气候变化领域集成服务门户(CCPortal): Transcriptome Analysis Reveals Genes Involved in Thermogenesis in Two Cold-Exposed Sheep Breeds

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DOI	10.3390/genes12030375
	Transcriptome Analysis Reveals Genes Involved in Thermogenesis in Two Cold-Exposed Sheep Breeds
	Jiao, Dan; Ji, Kaixi; Liu, Hu; Wang, Wenqiang; Wu, Xiukun; Zhou, Jianwei; Zhang, Yunsheng; Zhou, Huitong; Hickford, Jon G. H.; Degen, Allan A.; Yang, Guo
通讯作者	Yang, G (通讯作者)，Chinese Acad Sci, Northwest Inst Ecol Environm & Resources, Lanzhou 730070, Peoples R China.
发表日期	2021
EISSN	2073-4425
卷号	12 期号:3
英文摘要	Thermogenesis plays an important role in the survival of sheep exposed to low temperatures; however, little is known about the genetic mechanisms underlying cold adaptation in sheep. We examined 6 Altay (A) and 6 Hu (H) six-month-old ewe lambs. Altay sheep are raised in northern China and are adapted to dry, cold climates, while Hu sheep are raised in southern China and are adapted to warm, humid climates. Each breed was divided into two groups: chronic cold sheep, exposed to -5 degrees C for 25 days (3 A(C); 3 H(C)), and thermo-neutral sheep, maintained at 20 degrees C (3 A(w); 3 H-w). The transcriptome profiles of hypothalamus, tail-fat and perirenal fat tissues from these four groups were determined using paired-end sequencing for RNA expression analysis. There are differences in cold tolerance between Hu and Altay sheep. Under cold exposure of the lambs: (1) UCP1-dependent thermogenesis and calcium- and cAMP-signaling pathways were activated; and (2) different fat tissues were activated in Hu and Altay lambs. Several candidate genes involved in thermogenesis including UCP1, ADRB3, ADORA2A, ATP2A1, RYR1 and IP6K1 were identified. Molecular mechanisms of thermogenesis in the sheep are discussed and new avenues for research are suggested.
关键词	BROWN-ADIPOSE-TISSUE DIET-INDUCED OBESITY ACTIVATED PROTEIN-KINASE SARCOPLASMIC-RETICULUM ENERGY-EXPENDITURE LIPOPROTEIN-LIPASE INSULIN-RESISTANCE FATTY-ACIDS MITOCHONDRIA TEMPERATURE
英文关键词	sheep; cold exposure; transcriptome; adipose tissue
语种	英语
WOS研究方向	Genetics & Heredity
WOS类目	Genetics & Heredity
WOS记录号	WOS:000633642000001
来源期刊	GENES
来源机构	中国科学院西北生态环境资源研究院
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/253838
作者单位	[Jiao, Dan; Ji, Kaixi; Yang, Guo] Chinese Acad Sci, Northwest Inst Ecol Environm & Resources, Lanzhou 730070, Peoples R China; [Jiao, Dan; Ji, Kaixi] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Liu, Hu; Wang, Wenqiang; Zhou, Jianwei] Lanzhou Univ, Sch Life Sci, Lanzhou 730070, Peoples R China; [Wu, Xiukun] Chinese Acad Sci, Key Lab Desert & Desertificat, Northwest Inst Ecoenvironm & Resources, Lanzhou 730000, Peoples R China; [Wu, Xiukun] Key Lab Extreme Environm Microbial Resources & En, Lanzhou 730000, Peoples R China; [Zhang, Yunsheng] Xinjiang Acad Anim Sci, Inst Anim Husb, Xinjiang 830000, Peoples R China; [Zhou, Huitong; Hickford, Jon G. H.] Lincoln Univ, Dept Agr Sci, Gene Marker Lab, Lincoln 7647, New Zealand; [Degen, Allan A.] Ben Gurion Univ Negev, Wyler Dept Dryland Agr, Desert Anim Adaptat & Husb, Blaustein Inst Desert Res, IL-18410500 Beer Sheva, Israel
推荐引用方式 GB/T 7714	Jiao, Dan,Ji, Kaixi,Liu, Hu,et al. Transcriptome Analysis Reveals Genes Involved in Thermogenesis in Two Cold-Exposed Sheep Breeds[J]. 中国科学院西北生态环境资源研究院,2021,12(3).
APA	Jiao, Dan.,Ji, Kaixi.,Liu, Hu.,Wang, Wenqiang.,Wu, Xiukun.,...&Yang, Guo.(2021).Transcriptome Analysis Reveals Genes Involved in Thermogenesis in Two Cold-Exposed Sheep Breeds.GENES,12(3).
MLA	Jiao, Dan,et al."Transcriptome Analysis Reveals Genes Involved in Thermogenesis in Two Cold-Exposed Sheep Breeds".GENES 12.3(2021).