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期刊论文 [10]
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2020 [10]
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英语 [10]
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Science [10]
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CFLIPL protects macrophages from LPS-induced pyroptosis via inhibition of complex II formation
期刊论文
, 2020, 卷号: 367, 期号: 6484
作者:
Muendlein H.I.
;
Jetton D.
;
Connolly W.M.
;
Eidell K.P.
;
Magri Z.
;
Smirnova I.
;
Poltorak A.
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2020/07/28
FLICE inhibitory protein
interleukin 1beta
lipopolysaccharide
messenger RNA
succinate dehydrogenase (ubiquinone)
Casp1 protein, mouse
caspase 8
Cflar protein, mouse
cryopyrin
FLICE inhibitory protein
IL1B protein, mouse
inflammasome
interleukin 1beta
interleukin 1beta converting enzyme
lipopolysaccharide
succinate dehydrogenase (ubiquinone)
cell
enzyme activity
inhibition
maturation
protein
animal cell
animal experiment
Article
bone marrow derived macrophage
cell death
cell protection
complex formation
controlled study
cytokine release
in vitro study
inflammation
mouse
nonhuman
priority journal
protein analysis
protein degradation
protein function
protein interaction
pyroptosis
animal
gene knockdown
genetics
immunology
macrophage
macrophage activation
metabolism
physiology
Murinae
Animals
CASP8 and FADD-Like Apoptosis Regulating Protein
Caspase 1
Caspase 8
Electron Transport Complex II
Gene Knockdown Techniques
Inflammasomes
Interleukin-1beta
Lipopolysaccharides
Macrophage Activation
Macrophages
Mice
NLR Family, Pyrin Domain-Containing 3 Protein
Pyroptosis
Transcription polymerase-catalyzed emergence of novel RNA replicons
期刊论文
, 2020, 卷号: 368, 期号: 6487
作者:
Jain N.
;
Blauch L.R.
;
Szymanski M.R.
;
Das R.
;
Tang S.K.Y.
;
Yin Y.W.
;
Fire A.Z.
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2020/07/28
cell component
enzyme
enzyme activity
genetic analysis
RNA
article
bacteriophage
catalysis
DNA replication origin
heredity
in vitro study
nonhuman
plant seed
replicon
RNA replication
synthesis
transcription initiation
biocatalysis
biosynthesis
genetic transcription
metabolism
Animalia
Hepatitis delta virus
Viroids
bacteriophage T7 RNA polymerase
DNA directed RNA polymerase
RNA
viral protein
Biocatalysis
DNA-Directed RNA Polymerases
Replicon
RNA
Transcription, Genetic
Viral Proteins
A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV
期刊论文
, 2020, 卷号: 368, 期号: 6491
作者:
Yuan M.
;
Wu N.C.
;
Zhu X.
;
Lee C.-C.D.
;
So R.T.Y.
;
Lv H.
;
Mok C.K.P.
;
Wilson I.A.
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2020/07/28
angiotensin converting enzyme 2
epitope
neutralizing antibody
virus hemagglutinin
virus spike protein
angiotensin converting enzyme 2
coronavirus receptors
coronavirus spike glycoprotein
dipeptidyl carboxypeptidase
epitope
neutralizing antibody
spike glycoprotein, SARS-CoV
spike protein, SARS-CoV-2
virus antibody
virus antigen
virus receptor
antibody
antigen
chemical binding
crystal structure
protein
respiratory disease
viral disease
virus
amino terminal sequence
antibody isolation
antigen binding
antigenicity
Article
binding affinity
binding site
conservation biology
controlled study
coronavirus disease 2019
cross reaction
cryoelectron microscopy
crystal structure
enzyme linked immunosorbent assay
epidemic
glycosylation
human
hydrophobicity
immune response
in vitro study
in vivo study
light chain
nonhuman
priority journal
protein conformation
protein domain
protein interaction
protein localization
protein structure
protein targeting
receptor binding
SARS coronavirus
Severe acute respiratory syndrome coronavirus 2
amino acid sequence
antibody affinity
Betacoronavirus
binding site
chemistry
immunology
metabolism
molecular model
SARS coronavirus
X ray crystallography
Coronavirus
SARS coronavirus
Amino Acid Sequence
Antibodies, Neutralizing
Antibodies, Viral
Antibody Affinity
Antigens, Viral
Betacoronavirus
Binding Sites
Cross Reactions
Crystallography, X-Ray
Epitopes
Models, Molecular
Peptidyl-Dipeptidase A
Protein Conformation
Protein Domains
Protein Interaction Domains and Motifs
Receptors, Virus
SARS Virus
Spike Glycoprotein, Coronavirus
Dopaminylation of histone H3 in ventral tegmental area regulates cocaine seeking
期刊论文
, 2020, 卷号: 368, 期号: 6487
作者:
Lepack A.E.
