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Transcriptome Analysis Reveals Genes Involved in Thermogenesis in Two Cold-Exposed Sheep Breeds 期刊论文
GENES, 2021, 卷号: 12, 期号: 3
作者:  Jiao, Dan;  Ji, Kaixi;  Liu, Hu;  Wang, Wenqiang;  Wu, Xiukun;  Zhou, Jianwei;  Zhang, Yunsheng;  Zhou, Huitong;  Hickford, Jon G. H.;  Degen, Allan A.;  Yang, Guo
收藏  |  浏览/下载:40/0  |  提交时间:2022/04/28
BROWN-ADIPOSE-TISSUE  DIET-INDUCED OBESITY  ACTIVATED PROTEIN-KINASE  SARCOPLASMIC-RETICULUM  ENERGY-EXPENDITURE  LIPOPROTEIN-LIPASE  INSULIN-RESISTANCE  FATTY-ACIDS  MITOCHONDRIA  TEMPERATURE  
Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations 期刊论文
, 2020, 卷号: 367, 期号: 6478
作者:  Wilmes S.;  Hafer M.;  Vuorio J.;  Tucker J.A.;  Winkelmann H.;  Löchte S.;  Stanly T.A.;  Pulgar Prieto K.D.;  Poojari C.;  Sharma V.;  Richter C.P.;  Kurre R.;  Hubbard S.R.;  Christopher Garcia K.;  Moraga I.;  Vattulainen I.;  Hitchcock I.S.;  Piehler J.
收藏  |  浏览/下载:48/0  |  提交时间:2020/07/28
cytokine receptor  homodimer  Janus kinase 2  ligand  oncoprotein  cancer  enzyme  enzyme activity  membrane  molecular analysis  mutation  protein  activation analysis  Article  cell membrane  computer model  controlled study  dimerization  fluorescence microscopy  gene mutation  HeLa cell line  molecular dynamics  mutant  oncogene  priority journal  protein domain  protein interaction  quantitative analysis  signal transduction  
Temporal integration of mitogen history in mother cells controls proliferation of daughter cells 期刊论文
, 2020, 卷号: 368, 期号: 6496
作者:  Min M.;  Rong Y.;  Tian C.;  Spencer S.L.
收藏  |  浏览/下载:29/0  |  提交时间:2020/07/28
cyclin D  mitogen activated protein kinase kinase  mitogenic agent  cell cycle G1 phase  cell cycle G2 phase  cell proliferation  genetics  human  metabolism  physiology  protein synthesis  signal transduction  stem cell  Cell Proliferation  Cyclin D  G1 Phase  G2 Phase  Humans  Mitogen-Activated Protein Kinase Kinases  Mitogens  Protein Biosynthesis  Signal Transduction  Stem Cells  
Natural hybridization reveals incompatible alleles that cause melanoma in swordtail fish 期刊论文
, 2020, 卷号: 368, 期号: 6492
作者:  Powell D.L.;  García-Olazábal M.;  Keegan M.;  Reilly P.;  Du K.;  Díaz-Loyo A.P.;  Banerjee S.;  Blakkan D.;  Reich D.;  Andolfatto P.;  Rosenthal G.G.;  Schartl M.;  Schumer M.
收藏  |  浏览/下载:36/0  |  提交时间:2020/07/28
allele  cyprinid  hybrid  hybridization  new species  reproductive status  skin disorder  survival  Vertebrata  fish protein  protein tyrosine kinase  Xmrk protein, Xiphophorus  allele  animal  chimera  Cyprinodontiformes  fin (organ)  fish disease  gene locus  genetics  genome-wide association study  hybridization  melanoma  pathology  virology  Alleles  Animal Fins  Animals  Chimera  Cyprinodontiformes  Fish Diseases  Fish Proteins  Genetic Loci  Genome-Wide Association Study  Hybridization, Genetic  Melanoma  Receptor Protein-Tyrosine Kinases  
Golgi-derived PI(4)P-containing vesicles drive late steps of mitochondrial division 期刊论文
, 2020, 卷号: 367, 期号: 6484
作者:  Nagashima S.;  Tábara L.-C.;  Tilokani L.;  Paupe V.;  Anand H.;  Pogson J.H.;  Zunino R.;  McBride H.M.;  Prudent J.
