气候变化领域集成服务门户(CCPortal): Meissner corpuscles and their spatially intermingled afferents underlie gentle touch perception

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DOI	10.1126/science.abb2751
	Meissner corpuscles and their spatially intermingled afferents underlie gentle touch perception
	Neubarth N.L.; Emanuel A.J.; Liu Y.; Springel M.W.; Handler A.; Zhang Q.; Lehnert B.P.; Guo C.; Orefice L.L.; Abdelaziz A.; DeLisle M.M.; Iskols M.; Rhyins J.; Kim S.J.; Cattel S.J.; Regehr W.; Harvey C.D.; Drugowitsch J.; Ginty D.D.
发表日期	2020
ISSN	0036-8075
卷号	368 期号:6497
英文摘要	Meissner corpuscles are mechanosensory end organs that densely occupy mammalian glabrous skin. We generated mice that selectively lacked Meissner corpuscles and found them to be deficient in both perceiving the gentlest detectable forces acting on glabrous skin and fine sensorimotor control. We found that Meissner corpuscles are innervated by two mechanoreceptor subtypes that exhibit distinct responses to tactile stimuli. The anatomical receptive fields of these two mechanoreceptor subtypes homotypically tile glabrous skin in a manner that is offset with respect to one another. Electron microscopic analysis of the two Meissner afferents within the corpuscle supports a model in which the extent of lamellar cell wrappings of mechanoreceptor endings determines their force sensitivity thresholds and kinetic properties. © 2020 American Association for the Advancement of Science. All rights reserved.
关键词	chemical cue mechanoreception perception reaction kinetics skin visual cue Mammalia Mus Bdnf protein, mouse brain derived neurotrophic factor membrane protein Ntrk2 protein, mouse protein tyrosine kinase animal C57BL mouse electron microscopy epidermis female genetics innervation knockout mouse male Merkel cell metabolism mouse physiology signal transduction touch ultrastructure Animals Brain-Derived Neurotrophic Factor Epidermis Female Male Membrane Glycoproteins Merkel Cells Mice Mice, Inbred C57BL Mice, Knockout Microscopy, Electron Protein-Tyrosine Kinases Signal Transduction Touch Touch Perception
语种	英语
来源机构	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133409
推荐引用方式 GB/T 7714	Neubarth N.L.,Emanuel A.J.,Liu Y.,et al. Meissner corpuscles and their spatially intermingled afferents underlie gentle touch perception[J]. Science,2020,368(6497).
APA	Neubarth N.L..,Emanuel A.J..,Liu Y..,Springel M.W..,Handler A..,...&Ginty D.D..(2020).Meissner corpuscles and their spatially intermingled afferents underlie gentle touch perception.,368(6497).
MLA	Neubarth N.L.,et al."Meissner corpuscles and their spatially intermingled afferents underlie gentle touch perception".368.6497(2020).