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Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease 期刊论文
, 2020, 卷号: 368, 期号: 6497
作者:  Dai W.;  Zhang B.;  Jiang X.-M.;  Su H.;  Li J.;  Zhao Y.;  Xie X.;  Jin Z.;  Peng J.;  Liu F.;  Li C.;  Li Y.;  Bai F.;  Wang H.;  Cheng X.;  Cen X.;  Hu S.;  Yang X.;  Wang J.;  Liu X.;  Xiao G.;  Jiang H.;  Rao Z.;  Zhang L.-K.;  Xu Y.;  Yang H.;  Liu H.
收藏  |  浏览/下载：45/0  |  提交时间：2020/07/28
aldehyde  antimicrobial activity  drug  enzyme activity  infectivity  inhibitor  reaction kinetics  viral disease  Coronavirus  SARS coronavirus  3C-like proteinase, Coronavirus  antivirus agent  cysteine proteinase  viral protein  animal  Betacoronavirus  chemical structure  chemistry  Chlorocebus aethiops  Coronavirus infection  dog  drug design  drug effect  enzyme active site  enzymology  female  human  male  mouse  pandemic  preclinical study  protein tertiary structure  Sprague Dawley rat  toxicity testing  Vero cell line  virus pneumonia  Animals  Antiviral Agents  Betacoronavirus  Catalytic Domain  Chlorocebus aethiops  Coronavirus Infections  Cysteine Endopeptidases  Dogs  Drug Design  Drug Evaluation, Preclinical  Female  Humans  Male  Mice  Molecular Structure  Pandemics  Pneumonia, Viral  Protein Structure, Tertiary  Rats, Sprague-Dawley  Toxicity Tests  Vero Cells  Viral Nonstructural Proteins  
Structure of the RNA-dependent RNA polymerase from COVID-19 virus 期刊论文
, 2020, 卷号: 368, 期号: 6492
作者:  Gao Y.;  Yan L.;  Huang Y.;  Liu F.;  Zhao Y.;  Cao L.;  Wang T.;  Sun Q.;  Ming Z.;  Zhang L.;  Ge J.;  Zheng L.;  Zhang Y.;  Wang H.;  Zhu Y.;  Zhu C.;  Hu T.;  Hua T.;  Zhang B.;  Yang X.;  Li J.;  Yang H.;  Liu Z.;  Xu W.;  Guddat L.W.;  Wang Q.;  Lou Z.;  Rao Z.
收藏  |  浏览/下载：51/0  |  提交时间：2020/07/28
comparative study  drug  electron microscopy  enzyme  enzyme activity  RNA  virus  Coronavirus  SARS coronavirus  adenosine phosphate  alanine  antivirus agent  NSP7 protein, SARS-CoV-2  NSP8 protein, SARS-CoV-2  remdesivir  RNA directed RNA polymerase  RNA-dependent RNA polymerase, coronavirus  viral protein  beta sheet  Betacoronavirus  chemistry  cryoelectron microscopy  drug design  enzyme active site  enzymology  metabolism  molecular model  protein domain  ultrastructure  Adenosine Monophosphate  Alanine  Antiviral Agents  Betacoronavirus  Catalytic Domain  Cryoelectron Microscopy  Drug Design  Models, Molecular  Protein Conformation, beta-Strand  Protein Domains  RNA Replicase  Viral Nonstructural Proteins  
Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir 期刊论文
, 2020, 卷号: 368, 期号: 6498
作者:  Yin W.;  Mao C.;  Luan X.;  Shen D.-D.;  Shen Q.;  Su H.;  Wang X.;  Zhou F.;  Zhao W.;  Gao M.;  Chang S.;  Xie Y.-C.;  Tian G.;  Jiang H.-W.;  Tao S.-C.;  Shen J.;  Jiang Y.;  Jiang H.;  Xu Y.;  Zhang S.;  Zhang Y.;  Xu H.E.
收藏  |  浏览/下载：204/0  |  提交时间：2020/07/28
adenosine phosphate  alanine  antivirus agent  enzyme inhibitor  multiprotein complex  NSP7 protein, SARS-CoV-2  NSP8 protein, SARS-CoV-2  remdesivir  RNA directed RNA polymerase  RNA-dependent RNA polymerase, coronavirus  viral protein  virus RNA  Betacoronavirus  chemistry  cryoelectron microscopy  drug effect  enzyme active site  enzymology  metabolism  molecular model  physiology  protein conformation  virus replication  Adenosine Monophosphate  Alanine  Antiviral Agents  Betacoronavirus  Catalytic Domain  Cryoelectron Microscopy  Enzyme Inhibitors  Models, Molecular  Multiprotein Complexes  Protein Conformation  RNA Replicase  RNA, Viral  Viral Nonstructural Proteins  Virus Replication  
The histone H3-H4 tetramer is a copper reductase enzyme 期刊论文
, 2020, 卷号: 369, 期号: 6499
作者:  Attar N.;  Campos O.A.;  Vogelauer M.;  Cheng C.;  Xue Y.;  Schmollinger S.;  Salwinski L.;  Mallipeddi N.V.;  Boone B.A.;  Yen L.;  Yang S.;  Zikovich S.;  Dardine J.;  Carey M.F.;  Merchant S.S.;  Kurdistani S.K.
