistry  immunology  metabolism  molecular model  SARS coronavirus  X ray crystallography  Coronavirus  SARS coronavirus  Amino Acid Sequence  Antibodies, Neutralizing  Antibodies, Viral  Antibody Affinity  Antigens, Viral  Betacoronavirus  Binding Sites  Cross Reactions  Crystallography, X-Ray  Epitopes  Models, Molecular  Peptidyl-Dipeptidase A  Protein Conformation  Protein Domains  Protein Interaction Domains and Motifs  Receptors, Virus  SARS Virus  Spike Glycoprotein, Coronavirus  
Aerodynamic imaging by mosquitoes inspires a surface detector for autonomous flying vehicles 期刊论文
, 2020, 卷号: 368, 期号: 6491
作者:  Nakata T.;  Phillips N.;  Simões P.;  Russell I.J.;  Cheney J.A.;  Walker S.M.;  Bomphrey R.J.
收藏  |  浏览/下载：43/0  |  提交时间：2020/07/28
aerodynamics  antenna  behavioral response  collision avoidance  computational fluid dynamics  detection method  mosquito  altitude  article  avoidance behavior  computational fluid dynamics  control system  flying  in vivo study  mosquito  nonhuman  quantitative analysis  sensory system  simulation  velocity  aircraft  aircraft accident  animal  antenna (organ)  computer simulation  flying  mosquito  night vision  physiology  prevention and control  procedures  robotics  Animalia  Accidents, Aviation  Aircraft  Animals  Arthropod Antennae  Bionics  Computer Simulation  Culicidae  Flight, Animal  Night Vision  Robotics  
A central master driver of psychosocial stress responses in the rat 期刊论文
, 2020, 卷号: 367, 期号: 6482
作者:  Kataoka N.;  Shima Y.;  Nakajima K.;  Nakamura K.
收藏  |  浏览/下载：52/0  |  提交时间：2020/07/28
vesicular glutamate transporter 1  glutamic acid  Slc17a7 protein, rat  vesicular glutamate transporter 1  brain  homeostasis  physiological response  psychology  rodent  Article  behavioral stress  brain region  emotion  forebrain  homeostasis  human  hypothalamus  in vivo study  innervation  mental stress  nerve cell  nerve tract  nonhuman  optogenetics  priority journal  social defeat  social stress  tenia tecta  thermogenesis  animal  dorsomedial hypothalamic nucleus  female  Long Evans cinnamon rat  male  mental stress  metabolism  physiology  prefrontal cortex  psychosomatic disorder  rat  signal transduction  social behavior  Wistar rat  Rattus  Animals  Dorsomedial Hypothalamic Nucleus  Emotions  Female  Glutamic Acid  Homeostasis  Male  Neurons  Prefrontal Cortex  Prosencephalon  Psychophysiologic Disorders  Rats  Rats, Inbred LEC  Rats, Wistar  Signal Transduction  Social Behavior  Stress, Psychological  Vesicular Glutamate Transport Protein 1  
VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance 期刊论文
, 2020, 卷号: 367, 期号: 6475
作者:  ElTanbouly M.A.;  Zhao Y.;  Nowak E.;  Li J.;  Schaafsma E.;  Le Mercier I.;  Ceeraz S.;  Lines J.L.;  Peng C.;  Carriere C.;  Huang X.;  Day M.;  Koehn B.;  Lee S.W.;  Morales M.S.;  Hogquist K.A.;  Jameson S.C.;  Mueller D.;  Rothstein J.;  Blazar B.R.;  Cheng C.;  Noelle R.J.
收藏  |  浏览/下载：60/0  |  提交时间：2020/07/28
cell protein  interferon  kruppel like factor 2  T lymphocyte receptor  unclassified drug  V type immunoglobulin domain containing suppressor of T cell activation protein  B7 antigen  Dies1 protein, mouse  lymphocyte antigen receptor  membrane protein  monoclonal antibody  VSIR protein, human  biological development  cell  gene expression  heterogeneity  homeostasis  immune response  immunity  tolerance  acute graft versus host disease  animal cell  animal experiment  animal model  Article  CD4+ T lymphocyte  cell death  cell expansion  cell fate  cell heterogeneity  cell loss  cell survival  controlled study  female  gene  gene deletion  homeostasis  immunological tolerance  in vivo study  long term survival  male  mouse  nonhuman  phenotype  priority journal  protein expression  protein function  rheumatoid arthritis  RNA sequencing  systemic lupus erythematosus  T lymphocyte  T lymphocyte activation  T lymphocyte subpopulation  TCR gene  upregulation  VISTA gene  animal  C57BL mouse  genetics  immunological tolerance  immunology  knockout mouse  lymphocyte activation  physiology  T lymphocyte  Mus  Animals  Antibodies, Monoclonal  B7 Antigens  Lymphocyte Activation  Membrane Proteins  Mice  Mice, Inbred C57BL  Mice, Knockout  Peripheral Tolerance  Receptors, Antigen, T-Cell  T-Lymphocytes  
Interleukin-13 drives metabolic conditioning of muscle to endurance exercise 期刊论文
, 2020, 卷号: 368, 期号: 6490
作者:  Knudsen N.H.;  Stanya K.J.;  Hyde A.L.;  Chalom M.M.;  Alexander R.K.;  Liou Y.-H.;  Starost K.A.;  Gangl M.R.;  Jacobi D.;  Liu S.;  Sopariwala D.H.;  Fonseca-Pereira D.;  Li J.;  Hu F.B.;  Garrett W.S.;  Narkar V.A.;  Ortlund E.A.;  Kim J.H.;  Paton C.M.;  Cooper J.A.;  Lee C.-H.
