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| Membrane-proximal F-actin restricts local membrane protrusions and directs cell migration 期刊论文
, 2020, 卷号: 368, 期号: 6496
作者: Bisaria A.; Hayer A.; Garbett D.; Cohen D.; Meyer T.
  收藏 | 浏览/下载：41/0 | 提交时间：2020/07/28
cell component concentration (composition) membrane polymerization protein actin green fluorescent protein cell membrane cell motion cell polarity cell surface chemistry genetics human metabolism umbilical vein endothelial cell Actins Cell Membrane Cell Movement Cell Polarity Cell Surface Extensions Green Fluorescent Proteins Human Umbilical Vein Endothelial Cells Humans |
| Temporal integration of mitogen history in mother cells controls proliferation of daughter cells 期刊论文
, 2020, 卷号: 368, 期号: 6496
作者: Min M.; Rong Y.; Tian C.; Spencer S.L.
收藏 | 浏览/下载：31/0 | 提交时间：2020/07/28
cyclin D mitogen activated protein kinase kinase mitogenic agent cell cycle G1 phase cell cycle G2 phase cell proliferation genetics human metabolism physiology protein synthesis signal transduction stem cell Cell Proliferation Cyclin D G1 Phase G2 Phase Humans Mitogen-Activated Protein Kinase Kinases Mitogens Protein Biosynthesis Signal Transduction Stem Cells |
| Computing cancer's weak spots 期刊论文
, 2020, 卷号: 368, 期号: 6496
作者: Khamsi R.
收藏 | 浏览/下载：49/0 | 提交时间：2020/07/28
ruxolitinib STAT3 protein antineoplastic agent transcription factor algorithm cancer computer simulation disease treatment drug development medicine Article cancer cell cancer radiotherapy enzyme inhibition gene activity gene expression regulation gene interaction gene mutation gene repression gene targeting human laboratory test malignant neoplasm molecular dynamics nonhuman oncologist priority journal RNA sequencing algorithm genetics mutation neoplasm personalized medicine procedures systems biology Algorithms Antineoplastic Agents Humans Mutation Neoplasms Precision Medicine Systems Biology Transcription Factors |
| A neurodevelopmental origin of behavioral individuality in the Drosophila visual system 期刊论文
, 2020, 卷号: 367, 期号: 6482
作者: Linneweber G.A.; Andriatsilavo M.; Dutta S.B.; Bengochea M.; Hellbruegge L.; Liu G.; Ejsmont R.K.; Straw A.D.; Wernet M.; Hiesinger P.R.; Hassan B.A.
收藏 | 浏览/下载：63/0 | 提交时间：2020/07/28
anatomy asymmetry brain genome neurology orientation visual analysis article brain Drosophila melanogaster human experiment individuality nerve cell nonhuman stochastic model visual system walking anatomy and histology animal Drosophila melanogaster genetic variation genetics growth, development and aging nervous system development orientation physiology visual field visual system Drosophila melanogaster Animals Brain Drosophila melanogaster Genetic Variation Individuality Neurogenesis Orientation Visual Fields Visual Pathways |
| Pervasive functional translation of noncanonical human open reading frames 期刊论文
, 2020, 卷号: 367, 期号: 6482
作者: Chen J.; Brunner A.-D.; Cogan J.Z.; Nuñez J.K.; Fields A.P.; Adamson B.; Itzhak D.N.; Li J.Y.; Mann M.; Leonetti M.D.; Weissman J.S.
收藏 | 浏览/下载：33/0 | 提交时间：2020/07/28
messenger RNA peptide transcriptome CRISPR Cas system genetics human metabolism open reading frame operon protein synthesis ribosome CRISPR-Cas Systems Humans Open Reading Frames Operon Peptides Protein Biosynthesis Ribosomes RNA, Messenger Transcriptome |
| Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者: Walton R.T.; Christie K.A.; Whittaker M.N.; Kleinstiver B.P.
