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Temperature-dependent sex determination is mediated by pSTAT3 repression of Kdm6b 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者:  Weber C.;  Zhou Y.;  Lee J.G.;  Looger L.L.;  Qian G.;  Ge C.;  Capel B.
收藏  |  浏览/下载：24/0  |  提交时间：2020/07/28
STAT3 protein  calcium  histone demethylase  STAT3 protein  embryonic development  gene expression  sex determination  temperature effect  turtle  animal cell  animal experiment  Article  binding site  calcium transport  cell activation  chromatin immunoprecipitation  controlled study  dimerization  Dmrt1 gene  embryo  embryo development  environmental temperature  epigenetic repression  female  gene  gene activation  gene interaction  gene targeting  genetic transcription  gonad  high temperature  immunofluorescence test  Kdm6b gene  male  nonhuman  priority journal  protein phosphorylation  real time polymerase chain reaction  sex determination  signal transduction  temperature dependence  thermoregulation  transcription regulation  upregulation  Western blotting  animal  embryology  gene expression regulation  genetics  metabolism  phosphorylation  sex determination process  temperature  turtle  Reptilia  Trachemys scripta  Trachemys scripta elegans  Animals  Calcium  Female  Gene Expression Regulation, Developmental  Jumonji Domain-Containing Histone Demethylases  Male  Phosphorylation  Sex Determination Processes  STAT3 Transcription Factor  Temperature  Transcription, Genetic  Turtles  
Polymerization in the actin ATPase clan regulates hexokinase activity in yeast 期刊论文
, 2020, 卷号: 367, 期号: 6481
作者:  Stoddard P.R.;  Lynch E.M.;  Farrell D.P.;  dosey A.M.;  diMaio F.;  Williams T.A.;  Kollman J.M.;  Murray A.W.;  Garner E.C.
收藏  |  浏览/下载：21/0  |  提交时间：2020/07/28
actin  adenosine triphosphatase  Glk1 protein  glucokinase  glucose  hexokinase  monomer  polymer  unclassified drug  carbohydrate  cell component  enzyme  enzyme activity  mutation  nutrient availability  polymer  polymerization  ultrastructure  actin filament  actin polymerization  Article  depolymerization  enzyme activity  enzyme inhibition  enzyme phosphorylation  nonhuman  nutrient availability  priority journal  protein blood level  Saccharomyces cerevisiae  Saccharomyces cerevisiae  
HEM1 deficiency disrupts mTORC2 and F-actin control in inherited immunodysregulatory disease 期刊论文
, 2020, 卷号: 369, 期号: 6500
作者:  Cook S.A.;  Comrie W.A.;  Poli M.C.;  Similuk M.;  Oler A.J.;  Faruqi A.J.;  Kuhns D.B.;  Yang S.;  Vargas-Hernández A.;  Carisey A.F.;  Fournier B.;  Anderson D.E.;  Price S.;  Smelkinson M.;  Abou Chahla W.;  Forbes L.R.;  Mace E.M.;  Cao T.N.;  Coban-Akdemir Z.H.;  Jhangiani S.N.;  Muzny D.M.;  Gibbs R.A.;  Lupski J.R.;  Orange J.S.;  Cuvelier G.D.E.;  Al Hassani M.;  Al Kaabi N.;  Al Yafei Z.;  Jyonouchi S.;  Raje N.;  Caldwell J.W.;  Huang Y.;  Burkhardt J.K.;  Latour S.;  Chen B.;  ElGhazali G.;  Rao V.K.;  Chinn I.K.;  Lenardo M.J.