;
Werner C.T.
;
Stewart A.F.
;
Fulton S.L.
;
Zhong P.
;
Farrelly L.A.
;
Smith A.C.W.
;
Ramakrishnan A.
;
Lyu Y.
;
Bastle R.M.
;
Martin J.A.
;
Mitra S.
;
O'Connor R.M.
;
Wang Z.-J.
;
Molina H.
;
Turecki G.
;
Shen L.
;
Yan Z.
;
Calipari E.S.
;
Dietz D.M.
;
Kenny P.J.
;
Maze I.
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2020/07/28
amidase
dopamine
histone H3
histone transamidase
protein glutamine gamma glutamyltransferase 2
RNA
unclassified drug
brain
cell
chemical compound
chemical reaction
gene expression
genetic analysis
protein
action potential
amino acid substitution
amino terminal sequence
Article
cocaine dependence
controlled study
dopamine release
dopaminergic nerve cell
dopaminergic transmission
down regulation
drug seeking behavior
enzyme activity
gene expression
histone dopaminylation
histone modification
human
human tissue
hyperpolarization
in vitro study
motivation
nerve cell plasticity
nerve projection
neuropathology
nucleus accumbens
priority journal
protein expression
protein function
reward
RNA sequence
ventral tegmentum
Rattus
Lipid-gated monovalent ion fluxes regulate endocytic traffic and support immune surveillance
期刊论文
, 2020, 卷号: 367, 期号: 6475
作者:
Freeman S.A.
;
Uderhardt S.
;
Saric A.
;
Collins R.F.
;
Buckley C.M.
;
Mylvaganam S.
;
Boroumand P.
;
Plumb J.
;
Germain R.N.
;
Ren D.
;
Grinstein S.
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2020/07/28
cation channel
chemokine receptor CCR2
chloride
colony stimulating factor 1
epidermal growth factor
epidermal growth factor receptor
lipid
sialoadhesin
sodium ion
tetrandrine
two pore channel
unclassified drug
calcium channel
lipid
Mcoln1 protein, mouse
sodium
TPCN1 protein, mouse
TPCN2 protein, mouse
transient receptor potential channel
cation
homeostasis
immune system
protein
recycling
animal experiment
Article
bone marrow derived macrophage
cell vacuole
cell volume
channel gating
chloride transport
concentration (parameter)
controlled study
endocytosis
extracellular fluid
extracellular space
homeostasis
human
human cell
human tissue
immunosurveillance
in vitro study
internalization
ion current
knockout mouse
macropinocytosis
mouse
nonhuman
priority journal
protein stability
RNA interference
sodium transport
tonoplast
animal
cell organelle
endosome
genetics
immunology
ion transport
macrophage
metabolism
osmosis
physiology
pinocytosis
Animals
Calcium Channels
Endosomes
Immunologic Surveillance
Ion Transport
Lipids
Macrophages
Mice
Mice, Knockout
Organelles
Osmosis
Pinocytosis
Sodium
Transient Receptor Potential Channels
Vacuoles
Effect of tolerance on the evolution of antibiotic resistance under drug combinations
期刊论文
, 2020, 卷号: 367, 期号: 6474
作者:
Liu J.
