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| Liquid-liquid phase separation drives skin barrier formation 期刊论文
, 2020, 卷号: 367, 期号: 6483
作者: Quiroz F.G.; Fiore V.F.; Levorse J.; Polak L.; Wong E.; Pasolli H.A.; Fuchs E.
  收藏 | 浏览/下载：31/0 | 提交时间：2020/07/28
filaggrin keratohyalin coalescence differentiation separation skin skin disorder stratification amino acid composition Article bioengineering biophysics cell differentiation cell function cell structure epidermis cell genetic transfection human keratinocyte liquid live cell imaging molecular dynamics nonhuman pH phase separation phase transition priority journal proteomics sequence analysis signal transduction skin skin surface Mus |
| Single-cell transcriptional diversity is a hallmark of developmental potential 期刊论文
, 2020, 卷号: 367, 期号: 6476
作者: Gulati G.S.; Sikandar S.S.; Wesche D.J.; Manjunath A.; Bharadwaj A.; Berger M.J.; Ilagan F.; Kuo A.H.; Hsieh R.W.; Cai S.; Zabala M.; Scheeren F.A.; Lobo N.A.; Qian D.; Yu F.B.; Dirbas F.M.; Clarke M.F.; Newman A.M.
收藏 | 浏览/下载：47/0 | 提交时间：2020/07/28
cell cell component developmental biology experimental study genetic analysis tumor Article breast cancer breast carcinogenesis carcinogenesis cell differentiation computer model embryonic stem cell gene expression genetic code genetic variability human in vivo study nonhuman phenotype priority journal scoring system single cell RNA seq upregulation |
| Maternal gut microbiota in pregnancy influences offspring metabolic phenotype in mice 期刊论文
, 2020, 卷号: 367, 期号: 6481
作者: Kimura I.; Miyamoto J.; Ohue-Kitano R.; Watanabe K.; Yamada T.; Onuki M.; Aoki R.; Isobe Y.; Kashihara D.; Inoue D.; Inaba A.; Takamura Y.; Taira S.; Kumaki S.; Watanabe M.; Ito M.; Nakagawa F.; Irie J.; Kakuta H.; Shinohara M.; Iwatsuki K.; Tsujimoto G.; Ohno H.; Arita M.; Itoh H.; Hase K.
收藏 | 浏览/下载：45/0 | 提交时间：2020/07/28
G protein coupled receptor G protein coupled receptor 41 G protein coupled receptor 43 glucagon like peptide 1 short chain fatty acid unclassified drug disease incidence experimental study female microbial community phenotype pregnancy rodent adult animal cell animal experiment animal model animal tissue Article C57BL 6 mouse cell differentiation controlled study developmental stage diet composition diet supplementation dietary exposure disease exacerbation disease predisposition embryo embryo development energy metabolism enteroendocrine cell female fiber intake germfree animal glucose intolerance high risk pregnancy hyperglycemia Institute for Cancer Research mouse insulin metabolism intestine flora lipid diet low fiber diet male maternal nutrition metabolic syndrome X mouse newborn nonhuman obesity pancreas islet beta cell phenotype pregnancy prenatal development priority journal progeny protein expression risk reduction Mus |
| Translating preclinical models to humans 期刊论文
, 2020, 卷号: 367, 期号: 6479
作者: Brubaker D.K.; Lauffenburger D.A.
收藏 | 浏览/下载：40/0 | 提交时间：2020/07/28
detection method model Article bioengineering biomedicine cell differentiation cell proliferation computer model conceptual framework DNA sequence drug development epithelium cell gene expression profiling high throughput sequencing human machine learning molecular dynamics nonhuman phenotype priority journal proteomics RNA sequence sex difference signal transduction T lymphocyte transcription regulation transcriptomics translational research |
| A programmable fate decision landscape underlies single-cell aging in yeast 期刊论文
, 2020, 卷号: 369, 期号: 6501
作者: Li Y.; Jiang Y.; Paxman J.; O'Laughlin R.; Klepin S.; Zhu Y.; Pillus L.; Tsimring L.S.; Hasty J.; Hao N.
收藏 | 浏览/下载：43/0 | 提交时间：2020/07/28
apoptosis article cell aging cell differentiation chromatin epigenetics lifespan noise nonhuman yeast |
| Regenerative potential of prostate luminal cells revealed by single-cell analysis 期刊论文
, 2020, 卷号: 368, 期号: 6490
作者: Karthaus W.R.; Hofree M.; Choi D.; Linton E.L.; Turkekul M.; Bejnood A.; Carver B.; Gopalan A.; Abida W.; Laudone V.; Biton M.; Chaudhary O.; Xu T.; Masilionis I.; Manova K.; Mazutis L.; Pe’er D.; Regev A.; Sawyers C.L.
