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| Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease 期刊论文
, 2020, 卷号: 368, 期号: 6497
作者: Dai W.; Zhang B.; Jiang X.-M.; Su H.; Li J.; Zhao Y.; Xie X.; Jin Z.; Peng J.; Liu F.; Li C.; Li Y.; Bai F.; Wang H.; Cheng X.; Cen X.; Hu S.; Yang X.; Wang J.; Liu X.; Xiao G.; Jiang H.; Rao Z.; Zhang L.-K.; Xu Y.; Yang H.; Liu H.
  收藏 | 浏览/下载：36/0 | 提交时间：2020/07/28
aldehyde antimicrobial activity drug enzyme activity infectivity inhibitor reaction kinetics viral disease Coronavirus SARS coronavirus 3C-like proteinase, Coronavirus antivirus agent cysteine proteinase viral protein animal Betacoronavirus chemical structure chemistry Chlorocebus aethiops Coronavirus infection dog drug design drug effect enzyme active site enzymology female human male mouse pandemic preclinical study protein tertiary structure Sprague Dawley rat toxicity testing Vero cell line virus pneumonia Animals Antiviral Agents Betacoronavirus Catalytic Domain Chlorocebus aethiops Coronavirus Infections Cysteine Endopeptidases Dogs Drug Design Drug Evaluation, Preclinical Female Humans Male Mice Molecular Structure Pandemics Pneumonia, Viral Protein Structure, Tertiary Rats, Sprague-Dawley Toxicity Tests Vero Cells Viral Nonstructural Proteins |
| Intravital imaging of mouse embryos 期刊论文
, 2020, 卷号: 368, 期号: 6487
作者: Huang Q.; Cohen M.A.; Alsina F.C.; Devlin G.; Garrett A.; McKey J.; Havlik P.; Rakhilin N.; Wang E.; Xiang K.; Mathews P.; Wang L.; Bock C.; Ruthig V.; Wang Y.; Negrete M.; Wong C.W.; Murthy P.K.L.; Zhang S.; Daniel A.R.; Kirsch D.G.; Kang Y.; Capel B.; Asokan A.; Silver D.L.; Jaenisch R.; Shen X.
收藏 | 浏览/下载：36/0 | 提交时间：2020/07/28
cell embryo embryonic development imaging method physiology animal cell animal experiment article autophagy (cellular) brain cell cell division chimera controlled study diffusion electroporation embryo female microscopy mouse mouse embryo neural crest cell neurotransmission nonhuman placenta retina uterus vascularization viral gene delivery system |
| Nearly quantized conductance plateau of vortex zero mode in an iron-based superconductor 期刊论文
, 2020, 卷号: 367, 期号: 6474
作者: Zhu S.; Kong L.; Cao L.; Chen H.; Papaj M.; Du S.; Xing Y.; Liu W.; Wang D.; Shen C.; Yang F.; Schneeloch J.; Zhong R.; Gu G.; Fu L.; Zhang Y.-Y.; Ding H.; Gao H.-J.
收藏 | 浏览/下载：31/0 | 提交时间：2020/07/28
iron equipment iron plateau vortex Article controlled study electric conductance energy fractional quasiparticle mathematical computing non Abelian braiding statistics particle antiparticle equivalence physical parameters priority journal quantum computing scanning tunneling spectroscopy statistical analysis Abelia Majorana |
| Ultrafast control of vortex microlasers 期刊论文
, 2020, 卷号: 367, 期号: 6481
作者: Huang C.; Zhang C.; Xiao S.; Wang Y.; Fan Y.; Liu Y.; Zhang N.; Qu G.; Ji H.; Han J.; Ge L.; Kivshar Y.; Song Q.
