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期刊论文 [9]
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2020 [9]
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英语 [9]
来源机构
Science [9]
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Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease
期刊论文
, 2020, 卷号: 368, 期号: 6497
作者:
Dai W.
;
Zhang B.
;
Jiang X.-M.
;
Su H.
;
Li J.
;
Zhao Y.
;
Xie X.
;
Jin Z.
;
Peng J.
;
Liu F.
;
Li C.
;
Li Y.
;
Bai F.
;
Wang H.
;
Cheng X.
;
Cen X.
;
Hu S.
;
Yang X.
;
Wang J.
;
Liu X.
;
Xiao G.
;
Jiang H.
;
Rao Z.
;
Zhang L.-K.
;
Xu Y.
;
Yang H.
;
Liu H.
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2020/07/28
aldehyde
antimicrobial activity
drug
enzyme activity
infectivity
inhibitor
reaction kinetics
viral disease
Coronavirus
SARS coronavirus
3C-like proteinase, Coronavirus
antivirus agent
cysteine proteinase
viral protein
animal
Betacoronavirus
chemical structure
chemistry
Chlorocebus aethiops
Coronavirus infection
dog
drug design
drug effect
enzyme active site
enzymology
female
human
male
mouse
pandemic
preclinical study
protein tertiary structure
Sprague Dawley rat
toxicity testing
Vero cell line
virus pneumonia
Animals
Antiviral Agents
Betacoronavirus
Catalytic Domain
Chlorocebus aethiops
Coronavirus Infections
Cysteine Endopeptidases
Dogs
Drug Design
Drug Evaluation, Preclinical
Female
Humans
Male
Mice
Molecular Structure
Pandemics
Pneumonia, Viral
Protein Structure, Tertiary
Rats, Sprague-Dawley
Toxicity Tests
Vero Cells
Viral Nonstructural Proteins
Structure of the RNA-dependent RNA polymerase from COVID-19 virus
期刊论文
, 2020, 卷号: 368, 期号: 6492
作者:
Gao Y.
;
Yan L.
;
Huang Y.
;
Liu F.
;
Zhao Y.
;
Cao L.
;
Wang T.
;
Sun Q.
;
Ming Z.
;
Zhang L.
;
Ge J.
;
Zheng L.
;
Zhang Y.
;
Wang H.
;
Zhu Y.
;
Zhu C.
;
Hu T.
;
Hua T.
;
Zhang B.
;
Yang X.
;
Li J.
;
Yang H.
;
Liu Z.
;
Xu W.
;
Guddat L.W.
;
Wang Q.
;
Lou Z.
;
Rao Z.
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2020/07/28
comparative study
drug
electron microscopy
enzyme
enzyme activity
RNA
virus
Coronavirus
SARS coronavirus
adenosine phosphate
alanine
antivirus agent
NSP7 protein, SARS-CoV-2
NSP8 protein, SARS-CoV-2
remdesivir
RNA directed RNA polymerase
RNA-dependent RNA polymerase, coronavirus
viral protein
beta sheet
Betacoronavirus
chemistry
cryoelectron microscopy
drug design
enzyme active site
enzymology
metabolism
molecular model
protein domain
ultrastructure
Adenosine Monophosphate
Alanine
Antiviral Agents
Betacoronavirus
Catalytic Domain
Cryoelectron Microscopy
Drug Design
Models, Molecular
Protein Conformation, beta-Strand
Protein Domains
RNA Replicase
Viral Nonstructural Proteins
Nearly quantized conductance plateau of vortex zero mode in an iron-based superconductor
期刊论文
, 2020, 卷号: 367, 期号: 6474
作者:
Zhu S.
;
Kong L.
;
Cao L.
;
Chen H.
;
Papaj M.
;
Du S.
;
Xing Y.
;
Liu W.
;
Wang D.
;
Shen C.
;
Yang F.
;
Schneeloch J.
;
Zhong R.
;
Gu G.
;
Fu L.
;
Zhang Y.-Y.
;
Ding H.
;
Gao H.-J.
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2020/07/28
iron
equipment
iron
plateau
vortex
Article
controlled study
electric conductance
energy
fractional quasiparticle
mathematical computing
non Abelian braiding statistics
particle antiparticle equivalence
physical parameters
priority journal
quantum computing
scanning tunneling spectroscopy
statistical analysis
Abelia
Majorana
Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS-coronavirus 2
期刊论文
, 2020, 卷号: 368, 期号: 6494
作者:
Shi J.
;
Wen Z.
;
Zhong G.
;
Yang H.
;
Wang C.
;
Huang B.
;
Liu R.
;
He X.
;
Shuai L.
;
Sun Z.
;
Zhao Y.
;
Liu P.
;
Liang L.
;
Cui P.
;
Wang J.
;
Zhang X.
;
Guan Y.
;
Tan W.
;
Wu G.
;
Chen H.
;
Bu Z.
;
Bu Z.
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2020/07/28
bat
canid
disease control
disease transmission
felid
global perspective
infectious disease
poultry
severe acute respiratory syndrome
viral disease
virus
China
Hubei
Wuhan
Anas
Animalia
Canis familiaris
Coronavirus
Gallus gallus
Mustela
SARS coronavirus
Suidae
virus antibody
virus RNA
animal
Betacoronavirus
blood
cat
chicken
Coronavirus infection
disease model
disease predisposition
dog
domestic animal
duck
feces
female
immunology
isolation and purification
male
Mustela putorius furo
pandemic
physiology
pig
respiratory system
species difference
virology
virus attachment
virus pneumonia
virus replication
Animals
Animals, Domestic
Antibodies, Viral
Betacoronavirus
Cats
Chickens
Coronavirus Infections
Disease Models, Animal
Disease Susceptibility
Dogs
Ducks
Feces
Female
Ferrets
Male
Pandemics
Pneumonia, Viral
Respiratory System
RNA, Viral
Species Specificity
Sus scrofa
Virus Attachment
Virus Replication
An investigation of transmission control measures during the first 50 days of the COVID-19 epidemic in China
期刊论文
, 2020, 卷号: 368, 期号: 6491
作者:
Tian H.
