|
已选(0)清除
条数/页： 排序方式： |
| T cells with dysfunctional mitochondria induce multimorbidity and premature senescence 期刊论文
, 2020, 卷号: 368, 期号: 6497
作者: Desdín-Micó G.; Soto-Heredero G.; Aranda J.F.; Oller J.; Carrasco E.; Gabandé-Rodríguez E.; Blanco E.M.; Alfranca A.; Cussó L.; Desco M.; Ibañez B.; Gortazar A.R.; Fernández-Marcos P.; Navarro M.N.; Hernaez B.; Alcamí A.; Baixauli F.; Mittelbrunn M.
  收藏 | 浏览/下载：36/0 | 提交时间：2020/07/28
cardiovascular disease enzyme activity gene expression metabolism mitochondrial DNA morbidity senescence tumor Mus DNA binding protein mitochondrial protein mitochondrial transcription factor A nicotinamide adenine dinucleotide transcription factor tumor necrosis factor animal cytokine release syndrome female fitness gene deletion genetics immunology inflammation longevity male metabolism mitochondrion mouse multiple chronic conditions mutant mouse strain premature aging T lymphocyte ultrastructure Aging, Premature Animals Cytokine Release Syndrome DNA-Binding Proteins Female Gene Deletion Inflammation Longevity Male Mice Mice, Mutant Strains Mitochondria Mitochondrial Proteins Multimorbidity NAD Physical Fitness T-Lymphocytes Transcription Factors Tumor Necrosis Factor-alpha |
| Transcription polymerase-catalyzed emergence of novel RNA replicons 期刊论文
, 2020, 卷号: 368, 期号: 6487
作者: Jain N.; Blauch L.R.; Szymanski M.R.; Das R.; Tang S.K.Y.; Yin Y.W.; Fire A.Z.
收藏 | 浏览/下载：31/0 | 提交时间：2020/07/28
cell component enzyme enzyme activity genetic analysis RNA article bacteriophage catalysis DNA replication origin heredity in vitro study nonhuman plant seed replicon RNA replication synthesis transcription initiation biocatalysis biosynthesis genetic transcription metabolism Animalia Hepatitis delta virus Viroids bacteriophage T7 RNA polymerase DNA directed RNA polymerase RNA viral protein Biocatalysis DNA-Directed RNA Polymerases Replicon RNA Transcription, Genetic Viral Proteins |
| Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者: Walton R.T.; Christie K.A.; Whittaker M.N.; Kleinstiver B.P.
收藏 | 浏览/下载：18/0 | 提交时间：2020/07/28
adenine adenosine CRISPR associated endonuclease Cas9 cytosine guanosine SpG protein SpRY nuclease thymine unclassified drug Cas9 endonuclease Streptococcus pyogenes bacterium enzyme activity genetic engineering genetic variation genome Article CRISPR-CAS9 system DNA sequence enzyme activity gene editing gene targeting genetic variability human mutagenesis nonhuman priority journal protein engineering protein motif protein structure protospacer adjacent motif Streptococcus pyogenes chemistry CRISPR Cas system enzyme specificity gene editing gene targeting genetic predisposition genetics HEK293 cell line procedures protein domain Streptococcus pyogenes CRISPR-Associated Protein 9 CRISPR-Cas Systems Gene Editing Gene Targeting Genetic Predisposition to Disease HEK293 Cells Humans Mutagenesis Protein Domains Substrate Specificity |
| Very fast CRISPR on demand 期刊论文
, 2020, 卷号: 368, 期号: 6496
作者: Liu Y.; Zou R.S.; He S.; Nihongaki Y.; Li X.; Razavi S.; Wu B.; Ha T.
收藏 | 浏览/下载：20/0 | 提交时间：2020/07/28
Cas9 endonuclease Streptococcus pyogenes double strand break repair protein MRE11 H2AX protein, human histone MRE11 protein, human CRISPR Cas system DNA cleavage DNA repair double stranded DNA break fluorescence imaging gene editing genetics HEK293 cell line human light metabolism phosphorylation procedures radiation response single cell analysis CRISPR-Associated Protein 9 CRISPR-Cas Systems DNA Breaks, Double-Stranded DNA Cleavage DNA Repair Gene Editing HEK293 Cells Histones Humans Light MRE11 Homologue Protein Optical Imaging Phosphorylation Single-Cell Analysis |
| Insights into human genetic variation and population history from 929 diverse genomes 期刊论文
, 2020, 卷号: 367, 期号: 6484
作者: Bergström A.; McCarthy S.A.; Hui R.; Almarri M.A.; Ayub Q.; Danecek P.; Chen Y.; Felkel S.; Hallast P.; Kamm J.; Blanché H.; Deleuze J.-F.; Cann H.; Mallick S.; Reich D.; Sandhu M.S.; Skoglund P.; Scally A.; Xue Y.; Durbin R.; Tyler-Smith C.
