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Structure of the RNA-dependent RNA polymerase from COVID-19 virus 期刊论文
, 2020, 卷号: 368, 期号: 6492
作者:  Gao Y.;  Yan L.;  Huang Y.;  Liu F.;  Zhao Y.;  Cao L.;  Wang T.;  Sun Q.;  Ming Z.;  Zhang L.;  Ge J.;  Zheng L.;  Zhang Y.;  Wang H.;  Zhu Y.;  Zhu C.;  Hu T.;  Hua T.;  Zhang B.;  Yang X.;  Li J.;  Yang H.;  Liu Z.;  Xu W.;  Guddat L.W.;  Wang Q.;  Lou Z.;  Rao Z.
收藏  |  浏览/下载：50/0  |  提交时间：2020/07/28
comparative study  drug  electron microscopy  enzyme  enzyme activity  RNA  virus  Coronavirus  SARS coronavirus  adenosine phosphate  alanine  antivirus agent  NSP7 protein, SARS-CoV-2  NSP8 protein, SARS-CoV-2  remdesivir  RNA directed RNA polymerase  RNA-dependent RNA polymerase, coronavirus  viral protein  beta sheet  Betacoronavirus  chemistry  cryoelectron microscopy  drug design  enzyme active site  enzymology  metabolism  molecular model  protein domain  ultrastructure  Adenosine Monophosphate  Alanine  Antiviral Agents  Betacoronavirus  Catalytic Domain  Cryoelectron Microscopy  Drug Design  Models, Molecular  Protein Conformation, beta-Strand  Protein Domains  RNA Replicase  Viral Nonstructural Proteins  
Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir 期刊论文
, 2020, 卷号: 368, 期号: 6498
作者:  Yin W.;  Mao C.;  Luan X.;  Shen D.-D.;  Shen Q.;  Su H.;  Wang X.;  Zhou F.;  Zhao W.;  Gao M.;  Chang S.;  Xie Y.-C.;  Tian G.;  Jiang H.-W.;  Tao S.-C.;  Shen J.;  Jiang Y.;  Jiang H.;  Xu Y.;  Zhang S.;  Zhang Y.;  Xu H.E.
收藏  |  浏览/下载：199/0  |  提交时间：2020/07/28
adenosine phosphate  alanine  antivirus agent  enzyme inhibitor  multiprotein complex  NSP7 protein, SARS-CoV-2  NSP8 protein, SARS-CoV-2  remdesivir  RNA directed RNA polymerase  RNA-dependent RNA polymerase, coronavirus  viral protein  virus RNA  Betacoronavirus  chemistry  cryoelectron microscopy  drug effect  enzyme active site  enzymology  metabolism  molecular model  physiology  protein conformation  virus replication  Adenosine Monophosphate  Alanine  Antiviral Agents  Betacoronavirus  Catalytic Domain  Cryoelectron Microscopy  Enzyme Inhibitors  Models, Molecular  Multiprotein Complexes  Protein Conformation  RNA Replicase  RNA, Viral  Viral Nonstructural Proteins  Virus Replication  
The Ccr4-Not complex monitors the translating ribosome for codon optimality 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者:  Buschauer R.;  Matsuo Y.;  Sugiyama T.;  Chen Y.-H.;  Alhusaini N.;  Sweet T.;  Ikeuchi K.;  Cheng J.;  Matsuki Y.;  Nobuta R.;  Gilmozzi A.;  Berninghausen O.;  Tesina P.;  Becker T.;  Coller J.;  Inada T.;  Beckmann R.
收藏  |  浏览/下载：45/0  |  提交时间：2020/07/28
exonuclease  initiation factor 5A  messenger RNA  ribosome RNA  transfer RNA  ubiquitin protein ligase E3  bioassay  biomonitoring  cell component  plant and fungus structure and form  40S ribosomal subunit  adenylation  amino terminal sequence  Article  binding site  biochemical analysis  carbon catabolite repressor 4 negative on tata complex  codon  complex formation  controlled study  cryoelectron microscopy  homeostasis  molecular interaction  nonhuman  priority journal  protein conformation  ribosome  Saccharomyces cerevisiae  sequence analysis  ubiquitination  Saccharomyces cerevisiae  
Structure of the secretory immunoglobulin A core 期刊论文
, 2020, 卷号: 367, 期号: 6481
作者:  Kumar N.;  Arthur C.P.;  Ciferri C.;  Matsumoto M.L.
