|
已选(0)清除
条数/页： 排序方式： |
| Fluorination of arylboronic esters enabled by bismuth redox catalysis 期刊论文
, 2020, 卷号: 367, 期号: 6475
作者: Planas O.; Wang F.; Leutzsch M.; Cornella J.
  收藏 | 浏览/下载：23/0 | 提交时间：2020/07/28
aryl boronic ester aryl fluoride bismine bismuth bismuth derivative boronic acid derivative chloride chlorobismine difluorobismine ester fluoride fluorobenzene fluorobismine iron naphthalene ortho bromide pentavalent pentavalent bismine phenylboronic acid pinacol ester sulfone tetrafluoroborate bismine transition element trifluoromethyl trimethylsilyl derivative unclassified drug unindexed drug vinyl derivative bismuth catalysis catalyst crystallography ester ligand optimization oxidation redox potential transition element Article catalysis chemical bond crystal structure crystallography elimination reaction fluorination metallation oxidation reduction reaction oxidative coupling priority journal reaction analysis reaction optimization reduction (chemistry) transmetallation |
| Liquid-liquid phase separation drives skin barrier formation 期刊论文
, 2020, 卷号: 367, 期号: 6483
作者: Quiroz F.G.; Fiore V.F.; Levorse J.; Polak L.; Wong E.; Pasolli H.A.; Fuchs E.
收藏 | 浏览/下载：24/0 | 提交时间：2020/07/28
filaggrin keratohyalin coalescence differentiation separation skin skin disorder stratification amino acid composition Article bioengineering biophysics cell differentiation cell function cell structure epidermis cell genetic transfection human keratinocyte liquid live cell imaging molecular dynamics nonhuman pH phase separation phase transition priority journal proteomics sequence analysis signal transduction skin skin surface Mus |
| Enantioselective remote C-H activation directed by a chiral cation 期刊论文
, 2020, 卷号: 367, 期号: 6483
作者: Genov G.R.; Douthwaite J.L.; Lahdenperä A.S.K.; Gibson D.C.; Phipps R.J.
收藏 | 浏览/下载：20/0 | 提交时间：2020/07/28
anion bipyridine carbon cation iridium phosphorus quinine carbon catalysis cation ligand phosphorus transition element Article borylation catalysis chemical bond chemical structure chirality enantioselectivity priority journal |
| Valence and patterning of aromatic residues determine the phase behavior of prion-like domains 期刊论文
, 2020, 卷号: 367, 期号: 6478
作者: Martin E.W.; Holehouse A.S.; Peran I.; Farag M.; Incicco J.J.; Bremer A.; Grace C.R.; Soranno A.; Pappu R.V.; Mittag T.
收藏 | 浏览/下载：16/0 | 提交时间：2020/07/28
aromatic hydrocarbon biophysics concentration (composition) genetic analysis nuclear magnetic resonance prion disease protein separation temperature effect article nonhuman nuclear magnetic resonance spectroscopy phase separation prediction prion simulation X ray crystallography amino acid sequence chemistry phase transition prion protein domain small angle scattering X ray diffraction heterogeneous nuclear ribonucleoprotein A1 phenylalanine tyrosine Amino Acid Sequence Heterogeneous Nuclear Ribonucleoprotein A1 Magnetic Resonance Spectroscopy Phase Transition Phenylalanine Prions Protein Domains Scattering, Small Angle Tyrosine X-Ray Diffraction |
| Structural basis of Gs and Gi recognition by the human glucagon receptor 期刊论文
, 2020, 卷号: 367, 期号: 6484
作者: Qiao A.; Han S.; Li X.; Li Z.; Zhao P.; Dai A.; Chang R.; Tai L.; Tan Q.; Chu X.; Ma L.; Thorsen T.S.; Reedtz-Runge S.; Yang D.; Wang M.-W.; Sexton P.M.; Wootten D.; Sun F.; Zhao Q.; Wu B.
收藏 | 浏览/下载：31/0 | 提交时间：2020/07/28
cyclic AMP glucagon glucagon receptor inhibitory guanine nucleotide binding protein stimulatory guanine nucleotide binding protein glucagon receptor inhibitory guanine nucleotide binding protein protein binding stimulatory guanine nucleotide binding protein chemical binding enzyme activity gene expression mutagenicity protein alpha helix Article binding affinity carboxy terminal sequence conformational transition cryoelectron microscopy human molecular recognition mutagenesis priority journal protein binding protein function protein protein interaction protein structure signal transduction binding site chemistry metabolism molecular model protein conformation ultrastructure Binding Sites Cryoelectron Microscopy Glucagon GTP-Binding Protein alpha Subunits, Gi-Go GTP-Binding Protein alpha Subunits, Gs Humans Models, Molecular Protein Binding Protein Conformation Protein Conformation, alpha-Helical Receptors, Glucagon Signal Transduction |
| Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis 期刊论文
, 2020, 卷号: 367, 期号: 6485
作者: Ebright R.Y.; Lee S.; Wittner B.S.; Niederhoffer K.L.; Nicholson B.T.; Bardia A.; Truesdell S.; Wiley D.F.; Wesley B.; Li S.; Mai A.; Aceto N.; Vincent-Jordan N.; Szabolcs A.; Chirn B.; Kreuzer J.; Comaills V.; Kalinich M.; Haas W.; Ting D.T.; Toner M.; Vasudevan S.; Haber D.A.; Maheswaran S.; Micalizzi D.S.
