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期刊论文 [8]
发表日期
2020 [8]
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英语 [8]
来源机构
Science [8]
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Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease
期刊论文
, 2020, 卷号: 368, 期号: 6497
作者:
Dai W.
;
Zhang B.
;
Jiang X.-M.
;
Su H.
;
Li J.
;
Zhao Y.
;
Xie X.
;
Jin Z.
;
Peng J.
;
Liu F.
;
Li C.
;
Li Y.
;
Bai F.
;
Wang H.
;
Cheng X.
;
Cen X.
;
Hu S.
;
Yang X.
;
Wang J.
;
Liu X.
;
Xiao G.
;
Jiang H.
;
Rao Z.
;
Zhang L.-K.
;
Xu Y.
;
Yang H.
;
Liu H.
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2020/07/28
aldehyde
antimicrobial activity
drug
enzyme activity
infectivity
inhibitor
reaction kinetics
viral disease
Coronavirus
SARS coronavirus
3C-like proteinase, Coronavirus
antivirus agent
cysteine proteinase
viral protein
animal
Betacoronavirus
chemical structure
chemistry
Chlorocebus aethiops
Coronavirus infection
dog
drug design
drug effect
enzyme active site
enzymology
female
human
male
mouse
pandemic
preclinical study
protein tertiary structure
Sprague Dawley rat
toxicity testing
Vero cell line
virus pneumonia
Animals
Antiviral Agents
Betacoronavirus
Catalytic Domain
Chlorocebus aethiops
Coronavirus Infections
Cysteine Endopeptidases
Dogs
Drug Design
Drug Evaluation, Preclinical
Female
Humans
Male
Mice
Molecular Structure
Pandemics
Pneumonia, Viral
Protein Structure, Tertiary
Rats, Sprague-Dawley
Toxicity Tests
Vero Cells
Viral Nonstructural Proteins
Structure of the RNA-dependent RNA polymerase from COVID-19 virus
期刊论文
, 2020, 卷号: 368, 期号: 6492
作者:
Gao Y.
;
Yan L.
;
Huang Y.
;
Liu F.
;
Zhao Y.
;
Cao L.
;
Wang T.
;
Sun Q.
;
Ming Z.
;
Zhang L.
;
Ge J.
;
Zheng L.
;
Zhang Y.
;
Wang H.
;
Zhu Y.
;
Zhu C.
;
Hu T.
;
Hua T.
;
Zhang B.
;
Yang X.
;
Li J.
;
Yang H.
;
Liu Z.
;
Xu W.
;
Guddat L.W.
;
Wang Q.
;
Lou Z.
;
Rao Z.
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2020/07/28
comparative study
drug
electron microscopy
enzyme
enzyme activity
RNA
virus
Coronavirus
SARS coronavirus
adenosine phosphate
alanine
antivirus agent
NSP7 protein, SARS-CoV-2
NSP8 protein, SARS-CoV-2
remdesivir
RNA directed RNA polymerase
RNA-dependent RNA polymerase, coronavirus
viral protein
beta sheet
Betacoronavirus
chemistry
cryoelectron microscopy
drug design
enzyme active site
enzymology
metabolism
molecular model
protein domain
ultrastructure
Adenosine Monophosphate
Alanine
Antiviral Agents
Betacoronavirus
Catalytic Domain
Cryoelectron Microscopy
Drug Design
Models, Molecular
Protein Conformation, beta-Strand
Protein Domains
RNA Replicase
Viral Nonstructural Proteins
Structure of the secretory immunoglobulin A core
期刊论文
, 2020, 卷号: 367, 期号: 6481
作者:
Kumar N.
;
Arthur C.P.
;
Ciferri C.
;
Matsumoto M.L.
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2020/07/28
dimer
immunoglobulin receptor
oligomer
pentamer
secretory component
secretory immunoglobulin
tetramer
unclassified drug
antibody
immune response
immunity
pathogen
physiological response
protein
secretion
antigen antibody complex
antigen binding
Article
cryoelectron microscopy
human
immune reconstitution
immunity
immunoglobulin structure
oligomerization
priority journal
transcytosis
Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation
期刊论文
, 2020, 卷号: 368, 期号: 6489
作者:
Gilan O.