收藏 | 浏览/下载：216/0 | 提交时间：2020/07/28
androgen growth factor Nrg2 growth factor Rspo3 growth factor unclassified drug androgen binding protein antiandrogen ataxin 1 Atxn1 protein, mouse glycosylphosphatidylinositol anchored protein homeodomain protein nerve growth factor Nkx3-1 protein, mouse Nrg2 protein, mouse probasin Psca protein, mouse R-spondin3 protein, mouse thrombospondin transcription factor tumor antigen tumor protein androgen cancer cell gene expression RNA rodent ablation therapy animal cell animal tissue Article cell differentiation cell population cell regeneration cells by body anatomy controlled study gene gene expression human luminal cell male mesenchyme cell mouse nonhuman paracrine signaling priority journal prostate cell prostate tissue protein expression Psca gene RNA sequencing Sca1 gene single cell analysis animal genetics mesenchymal stem cell metabolism organ size organoid physiology prostate prostate tumor regeneration sequence analysis single cell analysis Mus Androgen Antagonists Androgen-Binding Protein Androgens Animals Antigens, Neoplasm Ataxin-1 Cell Differentiation Gene Expression GPI-Linked Proteins Homeodomain Proteins Humans Male Mesenchymal Stem Cells Mice Neoplasm Proteins Nerve Growth Factors Organ Size Organoids Prostate Prostatic Neoplasms Regeneration Sequence Analysis, RNA Single-Cell Analysis Thrombospondins Transcription Factors |
| Maintenance of neural stem cell positional identity by mixed-lineage leukemia 1 期刊论文
, 2020, 卷号: 368, 期号: 6486
作者: Delgado R.N.; Mansky B.; Ahanger S.H.; Lu C.; Andersen R.E.; Dou Y.; Alvarez-Buylla A.; Lim D.A.
收藏 | 浏览/下载：29/0 | 提交时间：2020/07/28
mixed lineage leukemia 1 protein mixed lineage leukemia protein morphogen sonic hedgehog protein unclassified drug anatomy brain cell component developmental biology inhibition adult animal cell animal experiment animal tissue Article controlled study embryo epigenetics forebrain in vivo study memory Mll1 gene mouse nerve cell nerve cell differentiation neural stem cell nonhuman priority journal Erinaceidae Murinae |
| A cell atlas of human thymic development defines T cell repertoire formation 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者: Park J.-E.; Botting R.A.; Conde C.D.; Popescu D.-M.; Lavaert M.; Kunz D.J.; Goh I.; Stephenson E.; Ragazzini R.; Tuck E.; Wilbrey-Clark A.; Roberts K.; Kedlian V.R.; Ferdinand J.R.; He X.; Webb S.; Maunder D.; Vandamme N.; Mahbubani K.T.; Polanski K.; Mamanova L.; Bolt L.; Crossland D.; De Rita F.; Fuller A.; Filby A.; Reynolds G.; Dixon D.; Saeb-Parsy K.; Lisgo S.; Henderson D.; Vento-Tormo R.; Bayraktar O.A.; Barker R.A.; Meyer K.B.; Saeys Y.; Bonfanti P.; Behjati S.; Clatworthy M.R.; Taghon T.; Haniffa M.; Teichmann S.A.
收藏 | 浏览/下载：69/0 | 提交时间：2020/07/28
T lymphocyte receptor cell component developmental biology differentiation genomics recombination RNA adaptive immunity Article CD4+ T lymphocyte CD8+ T lymphocyte cell fate cell maturation cell selection controlled study developmental stage gene gene expression gene expression profiling GNG4 gene human human cell human tissue lymphocyte differentiation priority journal protein expression regulatory T lymphocyte RNA sequencing sequence analysis T lymphocyte T lymphocyte activation thymic medulla thymocyte thymus XCL1 gene |
| SARS-CoV-2 productively infects human gut enterocytes 期刊论文
, 2020, 卷号: 369, 期号: 6499
作者: Lamers M.M.; Beumer J.; van der Vaart J.; Knoops K.; Puschhof J.; Breugem T.I.; Ravelli R.B.G.; Paul van Schayck J.; Mykytyn A.Z.; Duimel H.Q.; van Donselaar E.; Riesebosch S.; Kuijpers H.J.H.; Schipper D.; van de Wetering W.J.; de Graaf M.; Koopmans M.; Cuppen E.; Peters P.J.; Haagmans B.L.; Clevers H.
收藏 | 浏览/下载：38/0 | 提交时间：2020/07/28
angiotensin converting enzyme 2 dipeptidyl carboxypeptidase messenger RNA virus receptor Betacoronavirus cell culture technique cell differentiation cell lineage cell proliferation culture medium gene expression genetics human ileum intestine cell lung male metabolism organoid physiology respiratory mucosa SARS coronavirus ultrastructure virology virus replication Betacoronavirus Cell Culture Techniques Cell Differentiation Cell Lineage Cell Proliferation Culture Media Enterocytes Gene Expression Humans Ileum Lung Male Organoids Peptidyl-Dipeptidase A Receptors, Virus Respiratory Mucosa RNA, Messenger SARS Virus Virus Replication |
| MRNA destabilization by BTG1 and BTG2 maintains T cell quiescence 期刊论文
, 2020, 卷号: 367, 期号: 6483
作者: Hwang S.S.; Lim J.; Yu Z.; Kong P.; Sefik E.; Xu H.; Harman C.C.D.; Kim L.K.; Lee G.R.; Li H.-B.; Flavell R.A.
收藏 | 浏览/下载：36/0 | 提交时间：2020/07/28
CD69 antigen chemokine receptor CCR7 epidermal growth factor receptor 2 Hermes antigen interleukin 2 receptor alpha interleukin 2 receptor gamma interleukin 7 receptor kruppel like factor 2 messenger RNA polyadenylic acid T lymphocyte receptor transcription factor FKHR transcriptome biodegradation cell component RNA adenylation Article BTG1 gene BTG2 gene Ccr7 gene CD4+ T lymphocyte CD8+ T lymphocyte cell differentiation cell expansion cell maturation cell migration cell proliferation cell size cell specificity cell survival controlled study CRISPR-CAS9 system flow cytometry gene gene control gene expression gene function gene identification immunoprecipitation in vitro study in vivo study memory T lymphocyte nonhuman phylogenetic tree priority journal RNA degradation RNA sequencing S1pr1 gene Sell gene spleen T lymphocyte T lymphocyte activation tail length (comet assay) thymus upregulation |
