气候变化领域集成服务门户(CCPortal): MRNA destabilization by BTG1 and BTG2 maintains T cell quiescence

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DOI	10.1126/science.abb2507
	MRNA destabilization by BTG1 and BTG2 maintains T cell quiescence
	Hwang S.S.; Lim J.; Yu Z.; Kong P.; Sefik E.; Xu H.; Harman C.C.D.; Kim L.K.; Lee G.R.; Li H.-B.; Flavell R.A.
发表日期	2020
ISSN	0036-8075
起始页码	1255
结束页码	1260
卷号	367 期号:6483
英文摘要	T cells maintain a quiescent state prior to activation. As inappropriate T cell activation can cause disease, T cell quiescence must be preserved. Despite its importance, the mechanisms underlying the "quiescent state" remain elusive. Here, we identify BTG1 and BTG2 (BTG1/2) as factors responsible for T cell quiescence. BTG1/2-deficient T cells show an increased proliferation and spontaneous activation due to a global increase in messenger RNA (mRNA) abundance, which reduces the threshold to activation. BTG1/2 deficiency leads to an increase in polyadenylate tail length, resulting in a greater mRNA half-life. Thus, BTG1/2 promote the deadenylation and degradation of mRNA to secure T cell quiescence. Our study reveals a key mechanism underlying T cell quiescence and suggests that low mRNA abundance is a crucial feature for maintaining quiescence. © 2020 American Association for the Advancement of Science. All rights reserved.
关键词	CD69 antigen chemokine receptor CCR7 epidermal growth factor receptor 2 Hermes antigen interleukin 2 receptor alpha interleukin 2 receptor gamma interleukin 7 receptor kruppel like factor 2 messenger RNA polyadenylic acid T lymphocyte receptor transcription factor FKHR transcriptome biodegradation cell component RNA adenylation Article BTG1 gene BTG2 gene Ccr7 gene CD4+ T lymphocyte CD8+ T lymphocyte cell differentiation cell expansion cell maturation cell migration cell proliferation cell size cell specificity cell survival controlled study CRISPR-CAS9 system flow cytometry gene gene control gene expression gene function gene identification immunoprecipitation in vitro study in vivo study memory T lymphocyte nonhuman phylogenetic tree priority journal RNA degradation RNA sequencing S1pr1 gene Sell gene spleen T lymphocyte T lymphocyte activation tail length (comet assay)thymus upregulation
语种	英语
来源机构	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133633
推荐引用方式 GB/T 7714	Hwang S.S.,Lim J.,Yu Z.,et al. MRNA destabilization by BTG1 and BTG2 maintains T cell quiescence[J]. Science,2020,367(6483).
APA	Hwang S.S..,Lim J..,Yu Z..,Kong P..,Sefik E..,...&Flavell R.A..(2020).MRNA destabilization by BTG1 and BTG2 maintains T cell quiescence.,367(6483).
MLA	Hwang S.S.,et al."MRNA destabilization by BTG1 and BTG2 maintains T cell quiescence".367.6483(2020).