气候变化领域集成服务门户(CCPortal): Interleukin-13 drives metabolic conditioning of muscle to endurance exercise

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DOI	10.1126/science.aat3987
	Interleukin-13 drives metabolic conditioning of muscle to endurance exercise
	Knudsen N.H.; Stanya K.J.; Hyde A.L.; Chalom M.M.; Alexander R.K.; Liou Y.-H.; Starost K.A.; Gangl M.R.; Jacobi D.; Liu S.; Sopariwala D.H.; Fonseca-Pereira D.; Li J.; Hu F.B.; Garrett W.S.; Narkar V.A.; Ortlund E.A.; Kim J.H.; Paton C.M.; Cooper J.A.; Lee C.-H.
发表日期	2020
ISSN	0036-8075
卷号	368 期号:6490
英文摘要	Repeated bouts of exercise condition muscle mitochondria to meet increased energy demand—an adaptive response associated with improved metabolic fitness. We found that the type 2 cytokine interleukin-13 (IL-13) is induced in exercising muscle, where it orchestrates metabolic reprogramming that preserves glycogen in favor of fatty acid oxidation and mitochondrial respiration. Exercise training–mediated mitochondrial biogenesis, running endurance, and beneficial glycemic effects were lost in Il13–/– mice. By contrast, enhanced muscle IL-13 signaling was sufficient to increase running distance, glucose tolerance, and mitochondrial activity similar to the effects of exercise training. In muscle, IL-13 acts through both its receptor IL-13Ra1 and the transcription factor Stat3. The genetic ablation of either of these downstream effectors reduced running capacity in mice. Thus, coordinated immunological and physiological responses mediate exercise-elicited metabolic adaptations that maximize muscle fuel economy. © 2020 American Association for the Advancement of Science. All rights reserved.
关键词	glucose interleukin 13 interleukin 13 receptor alpha1 interleukin 6 STAT3 protein fatty acid glycogen interleukin 13 interleukin 13 receptor alpha1 STAT3 protein Stat3 protein, mouse fatty acid metabolism muscle oxidation physiological response protein respiration aerobic exercise animal cell animal experiment animal tissue Article C2C12 cell line cohort analysis controlled study endurance training energy metabolism ex vivo study exercise intensity female gastrocnemius muscle glucose tolerance human in vitro study male mitochondrial biogenesis mitochondrial dynamics mitochondrial respiration mouse muscle metabolism muscle mitochondrion nonhuman obesity priority journal protein blood level protein expression running sedentary lifestyle signal transduction treadmill exercise adaptation animal blood C57BL mouse cell line endurance genetics glucose blood level immunology knockout mouse metabolism myoblast oxidation reduction reaction skeletal muscle Mus Adaptation, Physiological Animals Blood Glucose Cell Line Fatty Acids Female Glycogen Humans Interleukin-13 Interleukin-13 Receptor alpha1 Subunit Male Mice Mice, Inbred C57BL Mice, Knockout Mitochondria, Muscle Muscle, Skeletal Myoblasts Oxidation-Reduction Physical Conditioning, Animal Physical Endurance Running STAT3 Transcription Factor
语种	英语
来源机构	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133532
推荐引用方式 GB/T 7714	Knudsen N.H.,Stanya K.J.,Hyde A.L.,et al. Interleukin-13 drives metabolic conditioning of muscle to endurance exercise[J]. Science,2020,368(6490).
APA	Knudsen N.H..,Stanya K.J..,Hyde A.L..,Chalom M.M..,Alexander R.K..,...&Lee C.-H..(2020).Interleukin-13 drives metabolic conditioning of muscle to endurance exercise.,368(6490).
MLA	Knudsen N.H.,et al."Interleukin-13 drives metabolic conditioning of muscle to endurance exercise".368.6490(2020).