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| Elesclomol alleviates Menkes pathology and mortality by escorting Cu to cuproenzymes in mice 期刊论文
, 2020, 卷号: 368, 期号: 6491
作者: Guthrie L.M.; Soma S.; Yuan S.; Silva A.; Zulkifli M.; Snavely T.C.; Greene H.F.; Nunez E.; Lynch B.; de Ville C.; Shanbhag V.; Lopez F.R.; Acharya A.; Petris M.J.; Kim B.-E.; Gohil V.M.; Sacchettini J.C.
  收藏 | 浏览/下载：36/0 | 提交时间：2020/07/28
copper copper zinc superoxide dismutase cytochrome c oxidase dopamine beta monooxygenase elesclomol monophenol monooxygenase protein lysine 6 oxidase copper cytochrome c oxidase elesclomol hydrazine derivative copper cytochrome enzyme enzyme activity mitochondrion mortality mutation pathology rodent survival animal cell animal experiment animal model animal tissue Article cohort analysis controlled study disease severity drug mechanism Golgi complex H9c2(2-1) cell line in vivo study male Menkes syndrome mitochondrial dynamics mortality rate mouse nerve degeneration nonhuman priority journal secretory pathway survival rate animal brain cell line degenerative disease disease model drug effect genetics knockout mouse Menkes syndrome metabolism mitochondrion pathology rat transport at the cellular level Murinae Mus Animals Biological Transport Brain Cell Line Copper Copper Transporter 1 Disease Models, Animal Electron Transport Complex IV Hydrazines Male Menkes Kinky Hair Syndrome Mice Mice, Knockout Mitochondria Neurodegenerative Diseases Rats |
| A neurodevelopmental origin of behavioral individuality in the Drosophila visual system 期刊论文
, 2020, 卷号: 367, 期号: 6482
作者: Linneweber G.A.; Andriatsilavo M.; Dutta S.B.; Bengochea M.; Hellbruegge L.; Liu G.; Ejsmont R.K.; Straw A.D.; Wernet M.; Hiesinger P.R.; Hassan B.A.
收藏 | 浏览/下载：37/0 | 提交时间：2020/07/28
anatomy asymmetry brain genome neurology orientation visual analysis article brain Drosophila melanogaster human experiment individuality nerve cell nonhuman stochastic model visual system walking anatomy and histology animal Drosophila melanogaster genetic variation genetics growth, development and aging nervous system development orientation physiology visual field visual system Drosophila melanogaster Animals Brain Drosophila melanogaster Genetic Variation Individuality Neurogenesis Orientation Visual Fields Visual Pathways |
| Microglia monitor and protect neuronal function through specialized somatic purinergic junctions 期刊论文
, 2020, 卷号: 367, 期号: 6477
作者: Cserép C.; Pósfai B.; Lénárt N.; Fekete R.; László Z.I.; Lele Z.; Orsolits B.; Molnár G.; Heindl S.; Schwarcz A.D.; Ujvári K.; Környei Z.; Tóth K.; Szabadits E.; Sperlágh B.; Baranyi M.; Csiba L.; Hortobágyi T.; Maglóczky Z.; Martinecz B.; Szabó G.; Erdélyi F.; Szipocs R.; Tamkun M.M.; Gesierich B.; Duering M.; Katona I.; Liesz A.; Tamás G.; Dénes Á.
收藏 | 浏览/下载：40/0 | 提交时间：2020/07/28
calcium purinergic P2Y12 receptor brain cell component homeostasis inhibition protein animal cell Article brain injury controlled study functional connectivity human human cell microglia mitochondrion mouse nerve cell neuroprotection nonhuman perikaryon priority journal signal transduction somatic microglia neuron junction |
| Meet the psychobiome 期刊论文
, 2020, 卷号: 368, 期号: 6491
作者: Pennisi E.
收藏 | 浏览/下载：29/0 | 提交时间：2020/07/28
4 aminobutyric acid antibiotic agent dopamine kynurenine probiotic agent queuine serotonin psychotropic agent bacterium biome drug microbial activity nervous system disorder allergy Alzheimer disease antimicrobial therapy anxiety disorder archaeon Article autism bacterium culture Bacteroides blood brain barrier blood vessel brain disease clinical effectiveness constipation depression drug use enteroendocrine cell enteropathy entrepreneurship epilepsy fecal microbiota transplantation feces analysis Food and Drug Administration fungus genomics human insomnia intestine flora irritable colon mammal cell microbiology microbiome nerve cell nervous system nervous system development neurologic disease nonhuman obesity pain threshold Parkinson disease physician priority journal psychobiome psychological aspect psychological well-being schizophrenia scientist United States vagus nerve virus animal bacterium chemistry drug development intestine flora isolation and purification metabolism microbiology physiology procedures Animals Bacteria Drug Discovery Gastrointestinal Microbiome Humans Nervous System Diseases Psychotropic Drugs |
| Dopaminylation of histone H3 in ventral tegmental area regulates cocaine seeking 期刊论文
, 2020, 卷号: 368, 期号: 6487
作者: Lepack A.E.; Werner C.T.; Stewart A.F.; Fulton S.L.; Zhong P.; Farrelly L.A.; Smith A.C.W.; Ramakrishnan A.; Lyu Y.; Bastle R.M.; Martin J.A.; Mitra S.; O'Connor R.M.; Wang Z.-J.; Molina H.; Turecki G.; Shen L.; Yan Z.; Calipari E.S.; Dietz D.M.; Kenny P.J.; Maze I.
