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| Temporal integration of mitogen history in mother cells controls proliferation of daughter cells 期刊论文
, 2020, 卷号: 368, 期号: 6496
作者: Min M.; Rong Y.; Tian C.; Spencer S.L.
  收藏 | 浏览/下载：29/0 | 提交时间：2020/07/28
cyclin D mitogen activated protein kinase kinase mitogenic agent cell cycle G1 phase cell cycle G2 phase cell proliferation genetics human metabolism physiology protein synthesis signal transduction stem cell Cell Proliferation Cyclin D G1 Phase G2 Phase Humans Mitogen-Activated Protein Kinase Kinases Mitogens Protein Biosynthesis Signal Transduction Stem Cells |
| N6-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription 期刊论文
, 2020, 卷号: 367, 期号: 6477
作者: Liu J.; Dou X.; Chen C.; Chen C.; Liu C.; Michelle Xu M.; Zhao S.; Shen B.; Gao Y.; Han D.; He C.
收藏 | 浏览/下载：14/0 | 提交时间：2020/07/28
6 n methyladenosine chromosome associated regulatory RNA enhancer RNA messenger RNA promoter associated RNA repeat RNA RNA unclassified drug cell component chemical compound chromosome methylation RNA animal cell Article biodegradation chemical modification chromatin controlled study demethylation embryo embryonic stem cell exosome methylation METTL3 gene mouse nonhuman nuclear degradation priority journal transcription regulation Ythdc1 gene |
| Single-cell transcriptional diversity is a hallmark of developmental potential 期刊论文
, 2020, 卷号: 367, 期号: 6476
作者: Gulati G.S.; Sikandar S.S.; Wesche D.J.; Manjunath A.; Bharadwaj A.; Berger M.J.; Ilagan F.; Kuo A.H.; Hsieh R.W.; Cai S.; Zabala M.; Scheeren F.A.; Lobo N.A.; Qian D.; Yu F.B.; Dirbas F.M.; Clarke M.F.; Newman A.M.
收藏 | 浏览/下载：46/0 | 提交时间：2020/07/28
cell cell component developmental biology experimental study genetic analysis tumor Article breast cancer breast carcinogenesis carcinogenesis cell differentiation computer model embryonic stem cell gene expression genetic code genetic variability human in vivo study nonhuman phenotype priority journal scoring system single cell RNA seq upregulation |
| The body's dangerous defenders 期刊论文
, 2020, 卷号: 367, 期号: 6482
作者: Leslie M.
收藏 | 浏览/下载：39/0 | 提交时间：2020/07/28
alvelestat avacopan chemokine receptor CXCR2 danirixin leukocyte elastase n [2 (2,3 difluorobenzylthio) 6 (2,3 dihydroxy 1 methylpropoxy) 4 pyrimidinyl] 1 azetidinesulfonamide nemiralisib simvastatin leukocyte elastase inhibitor antimicrobial activity apoptosis cell enzyme activity physiological response ANCA associated vasculitis Article autoimmune disease autoimmunity bacterial pneumonia bactericidal activity bronchiolitis obliterans drug targeting extracellular matrix extracellular trap hematopoietic stem cell transplantation human immunity immunocompetent cell infection inflammation lung disease neutrophil neutrophil chemotaxis nonhuman priority journal risk factor sepsis single cell RNA seq autoimmune disease chronic obstructive lung disease clinical trial (topic) drug effect enzymology immunology lung tumor neutrophil Autoimmune Diseases Clinical Trials as Topic Humans Lung Neoplasms Neutrophils Proteinase Inhibitory Proteins, Secretory Pulmonary Disease, Chronic Obstructive |
| The evolutionary dynamics and fitness landscape of clonal hematopoiesis 期刊论文
, 2020, 卷号: 367, 期号: 6485
作者: Watson C.J.; Papula A.L.; Poon G.Y.P.; Wong W.H.; Young A.L.; Druley T.E.; Fisher D.S.; Blundell J.R.
收藏 | 浏览/下载：35/0 | 提交时间：2020/07/28
DNA methyltransferase 3A blood cancer evolutionary biology fitness gene expression genetic drift hematology mutation pathogenicity acute myeloid leukemia age distribution allele Article cancer risk cell expansion cell population clonal hematopoiesis epigenetics gene mutation genetic variability hematological parameters hematopoiesis hematopoietic stem cell human molecular evolution mutational analysis nonhuman priority journal single nucleotide polymorphism somatic mutation stem cell self-renewal |
| Regenerative potential of prostate luminal cells revealed by single-cell analysis 期刊论文
, 2020, 卷号: 368, 期号: 6490
作者: Karthaus W.R.; Hofree M.; Choi D.; Linton E.L.; Turkekul M.; Bejnood A.; Carver B.; Gopalan A.; Abida W.; Laudone V.; Biton M.; Chaudhary O.; Xu T.; Masilionis I.; Manova K.; Mazutis L.; Pe’er D.; Regev A.; Sawyers C.L.