收藏 | 浏览/下载：43/0 | 提交时间：2020/07/28
CRISPR associated protein epidermal growth factor receptor 2 Ki 67 antigen ribosome protein ribosome RNA transcription factor E2F ribosome protein cancer cell gene expression genetic engineering protein RNA tumor animal experiment animal model animal tissue Article biogenesis bioluminescence breast cancer cell cycle progression cell cycle regulation cell proliferation circulating tumor cell controlled study enzyme activation epithelial mesenchymal transition gene expression profiling genetic transcription human human cell lung metastasis metastasis microfluidics mouse nonhuman overall survival phenotype priority journal progression free survival promoter region protein expression protein processing protein synthesis proteomics RNA sequence transcription regulation animal breast tumor cancer transplantation CRISPR Cas system female gene expression regulation genetics pathology sequence analysis tumor cell line tumor embolism Mus Animals Breast Neoplasms Cell Line, Tumor CRISPR-Cas Systems Female Gene Expression Regulation, Neoplastic Humans Mice Neoplasm Metastasis Neoplasm Transplantation Neoplastic Cells, Circulating Ribosomal Proteins Sequence Analysis, RNA |
| Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者: Wingler L.M.; Skiba M.A.; McMahon C.; Staus D.P.; Kleinhenz A.L.W.; Suomivuori C.-M.; Latorraca N.R.; Dror R.O.; Lefkowitz R.J.; Kruse A.C.
收藏 | 浏览/下载：23/0 | 提交时间：2020/07/28
angiotensin 1 receptor beta arrestin G protein coupled receptor biochemistry crystal chemistry crystal structure physiological response protein signaling allosterism alpha helix amino terminal sequence Article binding affinity binding site carboxy terminal sequence conformational transition crystallization hydrogen bond molecular dynamics priority journal protein binding protein conformation protein protein interaction protein stability signal transduction thermostability |
| Structural insights into immunoglobulin M 期刊论文
, 2020, 卷号: 367, 期号: 6481
作者: Li Y.; Wang G.; Li N.; Wang Y.; Zhu Q.; Chu H.; Wu W.; Tan Y.; Yu F.; Su X.-D.; Gao N.; Xiao J.
收藏 | 浏览/下载：29/0 | 提交时间：2020/07/28
immunoglobulin M secretory component antibody immunity molecular analysis polymer protein Article binding site conformational transition cryoelectron microscopy crystal structure human hydrophobicity nonhuman oligomerization priority journal protein assembly protein domain protein function protein interaction protein stability protein structure protein transport surface area |
| Molecular mechanism of biased signaling in a prototypical G protein-coupled receptor 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者: Suomivuori C.-M.; Latorraca N.R.; Wingler L.M.; Eismann S.; King M.C.; Kleinhenz A.L.W.; Skiba M.A.; Staus D.P.; Kruse A.C.; Lefkowitz R.J.; Dror R.O.
收藏 | 浏览/下载：16/0 | 提交时间：2020/07/28
angiotensin 1 receptor beta arrestin 1 beta arrestin 2 G protein coupled receptor rhodopsin chemical binding design method ligand molecular analysis protein signaling allosterism Article carboxy terminal sequence conformational transition controlled study crystal structure human ligand binding molecular dynamics priority journal protein conformation signal transduction structural model |
| Disassembling 2D van der Waals crystals into macroscopic monolayers and reassembling into artificial lattices 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者: Liu F.; Wu W.; Bai Y.; Chae S.H.; Li Q.; Wang J.; Hone J.; Zhu X.-Y.
收藏 | 浏览/下载：17/0 | 提交时间：2020/07/28
chemical compound transition metal dichalcogenide unclassified drug chemical bonding crystal chemistry layer symmetry transition element two-dimensional modeling Article broken inversion symmetry bulk crystal size chemical procedures chemical structure complex formation controlled study crystal crystal monolayer crystal structure high throughput analysis histogram image analysis particle size physical parameters priority journal quality control Scotch tape exfoliation two dimensional structure van der Waals crystal |
