CCPortal

浏览/检索结果: 共10条,第1-10条 帮助

已选(0)清除 条数/页:   排序方式:
CFLIPL protects macrophages from LPS-induced pyroptosis via inhibition of complex II formation 期刊论文
, 2020, 卷号: 367, 期号: 6484
作者:  Muendlein H.I.;  Jetton D.;  Connolly W.M.;  Eidell K.P.;  Magri Z.;  Smirnova I.;  Poltorak A.
收藏  |  浏览/下载:49/0  |  提交时间:2020/07/28
FLICE inhibitory protein  interleukin 1beta  lipopolysaccharide  messenger RNA  succinate dehydrogenase (ubiquinone)  Casp1 protein, mouse  caspase 8  Cflar protein, mouse  cryopyrin  FLICE inhibitory protein  IL1B protein, mouse  inflammasome  interleukin 1beta  interleukin 1beta converting enzyme  lipopolysaccharide  succinate dehydrogenase (ubiquinone)  cell  enzyme activity  inhibition  maturation  protein  animal cell  animal experiment  Article  bone marrow derived macrophage  cell death  cell protection  complex formation  controlled study  cytokine release  in vitro study  inflammation  mouse  nonhuman  priority journal  protein analysis  protein degradation  protein function  protein interaction  pyroptosis  animal  gene knockdown  genetics  immunology  macrophage  macrophage activation  metabolism  physiology  Murinae  Animals  CASP8 and FADD-Like Apoptosis Regulating Protein  Caspase 1  Caspase 8  Electron Transport Complex II  Gene Knockdown Techniques  Inflammasomes  Interleukin-1beta  Lipopolysaccharides  Macrophage Activation  Macrophages  Mice  NLR Family, Pyrin Domain-Containing 3 Protein  Pyroptosis  
Transcription polymerase-catalyzed emergence of novel RNA replicons 期刊论文
, 2020, 卷号: 368, 期号: 6487
作者:  Jain N.;  Blauch L.R.;  Szymanski M.R.;  Das R.;  Tang S.K.Y.;  Yin Y.W.;  Fire A.Z.
收藏  |  浏览/下载:38/0  |  提交时间:2020/07/28
cell component  enzyme  enzyme activity  genetic analysis  RNA  article  bacteriophage  catalysis  DNA replication origin  heredity  in vitro study  nonhuman  plant seed  replicon  RNA replication  synthesis  transcription initiation  biocatalysis  biosynthesis  genetic transcription  metabolism  Animalia  Hepatitis delta virus  Viroids  bacteriophage T7 RNA polymerase  DNA directed RNA polymerase  RNA  viral protein  Biocatalysis  DNA-Directed RNA Polymerases  Replicon  RNA  Transcription, Genetic  Viral Proteins  
A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV 期刊论文
, 2020, 卷号: 368, 期号: 6491
作者:  Yuan M.;  Wu N.C.;  Zhu X.;  Lee C.-C.D.;  So R.T.Y.;  Lv H.;  Mok C.K.P.;  Wilson I.A.
