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T cells with dysfunctional mitochondria induce multimorbidity and premature senescence 期刊论文
, 2020, 卷号: 368, 期号: 6497
作者:  Desdín-Micó G.;  Soto-Heredero G.;  Aranda J.F.;  Oller J.;  Carrasco E.;  Gabandé-Rodríguez E.;  Blanco E.M.;  Alfranca A.;  Cussó L.;  Desco M.;  Ibañez B.;  Gortazar A.R.;  Fernández-Marcos P.;  Navarro M.N.;  Hernaez B.;  Alcamí A.;  Baixauli F.;  Mittelbrunn M.
收藏  |  浏览/下载：44/0  |  提交时间：2020/07/28
cardiovascular disease  enzyme activity  gene expression  metabolism  mitochondrial DNA  morbidity  senescence  tumor  Mus  DNA binding protein  mitochondrial protein  mitochondrial transcription factor A  nicotinamide adenine dinucleotide  transcription factor  tumor necrosis factor  animal  cytokine release syndrome  female  fitness  gene deletion  genetics  immunology  inflammation  longevity  male  metabolism  mitochondrion  mouse  multiple chronic conditions  mutant mouse strain  premature aging  T lymphocyte  ultrastructure  Aging, Premature  Animals  Cytokine Release Syndrome  DNA-Binding Proteins  Female  Gene Deletion  Inflammation  Longevity  Male  Mice  Mice, Mutant Strains  Mitochondria  Mitochondrial Proteins  Multimorbidity  NAD  Physical Fitness  T-Lymphocytes  Transcription Factors  Tumor Necrosis Factor-alpha  
Structure of the RNA-dependent RNA polymerase from COVID-19 virus 期刊论文
, 2020, 卷号: 368, 期号: 6492
作者:  Gao Y.;  Yan L.;  Huang Y.;  Liu F.;  Zhao Y.;  Cao L.;  Wang T.;  Sun Q.;  Ming Z.;  Zhang L.;  Ge J.;  Zheng L.;  Zhang Y.;  Wang H.;  Zhu Y.;  Zhu C.;  Hu T.;  Hua T.;  Zhang B.;  Yang X.;  Li J.;  Yang H.;  Liu Z.;  Xu W.;  Guddat L.W.;  Wang Q.;  Lou Z.;  Rao Z.
收藏  |  浏览/下载：51/0  |  提交时间：2020/07/28
comparative study  drug  electron microscopy  enzyme  enzyme activity  RNA  virus  Coronavirus  SARS coronavirus  adenosine phosphate  alanine  antivirus agent  NSP7 protein, SARS-CoV-2  NSP8 protein, SARS-CoV-2  remdesivir  RNA directed RNA polymerase  RNA-dependent RNA polymerase, coronavirus  viral protein  beta sheet  Betacoronavirus  chemistry  cryoelectron microscopy  drug design  enzyme active site  enzymology  metabolism  molecular model  protein domain  ultrastructure  Adenosine Monophosphate  Alanine  Antiviral Agents  Betacoronavirus  Catalytic Domain  Cryoelectron Microscopy  Drug Design  Models, Molecular  Protein Conformation, beta-Strand  Protein Domains  RNA Replicase  Viral Nonstructural Proteins  
How flight feathers stick together to form a continuous morphing wing 期刊论文
, 2020, 卷号: 367, 期号: 6475
作者:  Matloff L.Y.;  Chang E.;  Feo T.J.;  Jeffries L.;  Stowers A.K.;  Thomson C.;  Lentink D.
收藏  |  浏览/下载：40/0  |  提交时间：2020/07/28
aircraft  bird  feather  flight activity  microstructure  nature-society relations  skeleton  wing morphology  aircraft  article  bird  flight feather  noise  nonhuman  robotics  wing  anatomy and histology  animal  Columbidae  elastic tissue  feather  flying  physiology  ultrastructure  wing  Aves  Animals  Columbidae  Elastic Tissue  Feathers  Flight, Animal  Wings, Animal  
Polymerization in the actin ATPase clan regulates hexokinase activity in yeast 期刊论文
, 2020, 卷号: 367, 期号: 6481
作者:  Stoddard P.R.;  Lynch E.M.;  Farrell D.P.;  dosey A.M.;  diMaio F.;  Williams T.A.;  Kollman J.M.;  Murray A.W.;  Garner E.C.
