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| Structure of the RNA-dependent RNA polymerase from COVID-19 virus 期刊论文
, 2020, 卷号: 368, 期号: 6492
作者: Gao Y.; Yan L.; Huang Y.; Liu F.; Zhao Y.; Cao L.; Wang T.; Sun Q.; Ming Z.; Zhang L.; Ge J.; Zheng L.; Zhang Y.; Wang H.; Zhu Y.; Zhu C.; Hu T.; Hua T.; Zhang B.; Yang X.; Li J.; Yang H.; Liu Z.; Xu W.; Guddat L.W.; Wang Q.; Lou Z.; Rao Z.
  收藏 | 浏览/下载：35/0 | 提交时间：2020/07/28
comparative study drug electron microscopy enzyme enzyme activity RNA virus Coronavirus SARS coronavirus adenosine phosphate alanine antivirus agent NSP7 protein, SARS-CoV-2 NSP8 protein, SARS-CoV-2 remdesivir RNA directed RNA polymerase RNA-dependent RNA polymerase, coronavirus viral protein beta sheet Betacoronavirus chemistry cryoelectron microscopy drug design enzyme active site enzymology metabolism molecular model protein domain ultrastructure Adenosine Monophosphate Alanine Antiviral Agents Betacoronavirus Catalytic Domain Cryoelectron Microscopy Drug Design Models, Molecular Protein Conformation, beta-Strand Protein Domains RNA Replicase Viral Nonstructural Proteins |
| Microenvironment mapping via Dexter energy transfer on immune cells 期刊论文
, 2020, 卷号: 367, 期号: 6482
作者: Geri J.B.; Oakley J.V.; Reyes-Robles T.; Wang T.; McCarver S.J.; White C.H.; Rodriguez-Rivera F.P.; Parker D.L.; Hett E.C.; Fadeyi O.O.; Oslund R.C.; MacMillan D.W.C.
收藏 | 浏览/下载：31/0 | 提交时间：2020/07/28
antibody conjugate carbene programmed death 1 ligand 1 methane programmed death 1 ligand 1 antibody catalysis catalyst cell component detection method enzyme enzyme activity protein antigen binding Article cell membrane energy transfer human immunocompetent cell immunological synapse lymphocyte photocatalysis priority journal protein analysis protein protein interaction tumor microenvironment catalysis chemistry energy transfer Jurkat cell line metabolism photochemistry procedures radiation response ultraviolet radiation B7-H1 Antigen Catalysis Cell Membrane Cellular Microenvironment Energy Transfer Humans Jurkat Cells Lymphocytes Methane Photochemical Processes Protein Interaction Mapping Protein Interaction Maps Ultraviolet Rays |
| De novo protein design enables the precise induction of RSV-neutralizing antibodies 期刊论文
, 2020, 卷号: 368, 期号: 6492
作者: Sesterhenn F.; Yang C.; Bonet J.; Cramer J.T.; Wen X.; Wang Y.; Chiang C.-I.; Abriata L.A.; Kucharska I.; Castoro G.; Vollers S.S.; Galloux M.; Dheilly E.; Rosset S.; Corthésy P.; Georgeon S.; Villard M.; Richard C.-A.; Descamps D.; Delgado T.; Oricchio E.; Rameix-Welti M.-A.; Más V.; Ervin S.; Eléouët J.-F.; Riffault S.; Bates J.T.; Julien J.-P.; Li Y.; Jardetzky T.; Krey T.; Correia B.E.
收藏 | 浏览/下载：37/0 | 提交时间：2020/07/28
algorithm antibody design neutralization protein vaccine Mus Primates Respiratory syncytial virus Rice stripe virus epitope fusion protein nanobody neutralizing antibody respiratory syncytial virus vaccine biology biosynthesis chemistry human Human respiratory syncytial virus immunology procedures protein conformation protein engineering protein motif Amino Acid Motifs Antibodies, Neutralizing Computational Biology Humans Immunodominant Epitopes Protein Conformation Protein Engineering Recombinant Fusion Proteins Respiratory Syncytial Virus Vaccines Respiratory Syncytial Virus, Human Single-Domain Antibodies |
| Quantum interference in H + HD → H2 + D between direct abstraction and roaming insertion pathways 期刊论文
, 2020, 卷号: 368, 期号: 6492
作者: Xie Y.; Zhao H.; Wang Y.; Huang Y.; Wang T.; Xu X.; Xiao C.; Sun Z.; Zhang D.H.; Yang X.
收藏 | 浏览/下载：17/0 | 提交时间：2020/07/28
chemical reaction energetics oscillation probe quantum mechanics topology vibration article oscillation physics |
| Balancing volumetric and gravimetric uptake in highly porous materials for clean energy 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者: Chen Z.; Li P.; Anderson R.; Wang X.; Zhang X.; Robison L.; Redfern L.R.; Moribe S.; Islamoglu T.; Gómez-Gualdrón D.A.; Yildirim T.; Stoddart J.F.; Farha O.K.