收藏  |  浏览/下载：38/0  |  提交时间：2020/07/28
dimer  immunoglobulin receptor  oligomer  pentamer  secretory component  secretory immunoglobulin  tetramer  unclassified drug  antibody  immune response  immunity  pathogen  physiological response  protein  secretion  antigen antibody complex  antigen binding  Article  cryoelectron microscopy  human  immune reconstitution  immunity  immunoglobulin structure  oligomerization  priority journal  transcytosis  
Correlative three-dimensional super-resolution and block-face electron microscopy of whole vitreously frozen cells 期刊论文
, 2020, 卷号: 367, 期号: 6475
作者:  Hoffman D.P.;  Shtengel G.;  Xu C.S.;  Campbell K.R.;  Freeman M.;  Wang L.;  Milkie D.E.;  Pasolli H.A.;  Iyer N.;  Bogovic J.A.;  Stabley D.R.;  Shirinifard A.;  Pang S.;  Peale D.;  Schaefer K.;  Pomp W.;  Chang C.-L.;  Lippincott-Schwartz J.;  Kirchhausen T.;  Solecki D.J.;  Betzig E.;  Hess H.F.
收藏  |  浏览/下载：50/0  |  提交时间：2020/07/28
cell  compartmentalization  cryopreservation  electron microscopy  image resolution  protein  three-dimensional modeling  ultrastructure  article  chromatin  electron microscopy  endoplasmic reticulum  genetic transcription  human cell  mammal cell  nerve cell culture  protein domain  ultrastructure  whole cell  workflow  animal  cell adhesion  cells  Chlorocebus aethiops  cryoelectron microscopy  CV-1 cell line  fluorescence microscopy  freezing  HeLa cell line  human  mouse  procedures  three-dimensional imaging  tumor cell line  ultrastructure  Mammalia  Animals  Cell Adhesion  Cell Line, Tumor  Cells  Chlorocebus aethiops  COS Cells  Cryoelectron Microscopy  Freezing  HeLa Cells  Humans  Imaging, Three-Dimensional  Mice  Microscopy, Fluorescence  
A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV 期刊论文
, 2020, 卷号: 368, 期号: 6491
作者:  Yuan M.;  Wu N.C.;  Zhu X.;  Lee C.-C.D.;  So R.T.Y.;  Lv H.;  Mok C.K.P.;  Wilson I.A.
收藏  |  浏览/下载：25/0  |  提交时间：2020/07/28
angiotensin converting enzyme 2  epitope  neutralizing antibody  virus hemagglutinin  virus spike protein  angiotensin converting enzyme 2  coronavirus receptors  coronavirus spike glycoprotein  dipeptidyl carboxypeptidase  epitope  neutralizing antibody  spike glycoprotein, SARS-CoV  spike protein, SARS-CoV-2  virus antibody  virus antigen  virus receptor  antibody  antigen  chemical binding  crystal structure  protein  respiratory disease  viral disease  virus  amino terminal sequence  antibody isolation  antigen binding  antigenicity  Article  binding affinity  binding site  conservation biology  controlled study  coronavirus disease 2019  cross reaction  cryoelectron microscopy  crystal structure  enzyme linked immunosorbent assay  epidemic  glycosylation  human  hydrophobicity  immune response  in vitro study  in vivo study  light chain  nonhuman  priority journal  protein conformation  protein domain  protein interaction  protein localization  protein structure  protein targeting  receptor binding  SARS coronavirus  Severe acute respiratory syndrome coronavirus 2  amino acid sequence  antibody affinity  Betacoronavirus  binding site  chemistry  immunology  metabolism  molecular model  SARS coronavirus  X ray crystallography  Coronavirus  SARS coronavirus  Amino Acid Sequence  Antibodies, Neutralizing  Antibodies, Viral  Antibody Affinity  Antigens, Viral  Betacoronavirus  Binding Sites  Cross Reactions  Crystallography, X-Ray  Epitopes  Models, Molecular  Peptidyl-Dipeptidase A  Protein Conformation  Protein Domains  Protein Interaction Domains and Motifs  Receptors, Virus  SARS Virus  Spike Glycoprotein, Coronavirus  
Structural basis of Gs and Gi recognition by the human glucagon receptor 期刊论文
, 2020, 卷号: 367, 期号: 6484
作者:  Qiao A.;  Han S.;  Li X.;  Li Z.;  Zhao P.;  Dai A.;  Chang R.;  Tai L.;  Tan Q.;  Chu X.;  Ma L.;  Thorsen T.S.;  Reedtz-Runge S.;  Yang D.;  Wang M.-W.;  Sexton P.M.;  Wootten D.;  Sun F.;  Zhao Q.;  Wu B.
