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文献类型
期刊论文 [70]
发表日期
2020 [70]
语种
英语 [70]
来源机构
Science [70]
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Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations
期刊论文
, 2020, 卷号: 367, 期号: 6478
作者:
Wilmes S.
;
Hafer M.
;
Vuorio J.
;
Tucker J.A.
;
Winkelmann H.
;
Löchte S.
;
Stanly T.A.
;
Pulgar Prieto K.D.
;
Poojari C.
;
Sharma V.
;
Richter C.P.
;
Kurre R.
;
Hubbard S.R.
;
Christopher Garcia K.
;
Moraga I.
;
Vattulainen I.
;
Hitchcock I.S.
;
Piehler J.
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2020/07/28
cytokine receptor
homodimer
Janus kinase 2
ligand
oncoprotein
cancer
enzyme
enzyme activity
membrane
molecular analysis
mutation
protein
activation analysis
Article
cell membrane
computer model
controlled study
dimerization
fluorescence microscopy
gene mutation
HeLa cell line
molecular dynamics
mutant
oncogene
priority journal
protein domain
protein interaction
quantitative analysis
signal transduction
Temporal integration of mitogen history in mother cells controls proliferation of daughter cells
期刊论文
, 2020, 卷号: 368, 期号: 6496
作者:
Min M.
;
Rong Y.
;
Tian C.
;
Spencer S.L.
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2020/07/28
cyclin D
mitogen activated protein kinase kinase
mitogenic agent
cell cycle G1 phase
cell cycle G2 phase
cell proliferation
genetics
human
metabolism
physiology
protein synthesis
signal transduction
stem cell
Cell Proliferation
Cyclin D
G1 Phase
G2 Phase
Humans
Mitogen-Activated Protein Kinase Kinases
Mitogens
Protein Biosynthesis
Signal Transduction
Stem Cells
Structure of the RNA-dependent RNA polymerase from COVID-19 virus
期刊论文
, 2020, 卷号: 368, 期号: 6492
作者:
Gao Y.
;
Yan L.
;
Huang Y.
;
Liu F.
;
Zhao Y.
;
Cao L.
;
Wang T.
;
Sun Q.
;
Ming Z.
;
Zhang L.
;
Ge J.
;
Zheng L.
;
Zhang Y.
;
Wang H.
;
Zhu Y.
;
Zhu C.
;
Hu T.
;
Hua T.
;
Zhang B.
;
Yang X.
;
Li J.
;
Yang H.
;
Liu Z.
;
Xu W.
;
Guddat L.W.
;
Wang Q.
;
Lou Z.
;
Rao Z.
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2020/07/28
comparative study
drug
electron microscopy
enzyme
enzyme activity
RNA
virus
Coronavirus
SARS coronavirus
adenosine phosphate
alanine
antivirus agent
NSP7 protein, SARS-CoV-2
NSP8 protein, SARS-CoV-2
remdesivir
RNA directed RNA polymerase
RNA-dependent RNA polymerase, coronavirus
viral protein
beta sheet
Betacoronavirus
chemistry
cryoelectron microscopy
drug design
enzyme active site
enzymology
metabolism
molecular model
protein domain
ultrastructure
Adenosine Monophosphate
Alanine
Antiviral Agents
Betacoronavirus
Catalytic Domain
Cryoelectron Microscopy
Drug Design
Models, Molecular
Protein Conformation, beta-Strand
Protein Domains
RNA Replicase
Viral Nonstructural Proteins
Elesclomol alleviates Menkes pathology and mortality by escorting Cu to cuproenzymes in mice
期刊论文
, 2020, 卷号: 368, 期号: 6491
作者:
Guthrie L.M.
;
Soma S.
;
Yuan S.
;
Silva A.
;
Zulkifli M.
;
Snavely T.C.
;
Greene H.F.
;
Nunez E.
;
Lynch B.
;
de Ville C.
;
Shanbhag V.
;
Lopez F.R.
;
Acharya A.
;
Petris M.J.
;
Kim B.-E.
;
Gohil V.M.
;
Sacchettini J.C.
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2020/07/28
copper
copper zinc superoxide dismutase
cytochrome c oxidase
dopamine beta monooxygenase
elesclomol
monophenol monooxygenase
protein lysine 6 oxidase
copper
cytochrome c oxidase
elesclomol
hydrazine derivative
copper
cytochrome
enzyme
enzyme activity
mitochondrion
mortality
mutation
pathology
rodent
survival
animal cell
animal experiment
animal model
animal tissue
Article
cohort analysis
controlled study
disease severity
drug mechanism
Golgi complex
H9c2(2-1) cell line
in vivo study
male
Menkes syndrome
mitochondrial dynamics
mortality rate
mouse
nerve degeneration
nonhuman
priority journal
secretory pathway
survival rate
animal
brain
cell line
degenerative disease
disease model
drug effect
genetics
knockout mouse
Menkes syndrome
metabolism
mitochondrion
pathology
rat
transport at the cellular level
Murinae
Mus
Animals
Biological Transport
Brain
Cell Line
Copper
Copper Transporter 1
Disease Models, Animal
Electron Transport Complex IV
Hydrazines
Male
Menkes Kinky Hair Syndrome
Mice
Mice, Knockout
Mitochondria
Neurodegenerative Diseases
Rats
Effective containment explains subexponential growth in recent confirmed COVID-19 cases in China
期刊论文
, 2020, 卷号: 368, 期号: 6492
作者:
Maier B.F.
;
Brockmann D.