收藏 | 浏览/下载：29/0 | 提交时间：2020/07/28
adenine adenosine CRISPR associated endonuclease Cas9 cytosine guanosine SpG protein SpRY nuclease thymine unclassified drug Cas9 endonuclease Streptococcus pyogenes bacterium enzyme activity genetic engineering genetic variation genome Article CRISPR-CAS9 system DNA sequence enzyme activity gene editing gene targeting genetic variability human mutagenesis nonhuman priority journal protein engineering protein motif protein structure protospacer adjacent motif Streptococcus pyogenes chemistry CRISPR Cas system enzyme specificity gene editing gene targeting genetic predisposition genetics HEK293 cell line procedures protein domain Streptococcus pyogenes CRISPR-Associated Protein 9 CRISPR-Cas Systems Gene Editing Gene Targeting Genetic Predisposition to Disease HEK293 Cells Humans Mutagenesis Protein Domains Substrate Specificity |
| Liquid-liquid phase separation drives skin barrier formation 期刊论文
, 2020, 卷号: 367, 期号: 6483
作者: Quiroz F.G.; Fiore V.F.; Levorse J.; Polak L.; Wong E.; Pasolli H.A.; Fuchs E.
收藏 | 浏览/下载：31/0 | 提交时间：2020/07/28
filaggrin intermediate filament protein keratin keratohyalin animal cytoplasm epidermis genetics human keratinocyte metabolism mouse phase transition physiology Animals Cytoplasm Epidermis Humans Intermediate Filament Proteins Keratinocytes Keratins Mice Phase Transition |
| Fraser offers AAAS a career driven by curiosity, collaboration, and discovery 期刊论文
, 2020, 卷号: 367, 期号: 6481
作者: Hoy A.Q.
收藏 | 浏览/下载：44/0 | 提交时间：2020/07/28
biography research and development science and technology algal bloom Article bioremediation climate change decision making environmental planning food security human medical education medical society medical specialist microbial genetics personal experience pollution priority journal publication species identification water contamination |
| HEM1 deficiency disrupts mTORC2 and F-actin control in inherited immunodysregulatory disease 期刊论文
, 2020, 卷号: 369, 期号: 6500
作者: Cook S.A.; Comrie W.A.; Poli M.C.; Similuk M.; Oler A.J.; Faruqi A.J.; Kuhns D.B.; Yang S.; Vargas-Hernández A.; Carisey A.F.; Fournier B.; Anderson D.E.; Price S.; Smelkinson M.; Abou Chahla W.; Forbes L.R.; Mace E.M.; Cao T.N.; Coban-Akdemir Z.H.; Jhangiani S.N.; Muzny D.M.; Gibbs R.A.; Lupski J.R.; Orange J.S.; Cuvelier G.D.E.; Al Hassani M.; Al Kaabi N.; Al Yafei Z.; Jyonouchi S.; Raje N.; Caldwell J.W.; Huang Y.; Burkhardt J.K.; Latour S.; Chen B.; ElGhazali G.; Rao V.K.; Chinn I.K.; Lenardo M.J.
收藏 | 浏览/下载：54/0 | 提交时间：2020/07/28
actin adenosine diphosphate ribosylation factor 1 ARF1 protein, human cytokine mammalian target of rapamycin complex 2 membrane protein NCKAP1L protein, human WASF1 protein, human WASF2 protein, human WASF3 protein, human Wiskott Aldrich syndrome protein biosynthesis CD4+ T lymphocyte cell proliferation chemistry genetics human immune deficiency immunology lymphoproliferative disease metabolism pedigree phosphorylation physiology Actins ADP-Ribosylation Factor 1 CD4-Positive T-Lymphocytes Cell Proliferation Cytokines Humans Immunologic Deficiency Syndromes Lymphoproliferative Disorders Mechanistic Target of Rapamycin Complex 2 Membrane Proteins Pedigree Phosphorylation Wiskott-Aldrich Syndrome Protein Family |
| Modulating microbiome metabolites in vivo 期刊论文
, 2020, 卷号: 369, 期号: 6500
作者: Guo C.-J.
收藏 | 浏览/下载：25/0 | 提交时间：2020/07/28
Clostridium CRISPR Cas system genetics human intestine flora metabolism Clostridium CRISPR-Cas Systems Gastrointestinal Microbiome Host Microbial Interactions Humans |