收藏 | 浏览/下载：48/0 | 提交时间：2020/07/28
amidase dopamine histone H3 histone transamidase protein glutamine gamma glutamyltransferase 2 RNA unclassified drug brain cell chemical compound chemical reaction gene expression genetic analysis protein action potential amino acid substitution amino terminal sequence Article cocaine dependence controlled study dopamine release dopaminergic nerve cell dopaminergic transmission down regulation drug seeking behavior enzyme activity gene expression histone dopaminylation histone modification human human tissue hyperpolarization in vitro study motivation nerve cell plasticity nerve projection neuropathology nucleus accumbens priority journal protein expression protein function reward RNA sequence ventral tegmentum Rattus |
| A central master driver of psychosocial stress responses in the rat 期刊论文
, 2020, 卷号: 367, 期号: 6482
作者: Kataoka N.; Shima Y.; Nakajima K.; Nakamura K.
收藏 | 浏览/下载：49/0 | 提交时间：2020/07/28
vesicular glutamate transporter 1 glutamic acid Slc17a7 protein, rat vesicular glutamate transporter 1 brain homeostasis physiological response psychology rodent Article behavioral stress brain region emotion forebrain homeostasis human hypothalamus in vivo study innervation mental stress nerve cell nerve tract nonhuman optogenetics priority journal social defeat social stress tenia tecta thermogenesis animal dorsomedial hypothalamic nucleus female Long Evans cinnamon rat male mental stress metabolism physiology prefrontal cortex psychosomatic disorder rat signal transduction social behavior Wistar rat Rattus Animals Dorsomedial Hypothalamic Nucleus Emotions Female Glutamic Acid Homeostasis Male Neurons Prefrontal Cortex Prosencephalon Psychophysiologic Disorders Rats Rats, Inbred LEC Rats, Wistar Signal Transduction Social Behavior Stress, Psychological Vesicular Glutamate Transport Protein 1 |
| A noncanonical inhibitory circuit dampens behavioral sensitivity to light 期刊论文
, 2020, 卷号: 368, 期号: 6490
作者: Sonoda T.; Li J.Y.; Hayes N.W.; Chan J.C.; Okabe Y.; Belin S.; Nawabi H.; Schmidt T.M.
收藏 | 浏览/下载：32/0 | 提交时间：2020/07/28
4 aminobutyric acid cre recombinase glutamic acid melanopsin neurotransmitter 4 aminobutyric acid 4 aminobutyric acid receptor glutamate decarboxylase glutamate decarboxylase 2 melanopsin scotopsin brain hormone inhibition light effect nanotechnology sensitivity analysis Adeno associated virus animal cell Article axon brain region GABAergic system immunohistochemistry lateral geniculate body light mouse nonhuman postsynaptic potential priority journal pupil reflex retina ganglion cell superior colliculus suprachiasmatic nucleus vision wild type animal drug effect female light male metabolism mutant mouse strain nerve tract physiology radiation response retina ganglion cell vision Mus Animals Female GABAergic Neurons gamma-Aminobutyric Acid Glutamate Decarboxylase Light Male Mice Mice, Mutant Strains Neural Pathways Reflex, Pupillary Retinal Ganglion Cells Rod Opsins Unconscious, Psychology Visual Perception |
| Maintenance of neural stem cell positional identity by mixed-lineage leukemia 1 期刊论文
, 2020, 卷号: 368, 期号: 6486
作者: Delgado R.N.; Mansky B.; Ahanger S.H.; Lu C.; Andersen R.E.; Dou Y.; Alvarez-Buylla A.; Lim D.A.
收藏 | 浏览/下载：29/0 | 提交时间：2020/07/28
mixed lineage leukemia 1 protein mixed lineage leukemia protein morphogen sonic hedgehog protein unclassified drug anatomy brain cell component developmental biology inhibition adult animal cell animal experiment animal tissue Article controlled study embryo epigenetics forebrain in vivo study memory Mll1 gene mouse nerve cell nerve cell differentiation neural stem cell nonhuman priority journal Erinaceidae Murinae |
| A common hub for sleep and motor control in the substantia nigra 期刊论文
, 2020, 卷号: 367, 期号: 6476
作者: Liu D.; Li W.; Ma C.; Zheng W.; Yao Y.; Tso C.F.; Zhong P.; Chen X.; Song J.H.; Choi W.; Paik S.-B.; Han H.; Dan Y.
收藏 | 浏览/下载：46/0 | 提交时间：2020/07/28
4 aminobutyric acid glutamate decarboxylase glutamate decarboxylase 2 parvalbumin unclassified drug brain chemical compound enzyme enzyme activity locomotion sleep animal experiment animal tissue arousal Article controlled study GABAergic system home-cage activity test locomotion motor control mouse nerve cell nerve projection nonhuman priority journal sleep substantia nigra pars reticulata wakefulness Animalia |
| Dendritic action potentials and computation in human layer 2/3 cortical neurons 期刊论文
, 2020, 卷号: 367, 期号: 6473
作者: Gidon A.; Zolnik T.A.; Fidzinski P.; Bolduan F.; Papoutsi A.; Poirazi P.; Holtkamp M.; Vida I.; Larkum M.E.
收藏 | 浏览/下载：31/0 | 提交时间：2020/07/28
n methyl dextro aspartic acid sodium ion brain electrical property nervous system neurology rodent Article brain cortex brain tumor calculation cell function compartment model controlled study dendrite epileptic patient ex vivo study human human cell neocortex nerve cell network nerve potential patch clamp technique priority journal pyramidal nerve cell spike temporal lobe Rodentia |
