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| Temperature-dependent sex determination is mediated by pSTAT3 repression of Kdm6b 期刊论文 , 2020, 卷号: 368, 期号: 6488 作者: Weber C.; Zhou Y.; Lee J.G.; Looger L.L.; Qian G.; Ge C.; Capel B. 收藏  |  浏览/下载:35/0  |  提交时间:2020/07/28 STAT3 protein calcium histone demethylase STAT3 protein embryonic development gene expression sex determination temperature effect turtle animal cell animal experiment Article binding site calcium transport cell activation chromatin immunoprecipitation controlled study dimerization Dmrt1 gene embryo embryo development environmental temperature epigenetic repression female gene gene activation gene interaction gene targeting genetic transcription gonad high temperature immunofluorescence test Kdm6b gene male nonhuman priority journal protein phosphorylation real time polymerase chain reaction sex determination signal transduction temperature dependence thermoregulation transcription regulation upregulation Western blotting animal embryology gene expression regulation genetics metabolism phosphorylation sex determination process temperature turtle Reptilia Trachemys scripta Trachemys scripta elegans Animals Calcium Female Gene Expression Regulation, Developmental Jumonji Domain-Containing Histone Demethylases Male Phosphorylation Sex Determination Processes STAT3 Transcription Factor Temperature Transcription, Genetic Turtles |
| Dopaminylation of histone H3 in ventral tegmental area regulates cocaine seeking 期刊论文 , 2020, 卷号: 368, 期号: 6487 作者: Lepack A.E.; Werner C.T.; Stewart A.F.; Fulton S.L.; Zhong P.; Farrelly L.A.; Smith A.C.W.; Ramakrishnan A.; Lyu Y.; Bastle R.M.; Martin J.A.; Mitra S.; O'Connor R.M.; Wang Z.-J.; Molina H.; Turecki G.; Shen L.; Yan Z.; Calipari E.S.; Dietz D.M.; Kenny P.J.; Maze I. 收藏  |  浏览/下载:49/0  |  提交时间:2020/07/28 amidase dopamine histone H3 histone transamidase protein glutamine gamma glutamyltransferase 2 RNA unclassified drug brain cell chemical compound chemical reaction gene expression genetic analysis protein action potential amino acid substitution amino terminal sequence Article cocaine dependence controlled study dopamine release dopaminergic nerve cell dopaminergic transmission down regulation drug seeking behavior enzyme activity gene expression histone dopaminylation histone modification human human tissue hyperpolarization in vitro study motivation nerve cell plasticity nerve projection neuropathology nucleus accumbens priority journal protein expression protein function reward RNA sequence ventral tegmentum Rattus |
| Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis 期刊论文 , 2020, 卷号: 367, 期号: 6485 作者: Ebright R.Y.; Lee S.; Wittner B.S.; Niederhoffer K.L.; Nicholson B.T.; Bardia A.; Truesdell S.; Wiley D.F.; Wesley B.; Li S.; Mai A.; Aceto N.; Vincent-Jordan N.; Szabolcs A.; Chirn B.; Kreuzer J.; Comaills V.; Kalinich M.; Haas W.; Ting D.T.; Toner M.; Vasudevan S.; Haber D.A.; Maheswaran S.; Micalizzi D.S. 收藏  |  浏览/下载:55/0  |  提交时间:2020/07/28 CRISPR associated protein epidermal growth factor receptor 2 Ki 67 antigen ribosome protein ribosome RNA transcription factor E2F ribosome protein cancer cell gene expression genetic engineering protein RNA tumor animal experiment animal model animal tissue Article biogenesis bioluminescence breast cancer cell cycle progression cell cycle regulation cell proliferation circulating tumor cell controlled study enzyme activation epithelial mesenchymal transition gene expression profiling genetic transcription human human cell lung metastasis metastasis microfluidics mouse nonhuman overall survival phenotype priority journal progression free survival promoter region protein expression protein processing protein synthesis proteomics RNA sequence transcription regulation animal breast tumor cancer transplantation CRISPR Cas system female gene expression regulation genetics pathology sequence analysis tumor cell line tumor embolism Mus Animals Breast Neoplasms Cell Line, Tumor CRISPR-Cas Systems Female Gene Expression Regulation, Neoplastic Humans Mice Neoplasm Metastasis Neoplasm Transplantation Neoplastic Cells, Circulating Ribosomal Proteins Sequence Analysis, RNA |
