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Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease 期刊论文
, 2020, 卷号: 368, 期号: 6497
作者:  Dai W.;  Zhang B.;  Jiang X.-M.;  Su H.;  Li J.;  Zhao Y.;  Xie X.;  Jin Z.;  Peng J.;  Liu F.;  Li C.;  Li Y.;  Bai F.;  Wang H.;  Cheng X.;  Cen X.;  Hu S.;  Yang X.;  Wang J.;  Liu X.;  Xiao G.;  Jiang H.;  Rao Z.;  Zhang L.-K.;  Xu Y.;  Yang H.;  Liu H.
收藏  |  浏览/下载:36/0  |  提交时间:2020/07/28
aldehyde  antimicrobial activity  drug  enzyme activity  infectivity  inhibitor  reaction kinetics  viral disease  Coronavirus  SARS coronavirus  3C-like proteinase, Coronavirus  antivirus agent  cysteine proteinase  viral protein  animal  Betacoronavirus  chemical structure  chemistry  Chlorocebus aethiops  Coronavirus infection  dog  drug design  drug effect  enzyme active site  enzymology  female  human  male  mouse  pandemic  preclinical study  protein tertiary structure  Sprague Dawley rat  toxicity testing  Vero cell line  virus pneumonia  Animals  Antiviral Agents  Betacoronavirus  Catalytic Domain  Chlorocebus aethiops  Coronavirus Infections  Cysteine Endopeptidases  Dogs  Drug Design  Drug Evaluation, Preclinical  Female  Humans  Male  Mice  Molecular Structure  Pandemics  Pneumonia, Viral  Protein Structure, Tertiary  Rats, Sprague-Dawley  Toxicity Tests  Vero Cells  Viral Nonstructural Proteins  
Structure of the RNA-dependent RNA polymerase from COVID-19 virus 期刊论文
, 2020, 卷号: 368, 期号: 6492
作者:  Gao Y.;  Yan L.;  Huang Y.;  Liu F.;  Zhao Y.;  Cao L.;  Wang T.;  Sun Q.;  Ming Z.;  Zhang L.;  Ge J.;  Zheng L.;  Zhang Y.;  Wang H.;  Zhu Y.;  Zhu C.;  Hu T.;  Hua T.;  Zhang B.;  Yang X.;  Li J.;  Yang H.;  Liu Z.;  Xu W.;  Guddat L.W.;  Wang Q.;  Lou Z.;  Rao Z.
收藏  |  浏览/下载:38/0  |  提交时间:2020/07/28
comparative study  drug  electron microscopy  enzyme  enzyme activity  RNA  virus  Coronavirus  SARS coronavirus  adenosine phosphate  alanine  antivirus agent  NSP7 protein, SARS-CoV-2  NSP8 protein, SARS-CoV-2  remdesivir  RNA directed RNA polymerase  RNA-dependent RNA polymerase, coronavirus  viral protein  beta sheet  Betacoronavirus  chemistry  cryoelectron microscopy  drug design  enzyme active site  enzymology  metabolism  molecular model  protein domain  ultrastructure  Adenosine Monophosphate  Alanine  Antiviral Agents  Betacoronavirus  Catalytic Domain  Cryoelectron Microscopy  Drug Design  Models, Molecular  Protein Conformation, beta-Strand  Protein Domains  RNA Replicase  Viral Nonstructural Proteins  
Nearly quantized conductance plateau of vortex zero mode in an iron-based superconductor 期刊论文
, 2020, 卷号: 367, 期号: 6474
作者:  Zhu S.;  Kong L.;  Cao L.;  Chen H.;  Papaj M.;  Du S.;  Xing Y.;  Liu W.;  Wang D.;  Shen C.;  Yang F.;  Schneeloch J.;  Zhong R.;  Gu G.;  Fu L.;  Zhang Y.-Y.;  Ding H.;  Gao H.-J.
收藏  |  浏览/下载:31/0  |  提交时间:2020/07/28
iron  equipment  iron  plateau  vortex  Article  controlled study  electric conductance  energy  fractional quasiparticle  mathematical computing  non Abelian braiding statistics  particle antiparticle equivalence  physical parameters  priority journal  quantum computing  scanning tunneling spectroscopy  statistical analysis  Abelia  Majorana  
Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS-coronavirus 2 期刊论文
, 2020, 卷号: 368, 期号: 6494
作者:  Shi J.;  Wen Z.;  Zhong G.;  Yang H.;  Wang C.;  Huang B.;  Liu R.;  He X.;  Shuai L.;  Sun Z.;  Zhao Y.;  Liu P.;  Liang L.;  Cui P.;  Wang J.;  Zhang X.;  Guan Y.;  Tan W.;  Wu G.;  Chen H.;  Bu Z.;  Bu Z.
收藏  |  浏览/下载:32/0  |  提交时间:2020/07/28
bat  canid  disease control  disease transmission  felid  global perspective  infectious disease  poultry  severe acute respiratory syndrome  viral disease  virus  China  Hubei  Wuhan  Anas  Animalia  Canis familiaris  Coronavirus  Gallus gallus  Mustela  SARS coronavirus  Suidae  virus antibody  virus RNA  animal  Betacoronavirus  blood  cat  chicken  Coronavirus infection  disease model  disease predisposition  dog  domestic animal  duck  feces  female  immunology  isolation and purification  male  Mustela putorius furo  pandemic  physiology  pig  respiratory system  species difference  virology  virus attachment  virus pneumonia  virus replication  Animals  Animals, Domestic  Antibodies, Viral  Betacoronavirus  Cats  Chickens  Coronavirus Infections  Disease Models, Animal  Disease Susceptibility  Dogs  Ducks  Feces  Female  Ferrets  Male  Pandemics  Pneumonia, Viral  Respiratory System  RNA, Viral  Species Specificity  Sus scrofa  Virus Attachment  Virus Replication  
An investigation of transmission control measures during the first 50 days of the COVID-19 epidemic in China 期刊论文
, 2020, 卷号: 368, 期号: 6491
作者:  Tian H.;  Liu Y.;  Li Y.;  Wu C.-H.;  Chen B.;  Kraemer M.U.G.;  Li B.;  Cai J.;  Xu B.;  Yang Q.;  Wang B.;  Yang P.;  Cui Y.;  Song Y.;  Zheng P.;  Wang Q.;  Bjornstad O.N.;  Yang R.;  Grenfell B.T.;  Pybus O.G.;  Dye C.