收藏  |  浏览/下载:26/0  |  提交时间:2020/07/28
angiotensin converting enzyme 2  epitope  neutralizing antibody  virus hemagglutinin  virus spike protein  angiotensin converting enzyme 2  coronavirus receptors  coronavirus spike glycoprotein  dipeptidyl carboxypeptidase  epitope  neutralizing antibody  spike glycoprotein, SARS-CoV  spike protein, SARS-CoV-2  virus antibody  virus antigen  virus receptor  antibody  antigen  chemical binding  crystal structure  protein  respiratory disease  viral disease  virus  amino terminal sequence  antibody isolation  antigen binding  antigenicity  Article  binding affinity  binding site  conservation biology  controlled study  coronavirus disease 2019  cross reaction  cryoelectron microscopy  crystal structure  enzyme linked immunosorbent assay  epidemic  glycosylation  human  hydrophobicity  immune response  in vitro study  in vivo study  light chain  nonhuman  priority journal  protein conformation  protein domain  protein interaction  protein localization  protein structure  protein targeting  receptor binding  SARS coronavirus  Severe acute respiratory syndrome coronavirus 2  amino acid sequence  antibody affinity  Betacoronavirus  binding site  chemistry  immunology  metabolism  molecular model  SARS coronavirus  X ray crystallography  Coronavirus  SARS coronavirus  Amino Acid Sequence  Antibodies, Neutralizing  Antibodies, Viral  Antibody Affinity  Antigens, Viral  Betacoronavirus  Binding Sites  Cross Reactions  Crystallography, X-Ray  Epitopes  Models, Molecular  Peptidyl-Dipeptidase A  Protein Conformation  Protein Domains  Protein Interaction Domains and Motifs  Receptors, Virus  SARS Virus  Spike Glycoprotein, Coronavirus  
Dopaminylation of histone H3 in ventral tegmental area regulates cocaine seeking 期刊论文
, 2020, 卷号: 368, 期号: 6487
作者:  Lepack A.E.;  Werner C.T.;  Stewart A.F.;  Fulton S.L.;  Zhong P.;  Farrelly L.A.;  Smith A.C.W.;  Ramakrishnan A.;  Lyu Y.;  Bastle R.M.;  Martin J.A.;  Mitra S.;  O'Connor R.M.;  Wang Z.-J.;  Molina H.;  Turecki G.;  Shen L.;  Yan Z.;  Calipari E.S.;  Dietz D.M.;  Kenny P.J.;  Maze I.
收藏  |  浏览/下载:48/0  |  提交时间:2020/07/28
amidase  dopamine  histone H3  histone transamidase  protein glutamine gamma glutamyltransferase 2  RNA  unclassified drug  brain  cell  chemical compound  chemical reaction  gene expression  genetic analysis  protein  action potential  amino acid substitution  amino terminal sequence  Article  cocaine dependence  controlled study  dopamine release  dopaminergic nerve cell  dopaminergic transmission  down regulation  drug seeking behavior  enzyme activity  gene expression  histone dopaminylation  histone modification  human  human tissue  hyperpolarization  in vitro study  motivation  nerve cell plasticity  nerve projection  neuropathology  nucleus accumbens  priority journal  protein expression  protein function  reward  RNA sequence  ventral tegmentum  Rattus  
Lipid-gated monovalent ion fluxes regulate endocytic traffic and support immune surveillance 期刊论文
, 2020, 卷号: 367, 期号: 6475
作者:  Freeman S.A.;  Uderhardt S.;  Saric A.;  Collins R.F.;  Buckley C.M.;  Mylvaganam S.;  Boroumand P.;  Plumb J.;  Germain R.N.;  Ren D.;  Grinstein S.
收藏  |  浏览/下载:35/0  |  提交时间:2020/07/28
cation channel  chemokine receptor CCR2  chloride  colony stimulating factor 1  epidermal growth factor  epidermal growth factor receptor  lipid  sialoadhesin  sodium ion  tetrandrine  two pore channel  unclassified drug  calcium channel  lipid  Mcoln1 protein, mouse  sodium  TPCN1 protein, mouse  TPCN2 protein, mouse  transient receptor potential channel  cation  homeostasis  immune system  protein  recycling  animal experiment  Article  bone marrow derived macrophage  cell vacuole  cell volume  channel gating  chloride transport  concentration (parameter)  controlled study  endocytosis  extracellular fluid  extracellular space  homeostasis  human  human cell  human tissue  immunosurveillance  in vitro study  internalization  ion current  knockout mouse  macropinocytosis  mouse  nonhuman  priority journal  protein stability  RNA interference  sodium transport  tonoplast  animal  cell organelle  endosome  genetics  immunology  ion transport  macrophage  metabolism  osmosis  physiology  pinocytosis  Animals  Calcium Channels  Endosomes  Immunologic Surveillance  Ion Transport  Lipids  Macrophages  Mice  Mice, Knockout  Organelles  Osmosis  Pinocytosis  Sodium  Transient Receptor Potential Channels  Vacuoles  
Effect of tolerance on the evolution of antibiotic resistance under drug combinations 期刊论文
, 2020, 卷号: 367, 期号: 6474
作者:  Liu J.;  Gefen O.;  Ronin I.;  Bar-Meir M.;  Balaban N.Q.
