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Horizontal gene transfer of Fhb7 from fungus underlies Fusarium head blight resistance in wheat 期刊论文
, 2020, 卷号: 368, 期号: 6493
作者:  Wang H.;  Sun S.;  Ge W.;  Zhao L.;  Hou B.;  Wang K.;  Lyu Z.;  Chen L.;  Xu S.;  Guo J.;  Li M.;  Su P.;  Li X.;  Wang G.;  Bo C.;  Fang X.;  Zhuang W.;  Cheng X.;  Wu J.;  Dong L.;  Chen W.;  Li W.;  Xiao G.;  Zhao J.;  Hao Y.;  Xu Y.;  Gao Y.;  Liu W.;  Liu Y.;  Yin H.;  Li J.;  Li X.;  Zhao Y.;  Wang X.;  Ni F.;  Ma X.;  Li A.;  Xu S.S.;  Bai G.;  Nevo E.;  Gao C.;  Ohm H.;  Kong L.
收藏  |  浏览/下载:51/0  |  提交时间:2020/07/28
fungus  gene transfer  genome  germplasm  toxin  wheat  Fungi  Fusarium  Lophopyrum elongatum  Triticum aestivum  glutathione transferase  disease resistance  Epichloe  Fusarium  genetics  horizontal gene transfer  microbiology  molecular cloning  pathogenicity  plant breeding  plant disease  Poaceae  wheat  Cloning, Molecular  Disease Resistance  Epichloe  Fusarium  Gene Transfer, Horizontal  Glutathione Transferase  Plant Breeding  Plant Diseases  Poaceae  Triticum  
Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease 期刊论文
, 2020, 卷号: 368, 期号: 6497
作者:  Dai W.;  Zhang B.;  Jiang X.-M.;  Su H.;  Li J.;  Zhao Y.;  Xie X.;  Jin Z.;  Peng J.;  Liu F.;  Li C.;  Li Y.;  Bai F.;  Wang H.;  Cheng X.;  Cen X.;  Hu S.;  Yang X.;  Wang J.;  Liu X.;  Xiao G.;  Jiang H.;  Rao Z.;  Zhang L.-K.;  Xu Y.;  Yang H.;  Liu H.
收藏  |  浏览/下载:36/0  |  提交时间:2020/07/28
aldehyde  antimicrobial activity  drug  enzyme activity  infectivity  inhibitor  reaction kinetics  viral disease  Coronavirus  SARS coronavirus  3C-like proteinase, Coronavirus  antivirus agent  cysteine proteinase  viral protein  animal  Betacoronavirus  chemical structure  chemistry  Chlorocebus aethiops  Coronavirus infection  dog  drug design  drug effect  enzyme active site  enzymology  female  human  male  mouse  pandemic  preclinical study  protein tertiary structure  Sprague Dawley rat  toxicity testing  Vero cell line  virus pneumonia  Animals  Antiviral Agents  Betacoronavirus  Catalytic Domain  Chlorocebus aethiops  Coronavirus Infections  Cysteine Endopeptidases  Dogs  Drug Design  Drug Evaluation, Preclinical  Female  Humans  Male  Mice  Molecular Structure  Pandemics  Pneumonia, Viral  Protein Structure, Tertiary  Rats, Sprague-Dawley  Toxicity Tests  Vero Cells  Viral Nonstructural Proteins  
Tunable topological charge vortex microlaser 期刊论文
, 2020, 卷号: 368, 期号: 6492
作者:  Zhang Z.;  Qiao X.;  Midya B.;  Liu K.;  Sun J.;  Wu T.;  Liu W.;  Agarwal R.;  Jornet J.M.;  Longhi S.;  Litchinitser N.M.;  Feng L.
收藏  |  浏览/下载:26/0  |  提交时间:2020/07/28
angular momentum  symmetry  topology  vortex  article  chirality  room temperature  telecommunication  
Photocurrent detection of the orbital angular momentum of light 期刊论文
, 2020, 卷号: 368, 期号: 6492
作者:  Ji Z.;  Liu W.;  Krylyuk S.;  Fan X.;  Zhang Z.;  Pan A.;  Feng L.;  Davydov A.;  Agarwal R.
收藏  |  浏览/下载:31/0  |  提交时间:2020/07/28
angular momentum  communication network  detection method  electrode  light effect  
N6-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription 期刊论文
, 2020, 卷号: 367, 期号: 6477
作者:  Liu J.;  Dou X.;  Chen C.;  Chen C.;  Liu C.;  Michelle Xu M.;  Zhao S.;  Shen B.;  Gao Y.;  Han D.;  He C.
收藏  |  浏览/下载:8/0  |  提交时间:2020/07/28
6 n methyladenosine  chromosome associated regulatory RNA  enhancer RNA  messenger RNA  promoter associated RNA  repeat RNA  RNA  unclassified drug  cell component  chemical compound  chromosome  methylation  RNA  animal cell  Article  biodegradation  chemical modification  chromatin  controlled study  demethylation  embryo  embryonic stem cell  exosome  methylation  METTL3 gene  mouse  nonhuman  nuclear degradation  priority journal  transcription regulation  Ythdc1 gene  
Very fast CRISPR on demand 期刊论文
, 2020, 卷号: 368, 期号: 6496
作者:  Liu Y.;  Zou R.S.;  He S.;  Nihongaki Y.;  Li X.;  Razavi S.;  Wu B.;  Ha T.
