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BSC2 induces multidrug resistance via contributing to the formation of biofilm in Saccharomyces cerevisiae
期刊论文
CELLULAR MICROBIOLOGY, 2021, 卷号: 23, 期号: 12
作者:
Huang, Zhiwei
;
Dai, Hongsheng
;
Zhang, Xiaoyu
;
Wang, Qiao
;
Sun, Jing
;
Deng, Yunxia
;
Shi, Ping
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2022/04/28
CELL-WALL
DRUG-RESISTANCE
CANDIDA-ALBICANS
YEAST
PROTEIN
GENES
GLYCOSYLATION
MANNOSYLATION
FLOCCULATION
EXPRESSION
CFLIPL protects macrophages from LPS-induced pyroptosis via inhibition of complex II formation
期刊论文
, 2020, 卷号: 367, 期号: 6484
作者:
Muendlein H.I.
;
Jetton D.
;
Connolly W.M.
;
Eidell K.P.
;
Magri Z.
;
Smirnova I.
;
Poltorak A.
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2020/07/28
FLICE inhibitory protein
interleukin 1beta
lipopolysaccharide
messenger RNA
succinate dehydrogenase (ubiquinone)
Casp1 protein, mouse
caspase 8
Cflar protein, mouse
cryopyrin
FLICE inhibitory protein
IL1B protein, mouse
inflammasome
interleukin 1beta
interleukin 1beta converting enzyme
lipopolysaccharide
succinate dehydrogenase (ubiquinone)
cell
enzyme activity
inhibition
maturation
protein
animal cell
animal experiment
Article
bone marrow derived macrophage
cell death
cell protection
complex formation
controlled study
cytokine release
in vitro study
inflammation
mouse
nonhuman
priority journal
protein analysis
protein degradation
protein function
protein interaction
pyroptosis
animal
gene knockdown
genetics
immunology
macrophage
macrophage activation
metabolism
physiology
Murinae
Animals
CASP8 and FADD-Like Apoptosis Regulating Protein
Caspase 1
Caspase 8
Electron Transport Complex II
Gene Knockdown Techniques
Inflammasomes
Interleukin-1beta
Lipopolysaccharides
Macrophage Activation
Macrophages
Mice
NLR Family, Pyrin Domain-Containing 3 Protein
Pyroptosis
Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations
期刊论文
, 2020, 卷号: 367, 期号: 6478
作者:
Wilmes S.
;
Hafer M.
;
Vuorio J.
;
Tucker J.A.
;
Winkelmann H.
;
Löchte S.
;
Stanly T.A.
;
Pulgar Prieto K.D.
;
Poojari C.
;
Sharma V.
;
Richter C.P.
;
Kurre R.
;
Hubbard S.R.
;
Christopher Garcia K.
;
Moraga I.
;
Vattulainen I.
;
Hitchcock I.S.
;
Piehler J.
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2020/07/28
cytokine receptor
homodimer
Janus kinase 2
ligand
oncoprotein
cancer
enzyme
enzyme activity
membrane
molecular analysis
mutation
protein
activation analysis
Article
cell membrane
computer model
controlled study
dimerization
fluorescence microscopy
gene mutation
HeLa cell line
molecular dynamics
mutant
oncogene
priority journal
protein domain
protein interaction
quantitative analysis
signal transduction
Structure and selectivity engineering of the M1 muscarinic receptor toxin complex
期刊论文
, 2020, 卷号: 369, 期号: 6500
作者:
Maeda S.
;
Xu J.
;
N Kadji F.M.
;
Clark M.J.
;
Zhao J.
;
Tsutsumi N.
;
Aoki J.
;
Sunahara R.K.
;
Inoue A.
;
Garcia K.C.
;
Kobilka B.K.
收藏
  |  
浏览/下载:54/0
  |  
提交时间:2020/07/28
atropine
m1-toxin
muscarinic M1 receptor
muscarinic receptor blocking agent
snake venom
animal
chemistry
genetic engineering
genetics
protein conformation
Sf9 cell line
X ray crystallography
Animals
Atropine
Crystallography, X-Ray
Elapid Venoms
Genetic Engineering
Muscarinic Antagonists
Protein Conformation
Receptor, Muscarinic M1
Sf9 Cells
Human CNS barrier-forming organoids with cerebrospinal fluid production
期刊论文
, 2020, 卷号: 369, 期号: 6500
作者:
Pellegrini L.
;
Bonfio C.
;
Chadwick J.
;
Begum F.
;
Skehel M.
;
Lancaster M.A.
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2020/07/28
blood brain barrier
cell culture technique
cerebrospinal fluid
choroid plexus
gene expression profiling
human
metabolism
organoid
physiology
protein cerebrospinal fluid level
proteomics
single cell analysis
Blood-Brain Barrier
Cell Culture Techniques
Cerebrospinal Fluid
Cerebrospinal Fluid Proteins
Choroid Plexus
Gene Expression Profiling
Humans
Organoids
Proteomics
Single-Cell Analysis
Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease
期刊论文
, 2020, 卷号: 368, 期号: 6497
作者:
Dai W.
;
Zhang B.
;
Jiang X.-M.
;
Su H.
;
Li J.
;
Zhao Y.
;
Xie X.
;
Jin Z.
;
Peng J.
;
Liu F.
;
Li C.
;
Li Y.
;
Bai F.
;
Wang H.
;
Cheng X.
