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DOI	10.1126/science.aay9501
	Nitromethane as a nitrogen donor in Schmidt-type formation of amides and nitriles
	Liu J.; Zhang C.; Zhang Z.; Wen X.; Dou X.; Wei J.; Qiu X.; Song S.; Jiao N.
发表日期	2020
ISSN	0036-8075
起始页码	281
结束页码	285
卷号	367 期号:6475
英文摘要	The Schmidt reaction has been an efficient and widely used synthetic approach to amides and nitriles since its discovery in 1923. However, its application often entails the use of volatile, potentially explosive, and highly toxic azide reagents. Here, we report a sequence whereby triflic anhydride and formic and acetic acids activate the bulk chemical nitromethane to serve as a nitrogen donor in place of azides in Schmidt-like reactions. This protocol further expands the substrate scope to alkynes and simple alkyl benzenes for the preparation of amides and nitriles. © 2020 American Association for the Advancement of Science. All rights reserved.
关键词	acetic acid aldehyde derivative alkylbenzene alkyne amide formic acid ketone derivative nitrile nitromethane acetic acid benzene methane nitrogen Article chemical reaction controlled study priority journal Schmidt like reaction synthesis
语种	英语
来源机构	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133771
推荐引用方式 GB/T 7714	Liu J.,Zhang C.,Zhang Z.,et al. Nitromethane as a nitrogen donor in Schmidt-type formation of amides and nitriles[J]. Science,2020,367(6475).
APA	Liu J..,Zhang C..,Zhang Z..,Wen X..,Dou X..,...&Jiao N..(2020).Nitromethane as a nitrogen donor in Schmidt-type formation of amides and nitriles.,367(6475).
MLA	Liu J.,et al."Nitromethane as a nitrogen donor in Schmidt-type formation of amides and nitriles".367.6475(2020).