气候变化领域集成服务门户(CCPortal): ZGLP1 is a determinant for the oogenic fate in mice

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DOI	10.1126/science.aay5947
	ZGLP1 is a determinant for the oogenic fate in mice
	Nagaoka S.I.; Nakaki F.; Miyauchi H.; Nosaka Y.; Ohta H.; Yabuta Y.; Kurimoto K.; Hayashi K.; Nakamura T.; Yamamoto T.; Saitou M.
发表日期	2020
ISSN	0036-8075
卷号	367 期号:6482
英文摘要	Sex determination of germ cells is vital to creating the sexual dichotomy of germ cell development, thereby ensuring sexual reproduction. However, the underlying mechanisms remain unclear. Here, we show that ZGLP1, a conserved transcriptional regulator with GATA-like zinc fingers, determines the oogenic fate inmice. ZGLP1 acts downstream of bone morphogenetic protein, but not retinoic acid (RA), and is essential for the oogenic program and meiotic entry. ZGLP1 overexpression induces differentiation of in vitro primordial germ cell-like cells (PGCLCs) into fetal oocytes by activating the oogenic programs repressed by Polycomb activities, whereas RA signaling contributes to oogenic program maturation and PGC program repression. Our findings elucidate the mechanism for mammalian oogenic fate determination, providing a foundation for promoting in vitro gametogenesis and reproductive medicine. © 2020 American Association for the Advancement of Science. All rights reserved.
关键词	bone morphogenetic protein bone cell gametogenesis germ cell maturation rodent signaling adult animal cell animal experiment animal model Article cell fate controlled study embryo female gain of function mutation gene gene overexpression genetic transcription in vitro study in vivo study loss of function mutation male meiotic prophase I mouse mouse embryonic stem cell nonhuman oocyte development priority journal retroposon RNA processing RNA sequencing signal transduction spermatogenesis Stra8 gene ZGLP1 gene Mammalia Mus
语种	英语
来源机构	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133647
推荐引用方式 GB/T 7714	Nagaoka S.I.,Nakaki F.,Miyauchi H.,et al. ZGLP1 is a determinant for the oogenic fate in mice[J]. Science,2020,367(6482).
APA	Nagaoka S.I..,Nakaki F..,Miyauchi H..,Nosaka Y..,Ohta H..,...&Saitou M..(2020).ZGLP1 is a determinant for the oogenic fate in mice.,367(6482).
MLA	Nagaoka S.I.,et al."ZGLP1 is a determinant for the oogenic fate in mice".367.6482(2020).