收藏  |  浏览/下载：43/0  |  提交时间：2020/07/28
cyclic AMP  glucagon  glucagon receptor  inhibitory guanine nucleotide binding protein  stimulatory guanine nucleotide binding protein  glucagon receptor  inhibitory guanine nucleotide binding protein  protein binding  stimulatory guanine nucleotide binding protein  chemical binding  enzyme activity  gene expression  mutagenicity  protein  alpha helix  Article  binding affinity  carboxy terminal sequence  conformational transition  cryoelectron microscopy  human  molecular recognition  mutagenesis  priority journal  protein binding  protein function  protein protein interaction  protein structure  signal transduction  binding site  chemistry  metabolism  molecular model  protein conformation  ultrastructure  Binding Sites  Cryoelectron Microscopy  Glucagon  GTP-Binding Protein alpha Subunits, Gi-Go  GTP-Binding Protein alpha Subunits, Gs  Humans  Models, Molecular  Protein Binding  Protein Conformation  Protein Conformation, alpha-Helical  Receptors, Glucagon  Signal Transduction  
Structural insights into immunoglobulin M 期刊论文
, 2020, 卷号: 367, 期号: 6481
作者:  Li Y.;  Wang G.;  Li N.;  Wang Y.;  Zhu Q.;  Chu H.;  Wu W.;  Tan Y.;  Yu F.;  Su X.-D.;  Gao N.;  Xiao J.
收藏  |  浏览/下载：43/0  |  提交时间：2020/07/28
immunoglobulin M  secretory component  antibody  immunity  molecular analysis  polymer  protein  Article  binding site  conformational transition  cryoelectron microscopy  crystal structure  human  hydrophobicity  nonhuman  oligomerization  priority journal  protein assembly  protein domain  protein function  protein interaction  protein stability  protein structure  protein transport  surface area  
Structure of nucleosome-bound human BAF complex 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者:  He S.;  Wu Z.;  Tian Y.;  Yu Z.;  Yu J.;  Wang X.;  Li J.;  Liu B.;  Xu Y.
收藏  |  浏览/下载：37/0  |  提交时间：2020/07/28
actin related protein  adenosine triphosphatase  BRG1 BRM associated factor  DNA  multiprotein complex  protein SWI  retinoblastoma binding protein 2  SMARCC protein  SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily B member 1  transcription factor  transcription factor SNF  unclassified drug  cancer  enzyme activity  gene expression  hydrolysis  mutation  protein  alpha helix  Article  carboxy terminal sequence  cell interaction  cryoelectron microscopy  disease association  human  malignant neoplasm  molecular recognition  mutation  nucleosome  priority journal  protein function  protein hydrolysis  protein structure  structure analysis  Mammalia  
TTC5 mediates autoregulation of tubulin via mRNA degradation 期刊论文
, 2020, 卷号: 367, 期号: 6473
作者:  Lin Z.;  Gasic I.;  Chandrasekaran V.;  Peters N.;  Shao S.;  Mitchison T.J.;  Hegde R.S.
收藏  |  浏览/下载：26/0  |  提交时间：2020/07/28
messenger RNA  mutant protein  polypeptide  recombinant protein  regulator protein  tetratricopeptide protein 5  tubulin  unclassified drug  biodegradation  chromosome  peptide  protein  RNA  amino terminal sequence  animal cell  Article  autoregulation  binding site  chromosome segregation  controlled study  cryoelectron microscopy  genetic code  human  human cell  Leporidae  mitosis  molecular model  nonhuman  priority journal  protein analysis  protein binding  protein interaction  protein structure  reticulocyte  ribosome  RNA degradation  RNA translation  tubulin gene