收藏  |  浏览/下载:18/0  |  提交时间:2020/07/28
daptomycin  rifampicin  vancomycin  antiinfective agent  beta' subunit of RNA polymerase  daptomycin  DNA directed RNA polymerase  rifampicin  vancomycin  antibiotic resistance  bacterium  emergence  evolutionary biology  experimental study  laboratory method  survival  adult  antibiotic resistance  Article  bacterial mutation  bacterial strain  bacterium isolation  clinical article  colony forming unit  combination drug therapy  drug effect  drug tolerance  human  in vitro study  minimum inhibitory concentration  nonhuman  phylogeny  priority journal  Staphylococcus aureus  whole genome sequencing  antibiotic resistance  combination drug therapy  drug effect  genetics  methicillin resistant Staphylococcus aureus  microbial sensitivity test  microbiology  molecular evolution  mutation  single nucleotide polymorphism  Staphylococcus infection  Staphylococcus aureus  Anti-Bacterial Agents  Daptomycin  DNA-Directed RNA Polymerases  Drug Resistance, Microbial  Drug Therapy, Combination  Evolution, Molecular  Humans  Methicillin-Resistant Staphylococcus aureus  Microbial Sensitivity Tests  Mutation  Polymorphism, Single Nucleotide  Rifampin  Staphylococcal Infections  Vancomycin  
Interleukin-13 drives metabolic conditioning of muscle to endurance exercise 期刊论文
, 2020, 卷号: 368, 期号: 6490
作者:  Knudsen N.H.;  Stanya K.J.;  Hyde A.L.;  Chalom M.M.;  Alexander R.K.;  Liou Y.-H.;  Starost K.A.;  Gangl M.R.;  Jacobi D.;  Liu S.;  Sopariwala D.H.;  Fonseca-Pereira D.;  Li J.;  Hu F.B.;  Garrett W.S.;  Narkar V.A.;  Ortlund E.A.;  Kim J.H.;  Paton C.M.;  Cooper J.A.;  Lee C.-H.
收藏  |  浏览/下载:51/0  |  提交时间:2020/07/28
glucose  interleukin 13  interleukin 13 receptor alpha1  interleukin 6  STAT3 protein  fatty acid  glycogen  interleukin 13  interleukin 13 receptor alpha1  STAT3 protein  Stat3 protein, mouse  fatty acid  metabolism  muscle  oxidation  physiological response  protein  respiration  aerobic exercise  animal cell  animal experiment  animal tissue  Article  C2C12 cell line  cohort analysis  controlled study  endurance training  energy metabolism  ex vivo study  exercise intensity  female  gastrocnemius muscle  glucose tolerance  human  in vitro study  male  mitochondrial biogenesis  mitochondrial dynamics  mitochondrial respiration  mouse  muscle metabolism  muscle mitochondrion  nonhuman  obesity  priority journal  protein blood level  protein expression  running  sedentary lifestyle  signal transduction  treadmill exercise  adaptation  animal  blood  C57BL mouse  cell line  endurance  genetics  glucose blood level  immunology  knockout mouse  metabolism  myoblast  oxidation reduction reaction  skeletal muscle  Mus  Adaptation, Physiological  Animals  Blood Glucose  Cell Line  Fatty Acids  Female  Glycogen  Humans  Interleukin-13  Interleukin-13 Receptor alpha1 Subunit  Male  Mice  Mice, Inbred C57BL  Mice, Knockout  Mitochondria, Muscle  Muscle, Skeletal  Myoblasts  Oxidation-Reduction  Physical Conditioning, Animal  Physical Endurance  Running  STAT3 Transcription Factor  
ZGLP1 is a determinant for the oogenic fate in mice 期刊论文
, 2020, 卷号: 367, 期号: 6482
作者:  Nagaoka S.I.;  Nakaki F.;  Miyauchi H.;  Nosaka Y.;  Ohta H.;  Yabuta Y.;  Kurimoto K.;  Hayashi K.;  Nakamura T.;  Yamamoto T.;  Saitou M.
