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Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease 期刊论文
, 2020, 卷号: 368, 期号: 6497
作者:  Dai W.;  Zhang B.;  Jiang X.-M.;  Su H.;  Li J.;  Zhao Y.;  Xie X.;  Jin Z.;  Peng J.;  Liu F.;  Li C.;  Li Y.;  Bai F.;  Wang H.;  Cheng X.;  Cen X.;  Hu S.;  Yang X.;  Wang J.;  Liu X.;  Xiao G.;  Jiang H.;  Rao Z.;  Zhang L.-K.;  Xu Y.;  Yang H.;  Liu H.
收藏  |  浏览/下载：36/0  |  提交时间：2020/07/28
aldehyde  antimicrobial activity  drug  enzyme activity  infectivity  inhibitor  reaction kinetics  viral disease  Coronavirus  SARS coronavirus  3C-like proteinase, Coronavirus  antivirus agent  cysteine proteinase  viral protein  animal  Betacoronavirus  chemical structure  chemistry  Chlorocebus aethiops  Coronavirus infection  dog  drug design  drug effect  enzyme active site  enzymology  female  human  male  mouse  pandemic  preclinical study  protein tertiary structure  Sprague Dawley rat  toxicity testing  Vero cell line  virus pneumonia  Animals  Antiviral Agents  Betacoronavirus  Catalytic Domain  Chlorocebus aethiops  Coronavirus Infections  Cysteine Endopeptidases  Dogs  Drug Design  Drug Evaluation, Preclinical  Female  Humans  Male  Mice  Molecular Structure  Pandemics  Pneumonia, Viral  Protein Structure, Tertiary  Rats, Sprague-Dawley  Toxicity Tests  Vero Cells  Viral Nonstructural Proteins  
Effective containment explains subexponential growth in recent confirmed COVID-19 cases in China 期刊论文
, 2020, 卷号: 368, 期号: 6492
作者:  Maier B.F.;  Brockmann D.
收藏  |  浏览/下载：11/0  |  提交时间：2020/07/28
disease control  disease prevalence  epidemic  health geography  public health  quarantine  symptom  viral disease  China  Coronavirus  basic reproduction number  behavior  Betacoronavirus  China  communicable disease control  contact examination  Coronavirus infection  disease predisposition  epidemic  human  pandemic  quarantine  statistical model  virus pneumonia  Basic Reproduction Number  Behavior  Betacoronavirus  China  Communicable Disease Control  Contact Tracing  Coronavirus Infections  Disease Outbreaks  Disease Susceptibility  Humans  Models, Statistical  Pandemics  Pneumonia, Viral  Quarantine  
Moving academic research forward during COVID-19 期刊论文
, 2020, 卷号: 368, 期号: 6496
作者:  Wigginton N.S.;  Cunningham R.M.;  Katz R.H.;  Lidstrom M.E.;  Moler K.A.;  Wirtz D.;  Zuber M.T.
收藏  |  浏览/下载：20/0  |  提交时间：2020/07/28
academic research  decision making  higher education  learning  public health  student  teaching  university sector  viral disease  virus  Coronavirus infection  health care policy  human  organization  pandemic  United States  virus pneumonia  Academies and Institutes  Coronavirus Infections  Health Policy  Humans  Pandemics  Pneumonia, Viral  United States  
Quantifying SARS-CoV-2 transmission suggests epidemic control with digital contact tracing 期刊论文
, 2020, 卷号: 368, 期号: 6491
作者:  Ferretti L.;  Wymant C.;  Kendall M.;  Zhao L.;  Nurtay A.;  Abeler-Dörner L.;  Parker M.;  Bonsall D.;  Fraser C.