收藏 | 浏览/下载：29/0 | 提交时间：2020/07/28
aluminum hydrogen iron metal organic framework methane adsorption gravimetry organometallic compound porous medium volume adsorption alternative energy Article environmental temperature gravimetry porosity pressure priority journal simulation surface area synthesis United States volumetry |
| Correlative three-dimensional super-resolution and block-face electron microscopy of whole vitreously frozen cells 期刊论文
, 2020, 卷号: 367, 期号: 6475
作者: Hoffman D.P.; Shtengel G.; Xu C.S.; Campbell K.R.; Freeman M.; Wang L.; Milkie D.E.; Pasolli H.A.; Iyer N.; Bogovic J.A.; Stabley D.R.; Shirinifard A.; Pang S.; Peale D.; Schaefer K.; Pomp W.; Chang C.-L.; Lippincott-Schwartz J.; Kirchhausen T.; Solecki D.J.; Betzig E.; Hess H.F.
收藏 | 浏览/下载：34/0 | 提交时间：2020/07/28
cell compartmentalization cryopreservation electron microscopy image resolution protein three-dimensional modeling ultrastructure article chromatin electron microscopy endoplasmic reticulum genetic transcription human cell mammal cell nerve cell culture protein domain ultrastructure whole cell workflow animal cell adhesion cells Chlorocebus aethiops cryoelectron microscopy CV-1 cell line fluorescence microscopy freezing HeLa cell line human mouse procedures three-dimensional imaging tumor cell line ultrastructure Mammalia Animals Cell Adhesion Cell Line, Tumor Cells Chlorocebus aethiops COS Cells Cryoelectron Microscopy Freezing HeLa Cells Humans Imaging, Three-Dimensional Mice Microscopy, Fluorescence |
| The genetic architecture of the human cerebral cortex 期刊论文
, 2020, 卷号: 367, 期号: 6484
作者: Grasby K.L.; Jahanshad N.; Painter J.N.; Colodro-Conde L.; Bralten J.; Hibar D.P.; Lind P.A.; Pizzagalli F.; Ching C.R.K.; McMahon M.A.B.; Shatokhina N.; Zsembik L.C.P.; Thomopoulos S.I.; Zhu A.H.; Strike L.T.; Agartz I.; Alhusaini S.; Almeida M.A.A.; Alnæs D.; Amlien I.K.; Andersson M.; Ard T.; Armstrong N.J.; Ashley-Koch A.; Atkins J.R.; Bernard M.; Brouwer R.M.; Buimer E.E.L.; Bülow R.; Bürger C.; Cannon D.M.; Chakravarty M.; Chen Q.; Cheung J.W.; Couvy-Duchesne B.; Dale A.M.; Dalvie S.; de Araujo T.K.; de Zubicaray G.I.; de Zwarte S.M.C.; den Braber A.; Doan N.T.; Dohm K.; Ehrlich S.; Engelbrecht H.-R.; Erk S.; Fan C.C.; Fedko I.O.; Foley S.F.; Ford J.M.; Fukunaga M.; Garrett M.E.; Ge T.; Giddaluru S.; Goldman A.L.; Green M.J.; Groenewold N.A.; Grotegerd D.; Gurholt T.P.; Gutman B.A.; Hansell N.K.; Harris M.A.; Harrison M.B.; Haswell C.C.; Hauser M.; Herms S.; Heslenfeld D.J.; Ho N.F.; Hoehn D.; Hoffmann P.; Holleran L.; Hoogman M.; Hottenga J.-J.; Ikeda M.; Janowitz D.; Jansen I.E.; Jia T.; Jockwitz C.; Kanai R.; Karama S.; Kasperaviciute D.; Kaufmann T.; Kelly S.; Kikuchi M.; Klein M.; Knapp M.; Knodt A.R.; Krämer B.; Lam M.; Lancaster T.M.; Lee P.H.; Lett T.A.; Lewis L.B.; Lopes-Cendes I.; Luciano M.; Macciardi F.; Marquand A.F.; Mathias S.R.; Melzer T.R.; Milaneschi Y.; Mirza-Schreiber N.; Moreira J.C.V.; Mühleisen T.W.; Müller-Myhsok B.; Najt P.; Nakahara S.; Nho K.; Olde Loohuis L.M.; Orfanos D.P.; Pearson J.F.; Pitcher T.L.; Pütz B.; Quidé Y.; Ragothaman A.; Rashid F.M.; Reay W.R.; Redlich R.; Reinbold C.S.; Repple J.; Richard G.; Riedel B.C.; Risacher S.L.; Rocha C.S.; Mota N.R.; Salminen L.; Saremi A.; Saykin A.J.; Schlag F.; Schmaal L.; Schofield P.R.; Secolin R.; Shapland C.Y.; Shen L.; Shin J.; Shumskaya E.; Sønderby I.E.; Sprooten E.; Tansey K.E.; Teumer A.; Thalamuthu A.; Tordesillas-Gutiérrez D.; Turner J.A.; Uhlmann A.; Vallerga C.L.; van der Meer D.; van Donkelaar M.M.J.; van Eijk L.; van Erp T.G.M.; van Haren N.E.M.; van Rooij D.; van Tol M.