收藏  |  浏览/下载：28/0  |  提交时间：2020/07/28
copper  copper oxidase  copper zinc superoxide dismutase  histone  MAC1 protein, S cerevisiae  nuclear protein  oxidoreductase  recombinant protein  Saccharomyces cerevisiae protein  transcription factor  animal  biocatalysis  chemistry  enzyme active site  enzymology  gain of function mutation  genetics  metabolism  mitochondrion  protein multimerization  Saccharomyces cerevisiae  Xenopus laevis  Animals  Biocatalysis  Catalytic Domain  Copper  Gain of Function Mutation  Histones  Mitochondria  Nuclear Proteins  Oxidoreductases  Protein Multimerization  Recombinant Proteins  Saccharomyces cerevisiae  Saccharomyces cerevisiae Proteins  Superoxide Dismutase-1  Transcription Factors  Xenopus laevis  
Structure of a trapped radical transfer pathway within a ribonucleotide reductase holocomplex 期刊论文
, 2020, 卷号: 368, 期号: 6489
作者:  Kang G.;  Taguchi A.T.;  Stubbe J.;  Drennan C.L.
收藏  |  浏览/下载：50/0  |  提交时间：2020/07/28
ribonucleotide reductase  DNA  enzyme  enzyme activity  radical  Article  beta sheet  binding site  catalysis  cryoelectron microscopy  enzyme active site  enzyme activity  enzyme binding  enzyme conformation  enzyme structure  enzyme subunit  nonhuman  priority journal  signal transduction  
Structural basis for strand-transfer inhibitor binding to HIV intasomes 期刊论文
, 2020, 卷号: 367, 期号: 6479
作者:  Passos D.O.;  Li M.;  Jóźwik I.K.;  Zhao X.Z.;  Santos-Martins D.;  Yang R.;  Smith S.J.;  Jeon Y.;  Forli S.;  Hughes S.H.;  Burke T.R.;  Jr.;  Craigie R.;  Lyumkis D.
收藏  |  浏览/下载：27/0  |  提交时间：2020/07/28
bictegravir  nucleoprotein  protein intasome  unclassified drug  viral protein  bictegravir  fused heterocyclic rings  integrase  integrase inhibitor  multiprotein complex  naphthyridine derivative  nucleoprotein  biochemistry  chemical binding  human immunodeficiency virus  inhibitor  protein  ultrastructure  amino terminal sequence  Article  carboxy terminal sequence  catalysis  cryoelectron microscopy  drug design  drug efficacy  drug protein binding  drug resistance  drug structure  enzyme active site  human  Human immunodeficiency virus infection  nonhuman  priority journal  protein purification  protein structure  antiviral resistance  chemistry  drug effect  genetics  Human immunodeficiency virus  virus DNA cell DNA interaction  Cryoelectron Microscopy  Drug Design  Drug Resistance, Viral  Heterocyclic Compounds, 4 or More Rings  HIV  HIV Integrase  HIV Integrase Inhibitors  Humans  Multiprotein Complexes  Naphthyridines  Nucleoproteins  Virus Integration  
Structural basis of second-generation HIV integrase inhibitor action and viral resistance 期刊论文
, 2020, 卷号: 367, 期号: 6479
作者:  Cook N.J.;  Li W.;  Berta D.;  Badaoui M.;  Ballandras-Colas A.;  Nans A.;  Kotecha A.;  Rosta E.;  Engelman A.N.;  Cherepanov P.
收藏  |  浏览/下载：38/0  |  提交时间：2020/07/28
bictegravir  dolutegravir  lens epithelium derived growth factor  magnesium ion  bictegravir  dolutegravir  fused heterocyclic rings  glutamine  glycine  histidine  integrase  integrase inhibitor  magnesium  serine  acquired immune deficiency syndrome  amino acid  drug  human immunodeficiency virus  inhibitor  protein  ultrastructure  virus  amino acid substitution  amino terminal sequence  Article  carboxy terminal sequence  cryoelectron microscopy  DNA binding  drug design  drug protein binding  drug structure  enzyme active site  gene mutation  Human immunodeficiency virus 1  in vitro study  molecular dynamics  molecular stability  nonhuman  pharmacophore  polarization  priority journal  protonation  virus resistance  antiviral resistance  chemistry  genetics  human  mutation  procedures  single molecule imaging  Amino Acid Substitution  Catalytic Domain  Cryoelectron Microscopy  Drug Resistance, Viral  Glutamine  Glycine  Heterocyclic Compounds, 3-Ring  Heterocyclic Compounds, 4 or More Rings  Histidine  HIV Integrase  HIV Integrase Inhibitors  Humans  Magnesium  Mutation  Serine  Single Molecule Imaging  
Structure of an active human histone pre-mRNA 3′-end processing machinery 期刊论文
, 2020, 卷号: 367, 期号: 6478
作者:  Sun Y.;  Zhang Y.;  Aik W.S.;  Yang X.-C.;  Marzluff W.F.;  Walz T.;  Dominski Z.;  Tong L.
收藏  |  浏览/下载：211/0  |  提交时间：2020/07/28
beta lactamase  cleavage and polyadenylation specificity factor  cleavage and polyadenylation specificity factor 100  cleavage and polyadenylation specificity factor 73  endonuclease  histone  membrane protein  messenger RNA precursor  recombinant protein  small nuclear ribonucleoprotein  small nuclear RNA  symplekin  U7 small nuclear ribonucleoprotein  unclassified drug  enzyme activity  genetic analysis  metazoan  protein  recombination  RNA  3' untranslated region  amino terminal sequence  Article  biochemical analysis  carboxy terminal sequence  conformational transition  controlled study  cryoelectron microscopy  enzyme active site  gene rearrangement  genetic analysis  hydrogen bond  molecular recognition  mutagenesis  polyadenylation  priority journal  protein conformation  protein protein interaction  RNA cleavage  RNA processing  RNA sequencing  Amphora  Metazoa