收藏  |  浏览/下载：23/0  |  提交时间：2020/07/28
disease control  epidemic  memory  parasite transmission  viral disease  Article  asymptomatic disease  China  contact examination  coronavirus disease 2019  disease control  disease transmission  health care system  human  incubation time  mathematical model  mobile application  mortality rate  priority journal  quarantine  rating scale  Severe acute respiratory syndrome coronavirus 2  virus transmission  algorithm  basic reproduction number  Betacoronavirus  contact examination  Coronavirus infection  epidemic  ethics  infection control  mobile application  mobile phone  pandemic  probability  procedures  theoretical model  time factor  virus pneumonia  Coronavirus  SARS coronavirus  Algorithms  Asymptomatic Diseases  Basic Reproduction Number  Betacoronavirus  Cell Phone  China  Contact Tracing  Coronavirus Infections  Epidemics  Humans  Infection Control  Mobile Applications  Models, Theoretical  Pandemics  Pneumonia, Viral  Probability  Quarantine  Time Factors  
Rapid implementation of mobile technology for real-time epidemiology of COVID-19 期刊论文
, 2020, 卷号: 368, 期号: 6497
作者:  Drew D.A.;  Nguyen L.H.;  Steves C.J.;  Menni C.;  Freydin M.;  Varsavsky T.;  Sudre C.H.;  Jorge Cardoso M.;  Ourselin S.;  Wolf J.;  Spector T.D.;  Chan A.T.;  COPE Consortium
收藏  |  浏览/下载：27/0  |  提交时间：2020/07/28
data assimilation  epidemiology  public health  real time  risk factor  severe acute respiratory syndrome  viral disease  United Kingdom  United States  Coronavirus  SARS coronavirus  Betacoronavirus  Coronavirus infection  devices  global health  human  information processing  international cooperation  mobile application  pandemic  procedures  theoretical model  United Kingdom  United States  virus pneumonia  Betacoronavirus  Big Data  Coronavirus Infections  Data Collection  Global Health  Humans  International Cooperation  Mobile Applications  Models, Theoretical  Pandemics  Pneumonia, Viral  United Kingdom  United States  
Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model 期刊论文
, 2020, 卷号: 368, 期号: 6494
作者:  Rockx B.;  Kuiken T.;  Herfst S.;  Bestebroer T.;  Lamers M.M.;  Munnink B.B.O.;  De Meulder D.;  Van Amerongen G.;  Van Den Brand J.;  Okba N.M.A.;  Schipper D.;  Van Run P.;  Leijten L.;  Sikkema R.;  Verschoor E.;  Verstrepen B.;  Bogers W.;  Langermans J.;  Langermans J.;  Drosten C.;  Van Vlissingen M.F.;  Fouchier R.;  De Swart R.;  Koopmans M.;  Haagmans B.L.
收藏  |  浏览/下载：21/0  |  提交时间：2020/07/28
pathogenicity  pathology  primate  severe acute respiratory syndrome  viral disease  virus  Middle East  Coronavirus  Macaca  Primates  SARS coronavirus  aging  animal  Betacoronavirus  comparative study  Coronavirus infection  disease model  female  isolation and purification  lung  lung alveolus  Macaca fascicularis  Middle East respiratory syndrome coronavirus  pandemic  pathogenicity  pathology  physiology  respiratory system  SARS coronavirus  severe acute respiratory syndrome  virology  virus pneumonia  virus replication  virus shedding  Aging  Animals  Betacoronavirus  Coronavirus Infections  Disease Models, Animal  Female  Lung  Macaca fascicularis  Middle East Respiratory Syndrome Coronavirus  Pandemics  Pneumonia, Viral  Pulmonary Alveoli  Respiratory System  SARS Virus  Severe Acute Respiratory Syndrome  Virus Replication  Virus Shedding  
Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS-coronavirus 2 期刊论文
, 2020, 卷号: 368, 期号: 6494
作者:  Shi J.;  Wen Z.;  Zhong G.;  Yang H.;  Wang C.;  Huang B.;  Liu R.;  He X.;  Shuai L.;  Sun Z.;  Zhao Y.;  Liu P.;  Liang L.;  Cui P.;  Wang J.;  Zhang X.;  Guan Y.;  Tan W.;  Wu G.;  Chen H.;  Bu Z.;  Bu Z.
