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Li J. [5]
Li C. [2]
Li Y. [2]
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期刊论文 [5]
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2020 [5]
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Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease
期刊论文
, 2020, 卷号: 368, 期号: 6497
作者:
Dai W.
;
Zhang B.
;
Jiang X.-M.
;
Su H.
;
Li J.
;
Zhao Y.
;
Xie X.
;
Jin Z.
;
Peng J.
;
Liu F.
;
Li C.
;
Li Y.
;
Bai F.
;
Wang H.
;
Cheng X.
;
Cen X.
;
Hu S.
;
Yang X.
;
Wang J.
;
Liu X.
;
Xiao G.
;
Jiang H.
;
Rao Z.
;
Zhang L.-K.
;
Xu Y.
;
Yang H.
;
Liu H.
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2020/07/28
aldehyde
antimicrobial activity
drug
enzyme activity
infectivity
inhibitor
reaction kinetics
viral disease
Coronavirus
SARS coronavirus
3C-like proteinase, Coronavirus
antivirus agent
cysteine proteinase
viral protein
animal
Betacoronavirus
chemical structure
chemistry
Chlorocebus aethiops
Coronavirus infection
dog
drug design
drug effect
enzyme active site
enzymology
female
human
male
mouse
pandemic
preclinical study
protein tertiary structure
Sprague Dawley rat
toxicity testing
Vero cell line
virus pneumonia
Animals
Antiviral Agents
Betacoronavirus
Catalytic Domain
Chlorocebus aethiops
Coronavirus Infections
Cysteine Endopeptidases
Dogs
Drug Design
Drug Evaluation, Preclinical
Female
Humans
Male
Mice
Molecular Structure
Pandemics
Pneumonia, Viral
Protein Structure, Tertiary
Rats, Sprague-Dawley
Toxicity Tests
Vero Cells
Viral Nonstructural Proteins
VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance
期刊论文
, 2020, 卷号: 367, 期号: 6475
作者:
ElTanbouly M.A.
;
Zhao Y.
;
Nowak E.
;
Li J.
;
Schaafsma E.
;
Le Mercier I.
;
Ceeraz S.
;
Lines J.L.
;
Peng C.
;
Carriere C.
;
Huang X.
;
Day M.
;
Koehn B.
;
Lee S.W.
;
Morales M.S.
;
Hogquist K.A.
;
Jameson S.C.
;
Mueller D.
;
Rothstein J.
;
Blazar B.R.
;
Cheng C.
;
Noelle R.J.
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2020/07/28
cell protein
interferon
kruppel like factor 2
T lymphocyte receptor
unclassified drug
V type immunoglobulin domain containing suppressor of T cell activation protein
B7 antigen
Dies1 protein, mouse
lymphocyte antigen receptor
membrane protein
monoclonal antibody
VSIR protein, human
biological development
cell
gene expression
heterogeneity
homeostasis
immune response
immunity
tolerance
acute graft versus host disease
animal cell
animal experiment
animal model
Article
CD4+ T lymphocyte
cell death
cell expansion
cell fate
cell heterogeneity
cell loss
cell survival
controlled study
female
gene
gene deletion
homeostasis
immunological tolerance
in vivo study
long term survival
male
mouse
nonhuman
phenotype
priority journal
protein expression
protein function
rheumatoid arthritis
RNA sequencing
systemic lupus erythematosus
T lymphocyte
T lymphocyte activation
T lymphocyte subpopulation
TCR gene
upregulation
VISTA gene
animal
C57BL mouse
genetics
immunological tolerance
immunology
knockout mouse
lymphocyte activation
physiology
T lymphocyte
Mus
Animals
Antibodies, Monoclonal
B7 Antigens
Lymphocyte Activation
Membrane Proteins
Mice
Mice, Inbred C57BL
Mice, Knockout
Peripheral Tolerance
Receptors, Antigen, T-Cell
T-Lymphocytes
Interleukin-13 drives metabolic conditioning of muscle to endurance exercise
期刊论文
, 2020, 卷号: 368, 期号: 6490
作者:
Knudsen N.H.
;
Stanya K.J.
;
Hyde A.L.
;
Chalom M.M.
;
Alexander R.K.
;
Liou Y.-H.
;
Starost K.A.
;
Gangl M.R.
;
Jacobi D.
;
Liu S.
;
Sopariwala D.H.
;
Fonseca-Pereira D.
;
Li J.
