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| CFLIPL protects macrophages from LPS-induced pyroptosis via inhibition of complex II formation 期刊论文
, 2020, 卷号: 367, 期号: 6484
作者: Muendlein H.I.; Jetton D.; Connolly W.M.; Eidell K.P.; Magri Z.; Smirnova I.; Poltorak A.
  收藏 | 浏览/下载：48/0 | 提交时间：2020/07/28
FLICE inhibitory protein interleukin 1beta lipopolysaccharide messenger RNA succinate dehydrogenase (ubiquinone) Casp1 protein, mouse caspase 8 Cflar protein, mouse cryopyrin FLICE inhibitory protein IL1B protein, mouse inflammasome interleukin 1beta interleukin 1beta converting enzyme lipopolysaccharide succinate dehydrogenase (ubiquinone) cell enzyme activity inhibition maturation protein animal cell animal experiment Article bone marrow derived macrophage cell death cell protection complex formation controlled study cytokine release in vitro study inflammation mouse nonhuman priority journal protein analysis protein degradation protein function protein interaction pyroptosis animal gene knockdown genetics immunology macrophage macrophage activation metabolism physiology Murinae Animals CASP8 and FADD-Like Apoptosis Regulating Protein Caspase 1 Caspase 8 Electron Transport Complex II Gene Knockdown Techniques Inflammasomes Interleukin-1beta Lipopolysaccharides Macrophage Activation Macrophages Mice NLR Family, Pyrin Domain-Containing 3 Protein Pyroptosis |
| Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations 期刊论文
, 2020, 卷号: 367, 期号: 6478
作者: Wilmes S.; Hafer M.; Vuorio J.; Tucker J.A.; Winkelmann H.; Löchte S.; Stanly T.A.; Pulgar Prieto K.D.; Poojari C.; Sharma V.; Richter C.P.; Kurre R.; Hubbard S.R.; Christopher Garcia K.; Moraga I.; Vattulainen I.; Hitchcock I.S.; Piehler J.
收藏 | 浏览/下载：47/0 | 提交时间：2020/07/28
cytokine receptor homodimer Janus kinase 2 ligand oncoprotein cancer enzyme enzyme activity membrane molecular analysis mutation protein activation analysis Article cell membrane computer model controlled study dimerization fluorescence microscopy gene mutation HeLa cell line molecular dynamics mutant oncogene priority journal protein domain protein interaction quantitative analysis signal transduction |
| Human CNS barrier-forming organoids with cerebrospinal fluid production 期刊论文
, 2020, 卷号: 369, 期号: 6500
作者: Pellegrini L.; Bonfio C.; Chadwick J.; Begum F.; Skehel M.; Lancaster M.A.
收藏 | 浏览/下载：39/0 | 提交时间：2020/07/28
blood brain barrier cell culture technique cerebrospinal fluid choroid plexus gene expression profiling human metabolism organoid physiology protein cerebrospinal fluid level proteomics single cell analysis Blood-Brain Barrier Cell Culture Techniques Cerebrospinal Fluid Cerebrospinal Fluid Proteins Choroid Plexus Gene Expression Profiling Humans Organoids Proteomics Single-Cell Analysis |
| Elesclomol alleviates Menkes pathology and mortality by escorting Cu to cuproenzymes in mice 期刊论文
, 2020, 卷号: 368, 期号: 6491
作者: Guthrie L.M.; Soma S.; Yuan S.; Silva A.; Zulkifli M.; Snavely T.C.; Greene H.F.; Nunez E.; Lynch B.; de Ville C.; Shanbhag V.; Lopez F.R.; Acharya A.; Petris M.J.; Kim B.-E.; Gohil V.M.; Sacchettini J.C.
收藏 | 浏览/下载：36/0 | 提交时间：2020/07/28
copper copper zinc superoxide dismutase cytochrome c oxidase dopamine beta monooxygenase elesclomol monophenol monooxygenase protein lysine 6 oxidase copper cytochrome c oxidase elesclomol hydrazine derivative copper cytochrome enzyme enzyme activity mitochondrion mortality mutation pathology rodent survival animal cell animal experiment animal model animal tissue Article cohort analysis controlled study disease severity drug mechanism Golgi complex H9c2(2-1) cell line in vivo study male Menkes syndrome mitochondrial dynamics mortality rate mouse nerve degeneration nonhuman priority journal secretory pathway survival rate animal brain cell line degenerative disease disease model drug effect genetics knockout mouse Menkes syndrome metabolism mitochondrion pathology rat transport at the cellular level Murinae Mus Animals Biological Transport Brain Cell Line Copper Copper Transporter 1 Disease Models, Animal Electron Transport Complex IV Hydrazines Male Menkes Kinky Hair Syndrome Mice Mice, Knockout Mitochondria Neurodegenerative Diseases Rats |
| Transcription polymerase-catalyzed emergence of novel RNA replicons 期刊论文
, 2020, 卷号: 368, 期号: 6487
作者: Jain N.; Blauch L.R.; Szymanski M.R.; Das R.; Tang S.K.Y.; Yin Y.W.; Fire A.Z.