收藏  |  浏览/下载：35/0  |  提交时间：2020/07/28
bat  canid  disease control  disease transmission  felid  global perspective  infectious disease  poultry  severe acute respiratory syndrome  viral disease  virus  China  Hubei  Wuhan  Anas  Animalia  Canis familiaris  Coronavirus  Gallus gallus  Mustela  SARS coronavirus  Suidae  virus antibody  virus RNA  animal  Betacoronavirus  blood  cat  chicken  Coronavirus infection  disease model  disease predisposition  dog  domestic animal  duck  feces  female  immunology  isolation and purification  male  Mustela putorius furo  pandemic  physiology  pig  respiratory system  species difference  virology  virus attachment  virus pneumonia  virus replication  Animals  Animals, Domestic  Antibodies, Viral  Betacoronavirus  Cats  Chickens  Coronavirus Infections  Disease Models, Animal  Disease Susceptibility  Dogs  Ducks  Feces  Female  Ferrets  Male  Pandemics  Pneumonia, Viral  Respiratory System  RNA, Viral  Species Specificity  Sus scrofa  Virus Attachment  Virus Replication  
Projecting the transmission dynamics of SARS-CoV-2 through the postpandemic period 期刊论文
, 2020, 卷号: 368, 期号: 6493
作者:  Kissler S.M.;  Tedijanto C.;  Goldstein E.;  Grad Y.H.;  Lipsitch M.
收藏  |  浏览/下载：12/0  |  提交时间：2020/07/28
data set  disease transmission  immunity  virus  United States  Coronavirus  SARS coronavirus  Betacoronavirus  biological model  Coronavirus infection  disease transmission  epidemic  human  Human coronavirus OC43  immunology  pandemic  physiology  season  virology  virus pneumonia  Betacoronavirus  Coronavirus Infections  Coronavirus OC43, Human  Disease Outbreaks  Disease Transmission, Infectious  Humans  Models, Biological  Pandemics  Pneumonia, Viral  Seasons  
An investigation of transmission control measures during the first 50 days of the COVID-19 epidemic in China 期刊论文
, 2020, 卷号: 368, 期号: 6491
作者:  Tian H.;  Liu Y.;  Li Y.;  Wu C.-H.;  Chen B.;  Kraemer M.U.G.;  Li B.;  Cai J.;  Xu B.;  Yang Q.;  Wang B.;  Yang P.;  Cui Y.;  Song Y.;  Zheng P.;  Wang Q.;  Bjornstad O.N.;  Yang R.;  Grenfell B.T.;  Pybus O.G.;  Dye C.
收藏  |  浏览/下载：29/0  |  提交时间：2020/07/28
data set  disease control  disease incidence  disease transmission  epidemic  public health  viral disease  Article  China  coronavirus disease 2019  disease duration  disease transmission  epidemic  health care planning  human  incidence  infection control  influenza A (H1N1)  pandemic  patient isolation  priority journal  public health  sample size  scale up  traffic and transport  Betacoronavirus  communicable disease control  Coronavirus infection  epidemic  pandemic  public health service  regression analysis  statistical model  travel  virus pneumonia  China  Hubei  Wuhan  Coronavirus  Betacoronavirus  China  Communicable Disease Control  Coronavirus Infections  Epidemics  Humans  Incidence  Models, Statistical  Pandemics  Pneumonia, Viral  Public Health Practice  Regression Analysis  Travel  
A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2 期刊论文
, 2020, 卷号: 368, 期号: 6496
作者:  Wu Y.;  Wang F.;  Shen C.;  Peng W.;  Li D.;  Zhao C.;  Li Z.;  Li S.;  Bi Y.;  Yang Y.;  Gong Y.;  Xiao H.;  Fan Z.;  Tan S.;  Wu G.;  Tan W.;  Lu X.;  Fan C.;  Wang Q.;  Liu Y.;  Zhang C.;  Qi J.;  Gao G.F.;  Gao F.;  Liu L.
收藏  |  浏览/下载：29/0  |  提交时间：2020/07/28
Coronavirus  angiotensin converting enzyme 2  coronavirus spike glycoprotein  dipeptidyl carboxypeptidase  epitope  monoclonal antibody  neutralizing antibody  virus antibody  virus receptor  animal  chemistry  Coronavirus infection  disease model  human  immunology  isolation and purification  lung  mouse  pandemic  protein domain  serodiagnosis  virology  virus load  virus pneumonia  Animals  Antibodies, Monoclonal  Antibodies, Neutralizing  Antibodies, Viral  Coronavirus Infections  Disease Models, Animal  Humans  Immunodominant Epitopes  Lung  Mice  Neutralization Tests  Pandemics  Peptidyl-Dipeptidase A  Pneumonia, Viral  Protein Domains  Receptors, Virus  Spike Glycoprotein, Coronavirus  Viral Load