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Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations 期刊论文
, 2020, 卷号: 367, 期号: 6478
作者:  Wilmes S.;  Hafer M.;  Vuorio J.;  Tucker J.A.;  Winkelmann H.;  Löchte S.;  Stanly T.A.;  Pulgar Prieto K.D.;  Poojari C.;  Sharma V.;  Richter C.P.;  Kurre R.;  Hubbard S.R.;  Christopher Garcia K.;  Moraga I.;  Vattulainen I.;  Hitchcock I.S.;  Piehler J.
收藏  |  浏览/下载:35/0  |  提交时间:2020/07/28
cytokine receptor  homodimer  Janus kinase 2  ligand  oncoprotein  cancer  enzyme  enzyme activity  membrane  molecular analysis  mutation  protein  activation analysis  Article  cell membrane  computer model  controlled study  dimerization  fluorescence microscopy  gene mutation  HeLa cell line  molecular dynamics  mutant  oncogene  priority journal  protein domain  protein interaction  quantitative analysis  signal transduction  
Temporal integration of mitogen history in mother cells controls proliferation of daughter cells 期刊论文
, 2020, 卷号: 368, 期号: 6496
作者:  Min M.;  Rong Y.;  Tian C.;  Spencer S.L.
收藏  |  浏览/下载:22/0  |  提交时间:2020/07/28
cyclin D  mitogen activated protein kinase kinase  mitogenic agent  cell cycle G1 phase  cell cycle G2 phase  cell proliferation  genetics  human  metabolism  physiology  protein synthesis  signal transduction  stem cell  Cell Proliferation  Cyclin D  G1 Phase  G2 Phase  Humans  Mitogen-Activated Protein Kinase Kinases  Mitogens  Protein Biosynthesis  Signal Transduction  Stem Cells  
Structure of the RNA-dependent RNA polymerase from COVID-19 virus 期刊论文
, 2020, 卷号: 368, 期号: 6492
作者:  Gao Y.;  Yan L.;  Huang Y.;  Liu F.;  Zhao Y.;  Cao L.;  Wang T.;  Sun Q.;  Ming Z.;  Zhang L.;  Ge J.;  Zheng L.;  Zhang Y.;  Wang H.;  Zhu Y.;  Zhu C.;  Hu T.;  Hua T.;  Zhang B.;  Yang X.;  Li J.;  Yang H.;  Liu Z.;  Xu W.;  Guddat L.W.;  Wang Q.;  Lou Z.;  Rao Z.
收藏  |  浏览/下载:40/0  |  提交时间:2020/07/28
comparative study  drug  electron microscopy  enzyme  enzyme activity  RNA  virus  Coronavirus  SARS coronavirus  adenosine phosphate  alanine  antivirus agent  NSP7 protein, SARS-CoV-2  NSP8 protein, SARS-CoV-2  remdesivir  RNA directed RNA polymerase  RNA-dependent RNA polymerase, coronavirus  viral protein  beta sheet  Betacoronavirus  chemistry  cryoelectron microscopy  drug design  enzyme active site  enzymology  metabolism  molecular model  protein domain  ultrastructure  Adenosine Monophosphate  Alanine  Antiviral Agents  Betacoronavirus  Catalytic Domain  Cryoelectron Microscopy  Drug Design  Models, Molecular  Protein Conformation, beta-Strand  Protein Domains  RNA Replicase  Viral Nonstructural Proteins  
Elesclomol alleviates Menkes pathology and mortality by escorting Cu to cuproenzymes in mice 期刊论文
, 2020, 卷号: 368, 期号: 6491
作者:  Guthrie L.M.;  Soma S.;  Yuan S.;  Silva A.;  Zulkifli M.;  Snavely T.C.;  Greene H.F.;  Nunez E.;  Lynch B.;  de Ville C.;  Shanbhag V.;  Lopez F.R.;  Acharya A.;  Petris M.J.;  Kim B.-E.;  Gohil V.M.;  Sacchettini J.C.
收藏  |  浏览/下载:28/0  |  提交时间:2020/07/28
copper  copper zinc superoxide dismutase  cytochrome c oxidase  dopamine beta monooxygenase  elesclomol  monophenol monooxygenase  protein lysine 6 oxidase  copper  cytochrome c oxidase  elesclomol  hydrazine derivative  copper  cytochrome  enzyme  enzyme activity  mitochondrion  mortality  mutation  pathology  rodent  survival  animal cell  animal experiment  animal model  animal tissue  Article  cohort analysis  controlled study  disease severity  drug mechanism  Golgi complex  H9c2(2-1) cell line  in vivo study  male  Menkes syndrome  mitochondrial dynamics  mortality rate  mouse  nerve degeneration  nonhuman  priority journal  secretory pathway  survival rate  animal  brain  cell line  degenerative disease  disease model  drug effect  genetics  knockout mouse  Menkes syndrome  metabolism  mitochondrion  pathology  rat  transport at the cellular level  Murinae  Mus  Animals  Biological Transport  Brain  Cell Line  Copper  Copper Transporter 1  Disease Models, Animal  Electron Transport Complex IV  Hydrazines  Male  Menkes Kinky Hair Syndrome  Mice  Mice, Knockout  Mitochondria  Neurodegenerative Diseases  Rats  
Effective containment explains subexponential growth in recent confirmed COVID-19 cases in China 期刊论文
, 2020, 卷号: 368, 期号: 6492
作者:  Maier B.F.;  Brockmann D.