收藏  |  浏览/下载：33/0  |  提交时间：2020/07/28
actin  adenosine triphosphatase  Glk1 protein  glucokinase  glucose  hexokinase  monomer  polymer  unclassified drug  carbohydrate  cell component  enzyme  enzyme activity  mutation  nutrient availability  polymer  polymerization  ultrastructure  actin filament  actin polymerization  Article  depolymerization  enzyme activity  enzyme inhibition  enzyme phosphorylation  nonhuman  nutrient availability  priority journal  protein blood level  Saccharomyces cerevisiae  Saccharomyces cerevisiae  
Correlative three-dimensional super-resolution and block-face electron microscopy of whole vitreously frozen cells 期刊论文
, 2020, 卷号: 367, 期号: 6475
作者:  Hoffman D.P.;  Shtengel G.;  Xu C.S.;  Campbell K.R.;  Freeman M.;  Wang L.;  Milkie D.E.;  Pasolli H.A.;  Iyer N.;  Bogovic J.A.;  Stabley D.R.;  Shirinifard A.;  Pang S.;  Peale D.;  Schaefer K.;  Pomp W.;  Chang C.-L.;  Lippincott-Schwartz J.;  Kirchhausen T.;  Solecki D.J.;  Betzig E.;  Hess H.F.
收藏  |  浏览/下载：50/0  |  提交时间：2020/07/28
cell  compartmentalization  cryopreservation  electron microscopy  image resolution  protein  three-dimensional modeling  ultrastructure  article  chromatin  electron microscopy  endoplasmic reticulum  genetic transcription  human cell  mammal cell  nerve cell culture  protein domain  ultrastructure  whole cell  workflow  animal  cell adhesion  cells  Chlorocebus aethiops  cryoelectron microscopy  CV-1 cell line  fluorescence microscopy  freezing  HeLa cell line  human  mouse  procedures  three-dimensional imaging  tumor cell line  ultrastructure  Mammalia  Animals  Cell Adhesion  Cell Line, Tumor  Cells  Chlorocebus aethiops  COS Cells  Cryoelectron Microscopy  Freezing  HeLa Cells  Humans  Imaging, Three-Dimensional  Mice  Microscopy, Fluorescence  
Structural basis of Gs and Gi recognition by the human glucagon receptor 期刊论文
, 2020, 卷号: 367, 期号: 6484
作者:  Qiao A.;  Han S.;  Li X.;  Li Z.;  Zhao P.;  Dai A.;  Chang R.;  Tai L.;  Tan Q.;  Chu X.;  Ma L.;  Thorsen T.S.;  Reedtz-Runge S.;  Yang D.;  Wang M.-W.;  Sexton P.M.;  Wootten D.;  Sun F.;  Zhao Q.;  Wu B.
收藏  |  浏览/下载：43/0  |  提交时间：2020/07/28
cyclic AMP  glucagon  glucagon receptor  inhibitory guanine nucleotide binding protein  stimulatory guanine nucleotide binding protein  glucagon receptor  inhibitory guanine nucleotide binding protein  protein binding  stimulatory guanine nucleotide binding protein  chemical binding  enzyme activity  gene expression  mutagenicity  protein  alpha helix  Article  binding affinity  carboxy terminal sequence  conformational transition  cryoelectron microscopy  human  molecular recognition  mutagenesis  priority journal  protein binding  protein function  protein protein interaction  protein structure  signal transduction  binding site  chemistry  metabolism  molecular model  protein conformation  ultrastructure  Binding Sites  Cryoelectron Microscopy  Glucagon  GTP-Binding Protein alpha Subunits, Gi-Go  GTP-Binding Protein alpha Subunits, Gs  Humans  Models, Molecular  Protein Binding  Protein Conformation  Protein Conformation, alpha-Helical  Receptors, Glucagon  Signal Transduction  
Golgi-derived PI(4)P-containing vesicles drive late steps of mitochondrial division 期刊论文
, 2020, 卷号: 367, 期号: 6484
作者:  Nagashima S.;  Tábara L.-C.;  Tilokani L.;  Paupe V.;  Anand H.;  Pogson J.H.;  Zunino R.;  McBride H.M.;  Prudent J.