-J.; Veldink J.H.; Verhoef E.; Walton E.; Wang M.; Wang Y.; Wardlaw J.M.; Wen W.; Westlye L.T.; Whelan C.D.; Witt S.H.; Wittfeld K.; Wolf C.; Wolfers T.; Wu J.Q.; Yasuda C.L.; Zaremba D.; Zhang Z.; Zwiers M.P.; Artiges E.; Assareh A.A.; Ayesa-Arriola R.; Belger A.; Brandt C.L.; Brown G.G.; Cichon S.; Curran J.E.; Davies G.E.; Degenhardt F.; Dennis M.F.; Dietsche B.; Djurovic S.; Doherty C.P.; Espiritu R.; Garijo D.; Gil Y.; Gowland P.A.; Green R.C.; Häusler A.N.; Heindel W.; Ho B.-C.; Hoffmann W.U.; Holsboer F.; Homuth G.; Hosten N.; Jack C.R.; Jang M.; Jansen A.; Kimbrel N.A.; Kolskår K.; Koops S.; Krug A.; Lim K.O.; Luykx J.J.; Mathalon D.H.; Mather K.A.; Mattay V.S.; Matthews S.; van Son J.M.; McEwen S.C.; Melle I.; Morris D.W.; Mueller B.A.; Nauck M.; Nordvik J.E.; Nöthen M.M.; O'Leary D.S.; Opel N.; Martinot M.-L.P.; Bruce Pike G.; Preda A.; Quinlan E.B.; Rasser P.E.; Ratnakar V.; Reppermund S.; Steen V.M.; Tooney P.A.; Torres F.R.; Veltman D.J.; Voyvodic J.T.; Whelan R.; White T.; Yamamori H.; Adams H.H.H.; Bis J.C.; Debette S.; Decarli C.; Fornage M.; Gudnason V.; Hofer E.; Arfan Ikram M.; Launer L.; Longstreth W.T.; Lopez O.L.; Mazoyer B.; Mosley T.H.; Roshchupkin G.V.; Satizabal C.L.; Schmidt R.; Seshadri S.; Yang Q.; Alvim M.K.M.; Ames D.; Anderson T.J.; Andreassen O.A.; Arias-Vasquez A.; Bastin M.E.; Baune B.T.; Beckham J.C.; Blangero J.; Boomsma D.I.; Brodaty H.; Brunner H.G.; Buckner R.L.; Buitelaar J.K.; Bustillo J.R.; Cahn W.; Cairns M.J.; Calhoun V.; Carr V.J.; Caseras X.; Caspers S.; Cavalleri G.L.; Cendes F.; Corvin A.; Crespo-Facorro B.; Dalrymple-Alford J.C.; Dannlowski U.; de Geus E.J.C.; Deary I.J.; Delanty N.; Depondt C.; Desrivières S.; Donohoe G.; Espeseth T.; Fernández G.; Fisher S.E.; Flor H.; Forstner A.J.; Francks C.; Franke B.; Glahn D.C.; Gollub R.L.; Grabe H.J.; Gruber O.; Håberg A.K.; Hariri A.R.; Hartman C.A.; Hashimoto R.; Heinz A.; Henskens F.A.; Hillegers M.H.J.; Hoekstra P.J.; Holmes A.J.; Elliot Hong L.; Hopkins W.D.; Hulshoff Pol H.E.; Jernigan T.L.; Jönsson E.G.; Kahn R.S.; Kennedy M.A.; Kircher T.T.J.; Kochunov P.; Kwok J.B.J.; Le Hellard S.; Loughland C.M.; Martin N.G.; Martinot J.-L.; McDonald C.; McMahon K.L.; Meyer-Lindenberg A.; Michie P.T.; Morey R.A.; Mowry B.; Nyberg L.; Oosterlaan J.; Ophoff R.A.; Pantelis C.; Paus T.; Pausova Z.; Penninx B.W.J.H.; Polderman T.J.C.; Posthuma D.; Rietschel M.; Roffman J.L.; Rowland L.M.; Sachdev P.S.; Sämann P.G.; Schall U.; Schumann G.; Scott R.J.; Sim K.; Sisodiya S.M.; Smoller J.W.; Sommer I.E.; Pourcain B.S.; Stein D.J.; Toga A.W.; Trollor J.N.; van der Wee N.J.A.; van't Ent D.; Völzke H.; Walter H.; Weber B.; Weinberger D.R.; Wright M.J.; Zhou J.; Stein J.L.; Thompson P.M.; Medland S.E.; Enhancing NeuroImaging Genetics through Meta-Analysis Consortium (ENIGMA)-Genetics working group
收藏 | 浏览/下载：45/0 | 提交时间：2020/07/28