收藏 | 浏览/下载：18/0 | 提交时间：2020/07/28
control system perovskite quantum mechanics vortex article controlled study energy consumption velocity |
| The genetic architecture of the human cerebral cortex 期刊论文
, 2020, 卷号: 367, 期号: 6484
作者: Grasby K.L.; Jahanshad N.; Painter J.N.; Colodro-Conde L.; Bralten J.; Hibar D.P.; Lind P.A.; Pizzagalli F.; Ching C.R.K.; McMahon M.A.B.; Shatokhina N.; Zsembik L.C.P.; Thomopoulos S.I.; Zhu A.H.; Strike L.T.; Agartz I.; Alhusaini S.; Almeida M.A.A.; Alnæs D.; Amlien I.K.; Andersson M.; Ard T.; Armstrong N.J.; Ashley-Koch A.; Atkins J.R.; Bernard M.; Brouwer R.M.; Buimer E.E.L.; Bülow R.; Bürger C.; Cannon D.M.; Chakravarty M.; Chen Q.; Cheung J.W.; Couvy-Duchesne B.; Dale A.M.; Dalvie S.; de Araujo T.K.; de Zubicaray G.I.; de Zwarte S.M.C.; den Braber A.; Doan N.T.; Dohm K.; Ehrlich S.; Engelbrecht H.-R.; Erk S.; Fan C.C.; Fedko I.O.; Foley S.F.; Ford J.M.; Fukunaga M.; Garrett M.E.; Ge T.; Giddaluru S.; Goldman A.L.; Green M.J.; Groenewold N.A.; Grotegerd D.; Gurholt T.P.; Gutman B.A.; Hansell N.K.; Harris M.A.; Harrison M.B.; Haswell C.C.; Hauser M.; Herms S.; Heslenfeld D.J.; Ho N.F.; Hoehn D.; Hoffmann P.; Holleran L.; Hoogman M.; Hottenga J.-J.; Ikeda M.; Janowitz D.; Jansen I.E.; Jia T.; Jockwitz C.; Kanai R.; Karama S.; Kasperaviciute D.; Kaufmann T.; Kelly S.; Kikuchi M.; Klein M.; Knapp M.; Knodt A.R.; Krämer B.; Lam M.; Lancaster T.M.; Lee P.H.; Lett T.A.; Lewis L.B.; Lopes-Cendes I.; Luciano M.; Macciardi F.; Marquand A.F.; Mathias S.R.; Melzer T.R.; Milaneschi Y.; Mirza-Schreiber N.; Moreira J.C.V.; Mühleisen T.W.; Müller-Myhsok B.; Najt P.; Nakahara S.; Nho K.; Olde Loohuis L.M.; Orfanos D.P.; Pearson J.F.; Pitcher T.L.; Pütz B.; Quidé Y.; Ragothaman A.; Rashid F.M.; Reay W.R.; Redlich R.; Reinbold C.S.; Repple J.; Richard G.; Riedel B.C.; Risacher S.L.; Rocha C.S.; Mota N.R.; Salminen L.; Saremi A.; Saykin A.J.; Schlag F.; Schmaal L.; Schofield P.R.; Secolin R.; Shapland C.Y.; Shen L.; Shin J.; Shumskaya E.; Sønderby I.E.; Sprooten E.; Tansey K.E.; Teumer A.; Thalamuthu A.; Tordesillas-Gutiérrez D.; Turner J.A.; Uhlmann A.; Vallerga C.L.; van der Meer D.; van Donkelaar M.M.J.; van Eijk L.; van Erp T.G.M.; van Haren N.E.M.; van Rooij D.; van Tol M.-J.; Veldink J.H.; Verhoef E.; Walton E.; Wang M.; Wang Y.; Wardlaw J.M.; Wen W.; Westlye L.T.; Whelan C.D.; Witt S.H.; Wittfeld K.; Wolf C.; Wolfers T.; Wu J.Q.; Yasuda C.L.; Zaremba D.; Zhang Z.; Zwiers M.P.; Artiges E.; Assareh A.A.; Ayesa-Arriola R.; Belger A.; Brandt C.L.; Brown G.G.; Cichon S.; Curran J.E.; Davies G.E.; Degenhardt F.; Dennis M.F.; Dietsche B.; Djurovic S.; Doherty C.P.; Espiritu R.; Garijo D.; Gil Y.; Gowland P.A.; Green R.C.; Häusler A.N.; Heindel W.; Ho B.-C.; Hoffmann W.U.; Holsboer F.; Homuth G.; Hosten N.; Jack C.R.; Jang M.; Jansen A.; Kimbrel N.A.; Kolskår K.; Koops S.; Krug A.; Lim K.O.; Luykx J.J.; Mathalon D.H.; Mather K.A.; Mattay V.S.; Matthews S.; van Son J.M.; McEwen S.C.; Melle I.; Morris D.W.; Mueller B.A.; Nauck M.; Nordvik J.E.; Nöthen M.M.; O'Leary D.S.; Opel N.; Martinot M.-L.P.; Bruce Pike G.; Preda A.; Quinlan E.B.; Rasser P.E.; Ratnakar V.; Reppermund S.; Steen V.M.; Tooney P.A.; Torres F.R.; Veltman D.J.; Voyvodic J.T.; Whelan R.; White T.; Yamamori H.; Adams H.H.H.; Bis J.C.; Debette S.; Decarli C.; Fornage M.; Gudnason V.; Hofer E.; Arfan Ikram M.; Launer L.; Longstreth W.T.; Lopez O.L.; Mazoyer B.; Mosley T.H.; Roshchupkin G.V.; Satizabal C.L.; Schmidt R.; Seshadri S.; Yang Q.; Alvim M.K.M.; Ames D.; Anderson T.J.; Andreassen O.A.; Arias-Vasquez A.; Bastin M.E.; Baune B.T.; Beckham J.C.; Blangero J.; Boomsma D.I.; Brodaty