收藏  |  浏览/下载:11/0  |  提交时间:2020/07/28
disease control  disease prevalence  epidemic  health geography  public health  quarantine  symptom  viral disease  China  Coronavirus  basic reproduction number  behavior  Betacoronavirus  China  communicable disease control  contact examination  Coronavirus infection  disease predisposition  epidemic  human  pandemic  quarantine  statistical model  virus pneumonia  Basic Reproduction Number  Behavior  Betacoronavirus  China  Communicable Disease Control  Contact Tracing  Coronavirus Infections  Disease Outbreaks  Disease Susceptibility  Humans  Models, Statistical  Pandemics  Pneumonia, Viral  Quarantine  
Demographic trade-offs predict tropical forest dynamics 期刊论文
, 2020, 卷号: 368, 期号: 6487
作者:  Rüger N.;  Condit R.;  Dent D.H.;  DeWalt S.J.;  Hubbell S.P.;  Lichstein J.W.;  Lopez O.R.;  Wirth C.;  Farrior C.E.
收藏  |  浏览/下载:48/0  |  提交时间:2020/07/28
basal area  demography  forest dynamics  forestry modeling  Neotropic Ecozone  prediction  succession  trade-off  tropical forest  article  body height  controlled study  demography  human  human impact (environment)  Neotropics  tropical rain forest  
Transcription polymerase-catalyzed emergence of novel RNA replicons 期刊论文
, 2020, 卷号: 368, 期号: 6487
作者:  Jain N.;  Blauch L.R.;  Szymanski M.R.;  Das R.;  Tang S.K.Y.;  Yin Y.W.;  Fire A.Z.
收藏  |  浏览/下载:31/0  |  提交时间:2020/07/28
cell component  enzyme  enzyme activity  genetic analysis  RNA  article  bacteriophage  catalysis  DNA replication origin  heredity  in vitro study  nonhuman  plant seed  replicon  RNA replication  synthesis  transcription initiation  biocatalysis  biosynthesis  genetic transcription  metabolism  Animalia  Hepatitis delta virus  Viroids  bacteriophage T7 RNA polymerase  DNA directed RNA polymerase  RNA  viral protein  Biocatalysis  DNA-Directed RNA Polymerases  Replicon  RNA  Transcription, Genetic  Viral Proteins  
A neurodevelopmental origin of behavioral individuality in the Drosophila visual system 期刊论文
, 2020, 卷号: 367, 期号: 6482
作者:  Linneweber G.A.;  Andriatsilavo M.;  Dutta S.B.;  Bengochea M.;  Hellbruegge L.;  Liu G.;  Ejsmont R.K.;  Straw A.D.;  Wernet M.;  Hiesinger P.R.;  Hassan B.A.
收藏  |  浏览/下载:31/0  |  提交时间:2020/07/28
anatomy  asymmetry  brain  genome  neurology  orientation  visual analysis  article  brain  Drosophila melanogaster  human experiment  individuality  nerve cell  nonhuman  stochastic model  visual system  walking  anatomy and histology  animal  Drosophila melanogaster  genetic variation  genetics  growth, development and aging  nervous system development  orientation  physiology  visual field  visual system  Drosophila melanogaster  Animals  Brain  Drosophila melanogaster  Genetic Variation  Individuality  Neurogenesis  Orientation  Visual Fields  Visual Pathways  
The pan-genome effector-triggered immunity landscape of a host-pathogen interaction 期刊论文
, 2020, 卷号: 367, 期号: 6479
作者:  Laflamme B.;  Dillon M.M.;  Martel A.;  Almeida R.N.D.;  Desveaux D.;  Guttman D.S.
收藏  |  浏览/下载:22/0  |  提交时间:2020/07/28
genome  herb  host-pathogen interaction  immunity  microbial ecology  protein  virulence  allele  Arabidopsis thaliana  article  host pathogen interaction  immunity  major clinical study  nonhuman  orthology  Pseudomonas syringae  Arabidopsis thaliana  Pseudomonas syringae  
On impact and volcanism across the Cretaceous-Paleogene boundary 期刊论文
, 2020, 卷号: 367, 期号: 6475
作者:  Hull P.M.;  Bornemann A.;  Penman D.E.;  Henehan M.J.;  Norris R.D.;  Wilson P.A.;  Blum P.;  Alegret L.;  Batenburg S.J.;  Bown P.R.;  Bralower T.J.;  Cournede C.;  Deutsch A.;  Donner B.;  Friedrich O.;  Jehle S.;  Kim H.;  Kroon D.;  Lippert P.C.;  Loroch D.;  Moebius I.;  Moriya K.;  Peppe D.J.;  Ravizza G.E.;  Röhl U.;  Schueth J.D.;  Sepúlveda J.;  Sexton P.F.;  Sibert E.C.;  Śliwińska K.K.;  Summons R.E.;  Thomas E.;  Westerhold T.;  Whiteside J.H.;  Yamaguchi T.;  Zachos J.C.
收藏  |  浏览/下载:38/0  |  提交时间:2020/07/28
carbon dioxide  carbon dioxide  carbon cycle  carbon dioxide  Cretaceous-Paleogene boundary  flood basalt  global warming  mass extinction  paleotemperature  volcanism  Article  astronomy  basalt  bolide  boundary layer  carbon cycle  confusion (uncertainty)  cosmological phenomena  end Cretaceous mass extinction  environmental impact  environmental temperature  greenhouse effect  paleoenvironment  Paleogene  priority journal  sea  volcanic outgassing  volcanism  carbon cycle  Mexico  species extinction  theoretical model  volcano  Carbon Cycle  Carbon Dioxide  Extinction, Biological  Global Warming  Mexico  Models, Theoretical  Volcanic Eruptions