收藏  |  浏览/下载：36/0  |  提交时间：2020/07/28
adenosine diphosphate ribosylation factor 1  dynamin related protein 1  mitochondrial protein  phosphatidylinositol 4 kinase IIIbeta  phosphatidylinositol 4 phosphate  phosphatidylinositol kinase  unclassified drug  adenosine diphosphate ribosylation factor 1  ARF1 protein, human  DNM1L protein, human  dynamin  phosphatidylinositol 4-phosphate  phosphatidylinositol kinase  polyphosphoinositide  cell component  cell organelle  chemical compound  enzyme  enzyme activity  mitochondrion  protein  Article  controlled study  COS-7 cell line  endoplasmic reticulum  fibroblast  gene silencing  HeLa cell line  human  human cell  membrane microdomain  mitochondrial division  mitochondrial dynamics  mitochondrial scission  priority journal  protein localization  trans Golgi network  U2OS cell line  animal  cell line  Chlorocebus aethiops  CV-1 cell line  genetics  metabolism  mitochondrial membrane  mitochondrion  RNA interference  trans Golgi network  ultrastructure  Mammalia  1-Phosphatidylinositol 4-Kinase  ADP-Ribosylation Factor 1  Animals  Cell Line  Chlorocebus aethiops  COS Cells  Dynamins  Endoplasmic Reticulum  HeLa Cells  Humans  Membrane Microdomains  Mitochondria  Mitochondrial Dynamics  Mitochondrial Membranes  Phosphatidylinositol Phosphates  RNA Interference  trans-Golgi Network  
One-dimensional van der Waals heterostructures 期刊论文
, 2020, 卷号: 367, 期号: 6477
作者:  Xiang R.;  Inoue T.;  Zheng Y.;  Kumamoto A.;  Qian Y.;  Sato Y.;  Liu M.;  Tang D.;  Gokhale D.;  Guo J.;  Hisama K.;  Yotsumoto S.;  Ogamoto T.;  Arai H.;  Kobayashi Y.;  Zhang H.;  Hou B.;  Anisimov A.;  Maruyama M.;  Miyata Y.;  Okada S.;  Chiashi S.;  Li Y.;  Kong J.;  Kauppinen E.I.;  Ikuhara Y.;  Suenaga K.;  Maruyama S.
收藏  |  浏览/下载：226/0  |  提交时间：2020/07/28
boron nitride  inorganic salt  molybdenum disulfide  single walled nanotube  unclassified drug  chemical bonding  experimental study  nanotube  one-dimensional modeling  ultrastructure  Article  chemical structure  crystal  one dimensional van der Waals heterostructure  particle size  priority journal  
SARS-CoV-2 productively infects human gut enterocytes 期刊论文
, 2020, 卷号: 369, 期号: 6499
作者:  Lamers M.M.;  Beumer J.;  van der Vaart J.;  Knoops K.;  Puschhof J.;  Breugem T.I.;  Ravelli R.B.G.;  Paul van Schayck J.;  Mykytyn A.Z.;  Duimel H.Q.;  van Donselaar E.;  Riesebosch S.;  Kuijpers H.J.H.;  Schipper D.;  van de Wetering W.J.;  de Graaf M.;  Koopmans M.;  Cuppen E.;  Peters P.J.;  Haagmans B.L.;  Clevers H.
收藏  |  浏览/下载：37/0  |  提交时间：2020/07/28
angiotensin converting enzyme 2  dipeptidyl carboxypeptidase  messenger RNA  virus receptor  Betacoronavirus  cell culture technique  cell differentiation  cell lineage  cell proliferation  culture medium  gene expression  genetics  human  ileum  intestine cell  lung  male  metabolism  organoid  physiology  respiratory mucosa  SARS coronavirus  ultrastructure  virology  virus replication  Betacoronavirus  Cell Culture Techniques  Cell Differentiation  Cell Lineage  Cell Proliferation  Culture Media  Enterocytes  Gene Expression  Humans  Ileum  Lung  Male  Organoids  Peptidyl-Dipeptidase A  Receptors, Virus  Respiratory Mucosa  RNA, Messenger  SARS Virus  Virus Replication  
Structural basis for strand-transfer inhibitor binding to HIV intasomes 期刊论文
, 2020, 卷号: 367, 期号: 6479
作者:  Passos D.O.;  Li M.;  Jóźwik I.K.;  Zhao X.Z.;  Santos-Martins D.;  Yang R.;  Smith S.J.;  Jeon Y.;  Forli S.;  Hughes S.H.;  Burke T.R.;  Jr.;  Craigie R.;  Lyumkis D.
收藏  |  浏览/下载：27/0  |  提交时间：2020/07/28
bictegravir  nucleoprotein  protein intasome  unclassified drug  viral protein  bictegravir  fused heterocyclic rings  integrase  integrase inhibitor  multiprotein complex  naphthyridine derivative  nucleoprotein  biochemistry  chemical binding  human immunodeficiency virus  inhibitor  protein  ultrastructure  amino terminal sequence  Article  carboxy terminal sequence  catalysis  cryoelectron microscopy  drug design  drug efficacy  drug protein binding  drug resistance  drug structure  enzyme active site  human  Human immunodeficiency virus infection  nonhuman  priority journal  protein purification  protein structure  antiviral resistance  chemistry  drug effect  genetics  Human immunodeficiency virus  virus DNA cell DNA interaction  Cryoelectron Microscopy  Drug Design  Drug Resistance, Viral  Heterocyclic Compounds, 4 or More Rings  HIV  HIV Integrase  HIV Integrase Inhibitors  Humans  Multiprotein Complexes  Naphthyridines  Nucleoproteins  Virus Integration