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| Computing cancer's weak spots 期刊论文
, 2020, 卷号: 368, 期号: 6496
作者: Khamsi R.
  收藏 | 浏览/下载：46/0 | 提交时间：2020/07/28
ruxolitinib STAT3 protein antineoplastic agent transcription factor algorithm cancer computer simulation disease treatment drug development medicine Article cancer cell cancer radiotherapy enzyme inhibition gene activity gene expression regulation gene interaction gene mutation gene repression gene targeting human laboratory test malignant neoplasm molecular dynamics nonhuman oncologist priority journal RNA sequencing algorithm genetics mutation neoplasm personalized medicine procedures systems biology Algorithms Antineoplastic Agents Humans Mutation Neoplasms Precision Medicine Systems Biology Transcription Factors |
| Circadian rhythms in the absence of the clock gene Bmal1 期刊论文
, 2020, 卷号: 367, 期号: 6479
作者: Ray S.; Valekunja U.K.; Stangherlin A.; Howell S.A.; Snijders A.P.; Damodaran G.; Reddy A.B.
收藏 | 浏览/下载：27/0 | 提交时间：2020/07/28
phosphoproteome proteome transcription factor ARNTL transcription factor Ets transcriptome unclassified drug cell component circadian rhythm gene gene expression genome molecular analysis animal experiment animal tissue Article Bmal1 gene circadian rhythm controlled study gene deletion gene expression regulation gene function gene knockout genotype knockout mouse light dark cycle liver mouse nonhuman oscillation oxidation reduction potential priority journal RNA sequence skin fibroblast temperature transcription regulation Mammalia Mus |
| Temperature-dependent sex determination is mediated by pSTAT3 repression of Kdm6b 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者: Weber C.; Zhou Y.; Lee J.G.; Looger L.L.; Qian G.; Ge C.; Capel B.
收藏 | 浏览/下载：35/0 | 提交时间：2020/07/28
STAT3 protein calcium histone demethylase STAT3 protein embryonic development gene expression sex determination temperature effect turtle animal cell animal experiment Article binding site calcium transport cell activation chromatin immunoprecipitation controlled study dimerization Dmrt1 gene embryo embryo development environmental temperature epigenetic repression female gene gene activation gene interaction gene targeting genetic transcription gonad high temperature immunofluorescence test Kdm6b gene male nonhuman priority journal protein phosphorylation real time polymerase chain reaction sex determination signal transduction temperature dependence thermoregulation transcription regulation upregulation Western blotting animal embryology gene expression regulation genetics metabolism phosphorylation sex determination process temperature turtle Reptilia Trachemys scripta Trachemys scripta elegans Animals Calcium Female Gene Expression Regulation, Developmental Jumonji Domain-Containing Histone Demethylases Male Phosphorylation Sex Determination Processes STAT3 Transcription Factor Temperature Transcription, Genetic Turtles |
| Dopaminylation of histone H3 in ventral tegmental area regulates cocaine seeking 期刊论文
, 2020, 卷号: 368, 期号: 6487
作者: Lepack A.E.; Werner C.T.; Stewart A.F.; Fulton S.L.; Zhong P.; Farrelly L.A.; Smith A.C.W.; Ramakrishnan A.; Lyu Y.; Bastle R.M.; Martin J.A.; Mitra S.; O'Connor R.M.; Wang Z.-J.; Molina H.; Turecki G.; Shen L.; Yan Z.; Calipari E.S.; Dietz D.M.; Kenny P.J.; Maze I.
收藏 | 浏览/下载：48/0 | 提交时间：2020/07/28
amidase dopamine histone H3 histone transamidase protein glutamine gamma glutamyltransferase 2 RNA unclassified drug brain cell chemical compound chemical reaction gene expression genetic analysis protein action potential amino acid substitution amino terminal sequence Article cocaine dependence controlled study dopamine release dopaminergic nerve cell dopaminergic transmission down regulation drug seeking behavior enzyme activity gene expression histone dopaminylation histone modification human human tissue hyperpolarization in vitro study motivation nerve cell plasticity nerve projection neuropathology nucleus accumbens priority journal protein expression protein function reward RNA sequence ventral tegmentum Rattus |
| Translating preclinical models to humans 期刊论文
, 2020, 卷号: 367, 期号: 6479
作者: Brubaker D.K.; Lauffenburger D.A.
收藏 | 浏览/下载：40/0 | 提交时间：2020/07/28
detection method model Article bioengineering biomedicine cell differentiation cell proliferation computer model conceptual framework DNA sequence drug development epithelium cell gene expression profiling high throughput sequencing human machine learning molecular dynamics nonhuman phenotype priority journal proteomics RNA sequence sex difference signal transduction T lymphocyte transcription regulation transcriptomics translational research |
| Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis 期刊论文
, 2020, 卷号: 367, 期号: 6485
作者: Ebright R.Y.; Lee S.; Wittner B.S.; Niederhoffer K.L.; Nicholson B.T.; Bardia A.; Truesdell S.; Wiley D.F.; Wesley B.; Li S.; Mai A.; Aceto N.; Vincent-Jordan N.; Szabolcs A.; Chirn B.; Kreuzer J.; Comaills V.; Kalinich M.; Haas W.; Ting D.T.; Toner M.; Vasudevan S.; Haber D.A.; Maheswaran S.; Micalizzi D.S.