;
Cen X.
;
Hu S.
;
Yang X.
;
Wang J.
;
Liu X.
;
Xiao G.
;
Jiang H.
;
Rao Z.
;
Zhang L.-K.
;
Xu Y.
;
Yang H.
;
Liu H.
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2020/07/28
aldehyde
antimicrobial activity
drug
enzyme activity
infectivity
inhibitor
reaction kinetics
viral disease
Coronavirus
SARS coronavirus
3C-like proteinase, Coronavirus
antivirus agent
cysteine proteinase
viral protein
animal
Betacoronavirus
chemical structure
chemistry
Chlorocebus aethiops
Coronavirus infection
dog
drug design
drug effect
enzyme active site
enzymology
female
human
male
mouse
pandemic
preclinical study
protein tertiary structure
Sprague Dawley rat
toxicity testing
Vero cell line
virus pneumonia
Animals
Antiviral Agents
Betacoronavirus
Catalytic Domain
Chlorocebus aethiops
Coronavirus Infections
Cysteine Endopeptidases
Dogs
Drug Design
Drug Evaluation, Preclinical
Female
Humans
Male
Mice
Molecular Structure
Pandemics
Pneumonia, Viral
Protein Structure, Tertiary
Rats, Sprague-Dawley
Toxicity Tests
Vero Cells
Viral Nonstructural Proteins
Membrane-proximal F-actin restricts local membrane protrusions and directs cell migration
期刊论文
, 2020, 卷号: 368, 期号: 6496
作者:
Bisaria A.
;
Hayer A.
;
Garbett D.
;
Cohen D.
;
Meyer T.
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2020/07/28
cell component
concentration (composition)
membrane
polymerization
protein
actin
green fluorescent protein
cell membrane
cell motion
cell polarity
cell surface
chemistry
genetics
human
metabolism
umbilical vein endothelial cell
Actins
Cell Membrane
Cell Movement
Cell Polarity
Cell Surface Extensions
Green Fluorescent Proteins
Human Umbilical Vein Endothelial Cells
Humans
Temporal integration of mitogen history in mother cells controls proliferation of daughter cells
期刊论文
, 2020, 卷号: 368, 期号: 6496
作者:
Min M.
;
Rong Y.
;
Tian C.
;
Spencer S.L.
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2020/07/28
cyclin D
mitogen activated protein kinase kinase
mitogenic agent
cell cycle G1 phase
cell cycle G2 phase
cell proliferation
genetics
human
metabolism
physiology
protein synthesis
signal transduction
stem cell
Cell Proliferation
Cyclin D
G1 Phase
G2 Phase
Humans
Mitogen-Activated Protein Kinase Kinases
Mitogens
Protein Biosynthesis
Signal Transduction
Stem Cells
Computing cancer's weak spots
期刊论文
, 2020, 卷号: 368, 期号: 6496
作者:
Khamsi R.
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2020/07/28
ruxolitinib
STAT3 protein
antineoplastic agent
transcription factor
algorithm
cancer
computer simulation
disease treatment
drug development
medicine
Article
cancer cell
cancer radiotherapy
enzyme inhibition
gene activity
gene expression regulation
gene interaction
gene mutation
gene repression
gene targeting
human
laboratory test
malignant neoplasm
molecular dynamics
nonhuman
oncologist
priority journal
RNA sequencing
algorithm
genetics
mutation
neoplasm
personalized medicine
procedures
systems biology
Algorithms
Antineoplastic Agents
Humans
Mutation
Neoplasms
Precision Medicine
Systems Biology
Transcription Factors
Elesclomol alleviates Menkes pathology and mortality by escorting Cu to cuproenzymes in mice
期刊论文
, 2020, 卷号: 368, 期号: 6491
作者:
Guthrie L.M.
;
Soma S.
;
Yuan S.
;
Silva A.
;
Zulkifli M.
;
Snavely T.C.
;
Greene H.F.
;
Nunez E.
;
Lynch B.
;
de Ville C.
;
Shanbhag V.
;
Lopez F.R.
;
Acharya A.
;
Petris M.J.
;
Kim B.-E.
;
Gohil V.M.
;
Sacchettini J.C.
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2020/07/28
copper
copper zinc superoxide dismutase
cytochrome c oxidase
dopamine beta monooxygenase
elesclomol
monophenol monooxygenase
protein lysine 6 oxidase
copper
cytochrome c oxidase
elesclomol
hydrazine derivative
copper
cytochrome
enzyme
enzyme activity
mitochondrion
mortality
mutation
pathology
rodent
survival
animal cell
animal experiment
animal model
animal tissue
Article
cohort analysis
controlled study
disease severity
drug mechanism
Golgi complex
H9c2(2-1) cell line
in vivo study
male
Menkes syndrome
mitochondrial dynamics
mortality rate
mouse
nerve degeneration
nonhuman
priority journal
secretory pathway
survival rate
animal
brain
cell line
degenerative disease
disease model
drug effect
genetics
knockout mouse
Menkes syndrome
metabolism
mitochondrion
pathology
rat
transport at the cellular level
Murinae
Mus
Animals
Biological Transport
Brain
Cell Line
Copper
Copper Transporter 1
Disease Models, Animal
Electron Transport Complex IV
Hydrazines
Male
Menkes Kinky Hair Syndrome
Mice
Mice, Knockout
Mitochondria
Neurodegenerative Diseases
Rats