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2020/07/28
disease control
disease prevalence
epidemic
health geography
public health
quarantine
symptom
viral disease
China
Coronavirus
basic reproduction number
behavior
Betacoronavirus
China
communicable disease control
contact examination
Coronavirus infection
disease predisposition
epidemic
human
pandemic
quarantine
statistical model
virus pneumonia
Basic Reproduction Number
Behavior
Betacoronavirus
China
Communicable Disease Control
Contact Tracing
Coronavirus Infections
Disease Outbreaks
Disease Susceptibility
Humans
Models, Statistical
Pandemics
Pneumonia, Viral
Quarantine
Demographic trade-offs predict tropical forest dynamics
期刊论文
, 2020, 卷号: 368, 期号: 6487
作者:
Rüger N.
;
Condit R.
;
Dent D.H.
;
DeWalt S.J.
;
Hubbell S.P.
;
Lichstein J.W.
;
Lopez O.R.
;
Wirth C.
;
Farrior C.E.
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2020/07/28
basal area
demography
forest dynamics
forestry modeling
Neotropic Ecozone
prediction
succession
trade-off
tropical forest
article
body height
controlled study
demography
human
human impact (environment)
Neotropics
tropical rain forest
Transcription polymerase-catalyzed emergence of novel RNA replicons
期刊论文
, 2020, 卷号: 368, 期号: 6487
作者:
Jain N.
;
Blauch L.R.
;
Szymanski M.R.
;
Das R.
;
Tang S.K.Y.
;
Yin Y.W.
;
Fire A.Z.
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2020/07/28
cell component
enzyme
enzyme activity
genetic analysis
RNA
article
bacteriophage
catalysis
DNA replication origin
heredity
in vitro study
nonhuman
plant seed
replicon
RNA replication
synthesis
transcription initiation
biocatalysis
biosynthesis
genetic transcription
metabolism
Animalia
Hepatitis delta virus
Viroids
bacteriophage T7 RNA polymerase
DNA directed RNA polymerase
RNA
viral protein
Biocatalysis
DNA-Directed RNA Polymerases
Replicon
RNA
Transcription, Genetic
Viral Proteins
A neurodevelopmental origin of behavioral individuality in the Drosophila visual system
期刊论文
, 2020, 卷号: 367, 期号: 6482
作者:
Linneweber G.A.
;
Andriatsilavo M.
;
Dutta S.B.
;
Bengochea M.
;
Hellbruegge L.
;
Liu G.
;
Ejsmont R.K.
;
Straw A.D.
;
Wernet M.
;
Hiesinger P.R.
;
Hassan B.A.
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2020/07/28
anatomy
asymmetry
brain
genome
neurology
orientation
visual analysis
article
brain
Drosophila melanogaster
human experiment
individuality
nerve cell
nonhuman
stochastic model
visual system
walking
anatomy and histology
animal
Drosophila melanogaster
genetic variation
genetics
growth, development and aging
nervous system development
orientation
physiology
visual field
visual system
Drosophila melanogaster
Animals
Brain
Drosophila melanogaster
Genetic Variation
Individuality
Neurogenesis
Orientation
Visual Fields
Visual Pathways
The pan-genome effector-triggered immunity landscape of a host-pathogen interaction
期刊论文
, 2020, 卷号: 367, 期号: 6479
作者:
Laflamme B.
;
Dillon M.M.
;
Martel A.
;
Almeida R.N.D.
;
Desveaux D.
;
Guttman D.S.
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2020/07/28
genome
herb
host-pathogen interaction
immunity
microbial ecology
protein
virulence
allele
Arabidopsis thaliana
article
host pathogen interaction
immunity
major clinical study
nonhuman
orthology
Pseudomonas syringae
Arabidopsis thaliana
Pseudomonas syringae
On impact and volcanism across the Cretaceous-Paleogene boundary
期刊论文
, 2020, 卷号: 367, 期号: 6475
作者:
Hull P.M.
;
Bornemann A.
;
Penman D.E.
;
Henehan M.J.
;
Norris R.D.
;
Wilson P.A.
;
Blum P.
;
Alegret L.
;
Batenburg S.J.
;
Bown P.R.
;
Bralower T.J.
;
Cournede C.
;
Deutsch A.
;
Donner B.
;
Friedrich O.
;
Jehle S.
;
Kim H.
;
Kroon D.
;
Lippert P.C.
;
Loroch D.
;
Moebius I.
;
Moriya K.
;
Peppe D.J.
;
Ravizza G.E.
;
Röhl U.
;
Schueth J.D.
;
Sepúlveda J.
;
Sexton P.F.
;
Sibert E.C.
;
Śliwińska K.K.
;
Summons R.E.
;
Thomas E.
;
Westerhold T.
;
Whiteside J.H.
;
Yamaguchi T.
;
Zachos J.C.
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2020/07/28
carbon dioxide
carbon dioxide
carbon cycle
carbon dioxide
Cretaceous-Paleogene boundary
flood basalt
global warming
mass extinction
paleotemperature
volcanism
Article
astronomy
basalt
bolide
boundary layer
carbon cycle
confusion (uncertainty)
cosmological phenomena
end Cretaceous mass extinction
environmental impact
environmental temperature
greenhouse effect
paleoenvironment
Paleogene
priority journal
sea
volcanic outgassing
volcanism
carbon cycle
Mexico
species extinction
theoretical model
volcano
Carbon Cycle
Carbon Dioxide
Extinction, Biological
Global Warming
Mexico
Models, Theoretical
Volcanic Eruptions