收藏 | 浏览/下载：38/0 | 提交时间：2020/07/28
cell component enzyme enzyme activity genetic analysis RNA article bacteriophage catalysis DNA replication origin heredity in vitro study nonhuman plant seed replicon RNA replication synthesis transcription initiation biocatalysis biosynthesis genetic transcription metabolism Animalia Hepatitis delta virus Viroids bacteriophage T7 RNA polymerase DNA directed RNA polymerase RNA viral protein Biocatalysis DNA-Directed RNA Polymerases Replicon RNA Transcription, Genetic Viral Proteins |
| Widespread receptor-driven modulation in peripheral olfactory coding 期刊论文
, 2020, 卷号: 368, 期号: 6487
作者: Xu L.; Li W.; Voleti V.; Zou D.-J.; Hillman E.M.C.; Firestein S.
收藏 | 浏览/下载：34/0 | 提交时间：2020/07/28
antagonism cell component detection method odor olfaction protein animal cell animal experiment article excitation high throughput analysis male microscopy mouse nonhuman odor olfactory epithelium olfactory receptor neuron animal confocal microscopy innervation mutant mouse strain olfactory mucosa physiology single cell analysis acetophenone acetophenone derivative benzyl acetate benzyl derivative citral fragrance Acetophenones Acyclic Monoterpenes Animals Benzyl Compounds Mice Mice, Mutant Strains Microscopy, Confocal Odorants Olfactory Mucosa Olfactory Receptor Neurons Single-Cell Analysis Smell |
| Microenvironment mapping via Dexter energy transfer on immune cells 期刊论文
, 2020, 卷号: 367, 期号: 6482
作者: Geri J.B.; Oakley J.V.; Reyes-Robles T.; Wang T.; McCarver S.J.; White C.H.; Rodriguez-Rivera F.P.; Parker D.L.; Hett E.C.; Fadeyi O.O.; Oslund R.C.; MacMillan D.W.C.
收藏 | 浏览/下载：39/0 | 提交时间：2020/07/28
antibody conjugate carbene programmed death 1 ligand 1 methane programmed death 1 ligand 1 antibody catalysis catalyst cell component detection method enzyme enzyme activity protein antigen binding Article cell membrane energy transfer human immunocompetent cell immunological synapse lymphocyte photocatalysis priority journal protein analysis protein protein interaction tumor microenvironment catalysis chemistry energy transfer Jurkat cell line metabolism photochemistry procedures radiation response ultraviolet radiation B7-H1 Antigen Catalysis Cell Membrane Cellular Microenvironment Energy Transfer Humans Jurkat Cells Lymphocytes Methane Photochemical Processes Protein Interaction Mapping Protein Interaction Maps Ultraviolet Rays |
| The evolving redox chemistry and bioavailability of vanadium in deep time 期刊论文
, 2020, 卷号: 18, 期号: 2
作者: Moore E.K.; Hao J.; Spielman S.J.; Yee N.
收藏 | 浏览/下载：25/0 | 提交时间：2020/07/28
alkali metal alkaline earth metal bioactivity enzyme enzyme activity inhibitor metabolism microbial activity network analysis phosphate protein redox conditions reduction speciation (chemistry) vanadium |
| The Ccr4-Not complex monitors the translating ribosome for codon optimality 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者: Buschauer R.; Matsuo Y.; Sugiyama T.; Chen Y.-H.; Alhusaini N.; Sweet T.; Ikeuchi K.; Cheng J.; Matsuki Y.; Nobuta R.; Gilmozzi A.; Berninghausen O.; Tesina P.; Becker T.; Coller J.; Inada T.; Beckmann R.
收藏 | 浏览/下载：45/0 | 提交时间：2020/07/28
exonuclease initiation factor 5A messenger RNA ribosome RNA transfer RNA ubiquitin protein ligase E3 bioassay biomonitoring cell component plant and fungus structure and form 40S ribosomal subunit adenylation amino terminal sequence Article binding site biochemical analysis carbon catabolite repressor 4 negative on tata complex codon complex formation controlled study cryoelectron microscopy homeostasis molecular interaction nonhuman priority journal protein conformation ribosome Saccharomyces cerevisiae sequence analysis ubiquitination Saccharomyces cerevisiae |
| Metabolomics and mass spectrometry imaging reveal channeled de novo purine synthesis in cells 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者: Pareek V.; Tian H.; Winograd N.; Benkovic S.J.
收藏 | 浏览/下载：35/0 | 提交时间：2020/07/28
adenosine phosphate guanosine phosphate multienzyme complex nucleotide purine purine purine derivative cell experimental study imaging method mass spectrometry metabolism protein Article biochemistry enzyme assay gas cluster ion beam secondary ion mass spectrometry image analysis mass spectrometry metabolomics mitochondrion molecular imaging molecular probe priority journal purine synthesis reaction analysis single cell analysis biosynthesis fluorescence imaging HeLa cell line human metabolism metabolomics procedures secondary ion mass spectrometry HeLa Cells Humans Metabolomics Mitochondria Multienzyme Complexes Optical Imaging Purines Single-Cell Analysis Spectrometry, Mass, Secondary Ion |