| Patterns of DNA methylation changes in elite Eucalyptus clones across contrasting environments 期刊论文 , 2020, 卷号: 474 作者: Jacinto Pereira W.; de Castro Rodrigues Pappas M.; Camargo Campoe O.; Stape J.L.; Grattapaglia D.; Joannis Pappas Jr G. 收藏  |  浏览/下载:28/0  |  提交时间:2020/07/28 Alkylation Climate change Cloning DNA Environmental regulations Forestry Gene encoding Association analysis Epigenetic modification Epigenetic regulation Global climate changes Multiple correspondence analysis Phenotypic plasticity Transposable elements Variable environment Methylation adaptation complexity correspondence analysis DNA environmental response evergreen tree genetic variation genome global change methylation phenotypic plasticity sampling xylem Alkylation Environmental Regulations Eucalyptus Grandis Forestry Methylation Nucleic Acids Patterns Sites Brazil Eucalyptus Eucalyptus grandis Eucalyptus urophylla |
| Vertebrate diapause preserves organisms long term through Polycomb complex members 期刊论文 , 2020, 卷号: 367, 期号: 6480 作者: Hu C.-K.; Wang W.; Brind'Amour J.; Singh P.P.; Adam Reeves G.; Lorincz M.C.; Alvarado A.S.; Brunet A. 收藏  |  浏览/下载:43/0  |  提交时间:2020/07/28 polycomb group protein protein CBX7 transcriptome unclassified drug diapause gene expression metabolism muscle vertebrate Article chromatin complex formation developmental gene diapause down regulation embryo development fertility gene gene expression regulation gene repression genetic regulation growth rate lifespan lipid metabolism metabolism muscle atrophy muscle gene neuromuscular junction nonhuman priority journal protein function tissue preservation upregulation vertebrate Cyprinodontoidei Nothobranchius furzeri Vertebrata |
| The malaria parasite has an intrinsic clock 期刊论文 , 2020, 卷号: 368, 期号: 6492 作者: Rijo-Ferreira F.; Acosta-Rodriguez V.A.; Abel J.H.; Kornblum I.; Bento I.; Kilaru G.; Klerman E.B.; Mota M.M.; Takahashi J.S. 收藏  |  浏览/下载:26/0  |  提交时间:2020/07/28 cell circadian rhythm food intake malaria Mus Plasmodium chabaudi transcription factor CLOCK animal association circadian rhythm darkness eating erythrocyte feeding behavior fever gene expression regulation genetic transcription genetics host parasite interaction malaria mouse mutant mouse strain parasitology pathophysiology physiology Plasmodium chabaudi Animals Circadian Rhythm CLOCK Proteins Cues Darkness Eating Erythrocytes Feeding Behavior Fever Gene Expression Regulation Host-Parasite Interactions Malaria Mice Mice, Mutant Strains Plasmodium chabaudi Transcription, Genetic |
| Pervasive functional translation of noncanonical human open reading frames 期刊论文 , 2020, 卷号: 367, 期号: 6482 作者: Chen J.; Brunner A.-D.; Cogan J.Z.; Nuñez J.K.; Fields A.P.; Adamson B.; Itzhak D.N.; Li J.Y.; Mann M.; Leonetti M.D.; Weissman J.S. 收藏  |  浏览/下载:53/0  |  提交时间:2020/07/28 messenger RNA antigen cell component cell organelle chemical binding growth phenotype protein Quaternary RNA Article cell function cell growth cellular distribution clustered regularly interspaced short palindromic repeat gene sequence genetic screening HLA system human non-canonical base pairing open reading frame operon priority journal protein analysis protein binding protein function transcriptomics translation regulation Mammalia |
| Next-generation epigenetic inhibitors 期刊论文 , 2020, 卷号: 368, 期号: 6489 作者: Filippakopoulos P.; Knapp S. 收藏  |  浏览/下载:21/0  |  提交时间:2020/07/28 biological marker bromodomain inhibitor DNA experiment genetic analysis inhibitor Article binding site down regulation gene expression histone modification human nonhuman pleiotropy priority journal protein domain protein folding protein interaction protein processing protein targeting transcription elongation transcription regulation |