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| Blaming climate change? How Indian mainstream media covered two extreme weather events in 2015 期刊论文
, 2020, 卷号: 63
作者: Painter J.; Osaka S.; Ettinger J.; Walton P.
  收藏 | 浏览/下载：9/0 | 提交时间：2020/07/28
climate change extreme event human activity maximum likelihood analysis weather Andhra Pradesh Chennai India Tamil Nadu |
| Influence of human activity on landslide susceptibility development in the Three Gorges area 期刊论文
Natural Hazards, 2020, 卷号: 104, 期号: 3
作者: Li Y.; Wang X.; Mao H.
收藏 | 浏览/下载：159/0 | 提交时间：2021/09/01
Convolutional neural network Human activity Landslide susceptibility Multiresolution segmentation |
| Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease 期刊论文
, 2020, 卷号: 368, 期号: 6497
作者: Dai W.; Zhang B.; Jiang X.-M.; Su H.; Li J.; Zhao Y.; Xie X.; Jin Z.; Peng J.; Liu F.; Li C.; Li Y.; Bai F.; Wang H.; Cheng X.; Cen X.; Hu S.; Yang X.; Wang J.; Liu X.; Xiao G.; Jiang H.; Rao Z.; Zhang L.-K.; Xu Y.; Yang H.; Liu H.
收藏 | 浏览/下载：36/0 | 提交时间：2020/07/28
aldehyde antimicrobial activity drug enzyme activity infectivity inhibitor reaction kinetics viral disease Coronavirus SARS coronavirus 3C-like proteinase, Coronavirus antivirus agent cysteine proteinase viral protein animal Betacoronavirus chemical structure chemistry Chlorocebus aethiops Coronavirus infection dog drug design drug effect enzyme active site enzymology female human male mouse pandemic preclinical study protein tertiary structure Sprague Dawley rat toxicity testing Vero cell line virus pneumonia Animals Antiviral Agents Betacoronavirus Catalytic Domain Chlorocebus aethiops Coronavirus Infections Cysteine Endopeptidases Dogs Drug Design Drug Evaluation, Preclinical Female Humans Male Mice Molecular Structure Pandemics Pneumonia, Viral Protein Structure, Tertiary Rats, Sprague-Dawley Toxicity Tests Vero Cells Viral Nonstructural Proteins |
| Computing cancer's weak spots 期刊论文
, 2020, 卷号: 368, 期号: 6496
作者: Khamsi R.
收藏 | 浏览/下载：36/0 | 提交时间：2020/07/28
ruxolitinib STAT3 protein antineoplastic agent transcription factor algorithm cancer computer simulation disease treatment drug development medicine Article cancer cell cancer radiotherapy enzyme inhibition gene activity gene expression regulation gene interaction gene mutation gene repression gene targeting human laboratory test malignant neoplasm molecular dynamics nonhuman oncologist priority journal RNA sequencing algorithm genetics mutation neoplasm personalized medicine procedures systems biology Algorithms Antineoplastic Agents Humans Mutation Neoplasms Precision Medicine Systems Biology Transcription Factors |
| Microenvironment mapping via Dexter energy transfer on immune cells 期刊论文
, 2020, 卷号: 367, 期号: 6482
作者: Geri J.B.; Oakley J.V.; Reyes-Robles T.; Wang T.; McCarver S.J.; White C.H.; Rodriguez-Rivera F.P.; Parker D.L.; Hett E.C.; Fadeyi O.O.; Oslund R.C.; MacMillan D.W.C.
收藏 | 浏览/下载：33/0 | 提交时间：2020/07/28
antibody conjugate carbene programmed death 1 ligand 1 methane programmed death 1 ligand 1 antibody catalysis catalyst cell component detection method enzyme enzyme activity protein antigen binding Article cell membrane energy transfer human immunocompetent cell immunological synapse lymphocyte photocatalysis priority journal protein analysis protein protein interaction tumor microenvironment catalysis chemistry energy transfer Jurkat cell line metabolism photochemistry procedures radiation response ultraviolet radiation B7-H1 Antigen Catalysis Cell Membrane Cellular Microenvironment Energy Transfer Humans Jurkat Cells Lymphocytes Methane Photochemical Processes Protein Interaction Mapping Protein Interaction Maps Ultraviolet Rays |
| Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者: Walton R.T.; Christie K.A.; Whittaker M.N.; Kleinstiver B.P.