收藏  |  浏览/下载：41/0  |  提交时间：2020/07/28
actin  adenosine diphosphate ribosylation factor 1  ARF1 protein, human  cytokine  mammalian target of rapamycin complex 2  membrane protein  NCKAP1L protein, human  WASF1 protein, human  WASF2 protein, human  WASF3 protein, human  Wiskott Aldrich syndrome protein  biosynthesis  CD4+ T lymphocyte  cell proliferation  chemistry  genetics  human  immune deficiency  immunology  lymphoproliferative disease  metabolism  pedigree  phosphorylation  physiology  Actins  ADP-Ribosylation Factor 1  CD4-Positive T-Lymphocytes  Cell Proliferation  Cytokines  Humans  Immunologic Deficiency Syndromes  Lymphoproliferative Disorders  Mechanistic Target of Rapamycin Complex 2  Membrane Proteins  Pedigree  Phosphorylation  Wiskott-Aldrich Syndrome Protein Family  
Very fast CRISPR on demand 期刊论文
, 2020, 卷号: 368, 期号: 6496
作者:  Liu Y.;  Zou R.S.;  He S.;  Nihongaki Y.;  Li X.;  Razavi S.;  Wu B.;  Ha T.
收藏  |  浏览/下载：20/0  |  提交时间：2020/07/28
Cas9 endonuclease Streptococcus pyogenes  double strand break repair protein MRE11  H2AX protein, human  histone  MRE11 protein, human  CRISPR Cas system  DNA cleavage  DNA repair  double stranded DNA break  fluorescence imaging  gene editing  genetics  HEK293 cell line  human  light  metabolism  phosphorylation  procedures  radiation response  single cell analysis  CRISPR-Associated Protein 9  CRISPR-Cas Systems  DNA Breaks, Double-Stranded  DNA Cleavage  DNA Repair  Gene Editing  HEK293 Cells  Histones  Humans  Light  MRE11 Homologue Protein  Optical Imaging  Phosphorylation  Single-Cell Analysis  
Ancient origins of allosteric activation in a Ser-Thr kinase 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者:  Hadzipasic A.;  Wilson C.;  Nguyen V.;  Kern N.;  Kim C.;  Pitsawong W.;  Villali J.;  Zheng Y.;  Kern D.
收藏  |  浏览/下载：39/0  |  提交时间：2020/07/28
aurora A kinase  microtubule associated protein  TPX2 protein  unclassified drug  activation energy  ancestry  cell  chemical binding  experimental study  fitness  protein  allosterism  amino acid sequence  Article  binding affinity  binding site  enzyme activation  enzyme activity  enzyme binding  enzyme localization  enzyme phosphorylation  gene duplication  horizontal gene transfer  human  hydrophobicity  intracellular signaling  phylogenetic tree  phylogeny  priority journal  protein binding  protein localization  protein protein interaction  
The integrated stress response: From mechanism to disease 期刊论文
, 2020, 卷号: 368, 期号: 6489
作者:  [无可用作者姓名]
收藏  |  浏览/下载：20/0  |  提交时间：2020/07/28
initiation factor 2  cell component  cognition  disease  homeostasis  protein  quality control  5' untranslated region  adulthood  Article  cell reprogramming technique  cellular stress response  cognitive defect  diabetes mellitus  disease activity  eukaryotic cell  gene expression  human  long term memory  malignant neoplasm  metabolic disorder  nerve degeneration  nonhuman  oxidative stress  pathogenesis  phosphorylation  priority journal  protein defect  protein homeostasis  RNA translation  signal transduction  translation initiation  virus infection  
Liquid droplets in the skin 期刊论文
, 2020, 卷号: 367, 期号: 6483
作者:  Rai A.;  Pelkmans L.