收藏 | 浏览/下载：55/0 | 提交时间：2020/07/28
CRISPR associated protein epidermal growth factor receptor 2 Ki 67 antigen ribosome protein ribosome RNA transcription factor E2F ribosome protein cancer cell gene expression genetic engineering protein RNA tumor animal experiment animal model animal tissue Article biogenesis bioluminescence breast cancer cell cycle progression cell cycle regulation cell proliferation circulating tumor cell controlled study enzyme activation epithelial mesenchymal transition gene expression profiling genetic transcription human human cell lung metastasis metastasis microfluidics mouse nonhuman overall survival phenotype priority journal progression free survival promoter region protein expression protein processing protein synthesis proteomics RNA sequence transcription regulation animal breast tumor cancer transplantation CRISPR Cas system female gene expression regulation genetics pathology sequence analysis tumor cell line tumor embolism Mus Animals Breast Neoplasms Cell Line, Tumor CRISPR-Cas Systems Female Gene Expression Regulation, Neoplastic Humans Mice Neoplasm Metastasis Neoplasm Transplantation Neoplastic Cells, Circulating Ribosomal Proteins Sequence Analysis, RNA |
| Peptide signaling for drought-induced tomato flower drop 期刊论文
, 2020, 卷号: 367, 期号: 6485
作者: Reichardt S.; Piepho H.-P.; Stintzi A.; Schaller A.
收藏 | 浏览/下载：32/0 | 提交时间：2020/07/28
mitogen activated protein kinase peptide hormone phytaspase 2 phytosulfokine unclassified drug abscission aspartic acid crop yield drought stress enzyme activity flower fruit gene expression hormone peptide abscission Arabidopsis Article bioassay cell separation controlled study cytokine production down regulation drought environmental stress enzyme activity enzyme specificity ERF4 gene ERT10 gene flower hydrolysis hydrophobicity IAA3 gene immunomodulation molecular dynamics nonhuman peptide signaling PK7 gene plant development plant genome priority journal productivity protein cleavage protein degradation protein expression protein function protein processing regulator gene signal transduction tomato TPRP gene Lycopersicon esculentum |
| Vertebrate diapause preserves organisms long term through Polycomb complex members 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者: Hu C.-K.; Wang W.; Brind'Amour J.; Singh P.P.; Adam Reeves G.; Lorincz M.C.; Alvarado A.S.; Brunet A.
收藏 | 浏览/下载：43/0 | 提交时间：2020/07/28
polycomb group protein protein CBX7 transcriptome unclassified drug diapause gene expression metabolism muscle vertebrate Article chromatin complex formation developmental gene diapause down regulation embryo development fertility gene gene expression regulation gene repression genetic regulation growth rate lifespan lipid metabolism metabolism muscle atrophy muscle gene neuromuscular junction nonhuman priority journal protein function tissue preservation upregulation vertebrate Cyprinodontoidei Nothobranchius furzeri Vertebrata |
| Protein-coding changes preceded cis-regulatory gains in a newly evolved transcription circuit 期刊论文
, 2020, 卷号: 367, 期号: 6473
作者: Britton C.S.; Sorrells T.R.; Johnson A.D.
收藏 | 浏览/下载：19/0 | 提交时间：2020/07/28
DNA binding protein fungal protein homeodomain protein Matalpha2 protein regulator protein transcription factor unclassified drug gene gene expression protein amino acid sequence Article cladistics controlled study gene deletion gene expression regulation gene repression gene sequence gene structure molecular evolution nonhuman priority journal protein DNA binding protein function protein structure Saccharomycotina sequence homology species transcription regulation Wickerhamomyces anomalus Fungi |
| The malaria parasite has an intrinsic clock 期刊论文
, 2020, 卷号: 368, 期号: 6492
作者: Rijo-Ferreira F.; Acosta-Rodriguez V.A.; Abel J.H.; Kornblum I.; Bento I.; Kilaru G.; Klerman E.B.; Mota M.M.; Takahashi J.S.
收藏 | 浏览/下载：20/0 | 提交时间：2020/07/28
cell circadian rhythm food intake malaria Mus Plasmodium chabaudi transcription factor CLOCK animal association circadian rhythm darkness eating erythrocyte feeding behavior fever gene expression regulation genetic transcription genetics host parasite interaction malaria mouse mutant mouse strain parasitology pathophysiology physiology Plasmodium chabaudi Animals Circadian Rhythm CLOCK Proteins Cues Darkness Eating Erythrocytes Feeding Behavior Fever Gene Expression Regulation Host-Parasite Interactions Malaria Mice Mice, Mutant Strains Plasmodium chabaudi Transcription, Genetic |