收藏  |  浏览/下载:36/0  |  提交时间:2020/07/28
adenosine diphosphate ribosylation factor 1  dynamin related protein 1  mitochondrial protein  phosphatidylinositol 4 kinase IIIbeta  phosphatidylinositol 4 phosphate  phosphatidylinositol kinase  unclassified drug  adenosine diphosphate ribosylation factor 1  ARF1 protein, human  DNM1L protein, human  dynamin  phosphatidylinositol 4-phosphate  phosphatidylinositol kinase  polyphosphoinositide  cell component  cell organelle  chemical compound  enzyme  enzyme activity  mitochondrion  protein  Article  controlled study  COS-7 cell line  endoplasmic reticulum  fibroblast  gene silencing  HeLa cell line  human  human cell  membrane microdomain  mitochondrial division  mitochondrial dynamics  mitochondrial scission  priority journal  protein localization  trans Golgi network  U2OS cell line  animal  cell line  Chlorocebus aethiops  CV-1 cell line  genetics  metabolism  mitochondrial membrane  mitochondrion  RNA interference  trans Golgi network  ultrastructure  Mammalia  1-Phosphatidylinositol 4-Kinase  ADP-Ribosylation Factor 1  Animals  Cell Line  Chlorocebus aethiops  COS Cells  Dynamins  Endoplasmic Reticulum  HeLa Cells  Humans  Membrane Microdomains  Mitochondria  Mitochondrial Dynamics  Mitochondrial Membranes  Phosphatidylinositol Phosphates  RNA Interference  trans-Golgi Network  
Peptide signaling for drought-induced tomato flower drop 期刊论文
, 2020, 卷号: 367, 期号: 6485
作者:  Reichardt S.;  Piepho H.-P.;  Stintzi A.;  Schaller A.
收藏  |  浏览/下载:35/0  |  提交时间:2020/07/28
mitogen activated protein kinase  peptide hormone  phytaspase 2  phytosulfokine  unclassified drug  abscission  aspartic acid  crop yield  drought stress  enzyme activity  flower  fruit  gene expression  hormone  peptide  abscission  Arabidopsis  Article  bioassay  cell separation  controlled study  cytokine production  down regulation  drought  environmental stress  enzyme activity  enzyme specificity  ERF4 gene  ERT10 gene  flower  hydrolysis  hydrophobicity  IAA3 gene  immunomodulation  molecular dynamics  nonhuman  peptide signaling  PK7 gene  plant development  plant genome  priority journal  productivity  protein cleavage  protein degradation  protein expression  protein function  protein processing  regulator gene  signal transduction  tomato  TPRP gene  Lycopersicon esculentum  
Ancient origins of allosteric activation in a Ser-Thr kinase 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者:  Hadzipasic A.;  Wilson C.;  Nguyen V.;  Kern N.;  Kim C.;  Pitsawong W.;  Villali J.;  Zheng Y.;  Kern D.
收藏  |  浏览/下载:49/0  |  提交时间:2020/07/28
aurora A kinase  microtubule associated protein  TPX2 protein  unclassified drug  activation energy  ancestry  cell  chemical binding  experimental study  fitness  protein  allosterism  amino acid sequence  Article  binding affinity  binding site  enzyme activation  enzyme activity  enzyme binding  enzyme localization  enzyme phosphorylation  gene duplication  horizontal gene transfer  human  hydrophobicity  intracellular signaling  phylogenetic tree  phylogeny  priority journal  protein binding  protein localization  protein protein interaction  
An AMPK–caspase-6 axis controls liver damage in nonalcoholic steatohepatitis 期刊论文
, 2020, 卷号: 367, 期号: 6478
作者:  Zhao P.;  Sun X.;  Chaggan C.;  Liao Z.;  Wong K.I.;  He F.;  Singh S.;  Loomba R.;  Karin M.;  Witztum J.L.;  Saltiel A.R.
