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Temporal integration of mitogen history in mother cells controls proliferation of daughter cells 期刊论文
, 2020, 卷号: 368, 期号: 6496
作者:  Min M.;  Rong Y.;  Tian C.;  Spencer S.L.
收藏  |  浏览/下载：29/0  |  提交时间：2020/07/28
cyclin D  mitogen activated protein kinase kinase  mitogenic agent  cell cycle G1 phase  cell cycle G2 phase  cell proliferation  genetics  human  metabolism  physiology  protein synthesis  signal transduction  stem cell  Cell Proliferation  Cyclin D  G1 Phase  G2 Phase  Humans  Mitogen-Activated Protein Kinase Kinases  Mitogens  Protein Biosynthesis  Signal Transduction  Stem Cells  
Transcription polymerase-catalyzed emergence of novel RNA replicons 期刊论文
, 2020, 卷号: 368, 期号: 6487
作者:  Jain N.;  Blauch L.R.;  Szymanski M.R.;  Das R.;  Tang S.K.Y.;  Yin Y.W.;  Fire A.Z.
收藏  |  浏览/下载：38/0  |  提交时间：2020/07/28
cell component  enzyme  enzyme activity  genetic analysis  RNA  article  bacteriophage  catalysis  DNA replication origin  heredity  in vitro study  nonhuman  plant seed  replicon  RNA replication  synthesis  transcription initiation  biocatalysis  biosynthesis  genetic transcription  metabolism  Animalia  Hepatitis delta virus  Viroids  bacteriophage T7 RNA polymerase  DNA directed RNA polymerase  RNA  viral protein  Biocatalysis  DNA-Directed RNA Polymerases  Replicon  RNA  Transcription, Genetic  Viral Proteins  
Pervasive functional translation of noncanonical human open reading frames 期刊论文
, 2020, 卷号: 367, 期号: 6482
作者:  Chen J.;  Brunner A.-D.;  Cogan J.Z.;  Nuñez J.K.;  Fields A.P.;  Adamson B.;  Itzhak D.N.;  Li J.Y.;  Mann M.;  Leonetti M.D.;  Weissman J.S.
收藏  |  浏览/下载：30/0  |  提交时间：2020/07/28
messenger RNA  peptide  transcriptome  CRISPR Cas system  genetics  human  metabolism  open reading frame  operon  protein synthesis  ribosome  CRISPR-Cas Systems  Humans  Open Reading Frames  Operon  Peptides  Protein Biosynthesis  Ribosomes  RNA, Messenger  Transcriptome  
De novo protein design enables the precise induction of RSV-neutralizing antibodies 期刊论文
, 2020, 卷号: 368, 期号: 6492
作者:  Sesterhenn F.;  Yang C.;  Bonet J.;  Cramer J.T.;  Wen X.;  Wang Y.;  Chiang C.-I.;  Abriata L.A.;  Kucharska I.;  Castoro G.;  Vollers S.S.;  Galloux M.;  Dheilly E.;  Rosset S.;  Corthésy P.;  Georgeon S.;  Villard M.;  Richard C.-A.;  Descamps D.;  Delgado T.;  Oricchio E.;  Rameix-Welti M.-A.;  Más V.;  Ervin S.;  Eléouët J.-F.;  Riffault S.;  Bates J.T.;  Julien J.-P.;  Li Y.;  Jardetzky T.;  Krey T.;  Correia B.E.
收藏  |  浏览/下载：43/0  |  提交时间：2020/07/28
algorithm  antibody  design  neutralization  protein  vaccine  Mus  Primates  Respiratory syncytial virus  Rice stripe virus  epitope  fusion protein  nanobody  neutralizing antibody  respiratory syncytial virus vaccine  biology  biosynthesis  chemistry  human  Human respiratory syncytial virus  immunology  procedures  protein conformation  protein engineering  protein motif  Amino Acid Motifs  Antibodies, Neutralizing  Computational Biology  Humans  Immunodominant Epitopes  Protein Conformation  Protein Engineering  Recombinant Fusion Proteins  Respiratory Syncytial Virus Vaccines  Respiratory Syncytial Virus, Human  Single-Domain Antibodies  
Metabolomics and mass spectrometry imaging reveal channeled de novo purine synthesis in cells 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者:  Pareek V.;  Tian H.;  Winograd N.;  Benkovic S.J.
