气候变化领域集成服务门户(CCPortal): A common hub for sleep and motor control in the substantia nigra

CCPortal

DOI	10.1126/science.aaz0956
	A common hub for sleep and motor control in the substantia nigra
	Liu D.; Li W.; Ma C.; Zheng W.; Yao Y.; Tso C.F.; Zhong P.; Chen X.; Song J.H.; Choi W.; Paik S.-B.; Han H.; Dan Y.
发表日期	2020
ISSN	0036-8075
起始页码	440
结束页码	445
卷号	367 期号:6476
英文摘要	The arousal state of the brain covaries with the motor state of the animal. How these state changes are coordinated remains unclear. We discovered that sleep–wake brain states and motor behaviors are coregulated by shared neurons in the substantia nigra pars reticulata (SNr). Analysis of mouse home-cage behavior identified four states with different levels of brain arousal and motor activity: locomotion, nonlocomotor movement, quiet wakefulness, and sleep; transitions occurred not randomly but primarily between neighboring states. The glutamic acid decarboxylase 2 but not the parvalbumin subset of SNr g-aminobutyric acid (GABA)–releasing (GABAergic) neurons was preferentially active in states of low motor activity and arousal. Their activation or inactivation biased the direction of natural behavioral transitions and promoted or suppressed sleep, respectively. These GABAergic neurons integrate wide-ranging inputs and innervate multiple arousal-promoting and motor-control circuits through extensive collateral projections. Copyright © 2020 The Authors,
关键词	4 aminobutyric acid glutamate decarboxylase glutamate decarboxylase 2 parvalbumin unclassified drug brain chemical compound enzyme enzyme activity locomotion sleep animal experiment animal tissue arousal Article controlled study GABAergic system home-cage activity test locomotion motor control mouse nerve cell nerve projection nonhuman priority journal sleep substantia nigra pars reticulata wakefulness Animalia
语种	英语
来源机构	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133764
推荐引用方式 GB/T 7714	Liu D.,Li W.,Ma C.,et al. A common hub for sleep and motor control in the substantia nigra[J]. Science,2020,367(6476).
APA	Liu D..,Li W..,Ma C..,Zheng W..,Yao Y..,...&Dan Y..(2020).A common hub for sleep and motor control in the substantia nigra.,367(6476).
MLA	Liu D.,et al."A common hub for sleep and motor control in the substantia nigra".367.6476(2020).