;
Hu F.B.
;
Garrett W.S.
;
Narkar V.A.
;
Ortlund E.A.
;
Kim J.H.
;
Paton C.M.
;
Cooper J.A.
;
Lee C.-H.
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2020/07/28
glucose
interleukin 13
interleukin 13 receptor alpha1
interleukin 6
STAT3 protein
fatty acid
glycogen
interleukin 13
interleukin 13 receptor alpha1
STAT3 protein
Stat3 protein, mouse
fatty acid
metabolism
muscle
oxidation
physiological response
protein
respiration
aerobic exercise
animal cell
animal experiment
animal tissue
Article
C2C12 cell line
cohort analysis
controlled study
endurance training
energy metabolism
ex vivo study
exercise intensity
female
gastrocnemius muscle
glucose tolerance
human
in vitro study
male
mitochondrial biogenesis
mitochondrial dynamics
mitochondrial respiration
mouse
muscle metabolism
muscle mitochondrion
nonhuman
obesity
priority journal
protein blood level
protein expression
running
sedentary lifestyle
signal transduction
treadmill exercise
adaptation
animal
blood
C57BL mouse
cell line
endurance
genetics
glucose blood level
immunology
knockout mouse
metabolism
myoblast
oxidation reduction reaction
skeletal muscle
Mus
Adaptation, Physiological
Animals
Blood Glucose
Cell Line
Fatty Acids
Female
Glycogen
Humans
Interleukin-13
Interleukin-13 Receptor alpha1 Subunit
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Mitochondria, Muscle
Muscle, Skeletal
Myoblasts
Oxidation-Reduction
Physical Conditioning, Animal
Physical Endurance
Running
STAT3 Transcription Factor
Development of an inactivated vaccine candidate for SARS-CoV-2
期刊论文
, 2020, 卷号: 369, 期号: 6499
作者:
Gao Q.
;
Bao L.
;
Mao H.
;
Wang L.
;
Xu K.
;
Yang M.
;
Li Y.
;
Zhu L.
;
Wang N.
;
Lv Z.
;
Gao H.
;
Ge X.
;
Kan B.
;
Hu Y.
;
Liu J.
;
Cai F.
;
Jiang D.
;
Yin Y.
;
Qin C.
;
Li J.
;
Gong X.
;
Lou X.
;
Shi W.
;
Wu D.
;
Zhang H.
;
Zhu L.
;
Deng W.
;
Li Y.
;
Lu J.
;
Li C.
;
Wang X.
;
Yin W.
;
Zhang Y.
;
Qin C.
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2020/07/28
COVID-19 vaccine
immunoglobulin G
inactivated vaccine
neutralizing antibody
virus antibody
virus vaccine
animal
Bagg albino mouse
Betacoronavirus
biosynthesis
blood
Chlorocebus aethiops
Coronavirus infection
dose response
female
immunology
isolation and purification
male
mouse
pandemic
pilot study
rat
rhesus monkey
vaccine immunogenicity
Vero cell line
virology
virus load
virus pneumonia
Wistar rat
Animals
Antibodies, Neutralizing
Antibodies, Viral
Betacoronavirus
Chlorocebus aethiops
Coronavirus Infections
Dose-Response Relationship, Immunologic
Female
Immunogenicity, Vaccine
Immunoglobulin G
Macaca mulatta
Male
Mice
Mice, Inbred BALB C
Pandemics
Pilot Projects
Pneumonia, Viral
Rats
Rats, Wistar
Vaccines, Inactivated
Vero Cells
Viral Load
Viral Vaccines
Microglia mediate forgetting via complement-dependent synaptic elimination
期刊论文
, 2020, 卷号: 367, 期号: 6478
作者:
Wang C.
;
Yue H.
;
Hu Z.
;
Shen Y.
;
Ma J.
;
Li J.
;
Wang X.-D.
;
Wang L.
;
Sun B.
;
Shi P.
;
Wang L.
;
Gu Y.
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2020/07/28
complement
complement component C1q
complement component C3
complement receptor
decay accelerating factor
adult
cell
inhibition
memory
nervous system
adult
aging
animal cell
animal experiment
Article
C57BL 6 mouse
cognition
controlled study
functional dissociation
hippocampus
memory
memory consolidation
microglia
mouse
nerve cell inhibition
nerve cell plasticity
nervous system development
nonhuman
phagocytosis
priority journal
synaptic inhibition
Mus