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AR-negative prostate cancer is vulnerable to loss of JMJD1C demethylase 期刊论文
Proceedings of the National Academy of Sciences of the United States of America, 2021, 卷号: 118, 期号: 36
作者:  Yoshihama Y.;  LaBella K.A.;  Kim E.;  Bertolet L.;  Colic M.;  Li J.;  Shang X.;  Wu C.-J.;  Spring D.J.;  Wang Y.A.;  Hart T.;  DePinho R.A.
收藏  |  浏览/下载：20/0  |  提交时间：2022/02/22
Structures of the human Mediator and Mediator-bound preinitiation complex 期刊论文
Science, 2021, 卷号: 372, 期号: 6546
作者:  Chen X.;  Yin X.;  Li J.;  Wu Z.;  Qi Y.;  Wang X.;  Liu W.;  Xu Y.
收藏  |  浏览/下载：1/0  |  提交时间：2022/01/14
A safe and highly efficacious measles virus-based vaccine expressing SARS-CoV-2 stabilized prefusion spike 期刊论文
Proceedings of the National Academy of Sciences of the United States of America, 2021, 卷号: 118, 期号: 12
作者:  Lu M.;  Dravid P.;  Zhang Y.;  Trivedi S.;  Li A.;  Harder O.;  Mahesh K.C.;  Chaiwatpongsakorn S.;  Zani A.;  Kenney A.;  Zeng C.;  Cai C.;  Ye C.;  Liang X.;  Shimamura M.;  Liu S.-L.;  Mejias A.;  Ramilo O.;  Boyaka P.N.;  Qiu J.;  Martinez-Sobrido L.;  Yount J.S.;  Peeples M.E.;  Kapoor A.;  Niewiesk S.;  Li J.
收藏  |  浏览/下载：34/0  |  提交时间：2021/05/24
Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease 期刊论文
, 2020, 卷号: 368, 期号: 6497
作者:  Dai W.;  Zhang B.;  Jiang X.-M.;  Su H.;  Li J.;  Zhao Y.;  Xie X.;  Jin Z.;  Peng J.;  Liu F.;  Li C.;  Li Y.;  Bai F.;  Wang H.;  Cheng X.;  Cen X.;  Hu S.;  Yang X.;  Wang J.;  Liu X.;  Xiao G.;  Jiang H.;  Rao Z.;  Zhang L.-K.;  Xu Y.;  Yang H.;  Liu H.
收藏  |  浏览/下载：36/0  |  提交时间：2020/07/28
aldehyde  antimicrobial activity  drug  enzyme activity  infectivity  inhibitor  reaction kinetics  viral disease  Coronavirus  SARS coronavirus  3C-like proteinase, Coronavirus  antivirus agent  cysteine proteinase  viral protein  animal  Betacoronavirus  chemical structure  chemistry  Chlorocebus aethiops  Coronavirus infection  dog  drug design  drug effect  enzyme active site  enzymology  female  human  male  mouse  pandemic  preclinical study  protein tertiary structure  Sprague Dawley rat  toxicity testing  Vero cell line  virus pneumonia  Animals  Antiviral Agents  Betacoronavirus  Catalytic Domain  Chlorocebus aethiops  Coronavirus Infections  Cysteine Endopeptidases  Dogs  Drug Design  Drug Evaluation, Preclinical  Female  Humans  Male  Mice  Molecular Structure  Pandemics  Pneumonia, Viral  Protein Structure, Tertiary  Rats, Sprague-Dawley  Toxicity Tests  Vero Cells  Viral Nonstructural Proteins  
Structure of the RNA-dependent RNA polymerase from COVID-19 virus 期刊论文
, 2020, 卷号: 368, 期号: 6492
作者:  Gao Y.;  Yan L.;  Huang Y.;  Liu F.;  Zhao Y.;  Cao L.;  Wang T.;  Sun Q.;  Ming Z.;  Zhang L.;  Ge J.;  Zheng L.;  Zhang Y.;  Wang H.;  Zhu Y.;  Zhu C.;  Hu T.;  Hua T.;  Zhang B.;  Yang X.;  Li J.;  Yang H.;  Liu Z.;  Xu W.;  Guddat L.W.;  Wang Q.;  Lou Z.;  Rao Z.