收藏  |  浏览/下载:50/0  |  提交时间:2020/07/28
bone morphogenetic protein  bone  cell  gametogenesis  germ cell  maturation  rodent  signaling  adult  animal cell  animal experiment  animal model  Article  cell fate  controlled study  embryo  female  gain of function mutation  gene  gene overexpression  genetic transcription  in vitro study  in vivo study  loss of function mutation  male  meiotic prophase I  mouse  mouse embryonic stem cell  nonhuman  oocyte development  priority journal  retroposon  RNA processing  RNA sequencing  signal transduction  spermatogenesis  Stra8 gene  ZGLP1 gene  Mammalia  Mus  
MRNA destabilization by BTG1 and BTG2 maintains T cell quiescence 期刊论文
, 2020, 卷号: 367, 期号: 6483
作者:  Hwang S.S.;  Lim J.;  Yu Z.;  Kong P.;  Sefik E.;  Xu H.;  Harman C.C.D.;  Kim L.K.;  Lee G.R.;  Li H.-B.;  Flavell R.A.
收藏  |  浏览/下载:29/0  |  提交时间:2020/07/28
CD69 antigen  chemokine receptor CCR7  epidermal growth factor receptor 2  Hermes antigen  interleukin 2 receptor alpha  interleukin 2 receptor gamma  interleukin 7 receptor  kruppel like factor 2  messenger RNA  polyadenylic acid  T lymphocyte receptor  transcription factor FKHR  transcriptome  biodegradation  cell component  RNA  adenylation  Article  BTG1 gene  BTG2 gene  Ccr7 gene  CD4+ T lymphocyte  CD8+ T lymphocyte  cell differentiation  cell expansion  cell maturation  cell migration  cell proliferation  cell size  cell specificity  cell survival  controlled study  CRISPR-CAS9 system  flow cytometry  gene  gene control  gene expression  gene function  gene identification  immunoprecipitation  in vitro study  in vivo study  memory T lymphocyte  nonhuman  phylogenetic tree  priority journal  RNA degradation  RNA sequencing  S1pr1 gene  Sell gene  spleen  T lymphocyte  T lymphocyte activation  tail length (comet assay)  thymus  upregulation  
Structural basis of second-generation HIV integrase inhibitor action and viral resistance 期刊论文
, 2020, 卷号: 367, 期号: 6479
作者:  Cook N.J.;  Li W.;  Berta D.;  Badaoui M.;  Ballandras-Colas A.;  Nans A.;  Kotecha A.;  Rosta E.;  Engelman A.N.;  Cherepanov P.
收藏  |  浏览/下载:38/0  |  提交时间:2020/07/28
bictegravir  dolutegravir  lens epithelium derived growth factor  magnesium ion  bictegravir  dolutegravir  fused heterocyclic rings  glutamine  glycine  histidine  integrase  integrase inhibitor  magnesium  serine  acquired immune deficiency syndrome  amino acid  drug  human immunodeficiency virus  inhibitor  protein  ultrastructure  virus  amino acid substitution  amino terminal sequence  Article  carboxy terminal sequence  cryoelectron microscopy  DNA binding  drug design  drug protein binding  drug structure  enzyme active site  gene mutation  Human immunodeficiency virus 1  in vitro study  molecular dynamics  molecular stability  nonhuman  pharmacophore  polarization  priority journal  protonation  virus resistance  antiviral resistance  chemistry  genetics  human  mutation  procedures  single molecule imaging  Amino Acid Substitution  Catalytic Domain  Cryoelectron Microscopy  Drug Resistance, Viral  Glutamine  Glycine  Heterocyclic Compounds, 3-Ring  Heterocyclic Compounds, 4 or More Rings  Histidine  HIV Integrase  HIV Integrase Inhibitors  Humans  Magnesium  Mutation  Serine  Single Molecule Imaging