H.; Brunner H.G.; Buckner R.L.; Buitelaar J.K.; Bustillo J.R.; Cahn W.; Cairns M.J.; Calhoun V.; Carr V.J.; Caseras X.; Caspers S.; Cavalleri G.L.; Cendes F.; Corvin A.; Crespo-Facorro B.; Dalrymple-Alford J.C.; Dannlowski U.; de Geus E.J.C.; Deary I.J.; Delanty N.; Depondt C.; Desrivières S.; Donohoe G.; Espeseth T.; Fernández G.; Fisher S.E.; Flor H.; Forstner A.J.; Francks C.; Franke B.; Glahn D.C.; Gollub R.L.; Grabe H.J.; Gruber O.; Håberg A.K.; Hariri A.R.; Hartman C.A.; Hashimoto R.; Heinz A.; Henskens F.A.; Hillegers M.H.J.; Hoekstra P.J.; Holmes A.J.; Elliot Hong L.; Hopkins W.D.; Hulshoff Pol H.E.; Jernigan T.L.; Jönsson E.G.; Kahn R.S.; Kennedy M.A.; Kircher T.T.J.; Kochunov P.; Kwok J.B.J.; Le Hellard S.; Loughland C.M.; Martin N.G.; Martinot J.-L.; McDonald C.; McMahon K.L.; Meyer-Lindenberg A.; Michie P.T.; Morey R.A.; Mowry B.; Nyberg L.; Oosterlaan J.; Ophoff R.A.; Pantelis C.; Paus T.; Pausova Z.; Penninx B.W.J.H.; Polderman T.J.C.; Posthuma D.; Rietschel M.; Roffman J.L.; Rowland L.M.; Sachdev P.S.; Sämann P.G.; Schall U.; Schumann G.; Scott R.J.; Sim K.; Sisodiya S.M.; Smoller J.W.; Sommer I.E.; Pourcain B.S.; Stein D.J.; Toga A.W.; Trollor J.N.; van der Wee N.J.A.; van't Ent D.; Völzke H.; Walter H.; Weber B.; Weinberger D.R.; Wright M.J.; Zhou J.; Stein J.L.; Thompson P.M.; Medland S.E.; Enhancing NeuroImaging Genetics through Meta-Analysis Consortium (ENIGMA)-Genetics working group
收藏 | 浏览/下载：47/0 | 提交时间：2020/07/28
brain genetic analysis meta-analysis resonance signaling surface area Article bioinformatics brain cortex brain function brain region brain tissue cortical thickness (brain) educational status evidence based medicine gene control gene locus genetic association genetic correlation genetic variability genome-wide association study human human genetics priority journal surface area tissue structure Wnt signaling anatomy and histology attention deficit disorder brain cortex brain mapping cognition genetic variation genetics meta analysis nuclear magnetic resonance imaging organ size Parkinson disease Attention Deficit Disorder with Hyperactivity Brain Mapping Cerebral Cortex Cognition Genetic Loci Genetic Variation Genome-Wide Association Study Humans Magnetic Resonance Imaging Organ Size Parkinson Disease |
| Precision measurement of the neutral pion lifetime 期刊论文
, 2020, 卷号: 368, 期号: 6490
作者: Larin I.; Zhang Y.; Gasparian A.; Gan L.; Miskimen R.; Khandaker M.; Dale D.; Danagoulian S.; Pasyuk E.; Gao H.; Ahmidouch A.; Ambrozewicz P.; Baturin V.; Burkert V.; Clinton E.; Deur A.; Dolgolenko A.; Dutta D.; Fedotov G.; Feng J.; Gevorkyan S.; Glamazdin A.; Guo L.; Isupov E.; Ito M.M.; Klein F.; Kowalski S.; Kubarovsky A.; Kubarovsky V.; Lawrence D.; Lu H.; Ma L.; Matveev V.; Morrison B.; Micherdzinska A.; Nakagawa I.; Park K.; Pedroni R.; Phelps W.; Protopopescu D.; Rimal D.; Romanov D.; Salgado C.; Shahinyan A.; Sober D.; Stepanyan S.; Tarasov V.V.; Taylor S.; Vasiliev A.; Wood M.; Ye L.; Zihlmann B.; PrimEx-II Collaboration
收藏 | 浏览/下载：31/0 | 提交时间：2020/07/28
carbon silicon silicon 28 unclassified drug asymmetry measurement method precision quantum mechanics Article chirality decay time constant measurement precision negative pi meson photon photosynthesis pion prediction priority journal quantum chromodynamics quantum mechanics |
| A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2 期刊论文
, 2020, 卷号: 368, 期号: 6496
作者: Wu Y.; Wang F.; Shen C.; Peng W.; Li D.; Zhao C.; Li Z.; Li S.; Bi Y.; Yang Y.; Gong Y.; Xiao H.; Fan Z.; Tan S.; Wu G.; Tan W.; Lu X.; Fan C.; Wang Q.; Liu Y.; Zhang C.; Qi J.; Gao G.F.; Gao F.; Liu L.