;
Gefen O.
;
Ronin I.
;
Bar-Meir M.
;
Balaban N.Q.
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2020/07/28
daptomycin
rifampicin
vancomycin
antiinfective agent
beta' subunit of RNA polymerase
daptomycin
DNA directed RNA polymerase
rifampicin
vancomycin
antibiotic resistance
bacterium
emergence
evolutionary biology
experimental study
laboratory method
survival
adult
antibiotic resistance
Article
bacterial mutation
bacterial strain
bacterium isolation
clinical article
colony forming unit
combination drug therapy
drug effect
drug tolerance
human
in vitro study
minimum inhibitory concentration
nonhuman
phylogeny
priority journal
Staphylococcus aureus
whole genome sequencing
antibiotic resistance
combination drug therapy
drug effect
genetics
methicillin resistant Staphylococcus aureus
microbial sensitivity test
microbiology
molecular evolution
mutation
single nucleotide polymorphism
Staphylococcus infection
Staphylococcus aureus
Anti-Bacterial Agents
Daptomycin
DNA-Directed RNA Polymerases
Drug Resistance, Microbial
Drug Therapy, Combination
Evolution, Molecular
Humans
Methicillin-Resistant Staphylococcus aureus
Microbial Sensitivity Tests
Mutation
Polymorphism, Single Nucleotide
Rifampin
Staphylococcal Infections
Vancomycin
Interleukin-13 drives metabolic conditioning of muscle to endurance exercise
期刊论文
, 2020, 卷号: 368, 期号: 6490
作者:
Knudsen N.H.
;
Stanya K.J.
;
Hyde A.L.
;
Chalom M.M.
;
Alexander R.K.
;
Liou Y.-H.
;
Starost K.A.
;
Gangl M.R.
;
Jacobi D.
;
Liu S.
;
Sopariwala D.H.
;
Fonseca-Pereira D.
;
Li J.
;
Hu F.B.
;
Garrett W.S.
;
Narkar V.A.
;
Ortlund E.A.
;
Kim J.H.
;
Paton C.M.
;
Cooper J.A.
;
Lee C.-H.
收藏
  |  
浏览/下载:51/0
  |  
提交时间:2020/07/28
glucose
interleukin 13
interleukin 13 receptor alpha1
interleukin 6
STAT3 protein
fatty acid
glycogen
interleukin 13
interleukin 13 receptor alpha1
STAT3 protein
Stat3 protein, mouse
fatty acid
metabolism
muscle
oxidation
physiological response
protein
respiration
aerobic exercise
animal cell
animal experiment
animal tissue
Article
C2C12 cell line
cohort analysis
controlled study
endurance training
energy metabolism
ex vivo study
exercise intensity
female
gastrocnemius muscle
glucose tolerance
human
in vitro study
male
mitochondrial biogenesis
mitochondrial dynamics
mitochondrial respiration
mouse
muscle metabolism
muscle mitochondrion
nonhuman
obesity
priority journal
protein blood level
protein expression
running
sedentary lifestyle
signal transduction
treadmill exercise
adaptation
animal
blood
C57BL mouse
cell line
endurance
genetics
glucose blood level
immunology
knockout mouse
metabolism
myoblast
oxidation reduction reaction
skeletal muscle
Mus
Adaptation, Physiological
Animals
Blood Glucose
Cell Line
Fatty Acids
Female
Glycogen
Humans
Interleukin-13
Interleukin-13 Receptor alpha1 Subunit
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Mitochondria, Muscle
Muscle, Skeletal
Myoblasts
Oxidation-Reduction
Physical Conditioning, Animal
Physical Endurance
Running
STAT3 Transcription Factor
ZGLP1 is a determinant for the oogenic fate in mice
期刊论文
, 2020, 卷号: 367, 期号: 6482
作者:
Nagaoka S.I.
;
Nakaki F.
;
Miyauchi H.