收藏 | 浏览/下载：205/0 | 提交时间：2020/07/28
androgen growth factor Nrg2 growth factor Rspo3 growth factor unclassified drug androgen binding protein antiandrogen ataxin 1 Atxn1 protein, mouse glycosylphosphatidylinositol anchored protein homeodomain protein nerve growth factor Nkx3-1 protein, mouse Nrg2 protein, mouse probasin Psca protein, mouse R-spondin3 protein, mouse thrombospondin transcription factor tumor antigen tumor protein androgen cancer cell gene expression RNA rodent ablation therapy animal cell animal tissue Article cell differentiation cell population cell regeneration cells by body anatomy controlled study gene gene expression human luminal cell male mesenchyme cell mouse nonhuman paracrine signaling priority journal prostate cell prostate tissue protein expression Psca gene RNA sequencing Sca1 gene single cell analysis animal genetics mesenchymal stem cell metabolism organ size organoid physiology prostate prostate tumor regeneration sequence analysis single cell analysis Mus Androgen Antagonists Androgen-Binding Protein Androgens Animals Antigens, Neoplasm Ataxin-1 Cell Differentiation Gene Expression GPI-Linked Proteins Homeodomain Proteins Humans Male Mesenchymal Stem Cells Mice Neoplasm Proteins Nerve Growth Factors Organ Size Organoids Prostate Prostatic Neoplasms Regeneration Sequence Analysis, RNA Single-Cell Analysis Thrombospondins Transcription Factors |
| Maintenance of neural stem cell positional identity by mixed-lineage leukemia 1 期刊论文
, 2020, 卷号: 368, 期号: 6486
作者: Delgado R.N.; Mansky B.; Ahanger S.H.; Lu C.; Andersen R.E.; Dou Y.; Alvarez-Buylla A.; Lim D.A.
收藏 | 浏览/下载：29/0 | 提交时间：2020/07/28
mixed lineage leukemia 1 protein mixed lineage leukemia protein morphogen sonic hedgehog protein unclassified drug anatomy brain cell component developmental biology inhibition adult animal cell animal experiment animal tissue Article controlled study embryo epigenetics forebrain in vivo study memory Mll1 gene mouse nerve cell nerve cell differentiation neural stem cell nonhuman priority journal Erinaceidae Murinae |
| ZGLP1 is a determinant for the oogenic fate in mice 期刊论文
, 2020, 卷号: 367, 期号: 6482
作者: Nagaoka S.I.; Nakaki F.; Miyauchi H.; Nosaka Y.; Ohta H.; Yabuta Y.; Kurimoto K.; Hayashi K.; Nakamura T.; Yamamoto T.; Saitou M.
收藏 | 浏览/下载：50/0 | 提交时间：2020/07/28
bone morphogenetic protein bone cell gametogenesis germ cell maturation rodent signaling adult animal cell animal experiment animal model Article cell fate controlled study embryo female gain of function mutation gene gene overexpression genetic transcription in vitro study in vivo study loss of function mutation male meiotic prophase I mouse mouse embryonic stem cell nonhuman oocyte development priority journal retroposon RNA processing RNA sequencing signal transduction spermatogenesis Stra8 gene ZGLP1 gene Mammalia Mus |
| Hope for hematological diseases 期刊论文
, 2020, 卷号: 367, 期号: 6483
作者: Wilkinson A.C.
收藏 | 浏览/下载：41/0 | 提交时间：2020/07/28
fibronectin polyvinyl alcohol serum albumin stem cell factor thrombopoietin blood disease incidence disease treatment laboratory method medicine public health Article cell differentiation cell self-renewal chemotherapy CRISPR-CAS9 system ex vivo study gene editing gene therapy genotoxicity graft versus host reaction hematologic disease hematopoiesis hematopoietic stem cell transplantation human morbidity mortality multipotent stem cell nonhuman priority journal radiotherapy stem cell culture stem cell expansion |
| Chromatin accessibility dynamics in a model of human forebrain development 期刊论文
, 2020, 卷号: 367, 期号: 6476
作者: Trevino A.E.; Sinnott-Armstrong N.; Andersen J.; Yoon S.-J.; Huber N.; Pritchard J.K.; Chang H.Y.; Greenleaf W.J.; Pașca S.P.
收藏 | 浏览/下载：25/0 | 提交时间：2020/07/28
brain cell component developmental biology developmental stage disease genetic analysis nervous system disorder Article brain cortex brain development brain nerve cell brain tissue cell differentiation cell migration chromatin controlled study environmental factor fluorescence activated cell sorting forebrain GABAergic system glia cell heredity high throughput sequencing human human cell human tissue pluripotent stem cell priority journal RNA isolation RNA sequence RNA sequencing |
