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| DOI | 10.1126/science.aax6089 |
| Golgi-derived PI(4)P-containing vesicles drive late steps of mitochondrial division | |
| Nagashima S.; Tábara L.-C.; Tilokani L.; Paupe V.; Anand H.; Pogson J.H.; Zunino R.; McBride H.M.; Prudent J. | |
| 发表日期 | 2020 |
| ISSN | 0036-8075 |
| 起始页码 | 1366 |
| 结束页码 | 1371 |
| 卷号 | 367期号:6484 |
| 英文摘要 | Mitochondrial plasticity is a key regulator of cell fate decisions. Mitochondrial division involves Dynamin-related protein-1 (Drp1) oligomerization, which constricts membranes at endoplasmic reticulum (ER) contact sites. The mechanisms driving the final steps of mitochondrial division are still unclear. Here, we found that microdomains of phosphatidylinositol 4-phosphate [PI(4)P] on trans-Golgi network (TGN) vesicles were recruited to mitochondria-ER contact sites and could drive mitochondrial division downstream of Drp1. The loss of the small guanosine triphosphatase ADP-ribosylation factor 1 (Arf1) or its effector, phosphatidylinositol 4-kinase IIIβ [PI(4)KIIIβ], in different mammalian cell lines prevented PI(4)P generation and led to a hyperfused and branched mitochondrial network marked with extended mitochondrial constriction sites. Thus, recruitment of TGN-PI(4)P-containing vesicles at mitochondria-ER contact sites may trigger final events leading to mitochondrial scission. © 2020 American Association for the Advancement of Science. All rights reserved. |
| 关键词 | adenosine diphosphate ribosylation factor 1dynamin related protein 1mitochondrial proteinphosphatidylinositol 4 kinase IIIbetaphosphatidylinositol 4 phosphatephosphatidylinositol kinaseunclassified drugadenosine diphosphate ribosylation factor 1ARF1 protein, humanDNM1L protein, humandynaminphosphatidylinositol 4-phosphatephosphatidylinositol kinasepolyphosphoinositidecell componentcell organellechemical compoundenzymeenzyme activitymitochondrionproteinArticlecontrolled studyCOS-7 cell lineendoplasmic reticulumfibroblastgene silencingHeLa cell linehumanhuman cellmembrane microdomainmitochondrial divisionmitochondrial dynamicsmitochondrial scissionpriority journalprotein localizationtrans Golgi networkU2OS cell lineanimalcell lineChlorocebus aethiopsCV-1 cell linegeneticsmetabolismmitochondrial membranemitochondrionRNA interferencetrans Golgi networkultrastructureMammalia1-Phosphatidylinositol 4-KinaseADP-Ribosylation Factor 1AnimalsCell LineChlorocebus aethiopsCOS CellsDynaminsEndoplasmic ReticulumHeLa CellsHumansMembrane MicrodomainsMitochondriaMitochondrial DynamicsMitochondrial MembranesPhosphatidylinositol PhosphatesRNA Interferencetrans-Golgi Network |
| 语种 | 英语 |
| 来源机构 | Science |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/133614 |
| 推荐引用方式 GB/T 7714 | Nagashima S.,Tábara L.-C.,Tilokani L.,et al. Golgi-derived PI(4)P-containing vesicles drive late steps of mitochondrial division[J]. Science,2020,367(6484). |
| APA | Nagashima S..,Tábara L.-C..,Tilokani L..,Paupe V..,Anand H..,...&Prudent J..(2020).Golgi-derived PI(4)P-containing vesicles drive late steps of mitochondrial division.,367(6484). |
| MLA | Nagashima S.,et al."Golgi-derived PI(4)P-containing vesicles drive late steps of mitochondrial division".367.6484(2020). |
| 条目包含的文件 | 条目无相关文件。 | |||||
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