气候变化领域集成服务门户(CCPortal): Microglia mediate forgetting via complement-dependent synaptic elimination

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DOI	10.1126/science.aaz2288
	Microglia mediate forgetting via complement-dependent synaptic elimination
	Wang C.; Yue H.; Hu Z.; Shen Y.; Ma J.; Li J.; Wang X.-D.; Wang L.; Sun B.; Shi P.; Wang L.; Gu Y.
发表日期	2020
ISSN	0036-8075
起始页码	688
结束页码	694
卷号	367 期号:6478
英文摘要	Synapses between engram cells are believed to be substrates for memory storage, and the weakening or loss of these synapses leads to the forgetting of related memories. We found engulfment of synaptic components by microglia in the hippocampi of healthy adult mice. Depletion of microglia or inhibition of microglial phagocytosis prevented forgetting and the dissociation of engram cells. By introducing CD55 to inhibit complement pathways, specifically in engram cells, we further demonstrated that microglia regulated forgetting in a complement- and activity-dependent manner. Additionally, microglia were involved in both neurogenesis-related and neurogenesis-unrelated memory degradation. Together, our findings revealed complement-dependent synapse elimination by microglia as a mechanism underlying the forgetting of remote memories. © 2020 American Association for the Advancement of Science. All rights reserved.
关键词	complement complement component C1q complement component C3 complement receptor decay accelerating factor adult cell inhibition memory nervous system adult aging animal cell animal experiment Article C57BL 6 mouse cognition controlled study functional dissociation hippocampus memory memory consolidation microglia mouse nerve cell inhibition nerve cell plasticity nervous system development nonhuman phagocytosis priority journal synaptic inhibition Mus
语种	英语
来源机构	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133733
推荐引用方式 GB/T 7714	Wang C.,Yue H.,Hu Z.,et al. Microglia mediate forgetting via complement-dependent synaptic elimination[J]. Science,2020,367(6478).
APA	Wang C..,Yue H..,Hu Z..,Shen Y..,Ma J..,...&Gu Y..(2020).Microglia mediate forgetting via complement-dependent synaptic elimination.,367(6478).
MLA	Wang C.,et al."Microglia mediate forgetting via complement-dependent synaptic elimination".367.6478(2020).