收藏 | 浏览/下载：20/0 | 提交时间：2020/07/28
adenine adenosine CRISPR associated endonuclease Cas9 cytosine guanosine SpG protein SpRY nuclease thymine unclassified drug Cas9 endonuclease Streptococcus pyogenes bacterium enzyme activity genetic engineering genetic variation genome Article CRISPR-CAS9 system DNA sequence enzyme activity gene editing gene targeting genetic variability human mutagenesis nonhuman priority journal protein engineering protein motif protein structure protospacer adjacent motif Streptococcus pyogenes chemistry CRISPR Cas system enzyme specificity gene editing gene targeting genetic predisposition genetics HEK293 cell line procedures protein domain Streptococcus pyogenes CRISPR-Associated Protein 9 CRISPR-Cas Systems Gene Editing Gene Targeting Genetic Predisposition to Disease HEK293 Cells Humans Mutagenesis Protein Domains Substrate Specificity |
| Exotic pine forestation shifts carbon accumulation to litter detritus and wood along a broad precipitation gradient in Patagonia, Argentina 期刊论文
, 2020, 卷号: 460
作者: Araujo P.I.; Austin A.T.
收藏 | 浏览/下载：18/0 | 提交时间：2020/07/28
Biodiversity Carbon dioxide Global warming Land use Reforestation Afforestation Carbon sequestration Land-use change Litter decomposition Pinus ponderosa Precipitation gradients Semi-arid ecosystems Temperate forests Ecosystems carbon carbon emission carbon sequestration coniferous forest decomposition environmental gradient human activity invasive species land use change litter precipitation assessment semiarid region temperate forest terrestrial ecosystem wood Biodiversity Carbon Dioxide Ecosystems Land Use Pinus Ponderosa Reforestation Argentina Patagonia Coniferophyta Pinus ponderosa |
| Cascading social-ecological costs and benefits triggered by a recovering keystone predator 期刊论文
, 2020, 卷号: 368, 期号: 6496
作者: Gregr E.J.; Christensen V.; Nichol L.; Martone R.G.; Markel R.W.; Watson J.C.; Harley C.D.G.; Pakhomov E.A.; Shurin J.B.; Chan K.M.A.
收藏 | 浏览/下载：10/0 | 提交时间：2020/07/28
biomass carbon sequestration coastal zone ecosystem function ecosystem service finfish grazing pressure human activity kelp forest keystone species shellfish fishery trophic cascade Pacific Ocean Pacific Ocean (North) Enhydra Invertebrata animal biomass carbon sequestration ecosystem restoration fishery food chain growth, development and aging herbivory human activities kelp otter predation shellfish Animals Biomass Carbon Sequestration Environmental Restoration and Remediation Fisheries Food Chain Herbivory Human Activities Kelp Otters Predatory Behavior Shellfish |
| Meet the psychobiome 期刊论文
, 2020, 卷号: 368, 期号: 6491
作者: Pennisi E.
收藏 | 浏览/下载：24/0 | 提交时间：2020/07/28
4 aminobutyric acid antibiotic agent dopamine kynurenine probiotic agent queuine serotonin psychotropic agent bacterium biome drug microbial activity nervous system disorder allergy Alzheimer disease antimicrobial therapy anxiety disorder archaeon Article autism bacterium culture Bacteroides blood brain barrier blood vessel brain disease clinical effectiveness constipation depression drug use enteroendocrine cell enteropathy entrepreneurship epilepsy fecal microbiota transplantation feces analysis Food and Drug Administration fungus genomics human insomnia intestine flora irritable colon mammal cell microbiology microbiome nerve cell nervous system nervous system development neurologic disease nonhuman obesity pain threshold Parkinson disease physician priority journal psychobiome psychological aspect psychological well-being schizophrenia scientist United States vagus nerve virus animal bacterium chemistry drug development intestine flora isolation and purification metabolism microbiology physiology procedures Animals Bacteria Drug Discovery Gastrointestinal Microbiome Humans Nervous System Diseases Psychotropic Drugs |
| Structural basis of Gs and Gi recognition by the human glucagon receptor 期刊论文
, 2020, 卷号: 367, 期号: 6484
作者: Qiao A.; Han S.; Li X.; Li Z.; Zhao P.; Dai A.; Chang R.; Tai L.; Tan Q.; Chu X.; Ma L.; Thorsen T.S.; Reedtz-Runge S.; Yang D.; Wang M.-W.; Sexton P.M.; Wootten D.; Sun F.; Zhao Q.; Wu B.
收藏 | 浏览/下载：36/0 | 提交时间：2020/07/28
cyclic AMP glucagon glucagon receptor inhibitory guanine nucleotide binding protein stimulatory guanine nucleotide binding protein glucagon receptor inhibitory guanine nucleotide binding protein protein binding stimulatory guanine nucleotide binding protein chemical binding enzyme activity gene expression mutagenicity protein alpha helix Article binding affinity carboxy terminal sequence conformational transition cryoelectron microscopy human molecular recognition mutagenesis priority journal protein binding protein function protein protein interaction protein structure signal transduction binding site chemistry metabolism molecular model protein conformation ultrastructure Binding Sites Cryoelectron Microscopy Glucagon GTP-Binding Protein alpha Subunits, Gi-Go GTP-Binding Protein alpha Subunits, Gs Humans Models, Molecular Protein Binding Protein Conformation Protein Conformation, alpha-Helical Receptors, Glucagon Signal Transduction |
