气候变化领域集成服务门户(CCPortal): Maternal gut microbiota in pregnancy influences offspring metabolic phenotype in mice

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DOI	10.1126/science.aaw8429
	Maternal gut microbiota in pregnancy influences offspring metabolic phenotype in mice
	Kimura I.; Miyamoto J.; Ohue-Kitano R.; Watanabe K.; Yamada T.; Onuki M.; Aoki R.; Isobe Y.; Kashihara D.; Inoue D.; Inaba A.; Takamura Y.; Taira S.; Kumaki S.; Watanabe M.; Ito M.; Nakagawa F.; Irie J.; Kakuta H.; Shinohara M.; Iwatsuki K.; Tsujimoto G.; Ohno H.; Arita M.; Itoh H.; Hase K.
发表日期	2020
ISSN	0036-8075
卷号	367 期号:6481
英文摘要	Antibiotics and dietary habits can affect the gut microbial community, thus influencing disease susceptibility. Although the effect of microbiota on the postnatal environment has been well documented, much less is known regarding the impact of gut microbiota at the embryonic stage. Here we show that maternal microbiota shapes the metabolic system of offspring in mice. During pregnancy, short-chain fatty acids produced by the maternal microbiota dictate the differentiation of neural, intestinal, and pancreatic cells through embryonic GPR41 and GPR43. This developmental process helps maintain postnatal energy homeostasis, as evidenced by the fact that offspring from germ-free mothers are highly susceptible to metabolic syndrome, even when reared under conventional conditions. Thus, our findings elaborate on a link between the maternal gut environment and the developmental origin of metabolic syndrome. Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works
关键词	G protein coupled receptor G protein coupled receptor 41 G protein coupled receptor 43 glucagon like peptide 1 short chain fatty acid unclassified drug disease incidence experimental study female microbial community phenotype pregnancy rodent adult animal cell animal experiment animal model animal tissue Article C57BL 6 mouse cell differentiation controlled study developmental stage diet composition diet supplementation dietary exposure disease exacerbation disease predisposition embryo embryo development energy metabolism enteroendocrine cell female fiber intake germfree animal glucose intolerance high risk pregnancy hyperglycemia Institute for Cancer Research mouse insulin metabolism intestine flora lipid diet low fiber diet male maternal nutrition metabolic syndrome X mouse newborn nonhuman obesity pancreas islet beta cell phenotype pregnancy prenatal development priority journal progeny protein expression risk reduction Mus
语种	英语
来源机构	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133672
推荐引用方式 GB/T 7714	Kimura I.,Miyamoto J.,Ohue-Kitano R.,et al. Maternal gut microbiota in pregnancy influences offspring metabolic phenotype in mice[J]. Science,2020,367(6481).
APA	Kimura I..,Miyamoto J..,Ohue-Kitano R..,Watanabe K..,Yamada T..,...&Hase K..(2020).Maternal gut microbiota in pregnancy influences offspring metabolic phenotype in mice.,367(6481).
MLA	Kimura I.,et al."Maternal gut microbiota in pregnancy influences offspring metabolic phenotype in mice".367.6481(2020).