气候变化领域集成服务门户(CCPortal): Dendritic action potentials and computation in human layer 2/3 cortical neurons

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DOI	10.1126/science.aax6239
	Dendritic action potentials and computation in human layer 2/3 cortical neurons
	Gidon A.; Zolnik T.A.; Fidzinski P.; Bolduan F.; Papoutsi A.; Poirazi P.; Holtkamp M.; Vida I.; Larkum M.E.
发表日期	2020
ISSN	0036-8075
起始页码	83
结束页码	87
卷号	367 期号:6473
英文摘要	The active electrical properties of dendrites shape neuronal input and output and are fundamental to brain function. However, our knowledge of active dendrites has been almost entirely acquired from studies of rodents. In this work, we investigated the dendrites of layer 2 and 3 (L2/3) pyramidal neurons of the human cerebral cortex ex vivo. In these neurons, we discovered a class of calcium-mediated dendritic action potentials (dCaAPs) whose waveform and effects on neuronal output have not been previously described. In contrast to typical all-or-none action potentials, dCaAPs were graded; their amplitudes were maximal for threshold-level stimuli but dampened for stronger stimuli. These dCaAPs enabled the dendrites of individual human neocortical pyramidal neurons to classify linearly nonseparable inputs-a computation conventionally thought to require multilayered networks. © 2020 American Association for the Advancement of Science. All rights reserved.
关键词	n methyl dextro aspartic acid sodium ion brain electrical property nervous system neurology rodent Article brain cortex brain tumor calculation cell function compartment model controlled study dendrite epileptic patient ex vivo study human human cell neocortex nerve cell network nerve potential patch clamp technique priority journal pyramidal nerve cell spike temporal lobe Rodentia
语种	英语
来源机构	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133813
推荐引用方式 GB/T 7714	Gidon A.,Zolnik T.A.,Fidzinski P.,et al. Dendritic action potentials and computation in human layer 2/3 cortical neurons[J]. Science,2020,367(6473).
APA	Gidon A..,Zolnik T.A..,Fidzinski P..,Bolduan F..,Papoutsi A..,...&Larkum M.E..(2020).Dendritic action potentials and computation in human layer 2/3 cortical neurons.,367(6473).
MLA	Gidon A.,et al."Dendritic action potentials and computation in human layer 2/3 cortical neurons".367.6473(2020).