收藏  |  浏览/下载：36/0  |  提交时间：2020/07/28
adenosine phosphate  guanosine phosphate  multienzyme complex  nucleotide  purine  purine  purine derivative  cell  experimental study  imaging method  mass spectrometry  metabolism  protein  Article  biochemistry  enzyme assay  gas cluster ion beam secondary ion mass spectrometry  image analysis  mass spectrometry  metabolomics  mitochondrion  molecular imaging  molecular probe  priority journal  purine synthesis  reaction analysis  single cell analysis  biosynthesis  fluorescence imaging  HeLa cell line  human  metabolism  metabolomics  procedures  secondary ion mass spectrometry  HeLa Cells  Humans  Metabolomics  Mitochondria  Multienzyme Complexes  Optical Imaging  Purines  Single-Cell Analysis  Spectrometry, Mass, Secondary Ion  
HEM1 deficiency disrupts mTORC2 and F-actin control in inherited immunodysregulatory disease 期刊论文
, 2020, 卷号: 369, 期号: 6500
作者:  Cook S.A.;  Comrie W.A.;  Poli M.C.;  Similuk M.;  Oler A.J.;  Faruqi A.J.;  Kuhns D.B.;  Yang S.;  Vargas-Hernández A.;  Carisey A.F.;  Fournier B.;  Anderson D.E.;  Price S.;  Smelkinson M.;  Abou Chahla W.;  Forbes L.R.;  Mace E.M.;  Cao T.N.;  Coban-Akdemir Z.H.;  Jhangiani S.N.;  Muzny D.M.;  Gibbs R.A.;  Lupski J.R.;  Orange J.S.;  Cuvelier G.D.E.;  Al Hassani M.;  Al Kaabi N.;  Al Yafei Z.;  Jyonouchi S.;  Raje N.;  Caldwell J.W.;  Huang Y.;  Burkhardt J.K.;  Latour S.;  Chen B.;  ElGhazali G.;  Rao V.K.;  Chinn I.K.;  Lenardo M.J.
收藏  |  浏览/下载：53/0  |  提交时间：2020/07/28
actin  adenosine diphosphate ribosylation factor 1  ARF1 protein, human  cytokine  mammalian target of rapamycin complex 2  membrane protein  NCKAP1L protein, human  WASF1 protein, human  WASF2 protein, human  WASF3 protein, human  Wiskott Aldrich syndrome protein  biosynthesis  CD4+ T lymphocyte  cell proliferation  chemistry  genetics  human  immune deficiency  immunology  lymphoproliferative disease  metabolism  pedigree  phosphorylation  physiology  Actins  ADP-Ribosylation Factor 1  CD4-Positive T-Lymphocytes  Cell Proliferation  Cytokines  Humans  Immunologic Deficiency Syndromes  Lymphoproliferative Disorders  Mechanistic Target of Rapamycin Complex 2  Membrane Proteins  Pedigree  Phosphorylation  Wiskott-Aldrich Syndrome Protein Family  
Structural basis for transcriptional start site control of HIV-1 RNA fate 期刊论文
, 2020, 卷号: 368, 期号: 6489
作者:  Brown J.D.;  Kharytonchyk S.;  Chaudry I.;  Iyer A.S.;  Carter H.;  Becker G.;  Desai Y.;  Glang L.;  Choi S.H.;  Singh K.;  Lopresti M.W.;  Orellana M.;  Rodriguez T.;  Oboh U.;  Hijji J.;  Ghinger F.G.;  Stewart K.;  Francis D.;  Edwards B.;  Chen P.;  Case D.A.;  Telesnitsky A.;  Summers M.F.
收藏  |  浏览/下载：41/0  |  提交时间：2020/07/28
capped RNA  initiation factor 4E  messenger RNA  virus RNA  capped RNA  guanosine  initiation factor 4E  messenger RNA  virus RNA  cell  chemical binding  deuterium  genome  human immunodeficiency virus  physiological response  RNA  Article  base pairing  deuteron nuclear magnetic resonance  dimerization  DNA helix  energy transfer  gene control  gene function  gene number  human  Human immunodeficiency virus 1  nonhuman  priority journal  promoter region  RNA probe  RNA structure  RNA transcription  virus replication  5' untranslated region  base pairing  chemistry  DNA base composition  gene expression regulation  genetics  Human immunodeficiency virus 1  metabolism  nuclear magnetic resonance  protein synthesis  transcription initiation site  Eukaryota  Human immunodeficiency virus 1  5' Untranslated Regions  Base Composition  Base Pairing  Eukaryotic Initiation Factor-4E  Gene Expression Regulation, Viral  Guanosine  HIV-1  Humans  Nuclear Magnetic Resonance, Biomolecular  Protein Biosynthesis  RNA Caps  RNA, Messenger  RNA, Viral  Transcription Initiation Site