收藏 | 浏览/下载：29/0 | 提交时间：2020/07/28
Coronavirus angiotensin converting enzyme 2 coronavirus spike glycoprotein dipeptidyl carboxypeptidase epitope monoclonal antibody neutralizing antibody virus antibody virus receptor animal chemistry Coronavirus infection disease model human immunology isolation and purification lung mouse pandemic protein domain serodiagnosis virology virus load virus pneumonia Animals Antibodies, Monoclonal Antibodies, Neutralizing Antibodies, Viral Coronavirus Infections Disease Models, Animal Humans Immunodominant Epitopes Lung Mice Neutralization Tests Pandemics Peptidyl-Dipeptidase A Pneumonia, Viral Protein Domains Receptors, Virus Spike Glycoprotein, Coronavirus Viral Load |
| Substantial undocumented infection facilitates the rapid dissemination of novel coronavirus (SARS-CoV-2) 期刊论文
, 2020, 卷号: 368, 期号: 6490
作者: Li R.; Pei S.; Chen B.; Song Y.; Zhang T.; Yang W.; Shaman J.
收藏 | 浏览/下载：26/0 | 提交时间：2020/07/28
disease prevalence disease spread disease transmission infectious disease metapopulation population modeling viral disease virus Article Bayes theorem China conceptual framework coronavirus disease 2019 data analysis disease severity disease transmission documentation human mathematical model metapopulation nonhuman priority journal Severe acute respiratory syndrome coronavirus 2 travel validation process China Coronavirus SARS coronavirus |
| One-dimensional van der Waals heterostructures 期刊论文
, 2020, 卷号: 367, 期号: 6477
作者: Xiang R.; Inoue T.; Zheng Y.; Kumamoto A.; Qian Y.; Sato Y.; Liu M.; Tang D.; Gokhale D.; Guo J.; Hisama K.; Yotsumoto S.; Ogamoto T.; Arai H.; Kobayashi Y.; Zhang H.; Hou B.; Anisimov A.; Maruyama M.; Miyata Y.; Okada S.; Chiashi S.; Li Y.; Kong J.; Kauppinen E.I.; Ikuhara Y.; Suenaga K.; Maruyama S.
收藏 | 浏览/下载：119/0 | 提交时间：2020/07/28
boron nitride inorganic salt molybdenum disulfide single walled nanotube unclassified drug chemical bonding experimental study nanotube one-dimensional modeling ultrastructure Article chemical structure crystal one dimensional van der Waals heterostructure particle size priority journal |
| Enhanced sustainable green revolution yield via nitrogen-responsive chromatin modulation in rice 期刊论文
, 2020, 卷号: 367, 期号: 6478
作者: Wu K.; Wang S.; Song W.; Zhang J.; Wang Y.; Liu Q.; Yu J.; Ye Y.; Li S.; Chen J.; Zhao Y.; Wang J.; Wu X.; Wang M.; Zhang Y.; Liu B.; Wu Y.; Harberd N.P.; Fu X.
收藏 | 浏览/下载：33/0 | 提交时间：2020/07/28
DELLA protein gibberellin gibberellin insensitive dwarf1 histone H3 polycomb repressive complex 2 receptor transcription factor unclassified drug alternative agriculture chromosome gene expression genetic engineering green revolution inhibition molecular analysis nitrogen nutrient use efficiency protein rice agriculture allele Article chromatin immunoprecipitation controlled study D14 gene gene mutation genetic screening genetic transcription grain yield green revolution histone modification modulation ngr5 gene nitrogen availability nitrogen responsive chromatin modulation nonhuman OsSPL14 gene plant gene polymerase chain reaction priority journal protein protein interaction rice RNA sequencing varietas |