;
Nosaka Y.
;
Ohta H.
;
Yabuta Y.
;
Kurimoto K.
;
Hayashi K.
;
Nakamura T.
;
Yamamoto T.
;
Saitou M.
收藏
  |  
浏览/下载:50/0
  |  
提交时间:2020/07/28
bone morphogenetic protein
bone
cell
gametogenesis
germ cell
maturation
rodent
signaling
adult
animal cell
animal experiment
animal model
Article
cell fate
controlled study
embryo
female
gain of function mutation
gene
gene overexpression
genetic transcription
in vitro study
in vivo study
loss of function mutation
male
meiotic prophase I
mouse
mouse embryonic stem cell
nonhuman
oocyte development
priority journal
retroposon
RNA processing
RNA sequencing
signal transduction
spermatogenesis
Stra8 gene
ZGLP1 gene
Mammalia
Mus
MRNA destabilization by BTG1 and BTG2 maintains T cell quiescence
期刊论文
, 2020, 卷号: 367, 期号: 6483
作者:
Hwang S.S.
;
Lim J.
;
Yu Z.
;
Kong P.
;
Sefik E.
;
Xu H.
;
Harman C.C.D.
;
Kim L.K.
;
Lee G.R.
;
Li H.-B.
;
Flavell R.A.
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2020/07/28
CD69 antigen
chemokine receptor CCR7
epidermal growth factor receptor 2
Hermes antigen
interleukin 2 receptor alpha
interleukin 2 receptor gamma
interleukin 7 receptor
kruppel like factor 2
messenger RNA
polyadenylic acid
T lymphocyte receptor
transcription factor FKHR
transcriptome
biodegradation
cell component
RNA
adenylation
Article
BTG1 gene
BTG2 gene
Ccr7 gene
CD4+ T lymphocyte
CD8+ T lymphocyte
cell differentiation
cell expansion
cell maturation
cell migration
cell proliferation
cell size
cell specificity
cell survival
controlled study
CRISPR-CAS9 system
flow cytometry
gene
gene control
gene expression
gene function
gene identification
immunoprecipitation
in vitro study
in vivo study
memory T lymphocyte
nonhuman
phylogenetic tree
priority journal
RNA degradation
RNA sequencing
S1pr1 gene
Sell gene
spleen
T lymphocyte
T lymphocyte activation
tail length (comet assay)
thymus
upregulation
Structural basis of second-generation HIV integrase inhibitor action and viral resistance
期刊论文
, 2020, 卷号: 367, 期号: 6479
作者:
Cook N.J.
;
Li W.
;
Berta D.
;
Badaoui M.
;
Ballandras-Colas A.
;
Nans A.
;
Kotecha A.
;
Rosta E.
;
Engelman A.N.
;
Cherepanov P.
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2020/07/28
bictegravir
dolutegravir
lens epithelium derived growth factor
magnesium ion
bictegravir
dolutegravir
fused heterocyclic rings
glutamine
glycine
histidine
integrase
integrase inhibitor
magnesium
serine
acquired immune deficiency syndrome
amino acid
drug
human immunodeficiency virus
inhibitor
protein
ultrastructure
virus
amino acid substitution
amino terminal sequence
Article
carboxy terminal sequence
cryoelectron microscopy
DNA binding
drug design
drug protein binding
drug structure
enzyme active site
gene mutation
Human immunodeficiency virus 1
in vitro study
molecular dynamics
molecular stability
nonhuman
pharmacophore
polarization
priority journal
protonation
virus resistance
antiviral resistance
chemistry
genetics
human
mutation
procedures
single molecule imaging
Amino Acid Substitution
Catalytic Domain
Cryoelectron Microscopy
Drug Resistance, Viral
Glutamine
Glycine
Heterocyclic Compounds, 3-Ring
Heterocyclic Compounds, 4 or More Rings
Histidine
HIV Integrase
HIV Integrase Inhibitors
Humans
Magnesium
Mutation
Serine
Single Molecule Imaging