收藏  |  浏览/下载：52/0  |  提交时间：2020/07/28
glucose  interleukin 13  interleukin 13 receptor alpha1  interleukin 6  STAT3 protein  fatty acid  glycogen  interleukin 13  interleukin 13 receptor alpha1  STAT3 protein  Stat3 protein, mouse  fatty acid  metabolism  muscle  oxidation  physiological response  protein  respiration  aerobic exercise  animal cell  animal experiment  animal tissue  Article  C2C12 cell line  cohort analysis  controlled study  endurance training  energy metabolism  ex vivo study  exercise intensity  female  gastrocnemius muscle  glucose tolerance  human  in vitro study  male  mitochondrial biogenesis  mitochondrial dynamics  mitochondrial respiration  mouse  muscle metabolism  muscle mitochondrion  nonhuman  obesity  priority journal  protein blood level  protein expression  running  sedentary lifestyle  signal transduction  treadmill exercise  adaptation  animal  blood  C57BL mouse  cell line  endurance  genetics  glucose blood level  immunology  knockout mouse  metabolism  myoblast  oxidation reduction reaction  skeletal muscle  Mus  Adaptation, Physiological  Animals  Blood Glucose  Cell Line  Fatty Acids  Female  Glycogen  Humans  Interleukin-13  Interleukin-13 Receptor alpha1 Subunit  Male  Mice  Mice, Inbred C57BL  Mice, Knockout  Mitochondria, Muscle  Muscle, Skeletal  Myoblasts  Oxidation-Reduction  Physical Conditioning, Animal  Physical Endurance  Running  STAT3 Transcription Factor  
Maintenance of neural stem cell positional identity by mixed-lineage leukemia 1 期刊论文
, 2020, 卷号: 368, 期号: 6486
作者:  Delgado R.N.;  Mansky B.;  Ahanger S.H.;  Lu C.;  Andersen R.E.;  Dou Y.;  Alvarez-Buylla A.;  Lim D.A.
收藏  |  浏览/下载：30/0  |  提交时间：2020/07/28
mixed lineage leukemia 1 protein  mixed lineage leukemia protein  morphogen  sonic hedgehog protein  unclassified drug  anatomy  brain  cell component  developmental biology  inhibition  adult  animal cell  animal experiment  animal tissue  Article  controlled study  embryo  epigenetics  forebrain  in vivo study  memory  Mll1 gene  mouse  nerve cell  nerve cell differentiation  neural stem cell  nonhuman  priority journal  Erinaceidae  Murinae  
ZGLP1 is a determinant for the oogenic fate in mice 期刊论文
, 2020, 卷号: 367, 期号: 6482
作者:  Nagaoka S.I.;  Nakaki F.;  Miyauchi H.;  Nosaka Y.;  Ohta H.;  Yabuta Y.;  Kurimoto K.;  Hayashi K.;  Nakamura T.;  Yamamoto T.;  Saitou M.
收藏  |  浏览/下载：54/0  |  提交时间：2020/07/28
bone morphogenetic protein  bone  cell  gametogenesis  germ cell  maturation  rodent  signaling  adult  animal cell  animal experiment  animal model  Article  cell fate  controlled study  embryo  female  gain of function mutation  gene  gene overexpression  genetic transcription  in vitro study  in vivo study  loss of function mutation  male  meiotic prophase I  mouse  mouse embryonic stem cell  nonhuman  oocyte development  priority journal  retroposon  RNA processing  RNA sequencing  signal transduction  spermatogenesis  Stra8 gene  ZGLP1 gene  Mammalia  Mus  
An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors 期刊论文
, 2020, 卷号: 367, 期号: 6476
作者:  Reinhard K.;  Rengstl B.;  Oehm P.;  Michel K.;  Billmeier A.;  Hayduk N.;  Klein O.;  Kuna K.;  Ouchan Y.;  Wöll S.;  Christ E.;  Weber D.;  Suchan M.;  Bukur T.;  Birtel M.;  Jahndel V.;  Mroz K.;  Hobohm K.;  Kranz L.;  Diken M.;  Kühlcke K.;  Türeci Ö.;  Sahin U.
收藏  |  浏览/下载：50/0  |  提交时间：2020/07/28
chimeric antigen receptor  claudin 6  RNA vaccine  antigen  cell component  protein  RNA  tumor  vaccine  animal cell  animal experiment  animal model  animal tissue  antigen presenting cell  antineoplastic activity  Article  cell stimulation  cell transport  chimeric antigen receptor T-cell immunotherapy  controlled study  drug efficacy  human  human cell  in vivo study  mouse  nonhuman  phenotype  priority journal  real time polymerase chain reaction  solid malignant neoplasm  therapy effect  vaccination coverage