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CFLIPL protects macrophages from LPS-induced pyroptosis via inhibition of complex II formation 期刊论文
, 2020, 卷号: 367, 期号: 6484
作者:  Muendlein H.I.;  Jetton D.;  Connolly W.M.;  Eidell K.P.;  Magri Z.;  Smirnova I.;  Poltorak A.
收藏  |  浏览/下载:48/0  |  提交时间:2020/07/28
FLICE inhibitory protein  interleukin 1beta  lipopolysaccharide  messenger RNA  succinate dehydrogenase (ubiquinone)  Casp1 protein, mouse  caspase 8  Cflar protein, mouse  cryopyrin  FLICE inhibitory protein  IL1B protein, mouse  inflammasome  interleukin 1beta  interleukin 1beta converting enzyme  lipopolysaccharide  succinate dehydrogenase (ubiquinone)  cell  enzyme activity  inhibition  maturation  protein  animal cell  animal experiment  Article  bone marrow derived macrophage  cell death  cell protection  complex formation  controlled study  cytokine release  in vitro study  inflammation  mouse  nonhuman  priority journal  protein analysis  protein degradation  protein function  protein interaction  pyroptosis  animal  gene knockdown  genetics  immunology  macrophage  macrophage activation  metabolism  physiology  Murinae  Animals  CASP8 and FADD-Like Apoptosis Regulating Protein  Caspase 1  Caspase 8  Electron Transport Complex II  Gene Knockdown Techniques  Inflammasomes  Interleukin-1beta  Lipopolysaccharides  Macrophage Activation  Macrophages  Mice  NLR Family, Pyrin Domain-Containing 3 Protein  Pyroptosis  
Circadian rhythms in the absence of the clock gene Bmal1 期刊论文
, 2020, 卷号: 367, 期号: 6479
作者:  Ray S.;  Valekunja U.K.;  Stangherlin A.;  Howell S.A.;  Snijders A.P.;  Damodaran G.;  Reddy A.B.
收藏  |  浏览/下载:27/0  |  提交时间:2020/07/28
phosphoproteome  proteome  transcription factor ARNTL  transcription factor Ets  transcriptome  unclassified drug  cell component  circadian rhythm  gene  gene expression  genome  molecular analysis  animal experiment  animal tissue  Article  Bmal1 gene  circadian rhythm  controlled study  gene deletion  gene expression regulation  gene function  gene knockout  genotype  knockout mouse  light dark cycle  liver  mouse  nonhuman  oscillation  oxidation reduction potential  priority journal  RNA sequence  skin fibroblast  temperature  transcription regulation  Mammalia  Mus  
Liquid-liquid phase separation drives skin barrier formation 期刊论文
, 2020, 卷号: 367, 期号: 6483
作者:  Quiroz F.G.;  Fiore V.F.;  Levorse J.;  Polak L.;  Wong E.;  Pasolli H.A.;  Fuchs E.
收藏  |  浏览/下载:31/0  |  提交时间:2020/07/28
filaggrin  keratohyalin  coalescence  differentiation  separation  skin  skin disorder  stratification  amino acid composition  Article  bioengineering  biophysics  cell differentiation  cell function  cell structure  epidermis cell  genetic transfection  human  keratinocyte  liquid  live cell imaging  molecular dynamics  nonhuman  pH  phase separation  phase transition  priority journal  proteomics  sequence analysis  signal transduction  skin  skin surface  Mus  
Dopaminylation of histone H3 in ventral tegmental area regulates cocaine seeking 期刊论文
, 2020, 卷号: 368, 期号: 6487
作者:  Lepack A.E.;  Werner C.T.;  Stewart A.F.;  Fulton S.L.;  Zhong P.;  Farrelly L.A.;  Smith A.C.W.;  Ramakrishnan A.;  Lyu Y.;  Bastle R.M.;  Martin J.A.;  Mitra S.;  O'Connor R.M.;  Wang Z.-J.;  Molina H.;  Turecki G.;  Shen L.;  Yan Z.;  Calipari E.S.;  Dietz D.M.;  Kenny P.J.;  Maze I.