;
Liu Y.
;
Li Y.
;
Wu C.-H.
;
Chen B.
;
Kraemer M.U.G.
;
Li B.
;
Cai J.
;
Xu B.
;
Yang Q.
;
Wang B.
;
Yang P.
;
Cui Y.
;
Song Y.
;
Zheng P.
;
Wang Q.
;
Bjornstad O.N.
;
Yang R.
;
Grenfell B.T.
;
Pybus O.G.
;
Dye C.
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2020/07/28
data set
disease control
disease incidence
disease transmission
epidemic
public health
viral disease
Article
China
coronavirus disease 2019
disease duration
disease transmission
epidemic
health care planning
human
incidence
infection control
influenza A (H1N1)
pandemic
patient isolation
priority journal
public health
sample size
scale up
traffic and transport
Betacoronavirus
communicable disease control
Coronavirus infection
epidemic
pandemic
public health service
regression analysis
statistical model
travel
virus pneumonia
China
Hubei
Wuhan
Coronavirus
Betacoronavirus
China
Communicable Disease Control
Coronavirus Infections
Epidemics
Humans
Incidence
Models, Statistical
Pandemics
Pneumonia, Viral
Public Health Practice
Regression Analysis
Travel
A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2
期刊论文
, 2020, 卷号: 368, 期号: 6496
作者:
Wu Y.
;
Wang F.
;
Shen C.
;
Peng W.
;
Li D.
;
Zhao C.
;
Li Z.
;
Li S.
;
Bi Y.
;
Yang Y.
;
Gong Y.
;
Xiao H.
;
Fan Z.
;
Tan S.
;
Wu G.
;
Tan W.
;
Lu X.
;
Fan C.
;
Wang Q.
;
Liu Y.
;
Zhang C.
;
Qi J.
;
Gao G.F.
;
Gao F.
;
Liu L.
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2020/07/28
Coronavirus
angiotensin converting enzyme 2
coronavirus spike glycoprotein
dipeptidyl carboxypeptidase
epitope
monoclonal antibody
neutralizing antibody
virus antibody
virus receptor
animal
chemistry
Coronavirus infection
disease model
human
immunology
isolation and purification
lung
mouse
pandemic
protein domain
serodiagnosis
virology
virus load
virus pneumonia
Animals
Antibodies, Monoclonal
Antibodies, Neutralizing
Antibodies, Viral
Coronavirus Infections
Disease Models, Animal
Humans
Immunodominant Epitopes
Lung
Mice
Neutralization Tests
Pandemics
Peptidyl-Dipeptidase A
Pneumonia, Viral
Protein Domains
Receptors, Virus
Spike Glycoprotein, Coronavirus
Viral Load
An atlas of the protein-coding genes in the human, pig, and mouse brain
期刊论文
, 2020, 卷号: 367, 期号: 6482
作者:
Sjöstedt E.
;
Zhong W.
;
Fagerberg L.
;
Karlsson M.
;
Mitsios N.
;
Adori C.
;
Oksvold P.
;
Edfors F.
;
Limiszewska A.
;
Hikmet F.
;
Huang J.
;
Du Y.
;
Lin L.
;
Dong Z.
;
Yang L.
;
Liu X.
;
Jiang H.
;
Xu X.
;
Wang J.
;
Yang H.
;
Bolund L.
;
Mardinoglu A.
;
Zhang C.
;
Von Feilitzen K.
;
Lindskog C.
;
Pontén F.
;
Luo Y.
;
Hökfelt T.
;
Uhlén M.
;
Mulder J.
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2020/07/28
G protein coupled receptor
neurotransmitter
atlas
brain
gene
gene expression
pig
protein
Article
astrocyte
cerebellum
gene expression level
gene expression profiling
gene mapping
genetic code
genome-wide association study
genomics
human
hypothalamus
in situ hybridization
microglia
nerve cell
nonhuman
oligodendroglia
pig
priority journal
species comparison
tissue specificity
transcriptomics
Mammalia
Suidae
Control of zeolite pore interior for chemoselective alkyne/olefin separations
期刊论文
, 2020, 卷号: 368, 期号: 6494
作者:
Chai Y.
;
Han X.
;
Li W.
;
Liu S.
;
Yao S.
;
Wang C.
;
Shi W.
;
Da-Silva I.
;
Manuel P.
;
Cheng Y.
;
Daemen L.D.
;
Ramirez-Cuesta A.J.
;
Tang C.C.
;
Jiang L.
;
Yang S.
;
Guan N.
;
Guan N.
;
Li L.
;
Li L.
收藏
  |  
浏览/下载:63/0
  |  
提交时间:2020/07/28
acetylene
adsorption
neutron diffraction
neutron scattering
polymer
zeolite
Simultaneous observation of nuclear and electronic dynamics by ultrafast electron diffraction
期刊论文
, 2020, 卷号: 368, 期号: 6493
作者:
Yang J.
;
Zhu X.
;
F. Nunes J.P.
;
Yu J.K.
;
Parrish R.M.
;
Wolf T.J.A.
;
Centurion M.
;
Gühr M.
;
Li R.
;
Liu Y.
;
Moore B.
;
Niebuhr M.
;
Park S.
;
Shen X.
;
Weathersby S.
;
Weinacht T.
;
Martinez T.J.
;
Wang X.
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/07/28
electron
electronic equipment
molecular analysis
observational method