;
Rioja I.
;
Knezevic K.
;
Bell M.J.
;
Yeung M.M.
;
Harker N.R.
;
Lam E.Y.N.
;
Chung C.
;
Bamborough P.
;
Petretich M.
;
Urh M.
;
Atkinson S.J.
;
Bassil A.K.
;
Roberts E.J.
;
Vassiliadis D.
;
Burr M.L.
;
Preston A.G.S.
;
Wellaway C.
;
Werner T.
;
Gray J.R.
;
Michon A.-M.
;
Gobbetti T.
;
Kumar V.
;
Soden P.E.
;
Haynes A.
;
Vappiani J.
;
Tough D.F.
;
Taylor S.
;
Dawson S.-J.
;
Bantscheff M.
;
Lindon M.
;
Drewes G.
;
Demont E.H.
;
Daniels D.L.
;
Grandi P.
;
Prinjha R.K.
;
Dawson M.A.
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2020/07/28
7 (3,5 dimethyl 4 isoxazolyl) 1,3 dihydro 8 methoxy 1 [1 (2 pyridinyl)ethyl] 2h imidazo[4,5 c]quinolin 2 one
apremilast
bromodomain and extraterminal domain protein 1
bromodomain and extraterminal domain protein 2
bromodomain inhibitor
gsk 046
gsk 620
gsk 778
transcription factor
unclassified drug
cancer
drug
gene expression
immune response
inhibitor
physiological response
acute myeloid leukemia
animal experiment
animal model
animal tissue
antibody response
antineoplastic activity
antiproliferative activity
apoptosis
Article
binding affinity
controlled study
crystal structure
drug design
drug efficacy
drug protein binding
drug selectivity
drug specificity
drug structure
drug targeting
gene expression
high throughput screening
human
human cell
IC50
immunomodulation
in vivo study
inflammation
K-562 cell line
malignant neoplasm
MDA-MB-453 cell line
MOLM-13 cell line
mouse
nonhuman
priority journal
psoriasis
Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved a-ketoamide inhibitors
期刊论文
, 2020, 卷号: 368, 期号: 6489
作者:
Zhang L.
;
Lin D.
;
Sun X.
;
Curth U.
;
Drosten C.
;
Sauerhering L.
;
Becker S.
;
Rox K.
;
Hilgenfeld R.
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2020/07/28
alanine
alpha ketoamide inhibitor
antivirus agent
isoleucine
leucine
proteinase
Severe acute respiratory syndrome coronavirus 2 main protease
threonine
unclassified drug
crystal structure
drug
enzyme
enzyme activity
inhibitor
reaction kinetics
amino acid sequence
animal cell
animal experiment
animal tissue
antiviral activity
Article
catalysis
catalytic efficiency
controlled study
crystal structure
dimerization
dissociation constant
drug clearance
drug design
drug distribution
drug half life
drug potency
drug protein binding
drug solubility
drug structure
EC50
enzyme inhibition
human
human cell
hydrogen bond
hydrophobicity
IC50
maximum concentration
mean residence time
metabolic stability
mouse
nonhuman
priority journal
protein structure
RNA replication
SARS coronavirus
Severe acute respiratory syndrome coronavirus 2
viral tropism
virus inhibition
Coronavirus
SARS coronavirus
Structural basis for strand-transfer inhibitor binding to HIV intasomes
期刊论文
, 2020, 卷号: 367, 期号: 6479
作者:
Passos D.O.
;
Li M.
;
Jóźwik I.K.
;
Zhao X.Z.
;
Santos-Martins D.
;
Yang R.
;
Smith S.J.
;
Jeon Y.
;
Forli S.
;
Hughes S.H.
;
Burke T.R.
;
Jr.
;
Craigie R.
;
Lyumkis D.