收藏  |  浏览/下载:48/0  |  提交时间:2020/07/28
amidase  dopamine  histone H3  histone transamidase  protein glutamine gamma glutamyltransferase 2  RNA  unclassified drug  brain  cell  chemical compound  chemical reaction  gene expression  genetic analysis  protein  action potential  amino acid substitution  amino terminal sequence  Article  cocaine dependence  controlled study  dopamine release  dopaminergic nerve cell  dopaminergic transmission  down regulation  drug seeking behavior  enzyme activity  gene expression  histone dopaminylation  histone modification  human  human tissue  hyperpolarization  in vitro study  motivation  nerve cell plasticity  nerve projection  neuropathology  nucleus accumbens  priority journal  protein expression  protein function  reward  RNA sequence  ventral tegmentum  Rattus  
Marching to another clock 期刊论文
, 2020, 卷号: 367, 期号: 6479
作者:  Brown S.A.;  Sato M.
收藏  |  浏览/下载:42/0  |  提交时间:2020/07/28
RNA  transcription factor ARNTL  transcription factor CLOCK  transcription factor Ets  brain  circadian rhythm  molecular analysis  physiological response  protein  animal cell  animal tissue  Article  binding site  cell metabolism  circadian rhythm  controlled study  feedback system  genetic transcription  molecular dynamics  mouse  nonhuman  oxidation reduction reaction  priority journal  protein analysis  protein binding  protein expression  protein function  RNA analysis  RNA transcription  RNA translation  suprachiasmatic nucleus  music  walking  Circadian Rhythm  Music  Walking  
VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance 期刊论文
, 2020, 卷号: 367, 期号: 6475
作者:  ElTanbouly M.A.;  Zhao Y.;  Nowak E.;  Li J.;  Schaafsma E.;  Le Mercier I.;  Ceeraz S.;  Lines J.L.;  Peng C.;  Carriere C.;  Huang X.;  Day M.;  Koehn B.;  Lee S.W.;  Morales M.S.;  Hogquist K.A.;  Jameson S.C.;  Mueller D.;  Rothstein J.;  Blazar B.R.;  Cheng C.;  Noelle R.J.
收藏  |  浏览/下载:56/0  |  提交时间:2020/07/28
cell protein  interferon  kruppel like factor 2  T lymphocyte receptor  unclassified drug  V type immunoglobulin domain containing suppressor of T cell activation protein  B7 antigen  Dies1 protein, mouse  lymphocyte antigen receptor  membrane protein  monoclonal antibody  VSIR protein, human  biological development  cell  gene expression  heterogeneity  homeostasis  immune response  immunity  tolerance  acute graft versus host disease  animal cell  animal experiment  animal model  Article  CD4+ T lymphocyte  cell death  cell expansion  cell fate  cell heterogeneity  cell loss  cell survival  controlled study  female  gene  gene deletion  homeostasis  immunological tolerance  in vivo study  long term survival  male  mouse  nonhuman  phenotype  priority journal  protein expression  protein function  rheumatoid arthritis  RNA sequencing  systemic lupus erythematosus  T lymphocyte  T lymphocyte activation  T lymphocyte subpopulation  TCR gene  upregulation  VISTA gene  animal  C57BL mouse  genetics  immunological tolerance  immunology  knockout mouse  lymphocyte activation  physiology  T lymphocyte  Mus  Animals  Antibodies, Monoclonal  B7 Antigens  Lymphocyte Activation  Membrane Proteins  Mice  Mice, Inbred C57BL  Mice, Knockout  Peripheral Tolerance  Receptors, Antigen, T-Cell  T-Lymphocytes  
Peptide signaling for drought-induced tomato flower drop 期刊论文
, 2020, 卷号: 367, 期号: 6485
作者:  Reichardt S.;  Piepho H.-P.;  Stintzi A.;  Schaller A.
收藏  |  浏览/下载:31/0  |  提交时间:2020/07/28
mitogen activated protein kinase  peptide hormone  phytaspase 2  phytosulfokine  unclassified drug  abscission  aspartic acid  crop yield  drought stress  enzyme activity  flower  fruit  gene expression  hormone  peptide  abscission  Arabidopsis  Article  bioassay  cell separation  controlled study  cytokine production  down regulation  drought  environmental stress  enzyme activity  enzyme specificity  ERF4 gene  ERT10 gene  flower  hydrolysis  hydrophobicity  IAA3 gene  immunomodulation  molecular dynamics  nonhuman  peptide signaling  PK7 gene  plant development  plant genome  priority journal  productivity  protein cleavage  protein degradation  protein expression  protein function  protein processing  regulator gene  signal transduction  tomato  TPRP gene  Lycopersicon esculentum  
Structure of nucleosome-bound human BAF complex 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者:  He S.;  Wu Z.;  Tian Y.;  Yu Z.;  Yu J.;  Wang X.;  Li J.;  Liu B.;  Xu Y.