收藏  |  浏览/下载:20/0  |  提交时间:2020/07/28
Cas9 endonuclease Streptococcus pyogenes  double strand break repair protein MRE11  H2AX protein, human  histone  MRE11 protein, human  CRISPR Cas system  DNA cleavage  DNA repair  double stranded DNA break  fluorescence imaging  gene editing  genetics  HEK293 cell line  human  light  metabolism  phosphorylation  procedures  radiation response  single cell analysis  CRISPR-Associated Protein 9  CRISPR-Cas Systems  DNA Breaks, Double-Stranded  DNA Cleavage  DNA Repair  Gene Editing  HEK293 Cells  Histones  Humans  Light  MRE11 Homologue Protein  Optical Imaging  Phosphorylation  Single-Cell Analysis  
Structure of nucleosome-bound human BAF complex 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者:  He S.;  Wu Z.;  Tian Y.;  Yu Z.;  Yu J.;  Wang X.;  Li J.;  Liu B.;  Xu Y.
收藏  |  浏览/下载:32/0  |  提交时间:2020/07/28
actin related protein  adenosine triphosphatase  BRG1 BRM associated factor  DNA  multiprotein complex  protein SWI  retinoblastoma binding protein 2  SMARCC protein  SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily B member 1  transcription factor  transcription factor SNF  unclassified drug  cancer  enzyme activity  gene expression  hydrolysis  mutation  protein  alpha helix  Article  carboxy terminal sequence  cell interaction  cryoelectron microscopy  disease association  human  malignant neoplasm  molecular recognition  mutation  nucleosome  priority journal  protein function  protein hydrolysis  protein structure  structure analysis  Mammalia  
A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2 期刊论文
, 2020, 卷号: 368, 期号: 6496
作者:  Wu Y.;  Wang F.;  Shen C.;  Peng W.;  Li D.;  Zhao C.;  Li Z.;  Li S.;  Bi Y.;  Yang Y.;  Gong Y.;  Xiao H.;  Fan Z.;  Tan S.;  Wu G.;  Tan W.;  Lu X.;  Fan C.;  Wang Q.;  Liu Y.;  Zhang C.;  Qi J.;  Gao G.F.;  Gao F.;  Liu L.
收藏  |  浏览/下载:29/0  |  提交时间:2020/07/28
Coronavirus  angiotensin converting enzyme 2  coronavirus spike glycoprotein  dipeptidyl carboxypeptidase  epitope  monoclonal antibody  neutralizing antibody  virus antibody  virus receptor  animal  chemistry  Coronavirus infection  disease model  human  immunology  isolation and purification  lung  mouse  pandemic  protein domain  serodiagnosis  virology  virus load  virus pneumonia  Animals  Antibodies, Monoclonal  Antibodies, Neutralizing  Antibodies, Viral  Coronavirus Infections  Disease Models, Animal  Humans  Immunodominant Epitopes  Lung  Mice  Neutralization Tests  Pandemics  Peptidyl-Dipeptidase A  Pneumonia, Viral  Protein Domains  Receptors, Virus  Spike Glycoprotein, Coronavirus  Viral Load  
Nitromethane as a nitrogen donor in Schmidt-type formation of amides and nitriles 期刊论文
, 2020, 卷号: 367, 期号: 6475
作者:  Liu J.;  Zhang C.;  Zhang Z.;  Wen X.;  Dou X.;  Wei J.;  Qiu X.;  Song S.;  Jiao N.
收藏  |  浏览/下载:26/0  |  提交时间:2020/07/28
acetic acid  aldehyde derivative  alkylbenzene  alkyne  amide  formic acid  ketone derivative  nitrile  nitromethane  acetic acid  benzene  methane  nitrogen  Article  chemical reaction  controlled study  priority journal  Schmidt like reaction  synthesis  
Synthesis of proteins by automated flow chemistry 期刊论文
, 2020, 卷号: 368, 期号: 6494
作者:  Hartrampf N.;  Saebi A.;  Poskus M.;  Gates Z.P.;  Callahan A.J.;  Cowfer A.E.;  Hanna S.;  Antilla S.;  Schissel C.K.;  Quartararo A.J.;  Ye X.;  Mijalis A.J.;  Simon M.D.;  Loas A.;  Liu S.;  Jessen C.;  Nielsen T.E.;  Pentelute B.L.
收藏  |  浏览/下载:37/0  |  提交时间:2020/07/28
amino acid  cell component  chemistry  instrumentation  peptide  protein  purification  peptide  protein  chemistry  isolation and purification  procedures  protein domain  protein folding  solid phase synthesis  synthesis  Peptides  Protein Domains  Protein Folding  Proteins  Solid-Phase Synthesis Techniques