收藏 | 浏览/下载：40/0 | 提交时间：2020/07/28
ecozone effective population size genetic variation genome geographical region hunter-gatherer Neanderthal population size Africa article genetic variation Homo denisovan human hunter-gatherer nonhuman population size ancestry group animal Asia copy number variation genetics haplotype hominid Homo neanderthalensis human genome indel mutation Pacific islands phylogeny population density population genetics single nucleotide polymorphism Western Hemisphere whole genome sequencing Africa Central America North America South America Africa Americas Animals Asia Continental Population Groups DNA Copy Number Variations Genetic Variation Genetics, Population Genome, Human Haplotypes Hominidae Humans INDEL Mutation Neanderthals Oceania Phylogeny Polymorphism, Single Nucleotide Population Density Whole Genome Sequencing |
| Mechanisms generating cancer genome complexity from a single cell division error 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者: Umbreit N.T.; Zhang C.-Z.; Lynch L.D.; Blaine L.J.; Cheng A.M.; Tourdot R.; Sun L.; Almubarak H.F.; Judge K.; Mitchell T.J.; Spektor A.; Pellman D.
收藏 | 浏览/下载：10/0 | 提交时间：2020/07/28
myosin adenosine triphosphatase cancer chromosome detection method DNA error correction gene expression genome genomics mutation Article cell division cellular, subcellular and molecular biological phenomena and functions chromosome breakage chromosome breakage fusion bridge chromosome bridge formation chromosomes and chromosomal phenomena chromothripsis DNA damage DNA replication human interphase malignant neoplasm micronucleus mitosis oncogenomics priority journal single cell division error |
| Translating preclinical models to humans 期刊论文
, 2020, 卷号: 367, 期号: 6479
作者: Brubaker D.K.; Lauffenburger D.A.
收藏 | 浏览/下载：31/0 | 提交时间：2020/07/28
detection method model Article bioengineering biomedicine cell differentiation cell proliferation computer model conceptual framework DNA sequence drug development epithelium cell gene expression profiling high throughput sequencing human machine learning molecular dynamics nonhuman phenotype priority journal proteomics RNA sequence sex difference signal transduction T lymphocyte transcription regulation transcriptomics translational research |
| The structure of human CST reveals a decameric assembly bound to telomeric DNA 期刊论文
, 2020, 卷号: 368, 期号: 6495
作者: Lim C.J.; Barbour A.T.; Zaug A.J.; Goodrich K.J.; McKay A.E.; Wuttke D.S.; Cech T.R.
收藏 | 浏览/下载：13/0 | 提交时间：2020/07/28
carboxylic acid chemical binding DNA genome microscopy protein yeast |
| The evolutionary dynamics and fitness landscape of clonal hematopoiesis 期刊论文
, 2020, 卷号: 367, 期号: 6485
作者: Watson C.J.; Papula A.L.; Poon G.Y.P.; Wong W.H.; Young A.L.; Druley T.E.; Fisher D.S.; Blundell J.R.
收藏 | 浏览/下载：21/0 | 提交时间：2020/07/28
DNA methyltransferase 3A blood cancer evolutionary biology fitness gene expression genetic drift hematology mutation pathogenicity acute myeloid leukemia age distribution allele Article cancer risk cell expansion cell population clonal hematopoiesis epigenetics gene mutation genetic variability hematological parameters hematopoiesis hematopoietic stem cell human molecular evolution mutational analysis nonhuman priority journal single nucleotide polymorphism somatic mutation stem cell self-renewal |
| Structure of nucleosome-bound human BAF complex 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者: He S.; Wu Z.; Tian Y.; Yu Z.; Yu J.; Wang X.; Li J.; Liu B.; Xu Y.
收藏 | 浏览/下载：31/0 | 提交时间：2020/07/28
actin related protein adenosine triphosphatase BRG1 BRM associated factor DNA multiprotein complex protein SWI retinoblastoma binding protein 2 SMARCC protein SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily B member 1 transcription factor transcription factor SNF unclassified drug cancer enzyme activity gene expression hydrolysis mutation protein alpha helix Article carboxy terminal sequence cell interaction cryoelectron microscopy disease association human malignant neoplasm molecular recognition mutation nucleosome priority journal protein function protein hydrolysis protein structure structure analysis Mammalia |