收藏  |  浏览/下载：38/0  |  提交时间：2020/07/28
comparative study  drug  electron microscopy  enzyme  enzyme activity  RNA  virus  Coronavirus  SARS coronavirus  adenosine phosphate  alanine  antivirus agent  NSP7 protein, SARS-CoV-2  NSP8 protein, SARS-CoV-2  remdesivir  RNA directed RNA polymerase  RNA-dependent RNA polymerase, coronavirus  viral protein  beta sheet  Betacoronavirus  chemistry  cryoelectron microscopy  drug design  enzyme active site  enzymology  metabolism  molecular model  protein domain  ultrastructure  Adenosine Monophosphate  Alanine  Antiviral Agents  Betacoronavirus  Catalytic Domain  Cryoelectron Microscopy  Drug Design  Models, Molecular  Protein Conformation, beta-Strand  Protein Domains  RNA Replicase  Viral Nonstructural Proteins  
VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance 期刊论文
, 2020, 卷号: 367, 期号: 6475
作者:  ElTanbouly M.A.;  Zhao Y.;  Nowak E.;  Li J.;  Schaafsma E.;  Le Mercier I.;  Ceeraz S.;  Lines J.L.;  Peng C.;  Carriere C.;  Huang X.;  Day M.;  Koehn B.;  Lee S.W.;  Morales M.S.;  Hogquist K.A.;  Jameson S.C.;  Mueller D.;  Rothstein J.;  Blazar B.R.;  Cheng C.;  Noelle R.J.
收藏  |  浏览/下载：42/0  |  提交时间：2020/07/28
cell protein  interferon  kruppel like factor 2  T lymphocyte receptor  unclassified drug  V type immunoglobulin domain containing suppressor of T cell activation protein  B7 antigen  Dies1 protein, mouse  lymphocyte antigen receptor  membrane protein  monoclonal antibody  VSIR protein, human  biological development  cell  gene expression  heterogeneity  homeostasis  immune response  immunity  tolerance  acute graft versus host disease  animal cell  animal experiment  animal model  Article  CD4+ T lymphocyte  cell death  cell expansion  cell fate  cell heterogeneity  cell loss  cell survival  controlled study  female  gene  gene deletion  homeostasis  immunological tolerance  in vivo study  long term survival  male  mouse  nonhuman  phenotype  priority journal  protein expression  protein function  rheumatoid arthritis  RNA sequencing  systemic lupus erythematosus  T lymphocyte  T lymphocyte activation  T lymphocyte subpopulation  TCR gene  upregulation  VISTA gene  animal  C57BL mouse  genetics  immunological tolerance  immunology  knockout mouse  lymphocyte activation  physiology  T lymphocyte  Mus  Animals  Antibodies, Monoclonal  B7 Antigens  Lymphocyte Activation  Membrane Proteins  Mice  Mice, Inbred C57BL  Mice, Knockout  Peripheral Tolerance  Receptors, Antigen, T-Cell  T-Lymphocytes  
Structure of nucleosome-bound human BAF complex 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者:  He S.;  Wu Z.;  Tian Y.;  Yu Z.;  Yu J.;  Wang X.;  Li J.;  Liu B.;  Xu Y.
收藏  |  浏览/下载：28/0  |  提交时间：2020/07/28
actin related protein  adenosine triphosphatase  BRG1 BRM associated factor  DNA  multiprotein complex  protein SWI  retinoblastoma binding protein 2  SMARCC protein  SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily B member 1  transcription factor  transcription factor SNF  unclassified drug  cancer  enzyme activity  gene expression  hydrolysis  mutation  protein  alpha helix  Article  carboxy terminal sequence  cell interaction  cryoelectron microscopy  disease association  human  malignant neoplasm  molecular recognition  mutation  nucleosome  priority journal  protein function  protein hydrolysis  protein structure  structure analysis  Mammalia  
Sequencing of 50 human exomes reveals adaptation to high altitude 期刊论文
Science, 2010, 卷号: 329, 期号: 5987
作者:  Yi X.;  Liang Y.;  Huerta-Sanchez E.;  Jin X.;  Cuo Z.X.P.;  Pool J.E.;  Xu N.;  Jiang H.;  Vinckenbosch N.;  Korneliussen T.S.;  Zheng H.;  Liu T.;  He W.;  Li K.;  Luo R.;  Nie X.;  Wu H.;  Zhao M.;  Cao H.;  Zou J.;  Shan Y.;  Li S.;  Yang Q.;  Asan;  Ni P.;  Tian G.;  Xu J.;  Liu X.;  Jiang T.;  Wu R.;  Zhou G.;  Tang M.;  Qin J.;  Wang T.;  Feng S.;  Li G.;  Huasang;  Luosang J.;  Wang W.;  Chen F.;  Wang Y.;  Zheng X.;  Li Z.;  Bianba Z.;  Yang G.;  Wang X.;  Tang S.;  Gao G.;  Chen Y.;  Luo Z.;  Gusang L.;  Cao Z.;  Zhang Q.;  Ouyang W.;  Ren X.;  Liang H.;  Zheng H.;  Huang Y.;  Li J.;  Bolund L.;  Kristiansen K.;  Li Y.;  Zhang Y.;  Zhang X.;  Li R.;  Li S.;  Yang H.;  Nielsen R.;  Wang J.;  Wang J.
收藏  |  浏览/下载：20/0  |  提交时间：2022/01/14