收藏  |  浏览/下载：22/0  |  提交时间：2020/07/28
keratin  keratohyalin  profilaggrin  filaggrin  keratohyalin  polyadenylic acid binding protein  droplet  membrane  physiological response  separation  skin  cell component  cell organelle  physiology  protein  acidification  Article  cell culture  cell differentiation  cell protection  cell structure  epidermis  human  keratinocyte  nonhuman  permeability barrier  pH  phase separation  priority journal  protein aggregation  protein expression  protein phosphorylation  protein processing  skin cell  skin permeability  stoichiometry  stratum corneum  tissue differentiation  liquid crystal  skin  surface property  calcium cell level  cell compartmentalization  degenerative disease  environmental stress  epidermis cell  ichthyosis vulgaris  iquid liquid phase separation  keratinocyte  macromolecular crowding  protein cross linking  protein degradation  Short Survey  signal transduction  Liquid Crystals  Skin  Surface Properties  
An AMPK–caspase-6 axis controls liver damage in nonalcoholic steatohepatitis 期刊论文
, 2020, 卷号: 367, 期号: 6478
作者:  Zhao P.;  Sun X.;  Chaggan C.;  Liao Z.;  Wong K.I.;  He F.;  Singh S.;  Loomba R.;  Karin M.;  Witztum J.L.;  Saltiel A.R.
收藏  |  浏览/下载：35/0  |  提交时间：2020/07/28
6,7 dihydro 4 hydroxy 3 (2' hydroxy 1,1' biphenyl 4 yl) 6 oxothieno[2,3 b]pyridine 5 carbonitrile  adenosine phosphate  caspase 3  caspase 6  caspase 7  cytochrome c  hydroxymethylglutaryl coenzyme A reductase kinase  matrix metalloproteinase  apoptosis  cytochrome  enzyme  enzyme activity  inhibition  protein  rodent  AMPK signaling  animal experiment  animal model  animal tissue  apoptosis  Article  C57BL 6 mouse  cell death  controlled study  drug mechanism  enzyme activation  enzyme activity  enzyme inhibition  enzyme phosphorylation  enzyme repression  gene knockout  human  human cell  human tissue  liver cell  liver fibrosis  liver injury  male  mouse  nonalcoholic steatohepatitis  nonhuman  priority journal  protein cleavage  protein secretion  
Glucose-dependent control of leucine metabolism by leucyl-tRNA synthetase 1 期刊论文
, 2020, 卷号: 367, 期号: 6474
作者:  Yoon I.;  Nam M.;  Kim H.K.;  Moon H.-S.;  Kim S.;  Jang J.;  Song J.A.;  Jeong S.J.;  Kim S.B.;  Cho S.;  Kim Y.;  Lee J.;  Yang W.S.;  Yoo H.C.;  Kim K.;  Kim M.-S.;  Yang A.;  Cho K.;  Park H.-S.;  Hwang G.-S.;  Hwang K.Y.;  Han J.M.;  Kim J.H.;  Kim S.
收藏  |  浏览/下载：29/0  |  提交时间：2020/07/28
glucose  leucine  leucine transfer RNA ligase  leucyl tRNA synthetase 1  mammalian target of rapamycin complex 1  S6 kinase  serine threonine protein kinase ULK1  unclassified drug  glucose  leucine  leucine transfer RNA ligase  mammalian target of rapamycin complex 1  monomeric guanine nucleotide binding protein  serine threonine protein kinase ULK1  catabolism  cell  enzyme  enzyme activity  glucose  metabolism  protein  survival  amino acid metabolism  animal cell  Article  binding affinity  cell survival  circular dichroism  controlled study  embryo  energy yield  enzyme activity  enzyme phosphorylation  enzyme regulation  fluorescence resonance energy transfer  human  human cell  mouse  nonhuman  priority journal  protein binding  protein domain  protein motif  protein processing  protein synthesis  signal transduction  starvation  animal  energy metabolism  fibroblast  genetics  HEK293 cell line  HeLa cell line  lysosome  metabolism  phosphorylation  Animals  Autophagy-Related Protein-1 Homolog  Energy Metabolism  Fibroblasts  Glucose  HEK293 Cells  HeLa Cells  Humans  Leucine  Leucine-tRNA Ligase  Lysosomes  Mechanistic Target of Rapamycin Complex 1  Mice  Monomeric GTP-Binding Proteins  Phosphorylation  Signal Transduction