收藏  |  浏览/下载:37/0  |  提交时间:2020/07/28
actin related protein  adenosine triphosphatase  BRG1 BRM associated factor  DNA  multiprotein complex  protein SWI  retinoblastoma binding protein 2  SMARCC protein  SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily B member 1  transcription factor  transcription factor SNF  unclassified drug  cancer  enzyme activity  gene expression  hydrolysis  mutation  protein  alpha helix  Article  carboxy terminal sequence  cell interaction  cryoelectron microscopy  disease association  human  malignant neoplasm  molecular recognition  mutation  nucleosome  priority journal  protein function  protein hydrolysis  protein structure  structure analysis  Mammalia  
Massively multiplex chemical transcriptomics at single-cell resolution 期刊论文
, 2020, 卷号: 367, 期号: 6473
作者:  Srivatsan S.R.;  McFaline-Figueroa J.L.;  Ramani V.;  Saunders L.;  Cao J.;  Packer J.;  Pliner H.A.;  Jackson D.L.;  Daza R.M.;  Christiansen L.;  Zhang F.;  Steemers F.;  Shendure J.;  Trapnell C.
收藏  |  浏览/下载:19/0  |  提交时间:2020/07/28
4 (2 aminoethylamino) 1,8 dimethylimidazo[1,2 a]quinoxaline  abexinostat  acetic acid  belinostat  cudc 101  fimepinostat  givinostat  histone deacetylase inhibitor  m 344  n [2 [3 (1 piperazinylmethyl)imidazo[2,1 b]thiazol 6 yl]phenyl] 2 quinoxalinecarboxamide  panobinostat  pracinostat  rec 2282  trametinib  transcriptome  trichostatin A  unclassified drug  transcriptome  cancer  cell  chemical analysis  detection method  experimental study  genetic analysis  resolution  A-549 cell line  animal cell  animal experiment  Article  cell function  cell heterogeneity  cell labeling  cell proliferation  chromatin  controlled study  dose response  drug activity  experimentation  gene control  genetic transcription  human  human cell  K-562 cell line  MCF-7 cell line  mouse  nonhuman  pilot study  priority journal  proof of concept  RNA sequence  screening  single cell analysis  transcriptomics  cell nucleus  drug effect  genetics  genomics  high throughput screening  metabolism  neoplasm  procedures  single cell analysis  A549 Cells  Acetates  Cell Nucleus  Chromatin  Genomics  High-Throughput Screening Assays  Histone Deacetylase Inhibitors  Humans  K562 Cells  MCF-7 Cells  Neoplasms  RNA-Seq  Single-Cell Analysis  Transcriptome  
A Kelch13-defined endocytosis pathway mediates artemisinin resistance in malaria parasites 期刊论文
, 2020, 卷号: 367, 期号: 6473
作者:  Birnbaum J.;  Scharf S.;  Schmidt S.;  Jonscher E.;  Maria Hoeijmakers W.A.;  Flemming S.;  Toenhake C.G.;  Schmitt M.;  Sabitzki R.;  Bergmann B.;  Fröhlke U.;  Mesén-Ramírez P.;  Soares A.B.;  Herrmann H.;  Bártfai R.;  Spielmann T.
收藏  |  浏览/下载:38/0  |  提交时间:2020/07/28
artemisinin  artemisinin derivative  cytosol receptor  hemoglobin  protein Kelch13  protozoal protein  unclassified drug  antimalarial agent  cell  drug resistance  hemoglobin  malaria  mutation  physiology  protein  antimalarial drug resistance  Article  controlled study  endocytosis  gene inactivation  gene mutation  host cell  Kelch13 gene  nonhuman  Plasmodium  priority journal  protein analysis  protein function