收藏  |  浏览/下载:29/0  |  提交时间:2020/07/28
data set  disease control  disease incidence  disease transmission  epidemic  public health  viral disease  Article  China  coronavirus disease 2019  disease duration  disease transmission  epidemic  health care planning  human  incidence  infection control  influenza A (H1N1)  pandemic  patient isolation  priority journal  public health  sample size  scale up  traffic and transport  Betacoronavirus  communicable disease control  Coronavirus infection  epidemic  pandemic  public health service  regression analysis  statistical model  travel  virus pneumonia  China  Hubei  Wuhan  Coronavirus  Betacoronavirus  China  Communicable Disease Control  Coronavirus Infections  Epidemics  Humans  Incidence  Models, Statistical  Pandemics  Pneumonia, Viral  Public Health Practice  Regression Analysis  Travel  
A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2 期刊论文
, 2020, 卷号: 368, 期号: 6496
作者:  Wu Y.;  Wang F.;  Shen C.;  Peng W.;  Li D.;  Zhao C.;  Li Z.;  Li S.;  Bi Y.;  Yang Y.;  Gong Y.;  Xiao H.;  Fan Z.;  Tan S.;  Wu G.;  Tan W.;  Lu X.;  Fan C.;  Wang Q.;  Liu Y.;  Zhang C.;  Qi J.;  Gao G.F.;  Gao F.;  Liu L.
收藏  |  浏览/下载:29/0  |  提交时间:2020/07/28
Coronavirus  angiotensin converting enzyme 2  coronavirus spike glycoprotein  dipeptidyl carboxypeptidase  epitope  monoclonal antibody  neutralizing antibody  virus antibody  virus receptor  animal  chemistry  Coronavirus infection  disease model  human  immunology  isolation and purification  lung  mouse  pandemic  protein domain  serodiagnosis  virology  virus load  virus pneumonia  Animals  Antibodies, Monoclonal  Antibodies, Neutralizing  Antibodies, Viral  Coronavirus Infections  Disease Models, Animal  Humans  Immunodominant Epitopes  Lung  Mice  Neutralization Tests  Pandemics  Peptidyl-Dipeptidase A  Pneumonia, Viral  Protein Domains  Receptors, Virus  Spike Glycoprotein, Coronavirus  Viral Load  
An atlas of the protein-coding genes in the human, pig, and mouse brain 期刊论文
, 2020, 卷号: 367, 期号: 6482
作者:  Sjöstedt E.;  Zhong W.;  Fagerberg L.;  Karlsson M.;  Mitsios N.;  Adori C.;  Oksvold P.;  Edfors F.;  Limiszewska A.;  Hikmet F.;  Huang J.;  Du Y.;  Lin L.;  Dong Z.;  Yang L.;  Liu X.;  Jiang H.;  Xu X.;  Wang J.;  Yang H.;  Bolund L.;  Mardinoglu A.;  Zhang C.;  Von Feilitzen K.;  Lindskog C.;  Pontén F.;  Luo Y.;  Hökfelt T.;  Uhlén M.;  Mulder J.
收藏  |  浏览/下载:34/0  |  提交时间:2020/07/28
G protein coupled receptor  neurotransmitter  atlas  brain  gene  gene expression  pig  protein  Article  astrocyte  cerebellum  gene expression level  gene expression profiling  gene mapping  genetic code  genome-wide association study  genomics  human  hypothalamus  in situ hybridization  microglia  nerve cell  nonhuman  oligodendroglia  pig  priority journal  species comparison  tissue specificity  transcriptomics  Mammalia  Suidae  
Control of zeolite pore interior for chemoselective alkyne/olefin separations 期刊论文
, 2020, 卷号: 368, 期号: 6494
作者:  Chai Y.;  Han X.;  Li W.;  Liu S.;  Yao S.;  Wang C.;  Shi W.;  Da-Silva I.;  Manuel P.;  Cheng Y.;  Daemen L.D.;  Ramirez-Cuesta A.J.;  Tang C.C.;  Jiang L.;  Yang S.;  Guan N.;  Guan N.;  Li L.;  Li L.
收藏  |  浏览/下载:63/0  |  提交时间:2020/07/28
acetylene  adsorption  neutron diffraction  neutron scattering  polymer  zeolite  
Simultaneous observation of nuclear and electronic dynamics by ultrafast electron diffraction 期刊论文
, 2020, 卷号: 368, 期号: 6493
作者:  Yang J.;  Zhu X.;  F. Nunes J.P.;  Yu J.K.;  Parrish R.M.;  Wolf T.J.A.;  Centurion M.;  Gühr M.;  Li R.;  Liu Y.;  Moore B.;  Niebuhr M.;  Park S.;  Shen X.;  Weathersby S.;  Weinacht T.;  Martinez T.J.;  Wang X.
收藏  |  浏览/下载:21/0  |  提交时间:2020/07/28
electron  electronic equipment  molecular analysis  observational method