收藏  |  浏览/下载:56/0  |  提交时间:2020/07/28
6,7 dihydro 4 hydroxy 3 (2' hydroxy 1,1' biphenyl 4 yl) 6 oxothieno[2,3 b]pyridine 5 carbonitrile  adenosine phosphate  caspase 3  caspase 6  caspase 7  cytochrome c  hydroxymethylglutaryl coenzyme A reductase kinase  matrix metalloproteinase  apoptosis  cytochrome  enzyme  enzyme activity  inhibition  protein  rodent  AMPK signaling  animal experiment  animal model  animal tissue  apoptosis  Article  C57BL 6 mouse  cell death  controlled study  drug mechanism  enzyme activation  enzyme activity  enzyme inhibition  enzyme phosphorylation  enzyme repression  gene knockout  human  human cell  human tissue  liver cell  liver fibrosis  liver injury  male  mouse  nonalcoholic steatohepatitis  nonhuman  priority journal  protein cleavage  protein secretion  
Meissner corpuscles and their spatially intermingled afferents underlie gentle touch perception 期刊论文
, 2020, 卷号: 368, 期号: 6497
作者:  Neubarth N.L.;  Emanuel A.J.;  Liu Y.;  Springel M.W.;  Handler A.;  Zhang Q.;  Lehnert B.P.;  Guo C.;  Orefice L.L.;  Abdelaziz A.;  DeLisle M.M.;  Iskols M.;  Rhyins J.;  Kim S.J.;  Cattel S.J.;  Regehr W.;  Harvey C.D.;  Drugowitsch J.;  Ginty D.D.
收藏  |  浏览/下载:44/0  |  提交时间:2020/07/28
chemical cue  mechanoreception  perception  reaction kinetics  skin  visual cue  Mammalia  Mus  Bdnf protein, mouse  brain derived neurotrophic factor  membrane protein  Ntrk2 protein, mouse  protein tyrosine kinase  animal  C57BL mouse  electron microscopy  epidermis  female  genetics  innervation  knockout mouse  male  Merkel cell  metabolism  mouse  physiology  signal transduction  touch  ultrastructure  Animals  Brain-Derived Neurotrophic Factor  Epidermis  Female  Male  Membrane Glycoproteins  Merkel Cells  Mice  Mice, Inbred C57BL  Mice, Knockout  Microscopy, Electron  Protein-Tyrosine Kinases  Signal Transduction  Touch  Touch Perception  
Glucose-dependent control of leucine metabolism by leucyl-tRNA synthetase 1 期刊论文
, 2020, 卷号: 367, 期号: 6474
作者:  Yoon I.;  Nam M.;  Kim H.K.;  Moon H.-S.;  Kim S.;  Jang J.;  Song J.A.;  Jeong S.J.;  Kim S.B.;  Cho S.;  Kim Y.;  Lee J.;  Yang W.S.;  Yoo H.C.;  Kim K.;  Kim M.-S.;  Yang A.;  Cho K.;  Park H.-S.;  Hwang G.-S.;  Hwang K.Y.;  Han J.M.;  Kim J.H.;  Kim S.
收藏  |  浏览/下载:37/0  |  提交时间:2020/07/28
glucose  leucine  leucine transfer RNA ligase  leucyl tRNA synthetase 1  mammalian target of rapamycin complex 1  S6 kinase  serine threonine protein kinase ULK1  unclassified drug  glucose  leucine  leucine transfer RNA ligase  mammalian target of rapamycin complex 1  monomeric guanine nucleotide binding protein  serine threonine protein kinase ULK1  catabolism  cell  enzyme  enzyme activity  glucose  metabolism  protein  survival  amino acid metabolism  animal cell  Article  binding affinity  cell survival  circular dichroism  controlled study  embryo  energy yield  enzyme activity  enzyme phosphorylation  enzyme regulation  fluorescence resonance energy transfer  human  human cell  mouse  nonhuman  priority journal  protein binding  protein domain  protein motif  protein processing  protein synthesis  signal transduction  starvation  animal  energy metabolism  fibroblast  genetics  HEK293 cell line  HeLa cell line  lysosome  metabolism  phosphorylation  Animals  Autophagy-Related Protein-1 Homolog  Energy Metabolism  Fibroblasts  Glucose  HEK293 Cells  HeLa Cells  Humans  Leucine  Leucine-tRNA Ligase  Lysosomes  Mechanistic Target of Rapamycin Complex 1  Mice  Monomeric GTP-Binding Proteins  Phosphorylation  Signal Transduction