气候变化领域集成服务门户(CCPortal): The malaria parasite has an intrinsic clock

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DOI	10.1126/science.aba2658
	The malaria parasite has an intrinsic clock
	Rijo-Ferreira F.; Acosta-Rodriguez V.A.; Abel J.H.; Kornblum I.; Bento I.; Kilaru G.; Klerman E.B.; Mota M.M.; Takahashi J.S.
发表日期	2020
ISSN	0036-8075
起始页码	746
结束页码	753
卷号	368 期号:6492
英文摘要	Malarial rhythmic fevers are the consequence of the synchronous bursting of red blood cells (RBCs) on completion of the malaria parasite asexual cell cycle. Here, we hypothesized that an intrinsic clock in the parasite Plasmodium chabaudi underlies the 24-hour-based rhythms of RBC bursting in mice. We show that parasite rhythms are flexible and lengthen to match the rhythms of hosts with long circadian periods. We also show that malaria rhythms persist even when host food intake is evenly spread across 24 hours, suggesting that host feeding cues are not required for synchrony. Moreover, we find that the parasite population remains synchronous and rhythmic even in an arrhythmic clock mutant host. Thus, we propose that parasite rhythms are generated by the parasite, possibly to anticipate its circadian environment. Copyright © 2020 The Authors,
关键词	cell circadian rhythm food intake malaria Mus Plasmodium chabaudi transcription factor CLOCK animal association circadian rhythm darkness eating erythrocyte feeding behavior fever gene expression regulation genetic transcription genetics host parasite interaction malaria mouse mutant mouse strain parasitology pathophysiology physiology Plasmodium chabaudi Animals Circadian Rhythm CLOCK Proteins Cues Darkness Eating Erythrocytes Feeding Behavior Fever Gene Expression Regulation Host-Parasite Interactions Malaria Mice Mice, Mutant Strains Plasmodium chabaudi Transcription, Genetic
语种	英语
来源机构	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133491
推荐引用方式 GB/T 7714	Rijo-Ferreira F.,Acosta-Rodriguez V.A.,Abel J.H.,et al. The malaria parasite has an intrinsic clock[J]. Science,2020,368(6492).
APA	Rijo-Ferreira F..,Acosta-Rodriguez V.A..,Abel J.H..,Kornblum I..,Bento I..,...&Takahashi J.S..(2020).The malaria parasite has an intrinsic clock.,368(6492).
MLA	Rijo-Ferreira F.,et al."The malaria parasite has an intrinsic clock".368.6492(2020).