气候变化领域集成服务门户(CCPortal): Glucose-dependent control of leucine metabolism by leucyl-tRNA synthetase 1

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DOI	10.1126/science.aau2753
	Glucose-dependent control of leucine metabolism by leucyl-tRNA synthetase 1
	Yoon I.; Nam M.; Kim H.K.; Moon H.-S.; Kim S.; Jang J.; Song J.A.; Jeong S.J.; Kim S.B.; Cho S.; Kim Y.; Lee J.; Yang W.S.; Yoo H.C.; Kim K.; Kim M.-S.; Yang A.; Cho K.; Park H.-S.; Hwang G.-S.; Hwang K.Y.; Han J.M.; Kim J.H.; Kim S.
发表日期	2020
ISSN	0036-8075
起始页码	205
结束页码	210
卷号	367 期号:6474
英文摘要	Despite the importance of glucose and amino acids for energy metabolism, interactions between the two nutrients are not well understood. We provide evidence for a role of leucyl-tRNA synthetase 1 (LARS1) in glucose-dependent control of leucine usage. Upon glucose starvation, LARS1 was phosphorylated by Unc-51 like autophagy activating kinase 1 (ULK1) at the residues crucial for leucine binding. The phosphorylated LARS1 showed decreased leucine binding, which may inhibit protein synthesis and help save energy. Leucine that is not used for anabolic processes may be available for catabolic pathway energy generation. The LARS1-mediated changes in leucine utilization might help support cell survival under glucose deprivation. Thus, depending on glucose availability, LARS1 may help regulate whether leucine is used for protein synthesis or energy production. © 2020 American Association for the Advancement of Science. All rights reserved.
关键词	glucose leucine leucine transfer RNA ligase leucyl tRNA synthetase 1 mammalian target of rapamycin complex 1 S6 kinase serine threonine protein kinase ULK1 unclassified drug glucose leucine leucine transfer RNA ligase mammalian target of rapamycin complex 1 monomeric guanine nucleotide binding protein serine threonine protein kinase ULK1 catabolism cell enzyme enzyme activity glucose metabolism protein survival amino acid metabolism animal cell Article binding affinity cell survival circular dichroism controlled study embryo energy yield enzyme activity enzyme phosphorylation enzyme regulation fluorescence resonance energy transfer human human cell mouse nonhuman priority journal protein binding protein domain protein motif protein processing protein synthesis signal transduction starvation animal energy metabolism fibroblast genetics HEK293 cell line HeLa cell line lysosome metabolism phosphorylation Animals Autophagy-Related Protein-1 Homolog Energy Metabolism Fibroblasts Glucose HEK293 Cells HeLa Cells Humans Leucine Leucine-tRNA Ligase Lysosomes Mechanistic Target of Rapamycin Complex 1 Mice Monomeric GTP-Binding Proteins Phosphorylation Signal Transduction
语种	英语
来源机构	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133790
推荐引用方式 GB/T 7714	Yoon I.,Nam M.,Kim H.K.,et al. Glucose-dependent control of leucine metabolism by leucyl-tRNA synthetase 1[J]. Science,2020,367(6474).
APA	Yoon I..,Nam M..,Kim H.K..,Moon H.-S..,Kim S..,...&Kim S..(2020).Glucose-dependent control of leucine metabolism by leucyl-tRNA synthetase 1.,367(6474).
MLA	Yoon I.,et al."Glucose-dependent control of leucine metabolism by leucyl-tRNA synthetase 1".367.6474(2020).