brain genetic analysis meta-analysis resonance signaling surface area Article bioinformatics brain cortex brain function brain region brain tissue cortical thickness (brain) educational status evidence based medicine gene control gene locus genetic association genetic correlation genetic variability genome-wide association study human human genetics priority journal surface area tissue structure Wnt signaling anatomy and histology attention deficit disorder brain cortex brain mapping cognition genetic variation genetics meta analysis nuclear magnetic resonance imaging organ size Parkinson disease Attention Deficit Disorder with Hyperactivity Brain Mapping Cerebral Cortex Cognition Genetic Loci Genetic Variation Genome-Wide Association Study Humans Magnetic Resonance Imaging Organ Size Parkinson Disease |
| Kinetic pathways of ionic transport in fast-charging lithium titanate 期刊论文
, 2020, 卷号: 367, 期号: 6481
作者: Zhang W.; Seo D.-H.; Chen T.; Wu L.; Topsakal M.; Zhu Y.; Lu D.; Ceder G.; Wang F.
收藏 | 浏览/下载：13/0 | 提交时间：2020/07/28
1 butyl 1 methylpyrrolidinium bis(trifluoromethylsulfonyl) imide electrolyte imide ionic liquid electrolyte lithium lithium bis (trifluoromethanesulfonyl)imide lithium ion lithium titanate oxygen unclassified drug diffusion electrode ionic composition lithium reaction kinetics titanate transformation two phase flow Article chemical bond chemical reaction kinetics concentration (parameter) cyclic voltammetry electricity electrochemical analysis electron energy loss spectroscopy energy ion transport kinetics neutron diffraction nuclear magnetic resonance spectroscopy priority journal quantitative analysis reduction (chemistry) transmission electron microscopy X ray absorption spectroscopy |
| Endoplasmic reticulum-associated degradation regulates mitochondrial dynamics in brown adipocytes 期刊论文
, 2020, 卷号: 368, 期号: 6486
作者: Zhou Z.; Torres M.; Sha H.; Halbrook C.J.; van den Bergh F.; Reinert R.B.; Yamada T.; Wang S.; Luo Y.; Hunter A.H.; Wang C.; Sanderson T.H.; Liu M.; Taylor A.; Sesaki H.; Lyssiotis C.A.; Wu J.; Kersten S.; Beard D.A.; Qi L.
收藏 | 浏览/下载：32/0 | 提交时间：2020/07/28
Hrd1 protein membrane protein Sel1L protein sigma opiate receptor sigma receptor 1 ubiquitin protein ligase E3 unclassified drug biodegradation cell organelle membrane mitochondrion physiology protein turnover animal cell Article brown adipocyte cell contact controlled study endoplasmic reticulum endoplasmic reticulum associated degradation megamitochondria mitochondrial dynamics mitochondrion mouse nonhuman priority journal protein metabolism protein protein interaction thermogenesis three-dimensional imaging Mus |
| An atlas of the protein-coding genes in the human, pig, and mouse brain 期刊论文
, 2020, 卷号: 367, 期号: 6482
作者: Sjöstedt E.; Zhong W.; Fagerberg L.; Karlsson M.; Mitsios N.; Adori C.; Oksvold P.; Edfors F.; Limiszewska A.; Hikmet F.; Huang J.; Du Y.; Lin L.; Dong Z.; Yang L.; Liu X.; Jiang H.; Xu X.; Wang J.; Yang H.; Bolund L.; Mardinoglu A.; Zhang C.; Von Feilitzen K.; Lindskog C.; Pontén F.; Luo Y.; Hökfelt T.; Uhlén M.; Mulder J.
收藏 | 浏览/下载：34/0 | 提交时间：2020/07/28
G protein coupled receptor neurotransmitter atlas brain gene gene expression pig protein Article astrocyte cerebellum gene expression level gene expression profiling gene mapping genetic code genome-wide association study genomics human hypothalamus in situ hybridization microglia nerve cell nonhuman oligodendroglia pig priority journal species comparison tissue specificity transcriptomics Mammalia Suidae |