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2020/07/28
bictegravir
nucleoprotein
protein intasome
unclassified drug
viral protein
bictegravir
fused heterocyclic rings
integrase
integrase inhibitor
multiprotein complex
naphthyridine derivative
nucleoprotein
biochemistry
chemical binding
human immunodeficiency virus
inhibitor
protein
ultrastructure
amino terminal sequence
Article
carboxy terminal sequence
catalysis
cryoelectron microscopy
drug design
drug efficacy
drug protein binding
drug resistance
drug structure
enzyme active site
human
Human immunodeficiency virus infection
nonhuman
priority journal
protein purification
protein structure
antiviral resistance
chemistry
drug effect
genetics
Human immunodeficiency virus
virus DNA cell DNA interaction
Cryoelectron Microscopy
Drug Design
Drug Resistance, Viral
Heterocyclic Compounds, 4 or More Rings
HIV
HIV Integrase
HIV Integrase Inhibitors
Humans
Multiprotein Complexes
Naphthyridines
Nucleoproteins
Virus Integration
Structural basis of second-generation HIV integrase inhibitor action and viral resistance
期刊论文
, 2020, 卷号: 367, 期号: 6479
作者:
Cook N.J.
;
Li W.
;
Berta D.
;
Badaoui M.
;
Ballandras-Colas A.
;
Nans A.
;
Kotecha A.
;
Rosta E.
;
Engelman A.N.
;
Cherepanov P.
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2020/07/28
bictegravir
dolutegravir
lens epithelium derived growth factor
magnesium ion
bictegravir
dolutegravir
fused heterocyclic rings
glutamine
glycine
histidine
integrase
integrase inhibitor
magnesium
serine
acquired immune deficiency syndrome
amino acid
drug
human immunodeficiency virus
inhibitor
protein
ultrastructure
virus
amino acid substitution
amino terminal sequence
Article
carboxy terminal sequence
cryoelectron microscopy
DNA binding
drug design
drug protein binding
drug structure
enzyme active site
gene mutation
Human immunodeficiency virus 1
in vitro study
molecular dynamics
molecular stability
nonhuman
pharmacophore
polarization
priority journal
protonation
virus resistance
antiviral resistance
chemistry
genetics
human
mutation
procedures
single molecule imaging
Amino Acid Substitution
Catalytic Domain
Cryoelectron Microscopy
Drug Resistance, Viral
Glutamine
Glycine
Heterocyclic Compounds, 3-Ring
Heterocyclic Compounds, 4 or More Rings
Histidine
HIV Integrase
HIV Integrase Inhibitors
Humans
Magnesium
Mutation
Serine
Single Molecule Imaging
Genetically targeted chemical assembly of functional materials in living cells, tissues, and animals
期刊论文
, 2020, 卷号: 367, 期号: 6484
作者:
Liu J.
;
Kim Y.S.
;
Richardson C.E.
;
Tom A.
;
Ramakrishnan C.
;
Birey F.
;
Katsumata T.
;
Chen S.
;
Wang C.
;
Wang X.
;
Joubert L.-M.
;
Jiang Y.
;
Wang H.
;
Fenno L.E.
;
Tok J.B.-H.
;
Paşca S.P.
;
Shen K.
;
Bao Z.
;
Deisseroth K.
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2020/07/28
poly(3,4 ethylenedioxythiophene)
polyaniline
polymer
unclassified drug
3-nitro-o-phenylenediamine
aniline
aniline derivative
ascorbate peroxidase
nitro derivative
phenylenediamine derivative
polymer
anatomy
genetic engineering
membrane
physiological response
polymer
animal cell
Article
biocompatibility
brain nerve cell
brain slice
Caenorhabditis elegans
cell membrane
cell viability
controlled study
genetic procedures
genetically targeted chemical assemby
hippocampal neuronal culture
human
human cell
in vivo study
nerve cell membrane
nonhuman
polymerization
priority journal
rat
synthesis
action potential
animal
cell culture
cell survival
chemistry
electric conductivity
enzymology
genetic engineering
genetic transduction
genetics
HEK293 cell line
hippocampus
membrane potential
metabolism
motoneuron
mouse
muscle cell
nerve cell
patch clamp technique
physiology
Animalia
Action Potentials
Aniline Compounds
Animals
Ascorbate Peroxidases
Caenorhabditis elegans
Cell Membrane
Cell Survival
Cells, Cultured
Electric Conductivity
Genetic Engineering
HEK293 Cells
Hippocampus
Humans
Membrane Potentials
Mice
Motor Neurons
Muscle Cells
Neurons
Nitro Compounds
Patch-Clamp Techniques
Phenylenediamines
Polymers
Rats
Transduction, Genetic